1. Articles from Kazuhisa Sugiyama

    1-18 of 18
    1. Clinical Evaluation of Electrolysis for Reis-Bücklers Corneal Dystrophies and In Vivo Histological Analysis Using Anterior Segment Optical Coherence Tomography

      Clinical Evaluation of Electrolysis for Reis-Bücklers Corneal Dystrophies and In Vivo Histological Analysis Using Anterior Segment Optical Coherence Tomography

      Purpose: To report the effectiveness and clinical outcomes of corneal electrolysis for Reis-Bücklers corneal dystrophies (RBCDs) and provide in vivo histological analysis using anterior segment optical coherence tomography (AS-OCT). Methods: A total of 7 patients with RBCD (2 male patients, 5 female patients; mean age, 50.0 years) from 3 pedigrees were enrolled in this prospective study. All patients underwent corneal electrolysis for decreased visual acuity or blurred vision. Changes in visual acuity, refraction, and corneal thickness were evaluated 1 month after electrolysis and statistically analyzed. Changes observed in AS-OCT images before and after electrolysis were qualitatively and quantitatively ...

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    2. In vivo Imaging of Reis–Bücklers and Thiel–Behnke Corneal Dystrophies Using Anterior Segment Optical Coherence Tomography

      In vivo Imaging of Reis–Bücklers and Thiel–Behnke Corneal Dystrophies Using Anterior Segment Optical Coherence Tomography

      Purpose: To investigate in vivo corneal changes of genetically confirmed Reis–Bücklers corneal dystrophy (RBCD) and Thiel–Behnke corneal dystrophy (TBCD) using anterior segment optical coherence tomography (AS-OCT). Design: A single-center, prospective, comparative case series. Methods: Seven patients from 3 pedigrees (3 males, 4 females) with RBCD [Arg124Leu (R124L) heterozygous missense mutation of human transforming growth factor beta-induced ( TGFBI ) gene] and 4 patients from 3 pedigrees (3 males, 1 female) with TBCD [Arg555Gln (R555Q) heterozygous missense mutation of TGFBI gene] were examined. Six patients with RBCD and three patients with TBCD exhibited recurrence after corneal surgery including penetrating keratoplasty ...

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    3. Ability of Macular Inner Retinal Layer Thickness Asymmetry Evaluated by Optical Coherence Tomography to Detect Preperimetric Glaucoma

      Ability of Macular Inner Retinal Layer Thickness Asymmetry Evaluated by Optical Coherence Tomography to Detect Preperimetric Glaucoma

      Purpose : We assessed the ability to detect preperimetric glaucoma (PPG) based on asymmetry in the thickness of the macular inner retinal layers measured by spectral-domain optical coherence tomography. Methods : We studied 45 normal eyes and 50 PPG eyes retrospectively. Three-dimensional optical coherence tomography macular area scans were used to obtain the thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer/inner plexiform layer (GCL/IPL), and ganglion cell complex (GCC). We calculated the thickness differences between the upper and lower macular hemispheres for the corresponding superpixels, then evaluated the mean absolute value of the thickness differences and the ...

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    4. Influence of Clinical Factors and Magnification Correction on Normal Thickness Profiles of Macular Retinal Layers Using Optical Coherence Tomography

      Influence of Clinical Factors and Magnification Correction on Normal Thickness Profiles of Macular Retinal Layers Using Optical Coherence Tomography

      Purpose To identify the factors which significantly contribute to the thickness variabilities in macular retinal layers measured by optical coherence tomography with or without magnification correction of analytical areas in normal subjects. Methods The thickness of retinal layers {retinal nerve fiber layer (RNFL), ganglion cell layer plus inner plexiform layer (GCLIPL), RNFL plus GCLIPL (ganglion cell complex, GCC), total retina, total retina minus GCC (outer retina)} were measured by macular scans (RS-3000, NIDEK) in 202 eyes of 202 normal Asian subjects aged 20 to 60 years. The analytical areas were defined by three concentric circles (1-, 3- and 6-mm nominal ...

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    5. Influences of the inner retinal sublayers and analytical areas in macular scans by spectral domain OCT on the diagnostic ability of early glaucoma

      Influences of the inner retinal sublayers and analytical areas in macular scans by spectral domain OCT on the diagnostic ability of early glaucoma

      Purpose: To investigate the influences of the inner retinal sublayers and analytical areas in macular scans by spectral domain optical coherence tomography (OCT) on the diagnostic ability of early glaucoma. Methods: Sixty-four early (including 24 pre-perimetric) glaucomatous and 40 normal eyes underwent macular and peripapillary retinal nerve fiber layer (pRNFL) scans (3D-OCT-2000, Topcon). The area under the receiver operating characteristics (AUC) for glaucoma diagnosis was determined from the average thickness of the total 100 grids (6x6 mm), the central 44 grids (3.6x4.8 mm) and the peripheral 56 grids (outside of the 44 grids) and for each macular sublayer ...

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    6. In Vivo Imaging of Radial Keratoneuritis in Patients with Acanthamoeba keratitis by Anterior-Segment Optical Coherence Tomography

      In Vivo Imaging of Radial Keratoneuritis in Patients with Acanthamoeba keratitis by Anterior-Segment Optical Coherence Tomography

      Purpose To investigate in vivo corneal changes of radial keratoneuritis in early-stage Acanthamoeba keratitis (AK) using anterior-segment optical coherence tomography (AS-OCT). Design Single-center, prospective clinical study. Participants Four eyes (4 patients with a mean age of 28.5 years) with early-stage AK showing radial keratoneuritis were included in this study. Definitive diagnosis was made by confirmation of AK cysts using in vivo confocal microscopy and culture. Methods Anterior-segment OCT examination was performed on the initial visit and at follow-up visits paying special attention to radial keratoneuritis. Main Outcome Measures Selected AS-OCT images of the cornea were evaluated qualitatively for the ...

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    7. OCT evaluation of neuroprotective effects of tafluprost on retinal injury after intravitreal injection of endothelin-1 in the rat eye

      OCT evaluation of neuroprotective effects of tafluprost on retinal injury after intravitreal injection of endothelin-1 in the rat eye

      Purpose: To determine whether optical coherence tomography (OCT) is a useful technique to monitor retinal damage and to evaluate the neuroprotective effect of topical tafluprost in a rat model of intravitreal endothelin-1 (ET-1) injection. Methods: A single intravitreal injection of ET-1 (0.2-200 pmol/eye) was performed in one eye. OCT imaging was performed until 2 weeks after ET-1 injection. Subsequently, an intravitreal injection of ET-1 (20 pmol/eye) was performed in one eye of each rat, which was followed by topical instillation of tafluprost or saline once daily for 4 weeks. OCT imaging was performed until 4 weeks after ...

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    8. Circle and Grid-wise Analyses of Peripapillary Nerve Fiber Layers by Spectral Domain Optical Coherence Tomography in Early Stage Glaucoma

      Circle and Grid-wise Analyses of Peripapillary Nerve Fiber Layers by Spectral Domain Optical Coherence Tomography in Early Stage Glaucoma

      PURPOSE. To study diagnostic performances of circle and grid-wise analyses of peripapillary retinal nerve fiber layer thickness (RNFLT) using spectral domain optical coherence tomography (SD-OCT) in early stage glaucoma. METHODS. Eighty-nine open-angle glaucoma (OAG) eyes (mean deviation, -2.5 ± 1.8 dB) and 89 age-matched normal eyes were studied. Peripapillary RNFLT was analyzed using SD-OCT raster scan in a 6.0 × 6.0 mm area. Averaged RNFLT was calculated over 0.1 × 0.1, 0.21 × 0.21, or 0.42 × 0.42 mm grids in the peripapillary area (grid method), or arcuate sector areas between 2.8 and 4 ...

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    9. Reproducibility of Thickness Measurements of Macular Inner Retinal Layers Using SD-OCT with or without Correction of Ocular Rotation

      Reproducibility of Thickness Measurements of Macular Inner Retinal Layers Using SD-OCT with or without Correction of Ocular Rotation

      Purpose. To evaluate the inter-visit reproducibility of spectral-domain optical coherence tomography (SD-OCT) measurement of the macular retinal nerve fiber layer thickness (mRNFLT), combined ganglion cell layer and inner plexiform layer (GCL+IPL) thickness, and ganglion cell complex (GCC) thicknesses (sum of mRNFLT and GCL+IPL thicknesses) compared with that of circumpapillary RNFLT (cpRNFLT) and the effect of ocular rotation on reproducibility. Methods. SD-OCT imaging was performed twice on different days in one eye of 58 normal subjects and 73 glaucoma patients. The reproducibility was evaluated for the entire 4.8 mm x 4.8 mm macular area and sub-areas (upper ...

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    10. Effect of Cataract and Its Removal on Ganglion Cell Complex Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness Measurements by Fourier-Domain Optical Coherence Tomograph

      Effect of Cataract and Its Removal on Ganglion Cell Complex Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness Measurements by Fourier-Domain Optical Coherence Tomograph

      Purpose: To examine the effect of cataract on signal strength index (SSI) and thickness measurements of the ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (pRNFL) with the RTVue-100 Fourier-domain optical coherence tomography device. Method: GCC and pRNFL measurements were obtained preoperatively in 53 eyes of 53 patients, including 13 glaucoma patients and measurements were repeated postoperatively. Cataract degree was graded by the Lens Opacities Classification System III. Factors associated with segmentation error and with changes in SSI or average thickness of GCC and pRNFL were determined. Results: The prevalence and proportion of segmentation error were higher in ...

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      Mentions: Optovue
    11. Relationship between optic disc ovality and horizontal disc tilt in normal young subjects

      Relationship between optic disc ovality and horizontal disc tilt in normal young subjects

      Purpose To investigate the relationship between optic disc ovality and horizontal disc tilt. Methods The ovality index (the ratio of minimum to maximum disc diameter), horizontal and vertical optic disc tilt, and optic disc torsion were measured on the Heidelberg Retina Tomograph 3 printout in 381 right eyes of 381 normal young subjects. Stereophotographically obvious horizontal tilt and the relationship between the ovality index and horizontal tilt were determined in non-torted discs with an absolute value of disc torsion ≤15°. Results The median values of the ovality index, horizontal and vertical tilt, and disc torsion in all subjects were 0 ...

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    12. Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures

      Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures
      Purpose. To identify sex-related differences and age-related changes in individual retinal layer thicknesses in a population of healthy eyes across the lifespan, using spectral domain optical coherence tomography (SD-OCT). Methods. In seven institutes in Japan, mean thicknesses of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor inner segment (IS), and photoreceptor outer segment (OS) were measured using SD-OCT with a new automated segmentation protocol in 256 healthy subjects. Results. Interoperator coefficients of variability for measurements of each layer ranged from 0 ...
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    13. Peripapillary Retinal Nerve Fiber Layer Thickness Determined by Spectral-Domain Optical Coherence Tomography in Ophthalmologically Normal Eyes

      Peripapillary Retinal Nerve Fiber Layer Thickness Determined by Spectral-Domain Optical Coherence Tomography in Ophthalmologically Normal Eyes
      Objectives  To evaluate the peripapillary distribution of retinal nerve fiber layer thickness (RNFLT) in normal eyes using spectral-domain optical coherence tomography and to study potentially related factors. Methods  In 7 institutes in Japan, RNFLT in 7 concentric peripapillary circles with diameters ranging from 2.2 to 4.0 mm were measured using spectral-domain optical coherence tomography in 251 ophthalmologically normal subjects. Multiple regression analysis for the association of RNFLT with sex, age, axial length, and disc area was performed. Results  Retinal nerve fiber layer thickness decreased linearly from 125 to 89 µm as the measurement diameter increased (P < .001, mixed linear model). Retinal nerve fiber layer thickness correlated with age in all diameters (partial correlation coefficient [PCC] = –0.40 to –0.32; P < .001) and negatively correlated with disc area in the 2 innermost circles but positively correlated in the 3 outermost circles (PCC = –0.30 to –0.22 and 0.17 to 0.20; P ≤ .005). Sex and axial length did not correlate with RNFLT (P > .08). The ...
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    14. Evaluation of Macular Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness for Detection of Early Glaucoma Using Spectral Domain Optical Coherence Tomography

      Evaluation of Macular Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness for Detection of Early Glaucoma Using Spectral Domain Optical Coherence Tomography
      Purpose: To evaluate the diagnostic ability of macular parameters and peripapillary retinal nerve fiber layer (RNFL) parameters for early glaucoma using spectral domain optical coherence tomography (SD-OCT). Materials and methods: One eye from 32 early glaucoma patients (including preperimetric glaucoma) and 32 normal participants underwent macular scans and peripapillary RNFL scans with SD-OCT 3 times on the same day. The discrimination power of each parameter to detect early glaucoma was determined by areas under receiver operating characteristics curve (AROC) and sensitivity at fixed specificity. Correlation of OCT data with visual field defects was evaluated by linear regression analysis. Reproducibility was ...
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    15. Fundus autofluorescence and spectral-domain optical coherence tomography findings of leopard spots in nanophthalmic uveal effusion syndrome

      Fundus autofluorescence and spectral-domain optical coherence tomography findings of leopard spots in nanophthalmic uveal effusion syndrome
      Purpose To describe fundus autofluorescence (FAF) imaging and spectral domain optical coherence tomography (SD-OCT) findings of leopard spots in nanophthalmic uveal effusion syndrome. Methods A 34-year-old man with retinal detachment associated with nanophthalmic uveal effusion syndrome in the right eye underwent sclerotomy three times. After the final surgery, the subretinal fluid resolved gradually. Then, SD-OCT examination, FAF photography, fluorescein angiography (FA), and indocyanine green angiography (ICGA) were performed simultaneously with the spectralis Heidelberg retina angiograph + OCT system. Results SD-OCT revealed focal thickening of the retinal pigment epithelium (RPE) layer at the same locations as leopard spots, which appeared hypofluorescent on ...
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    16. Three-dimensional Profile of Macular Retinal Thickness in Normal Japanese Eyes

      Purpose: To demonstrate the 3-dimensional macular thickness distribution in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate its association with sex, age, and axial length. Methods: Mean regional retinal thickness measurements on the Early Treatment Diabetic Retinopathy Study (ETDRS) layout were obtained by 3-dimensional raster scanning (6 X 6 mm) using SD-OCT in 248 normal eyes of 248 Japanese subjects. Results: Mean foveal thickness was 222 ± 19 µm; it was significantly greater in men (226 ± 19 µm) than in women (218 ± 18 µm; P = 0.002) and did not correlate with age in either sex. Mean sectorial ...
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    17. Anterior segment optical coherence tomography findings of reverse pupillary block after scleral-fixated sutured posterior chamber intraocular lens implantation

      Purpose: To evaluate findings of reverse pupillary block after scleral-fixated sutured posterior chamber intraocular lens (PC IOL) implantation using anterior segment optical coherence tomography (AS-OCT) and report a possible association with postoperative complications.Setting: Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.Methods: Anterior segment OCT was used to evaluate eyes with reverse pupillary block (ie, deep anterior chamber, concave iris configuration, contact between pupil and IOL) after IOL explantation or cataract extraction combined with vitrectomy and scleral-fixated sutured PC IOL implantation. The PC IOL was implanted using an ab externo method in all cases. After ...
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    18. In Vivo Quantitative Evaluation of Rat Retinal Nerve Fiber Layer Using Optical Coherence Tomography

      Purpose: To determine whether optical coherence tomography (OCT) is useful for quantitative evaluation of the thickness of rat retinal nerve fiber layer (RNFL) in an optic nerve crush model. Methods: An OCT system was developed with a modified commercial time-domain OCT and a superluminescent diode with a bandwidth of 150 nm. Optical components were optimized to acquire rat retinal images. The right optic nerve was crushed intraorbitally with a clip. The left eye served as the untreated control. Circumpapillary OCT scans with a circle diameter of 500 µm centered on the optic disc were performed before and 1, 2, and ...
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    1-18 of 18
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    Fundus autofluorescence and spectral-domain optical coherence tomography findings of leopard spots in nanophthalmic uveal effusion syndrome Evaluation of Macular Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness for Detection of Early Glaucoma Using Spectral Domain Optical Coherence Tomography Peripapillary Retinal Nerve Fiber Layer Thickness Determined by Spectral-Domain Optical Coherence Tomography in Ophthalmologically Normal Eyes Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures Effect of Cataract and Its Removal on Ganglion Cell Complex Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness Measurements by Fourier-Domain Optical Coherence Tomograph Reproducibility of Thickness Measurements of Macular Inner Retinal Layers Using SD-OCT with or without Correction of Ocular Rotation Circle and Grid-wise Analyses of Peripapillary Nerve Fiber Layers by Spectral Domain Optical Coherence Tomography in Early Stage Glaucoma Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema Ciliary body length revisited by anterior segment optical coherence tomography: implications for safe access to the pars plana for intravitreal injections Evaluation of retinal vascular structure after epiretinal membrane surgery by optical coherence tomography angiography Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study Superficial Calcification With Rotund Shape Is Associated With Carotid Plaque Rupture: An Optical Coherence Tomography Study