1. Featured Articles

    25-48 of 52 « 1 2 3 »
    1. OCT in Central Nervous System Disease: The Eye as a Window to the Brain (Textbook)

      OCT in Central Nervous System Disease: The Eye as a Window to the Brain (Textbook)

      This book reviews recent important advances in the use of optical coherence tomography (OCT) in order to analyze neurodegeneration within the retina through the quantification of axonal loss. Detailed information is provided on the role of OCT as a promising tool for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. The disorders considered include multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment ...

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    2. Michael Jenkins Wins American Association of Anatomists (AAA) Young Investigator Award

      Michael Jenkins Wins American Association of Anatomists (AAA) Young Investigator Award

      Ceremony at AAA's 2016 annual meeting at Experimental Biology (EB) in San Diego, CA. The ceremony is being held at The Marriot Marquis San Diego Marina on Tuesday, April 5, 2016, at 7pm. Young Investigator awards recognize investigators in the early stages of their careers who have made important contributions to biomedical science through their research in cell/molecular biology, comparative neuroanatomy, developmental biology, or the morphological sciences. The 2016 Young Investigator Award winners are:...Michael Jenkins, Ph.D. , of Case Western Reserve University , will be honored with a plaque for his early contributions to the field of developmental ...

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    3. Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows

      Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows

      We present a new OCT method for flow speed quantification and directional velocimetry: particle streak velocimetry-OCT (PSV-OCT). PSV-OCT generates two-dimensional, 2.5-vector component ( v x ,| v y |, v z ) maps of microscale flow velocity fields. Knowledge of 2.5-vector components also enables the estimation of total flow speed. The enabling insight behind PSV-OCT is that tracer particles in sparsely-seeded fluid flow trace out streaks in ( x,z,t )-space. The streak orientations in x-t and z-t yield v x and v z , respectively. The in-plane ( x-z plane) residence time yields the out-of-plane speed | v y |. Vector component values are generated ...

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    4. Choice of Intracoronary Imaging: When to Use Intravascular Ultrasound or Optical Coherence Tomography

      Choice of Intracoronary Imaging: When to Use Intravascular Ultrasound or Optical Coherence Tomography

      Intracoronary imaging has the capability of accurately measuring vessel and stenosis dimensions, assessing vessel integrity, characterising lesion morphology and guiding optimal percutaneous coronary intervention (PCI). Coronary angiography used to detect and assess coronary stenosis severity has limitations. The 2D nature of fluoroscopic imaging provides lumen profile only and the assessment of coronary stenosis by visual estimation is subjective and prone to error. Performing PCI based on coronary angiography alone is inadequate for determining key metrics of the vessel such as dimension, extent of disease, and plaque distribution and composition. The advent of intracoronary imaging has offset the limitations of angiography ...

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    5. Classification of calcium in intravascular OCT images for the purpose of intervention planning

      Classification of calcium in intravascular OCT images for the purpose of intervention planning

      The presence of extensive calcification is a primary concern when planning and implementing a vascular percutaneous intervention such as stenting. If the balloon does not expand, the interventionalist must blindly apply high balloon pressure, use an atherectomy device, or abort the procedure. As part of a project to determine the ability of Intravascular Optical Coherence Tomography (IVOCT) to aid intervention planning, we developed a method for automatic classification of calcium in coronary IVOCT images. We developed an approach where plaque texture is modeled by the joint probability distribution of a bank of filter responses where the filter bank was chosen ...

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    6. Development of in vivo tissue-engineered microvascular grafts with an ultra small diameter of 0.6 mm (MicroBiotubes): acute phase evaluation by optical coherence tomography and magnetic resonance angiography

      Development of in vivo tissue-engineered microvascular grafts with an ultra small diameter of 0.6 mm (MicroBiotubes): acute phase evaluation by optical coherence tomography and magnetic resonance angiography

      Biotubes, i.e., in vivo tissue-engineered connective tubular tissues, are known to be effective as vascular replacement grafts with a diameter greater than several millimeters. However, the performance of biotubes with smaller diameters is less clear. In this study, MicroBiotubes with diameters <1 mm were prepared, and their patency was evaluated noninvasively by optical coherence tomography (OCT) and magnetic resonance angiography (MRA). MicroBiotube molds, containing seven stainless wires (diameter 0.5 mm) covered with silicone tubes (outer diameter 0.6 mm) per mold, were embedded into the dorsal subcutaneous pouches of rats. After 2 months, the molds were harvested with ...

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    7. Non-invasive optical assessment of viscosity of middle ear effusions in otitis media

      Non-invasive optical assessment of viscosity of middle ear effusions in otitis media

      In vivo Optical Coherence Tomography (OCT) image of a human tympanic membrane and Middle Ear Effusion (MEE) (top), with a CCD image of the tympanic membrane surface (inset). Below is the corresponding time-lapse M-mode OCT data acquired along the white dotted line over time, which can be analyzed to determine the Stokes–Einstein diffusion coefficient of the effusion. Eustachian tube dysfunction can cause fluid to collect within the middle ear cavity and form a middle ear effusion (MEE). MEEs can persist for weeks or months and cause hearing loss as well as speech and learning delays in young children. The ...

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    8. μOCT imaging using depth of focus extension by self-imaging wavefront division in a common-path fiber optic probe

      μOCT imaging using depth of focus extension by self-imaging wavefront division in a common-path fiber optic probe

      Optical coherence tomography (OCT) is an attractive medical modality due to its ability to acquire high-resolution, cross-sectional images inside the body using flexible, small-diameter, scanning fiber optic probes. Conventional, cross-sectional OCT imaging technologies have approximately 10-μm axial resolution and 30-μm lateral resolution, specifications that enable the visualization of microscopic architectural morphology. While this resolution is useful for many clinical applications, it is insufficient for resolving individual cells that characterize many diseases. To address this gap, a supercontinuum-laser-based, μm-resolution OCT (μOCT) system and a 500 μm-diameter, extended depth of focus single fiber optic probe for endoscopic and intravascular imaging ...

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    9. Research Fellow Opening at the University of Western Australia in Nanoscope-In-a-Needle | Ref: 496429

      Research Fellow Opening at the University of Western Australia in Nanoscope-In-a-Needle | Ref: 496429

      SCHOOL OF ELECTRICAL, ELECTRONIC & COMPUTER ENGINEERING OPTICAL+BIOMEDICAL ENGINEERING LABORATORY 3-year appointment, (continuous employment subject to funding) Salary range: Level B $93,182 - $110,654 p.a. Research & Development In Biomedical Photonics/Optical Microscopy (Australia) The University of Western Australia (UWA) is ranked amongst the top Australian universities and a member of the prestigious Group of Eight research-intensive universities ranked among the top 100 universities in the world. Do you have a flare for building optical systems and want to make a difference in biology? Building on our Microscope-in-a-Needle programme, we are taking the next step in resolution to build ...

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    10. Myocardial imaging using ultrahigh-resolution spectral domain optical coherence tomography

      Myocardial imaging using ultrahigh-resolution spectral domain optical coherence tomography

      We present an ultrahigh-resolution spectral domain optical coherence tomography (OCT) system in 800 nm with a low-noise supercontinuum source (SC) optimized for myocardial imaging. The system was demonstrated to have an axial resolution of 2.72 μm  with a large imaging depth of 1.78 mm and a 6-dB falloff range of 0.89 mm. The lateral resolution ( 5.52  μm ) was compromised to enhance the image penetration required for myocardial imaging. The noise of the SC source was analyzed extensively and an imaging protocol was proposed for SC-based OCT imaging with appreciable contrast. Three-dimensional datasets were acquired ex vivo ...

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    11. Optical coherence tomography: A pathway from research to clinical practice

      Optical coherence tomography: A pathway from research to clinical practice

      For more than half a century, coronary angiography has been the goldstandard diagnostic test for the assessment of coronary artery disease, but it does not provide information about the components of the vascular wall, atherosclerosic disease burden, or the interaction of local devices with coronary artery walls.  The development of intracoronary imaging techniques, such as optical coherence tomography (OCT), was conceived with the objective to overcome coronary angiography limitations.

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    12. Comparison of caries diagnostic modalities: A clinical study in 40 subjects

      Comparison of caries diagnostic modalities: A clinical study in 40 subjects

      Background and Objectives Few studies have been published that evaluate the usefulness of different caries- diagnostic modalities in general dental practice. The goal of this study was to compare the results of screening for coronal dental caries in a general dental practice using clinical observations, radiographs, laser fluorescence (DIAGNOdent™) (LF), and optical coherence tomography (OCT). Diagnostic agreement between OCT and LF versus standard clinical techniques for detecting caries was determined in 40 subjects. Study Designs/Materials and Methods Forty patients with >1 coronal carious lesion as determined by prescreening using clinical examination and radiographs were enrolled in this study. Subjects ...

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    13. Safety of optical coherence tomography in daily practice: a comparison with intravascular ultrasound

      Safety of optical coherence tomography in daily practice: a comparison with intravascular ultrasound

      Aims Previous studies have reported the safety and feasibility of both time-domain optical coherence tomography (TD-OCT) and Fourier-domain OCT (FD-OCT) in highly selected patients and clinical settings. However, the generalizability of these data is limited, and data in unselected patient populations reflecting a routine cathlab practice are lacking. We compared safety of intracoronary FD-OCT imaging to intravascular ultrasound (IVUS) imaging in a large real-world series of consecutive patients who underwent invasive imaging during coronary catheterization in our centre. Methods and results This is a prospective, single-centre registry of patients scheduled for coronary angiography or intervention undergoing intracoronary imaging with FD-OCT ...

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    14. Wasatch Photonics launches label-free angiography technique based on optical coherence tomography

      Wasatch Photonics launches label-free angiography technique based on optical coherence tomography

      Wasatch Photonics Inc., a leading provider for gratings, spectrometers and optical coherence tomography instrumentation, announced Monday (March 21), the launch of a new imaging device, WP MicroAngio, for high-resolution angiographic imaging for research and original equipment manufacturer (OEM) applications. MicroAngio technology allows visualization of blood vessels at a microscopic level without using external contrast agents. The device, based on a variation of optical coherence tomography (OCT), creates a three-dimensional profile of the micro vasculature. WP MicroAngio is to be used for several medical research applications related to animal model imaging in ophthalmology, dermatology, oncology and other areas. MicroAngio, the new ...

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    15. Study shows VivoSight OCT is able to differentiate between actinic keratosis (AK) and basal cell carcinoma (BCC) by quantification of signal intensity and layer thickness

      Study shows VivoSight OCT is able to differentiate between actinic keratosis (AK) and basal cell carcinoma (BCC) by quantification of signal intensity and layer thickness

      Michelson Diagnostics, a medical device company focused on applications of multi-beam Optical Coherence Tomography (‘OCT’) technology, announces data confirming the ability for VivoSight OCT to differentiate between actinic keratosis (AK) and basal cell carcinoma (BCC). This statistically significant data proves VivoSight’s capabilities as a non-invasive, objective method for diagnosing and monitoring the treatment of these diseases. Data from this study, published in The Journal of the European Academy of Dermatology and Venereology (JEADV) , showed statistically significant differences in the signal intensities and the epidermal thickness measurements of AK and BCC. Results also showed an excellent correlation between OCT and ...

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    16. Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging

      Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging

      Optical Coherence Tomography (OCT) enables real-time imaging of living tissues at cell-scale resolution over millimeters in three dimensions. Despite these advantages, functional biological studies with OCT have been limited by a lack of exogenous contrast agents that can be distinguished from tissue. Here we report an approach to functional OCT imaging that implements custom algorithms to spectrally identify unique contrast agents: large gold nanorods (LGNRs). LGNRs exhibit 110-fold greater spectral signal per particle than conventional GNRs, which enables detection of individual LGNRs in water and concentrations as low as 250 pM in the circulation of living mice. This translates to ...

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    17. Effect of saline inhalation on vocal fold epithelial morphology evaluated by optical coherence tomography

      Effect of saline inhalation on vocal fold epithelial morphology evaluated by optical coherence tomography

      Objectives/Hypothesis Examination of tissue structures by optical coherence tomography (OCT) has been shown to be useful on mucous membranes of the vocal folds, but so far its application to the human larynx has been limited because it is technically cumbersome and usually needs to be performed with sedation. Here a newly developed, noninvasive combined laryngoscopy and OCT procedure is described and its suitability for ambulatory OCT studies evaluated. Because inhalation therapies utilizing saline solutions are commonly used as a treatment option for disorders of the airways, and vocal fold epithelium is most likely to be affected due to its ...

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    18. In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography

      In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography

      Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fiber-optic or rigid endoscopy and using stroboscopic or high-speed video to infer information about submucosal processes. Previous efforts using optical coherence tomography (OCT) have been limited by small working distances and imaging ranges. Here we report the first full field, high-speed, and long-range OCT images of awake patients’ vocal folds as well as cross-sectional ...

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    19. Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging

      Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging

      Objectives We present the clinical imaging of human coronary arteries in vivo using a multimodality optical coherence tomography (OCT) and near-infrared autofluorescence (NIRAF) intravascular imaging system and catheter. Background Although intravascular OCT is capable of providing microstructural images of coronary atherosclerotic lesions, it is limited in its capability to ascertain the compositional/molecular features of plaque. A recent study in cadaver coronary plaque showed that endogenous NIRAF is elevated in necrotic core lesions. The combination of these 2 technologies in 1 device may therefore provide synergistic data to aid in the diagnosis of coronary pathology in vivo. Methods We developed ...

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    20. Fourth international meeting on OCT Angiography, advances in OCT, and “en face” OCT will be held in Rome December 16 and 17 2016.

      Fourth international meeting on OCT Angiography, advances in OCT, and “en face” OCT will be held in Rome December 16 and 17 2016.

      The Fourth international meeting on OCT Angiography, advances in OCT, and “en face” OCT will be held in Rome December 16 and 17 2016. This organization committee includes: Bruno Lumbroso, David Huang,Gabriel Coscas, Jay Duker, K. Bailey Freund, Yali Jia, Richard Rosen,Phil Rosenfeld, David Sarraf, Eric Souied, Richard Spaide, Giovanni Staurenghi, Nadia Waheed. President of Honor: James Fujimoto Coordinators: Amani Fawzi, Martine Mauget Faysse, Andre Romano, Marco Rispoli. For more information www.apmeetings.com .

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    21. Repeatability and agreement in optical biometry of a new swept-source optical coherence tomography–based biometer versus partial coherence interferometry and optical low-coherence reflectometry

      Repeatability and agreement in optical biometry of a new swept-source optical coherence tomography–based biometer versus partial coherence interferometry and optical low-coherence reflectometry

      Purpose To estimate the repeatability of biometric parameters obtained with a new swept-source biometer and to compare the agreement with that of partial coherence interferometry (PCI) and optical low-coherence reflectometry (OLCR). Setting Department of Ophthalmology, Helios Hospital Erfurt, Erfurt, Julius-Maximilians University, Würzburg, and Philipps University, Marburg, Germany. Design Prospective comparative multicenter clinical study. Methods Biometry was taken with the use of 3 different biometers: the IOLMaster 700 swept-source biometer, the PCI-based IOLMaster 500, and the OCLR-based Lenstar LS 900. Axial length (AL), anterior chamber depth (ACD), and spherical equivalent (SE) were compared between swept-source and PCI biometry and central ...

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    22. Clinical monitoring of smooth surface enamel lesions using CP-OCT during nonsurgical intervention

      Clinical monitoring of smooth surface enamel lesions using CP-OCT during nonsurgical intervention

      Introduction Studies have shown that cross-polarization optical coherence tomography (CP-OCT) can be used to image the internal structure of carious lesions in vivo . The objective of this study was to show that CP-OCT can be used to monitor changes in the internal structure of early active carious lesions on smooth surfaces during non-surgical intervention with fluoride. Methods Lesions on the smooth surfaces of teeth were imaged using CP-OCT on 17 test subjects. Lesion structural changes were monitored during fluoride varnish application at 6-week intervals for 30 weeks. The lesion depth ( L d ), integrated reflectivity (Δ R ), and surface zone thickness ( S ...

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    23. Longitudinal, 3D Imaging of Collagen Remodeling in Murine Hypertrophic Scars In Vivo Using Polarization-Sensitive Optical Frequency Domain Imaging

      Longitudinal, 3D Imaging of Collagen Remodeling in Murine Hypertrophic Scars In Vivo Using Polarization-Sensitive Optical Frequency Domain Imaging

      Hypertrophic scars (HTS), frequently seen after traumatic injuries and surgery, remain a major clinical challenge because of the limited success of existing therapies. A significant obstacle to understanding HTS etiology is the lack of tools to monitor scar remodeling longitudinally and noninvasively. We present an in vivo, label-free technique using polarization-sensitive optical frequency domain imaging for the 3D, longitudinal assessment of collagen remodeling in murine HTS. In this study, HTS was induced with a mechanical tension device for 4–10 days on incisional wounds and imaged up to 1 month after device removal; an excisional HTS model was also imaged ...

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    24. Avinger Announces FDA Clearance and U.S. Launch of Breakthrough Treatment for Patients with Peripheral Artery Disease

      Avinger Announces FDA Clearance and U.S. Launch of Breakthrough Treatment for Patients with Peripheral Artery Disease

      Avinger, Inc. (NASDAQ: AVGR), a leading developer of innovative treatments for peripheral artery disease (PAD), today announced that the company has received 510(k) clearance from the United States Food and Drug Administration (FDA) for an enhanced version of its Pantheris™ lumivascular atherectomy system, the first-ever image-guided atherectomy device for the treatment of PAD. Avinger will commence U.S. commercialization of this enhanced version of Pantheris immediately, which features improved ergonomics, physician controls and manufacturability “I am excited and eager to commercially launch the most recent version of Pantheris. I offer a special thanks to all the patients and investigators ...

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