1. Articles from Eric Moult

    1-11 of 11
    1. Maximum A Posteriori Signal Recovery for Optical Coherence Tomography Angiography Image Generation and Denoising

      Maximum A Posteriori Signal Recovery for Optical Coherence Tomography Angiography Image Generation and Denoising

      Optical coherence tomography angiography (OCTA) is a novel and clinically promising imaging modality to image retinal and sub-retinal vasculature. Based on repeated optical coherence tomography (OCT) scans, intensity changes are observed over time and used to compute OCTA image data. OCTA data are prone to noise and artifacts caused by variations in flow speed and patientmovement. We propose a novel iterativemaximuma posteriori signal recovery algorithm in order to generate OCTA volumes with reduced noise and increased image quality. This algorithm is based on previous work on probabilistic OCTA signal models and maximum likelihood estimates. Reconstruction results using total variation minimization ...

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    2. The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration

      The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration

      Background The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on macular neovascularization (MNV) morphology is well described, but long-term studies on morphologic changes and correlation of such changes to the type of MNV have not been conducted. This study aims to determine if different types of MNVs in neovascular AMD (nAMD) behave differently with anti-VEGF treatment as visualized on optical coherence tomography angiography (OCTA). Methods Treatment-naïve nAMD patients were retrospectively screened for baseline and follow-up OCTA imaging 10 or more months after initial treatment. Images were graded for MNV type, area, activity, mature versus immature vessels, vessel ...

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    3. Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.

      Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.

      Purpose : In central serous chorioretinopathy (CSCR), choroidal hyperpermeability associated with retinal pigment epithelium (RPE) impairment causes a leakage of fluid from the choroid into the subretinal space, with potential damage to the photoreceptors. We hypothesize that ultrahigh-resolution spectral domain optical coherence tomography (UHR SD-OCT) will enable more detailed assessment of structural changes in this condition. Methods : Patients in all stages of CSCR (acute, chronic and post-resolution) were imaged using an UHR SD-OCT prototype, with an 850 nm center wavelength and an axial resolution of ~2.7 µm in tissue at a 128kHz A-scan rate. Volumetric cube scans and high-density (HD ...

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    4. Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography

      Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography

      Purpose : Optical coherence tomography angiography (OCTA) allows for precise, non-invasive monitoring of changes to choroidal neovascularization (CNV) structure over time. The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on CNV morphology is well described, but long-term studies on morphologic changes and correlation of such to the type of CNV have not been conducted. This study aims to determine if different types of CNVs in neovascular AMD (nAMD) behave differently with anti-VEGF treatment as visualized on OCTA. Methods : AMD Patients with treatment naive type 1, type 2, and type 3 CNVs were retrospectively screened for baseline and follow-up OCTA ...

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    5. Ultrahigh-Resolution Optical Coherence Tomography Investigation of Age-Related Changes in the Photoreceptors, Retinal Pigment Epithelium and Bruch’s Membrane

      Ultrahigh-Resolution Optical Coherence Tomography Investigation of Age-Related Changes in the Photoreceptors, Retinal Pigment Epithelium and Bruch’s Membrane

      Purpose : Aging is the biggest risk factor for age-related macular degeneration (AMD). Previous histological and ultrastructural studies have suggested that photoreceptors (PR), retinal pigment epithelium (RPE), and Bruch’s membrane (BM) undergo changes with aging and in AMD. A new high-speed, ultrahigh-resolution optical coherence tomography (UHR OCT) prototype instrument with depth tracking and software motion correction was used to investigate PR/RPE/BM alterations in normal aging and early AMD. Methods : We developed a high-speed UHR OCT instrument with 2.7 µm axial resolution and 128 kHz A-scan rate. A galvanometer scanner actuates the OCT reference arm to match the ...

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    6. SPATIAL DISTRIBUTION OF CHORIOCAPILLARIS IMPAIRMENT IN EYES WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Quantitative OCT Angiography Study

      SPATIAL DISTRIBUTION OF CHORIOCAPILLARIS IMPAIRMENT IN EYES WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Quantitative OCT Angiography Study

      Purpose: To develop an optical coherence tomography angiography ( OCTA )-based framework for quantitatively analyzing the spatial distribution of choriocapillaris (CC) impairment around choroidal neovascularization ( CNV ) secondary to age-related macular degeneration. Methods: In a retrospective, cross-sectional study, 400-kHz swept-source OCTA images from 7 eyes of 6 patients with CNV secondary to age-related macular degeneration were quantitatively analyzed using custom software. A lesion-centered zonal OCTA analysis technique—which portioned the field-of-view into zones relative to CNV boundaries—was developed to quantify the spatial dependence of CC flow deficits. Results: Quantitative, lesion-centered zonal analysis of CC OCTA images revealed highest flow-deficit percentages near ...

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    7. Compressed Sensing for Optical Coherence Tomography Angiography Volume Generation

      Compressed Sensing for Optical Coherence Tomography Angiography Volume Generation

      Optical coherence tomography angiography (OCTA) is an increasingly popular modality for imaging of the retinal vasculature. Repeated optical coherence tomography (OCT) scans of the retina allow the computation of motion contrast to display the retinal vasculature. To the best of our knowledge, we present the first application of compressed sensing for the generation of OCTA volumes. Using a probabilistic signal model for the computation of OCTA volumes and a 3D median filter, it is possible to perform compressed sensing reconstruction of OCTA volumes while suppressing noise. The presented approach was tested on a ground truth, averaged from ten individual OCTA ...

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    8. COmbined multimodal analysis of Peripheral Retinal and mAcular circulation in Diabetic Retinopathy (COPRA Study)

      COmbined multimodal analysis of Peripheral Retinal and mAcular circulation in Diabetic Retinopathy (COPRA Study)

      Importance The relationship between peripheral retinal capillary non-perfusion with central NP is non-linear. Objective To systematically examine the relationships between the microvascular indices that are measured on OCTA and the presence and extent of peripheral non-perfusion in persons with diabetic retinopathy Design Retrospective cross-sectional study of patients with varying degrees of diabetic retinopathy ; Setting: Two large tertiary referral retina clinics Participants Eighty-two eyes of forty-five patients with varying degrees of diabetic retinopathy were enrolled and analyzed Main outcome Relationships between peripheral ischemia measured on FA and OCTA metrics, including FAZ and vessel density measurements. Results A significant decrease in mean ...

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    9. Analysis of Scleral Feeder Vessel in Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography

      Analysis of Scleral Feeder Vessel in Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography

      To describe the appearance of a scleral-derived feeder vessel in a highly myopic eye with secondary choroidal neovascularization (CNV) as visualized on both en face high-speed swept-source (SS) optical coherence tomography angiography (OCTA) prototype, and a commercially available spectral-domain (SD) OCTA, with the corresponding en face and cross-sectional structural OCT images. In this case report, a 60-year-old white male presented with high myopia and secondary CNV in the right eye, previously treated with anti-vascular endothelial growth factor, and was imaged on both SD-OCT and SS-OCT. The neovascular complex could be visualized on both devices. Structural en face SS-OCT images demonstrated ...

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    10. Select Features of Diabetic Retinopathy on Swept-Source Optical Coherence Tomographic Angiography Compared With Fluorescein Angiography and Normal Eyes

      Select Features of Diabetic Retinopathy on Swept-Source Optical Coherence Tomographic Angiography Compared With Fluorescein Angiography and Normal Eyes

      Importance Optical coherence tomographic angiography (OCTA) is a recently developed noninvasive imaging technique that can visualize the retinal and choroidal microvasculature without the injection of exogenous dyes. Objective To evaluate the potential clinical utility of OCTA using a prototype swept-source OCT (SS-OCT) device and compare it with fluorescein angiography (FA) for analysis of the retinal microvasculature in diabetic retinopathy. Design, Setting, and Participants Prospective, observational cross-sectional study conducted at a tertiary care academic retina practice from November 2013 through November 2014. A cohort of diabetic and normal control eyes were imaged with a prototype SS-OCT system. The stage of diabetic ...

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    11. Ultrahigh-Speed Swept-Source OCT Angiography in Exudative AMD

      Ultrahigh-Speed Swept-Source OCT Angiography in Exudative AMD

      BACKGROUND AND OBJECTIVE: To investigate the potential of ultrahigh-speed swept-source optical coherence tomography angiography (OCTA) to visualize retinal and choroidal vascular changes in patients with exudative age-related macular degeneration (AMD). PATIENTS AND METHODS: Observational, prospective cross-sectional study. An ultrahigh-speed swept-source prototype was used to perform OCTA of the retinal and choriocapillaris microvasculature in 63 eyes of 32 healthy controls and 19 eyes of 15 patients with exudative AMD. MAIN OUTCOME MEASURE: qualitative comparison of the retinal and choriocapillaris microvasculature in the two groups. RESULTS: Choroidal neovascularization (CNV) was clearly visualized in 16 of the 19 eyes with exudative AMD, located ...

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    1-11 of 11
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    Ultrahigh-Speed Swept-Source OCT Angiography in Exudative AMD Select Features of Diabetic Retinopathy on Swept-Source Optical Coherence Tomographic Angiography Compared With Fluorescein Angiography and Normal Eyes Analysis of Scleral Feeder Vessel in Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography COmbined multimodal analysis of Peripheral Retinal and mAcular circulation in Diabetic Retinopathy (COPRA Study) Compressed Sensing for Optical Coherence Tomography Angiography Volume Generation SPATIAL DISTRIBUTION OF CHORIOCAPILLARIS IMPAIRMENT IN EYES WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Quantitative OCT Angiography Study Ultrahigh-Resolution Optical Coherence Tomography Investigation of Age-Related Changes in the Photoreceptors, Retinal Pigment Epithelium and Bruch’s Membrane Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study. The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration Evaluating Retinal and Choroidal Perfusion Changes After Ocular Massage of Healthy Eyes Using Optical Coherence Tomography Angiography Dermal Epidermal Junction Detection for Full-Field Optical Coherence Tomography Data of Human Skin by Deep Learning