1. Articles from Nicolás Cuenca

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    1. Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease

      Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease

      Parkinson disease (PD) is a progressive disorder characterized by dopaminergic neurodegeneration in the brain. The development of parkinsonism is preceded by a long prodromal phase, and >50% of dopaminergic neurons can be lost from the substantia nigra by the time of the initial diagnosis. Therefore, validation of in vivo imaging biomarkers for early diagnosis and monitoring of disease progression is essential for future therapeutic developments. PET and single-photon emission CT targeting the presynaptic terminals of dopaminergic neurons can be used for early diagnosis by detecting axonal degeneration in the striatum. However, these techniques poorly differentiate atypical parkinsonian syndromes from PD ...

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    2. Optical Coherence Tomography Angiography in Diabetic Patients: A Systematic Review

      Optical Coherence Tomography Angiography in Diabetic Patients: A Systematic Review

      Background: Diabetic retinopathy (DR) is the leading cause of legal blindness in the working population in developed countries. Optical coherence tomography (OCT) angiography (OCTA) has risen as an essential tool in the diagnosis and control of diabetic patients, with and without DR, allowing visualisation of the retinal and choroidal microvasculature, their qualitative and quantitative changes, the progression of vascular disease, quantification of ischaemic areas, and the detection of preclinical changes. The aim of this article is to analyse the current applications of OCTA and provide an updated overview of them in the evaluation of DR. Methods: A systematic literature search ...

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    3. Characterization of the Canine Retinal Vasculature With Optical Coherence Tomography Angiography: Comparisons With Histology and Fluorescein Angiography

      Characterization of the Canine Retinal Vasculature With Optical Coherence Tomography Angiography: Comparisons With Histology and Fluorescein Angiography

      Purpose: To present a methodology for quantification of the canine retinal vasculature imaged by optical coherence tomography angiography (OCTA) and validate this approach by comparison with fluorescein angiography (FA) and confocal imaging of retinal wholemounts labelled by immunohistochemistry (IHC). Methods: Six normal adult dogs underwent retinal OCTA imaging in both eyes. The images extracted from the different microvascular plexuses at eight retinal locations spanning the central and mid-peripheral fundus were analyzed using the AngioTool software. FA was performed in one eye and was compared to the OCTA images. Six eyes from three dogs were processed by IHC to examine the ...

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    4. Phenotypic Differences in a PRPH2 Mutation in Members of the Same Family Assessed with OCT and OCTA

      Phenotypic Differences in a PRPH2 Mutation in Members of the Same Family Assessed with OCT and OCTA

      Choroidal dystrophies comprise a group of chorioretinal degenerations. However, the different findings observed among these patients make it difficult to establish a correct clinical diagnosis. The objective of this study was to characterize new clinical findings by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in these patients. Four family members with a PRPH2 gene mutation (p.Arg195Leu) were included. OCT was performed at the macula, and the thickness of the outer and inner retina, total retina, and choroid was measured. The features of the vascular network were analyzed by OCTA. Patients showed a decreased outer nuclear layer ...

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    5. Deep Learning Estimation of 10-2 and 24-2 Visual Field Metrics based on Thickness Maps from Macula Optical Coherence Tomography

      Deep Learning Estimation of 10-2 and 24-2 Visual Field Metrics based on Thickness Maps from Macula Optical Coherence Tomography

      Choroidal dystrophies comprise a group of chorioretinal degenerations. However, the different findings observed among these patients make it difficult to establish a correct clinical diagnosis. The objective of this study was to characterize new clinical findings by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in these patients. Four family members with a PRPH2 gene mutation (p.Arg195Leu) were included. OCT was performed at the macula, and the thickness of the outer and inner retina, total retina, and choroid was measured. The features of the vascular network were analyzed by OCTA. Patients showed a decreased outer nuclear layer ...

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    6. Cellular Characterization of Optical Coherence Tomography and Outer Retinal Bands Using Specific Immunohistochemistry Markers and Clinical Implications

      Cellular Characterization of Optical Coherence Tomography and Outer Retinal Bands Using Specific Immunohistochemistry Markers and Clinical Implications

      Purpose Optical coherence tomography has been a technological breakthrough in the diagnosis, treatment, and follow-up of many ocular diseases, especially retinal and neuro-ophthalmologic pathologic conditions. Until now, several controversies have arisen over the specific cell types that the bands observed in the OCT represent, especially over the 4 outer retinal bands. Design To correlate the 4 outer hyperreflective bands observed in the OCT with the histologic structures using human retinal sections and immunocytochemistry at the fovea level. Participants Eyes from human donors. Methods Vertical cryosections of human retinas were immunostained with antibodies specific for cones photoreceptors, bipolar cells, mitochondria, M ...

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    7. Long time remodeling during retinal degeneration evaluated by Optical Coherence Tomography, immunocytochemistry and Fundus Autofluorescence

      Long time remodeling during retinal degeneration evaluated by Optical Coherence Tomography, immunocytochemistry and Fundus Autofluorescence

      Purpose To characterize the relationship between fundus autofluorescence (FAF), Optical Coherence Tomography (OCT) and immunohistochemistry over the course of chronic retinal degeneration in the P23H rat. Methods Homozygous albino P23H rats, Sprague-Dawley (SD) rats and pigmented Long Evans (LE) rats were used. A Spectralis HRA OCT system was used for scanning laser ophthalmoscopy (SLO) imaging OCT and angiography. To determine FAF, fluorescence was excited using diode laser at 488 nm. A fast retina map OCT was performed using the optic nerve as a landmark. Immunohistochemistry (IHC) was performed to correlate with the findings of OCT and FAF changes. Results During ...

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    8. Correlation between SD-OCT, immunocytochemistry and functional findings in an animal model of retinal degeneration

      Correlation between SD-OCT, immunocytochemistry and functional findings in an animal model of retinal degeneration

      Purpose: The P23H rhodopsin mutation is an autosomal dominant cause of retinitis pigmentosa (RP). The degeneration can be tracked using different anatomical and functional methods. In our case, we evaluated the anatomical changes using Spectral-Domain Optical Coherence Tomography (SD-OCT) and correlated the findings with retinal thickness values determined by immunocytochemistry.Methods: Pigmented rats heterozygous for the P23H mutation, with ages between P18 and P180 were studied. Function was assessed by means of optomotor testing and ERGs. Retinal thicknesses measurements, autofluorescence and fluorescein angiography were performed using Spectralis OCT. Retinas were studied by means of immunohistochemistry. Results: Between P30 and P180 ...

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    1-8 of 8
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    1. (1 articles) University of Alberta
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    Correlation between SD-OCT, immunocytochemistry and functional findings in an animal model of retinal degeneration Long time remodeling during retinal degeneration evaluated by Optical Coherence Tomography, immunocytochemistry and Fundus Autofluorescence Cellular Characterization of Optical Coherence Tomography and Outer Retinal Bands Using Specific Immunohistochemistry Markers and Clinical Implications Deep Learning Estimation of 10-2 and 24-2 Visual Field Metrics based on Thickness Maps from Macula Optical Coherence Tomography Phenotypic Differences in a PRPH2 Mutation in Members of the Same Family Assessed with OCT and OCTA Characterization of the Canine Retinal Vasculature With Optical Coherence Tomography Angiography: Comparisons With Histology and Fluorescein Angiography Optical Coherence Tomography Angiography in Diabetic Patients: A Systematic Review Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease New insights from non-invasive imaging: from prospection of skin photodamages to training with mobile application Short-sighted woman assumes debilitating headaches mean she needs new glasses but discovers she has multiple sclerosis Shedding light on the impact of microplastics on lentil seedling growth Comparison of radial peripapillary capillary density results of individuals with and without Helicobacter pylori infection