1. Articles from Antonio Morilla-Grasa

    1-5 of 5
    1. Quantitative assessment of macular and circumpapillary retinal vessel density across all stages of Leber hereditary optic neuropathy using swept source optical coherence tomography angiography

      Quantitative assessment of macular and circumpapillary retinal vessel density across all stages of Leber hereditary optic neuropathy using swept source optical coherence tomography angiography

      Purpose: To investigate the macular and circumpapillary retinal microvasculature across all stages of Leber hereditary optic neuropathy (LHON) using swept source optical coherence tomography angiography (OCTA). Methods: This prospective, multicentre, cross-sectional, observational study analysed a total of 119 eyes of 60 patients with molecularly confirmed LHON across all stages and 120 eyes of 60 control subjects. Optical coherence tomography angiography maps centred on the fovea and optic disc were obtained to measure vessel densities (VDs) in the macular superficial (SCP) and deep (DCP) capillary plexuses, and the radial peripapillary capillary plexus (RPCP) respectively. Results: In asymptomatic eyes, only the SCP ...

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    2. Diagnostic Accuracy and Detection Rate of Glaucoma Screening with Optic Disk Photos, Optical Coherence Tomography Images, and Telemedicine

      Diagnostic Accuracy and Detection Rate of Glaucoma Screening with Optic Disk Photos, Optical Coherence Tomography Images, and Telemedicine

      Purpose: The aim of this study was to evaluate the diagnostic accuracy of optical coherence tomography (OCT) and retinography in the detection of glaucoma through a telemedicine program. Methods: A population-based sample of 4113 persons was randomly selected. The screening examination included a fundus photograph and OCT images. Images were evaluated on a deferred basis. All participants were then invited to a complete glaucoma examination, including gonioscopy, visual field, and dilated fundus examination. The detection rate, sensitivity, specificity, and positive and negative predictive values were calculated. Results: We screened 1006 persons. Of these, 201 (19.9%) were classified as glaucoma ...

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    3. Interobserver and Intertest Agreement in Telemedicine Glaucoma Screening with Optic Disk Photos and Optical Coherence Tomography

      Interobserver and Intertest Agreement in Telemedicine Glaucoma Screening with Optic Disk Photos and Optical Coherence Tomography

      Purpose : To evaluate interobserver and intertest agreement between optical coherence tomography (OCT) and retinography in the detection of glaucoma through a telemedicine program. Methods : A stratified sample of 4113 individuals was randomly selected, and those who accepted underwent examination including visual acuity, intraocular pressure (IOP), non-mydriatic retinography, and imaging using a portable OCT device. Participants' data and images were uploaded and assessed by 16 ophthalmologists on a deferred basis. Two independent evaluations were performed for all participants. Agreement between methods was assessed using the kappa coefficient and the prevalence-adjusted bias-adjusted kappa (PABAK). We analyzed potential factors possibly influencing the level ...

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    4. Agreement Among Spectral-Domain Optical Coherence Tomography, Standard Automated Perimetry, and Stereophotography in the Detection of Glaucoma Progression

      Agreement Among Spectral-Domain Optical Coherence Tomography, Standard Automated Perimetry, and Stereophotography in the Detection of Glaucoma Progression

      Purpose. The purpose of this study was to evaluate the agreement among spectral-domain optical coherence tomography, standard automated perimetry (SAP), and optic disc stereo photography in the detection of glaucomatous progression. Methods. This was an observational cohort study enrolling 246 eyes (148 patients) followed for an average of 31.8 ± 9 months. Images were obtained every 6 to 12 months with optical coherence tomography (OCT), visual field test, and optic disc stereo photography. Progression was determined with OCT using guided progression analysis (GPA) software, in perimetry with Humphrey field analyzer GPA, and by masked assessment of stereo photograph series. Agreement ...

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    5. Agreement between SD-OCT, Standard Automated Perimetry and Stereophotography in the detection of glaucomatous progression

      Agreement between SD-OCT, Standard Automated Perimetry and Stereophotography in the detection of glaucomatous progression

      PURPOSE. To evaluate the agreement between spectral domain optical coherence tomography, standard automated perimetry and optic disc stereophotos in the detection of glaucomatous progression. METHODS. Observational cohort study enrolling 246 eyes (148 patients) followed-up for an average of 31.8 ± 9 months. Images were obtained every 6-12 months with optical coherence tomography, visual field and optic disc stereophotos. Progression was determined in OCT with the Glaucoma Progression Analysis software (GPA), in perimetry with the Humphrey Field Analyzer GPA and by masked assessment of stereophotographs series. Agreement among methods was reported using the Kappa coefficient (K), PABAK (prevalence-adjusted bias-adjusted kappa), Gwet ...

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    1-5 of 5
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