1. Featured Articles

    25-38 of 38 « 1 2
    1. Study shows VivoSight OCT is able to differentiate between actinic keratosis (AK) and basal cell carcinoma (BCC) by quantification of signal intensity and layer thickness

      Study shows VivoSight OCT is able to differentiate between actinic keratosis (AK) and basal cell carcinoma (BCC) by quantification of signal intensity and layer thickness

      Michelson Diagnostics, a medical device company focused on applications of multi-beam Optical Coherence Tomography (‘OCT’) technology, announces data confirming the ability for VivoSight OCT to differentiate between actinic keratosis (AK) and basal cell carcinoma (BCC). This statistically significant data proves VivoSight’s capabilities as a non-invasive, objective method for diagnosing and monitoring the treatment of these diseases. Data from this study, published in The Journal of the European Academy of Dermatology and Venereology (JEADV) , showed statistically significant differences in the signal intensities and the epidermal thickness measurements of AK and BCC. Results also showed an excellent correlation between OCT and ...

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    2. Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging

      Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging

      Optical Coherence Tomography (OCT) enables real-time imaging of living tissues at cell-scale resolution over millimeters in three dimensions. Despite these advantages, functional biological studies with OCT have been limited by a lack of exogenous contrast agents that can be distinguished from tissue. Here we report an approach to functional OCT imaging that implements custom algorithms to spectrally identify unique contrast agents: large gold nanorods (LGNRs). LGNRs exhibit 110-fold greater spectral signal per particle than conventional GNRs, which enables detection of individual LGNRs in water and concentrations as low as 250 pM in the circulation of living mice. This translates to ...

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    3. Effect of saline inhalation on vocal fold epithelial morphology evaluated by optical coherence tomography

      Effect of saline inhalation on vocal fold epithelial morphology evaluated by optical coherence tomography

      Objectives/Hypothesis Examination of tissue structures by optical coherence tomography (OCT) has been shown to be useful on mucous membranes of the vocal folds, but so far its application to the human larynx has been limited because it is technically cumbersome and usually needs to be performed with sedation. Here a newly developed, noninvasive combined laryngoscopy and OCT procedure is described and its suitability for ambulatory OCT studies evaluated. Because inhalation therapies utilizing saline solutions are commonly used as a treatment option for disorders of the airways, and vocal fold epithelium is most likely to be affected due to its ...

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    4. In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography

      In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography

      Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fiber-optic or rigid endoscopy and using stroboscopic or high-speed video to infer information about submucosal processes. Previous efforts using optical coherence tomography (OCT) have been limited by small working distances and imaging ranges. Here we report the first full field, high-speed, and long-range OCT images of awake patients’ vocal folds as well as cross-sectional ...

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    5. Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging

      Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging

      Objectives We present the clinical imaging of human coronary arteries in vivo using a multimodality optical coherence tomography (OCT) and near-infrared autofluorescence (NIRAF) intravascular imaging system and catheter. Background Although intravascular OCT is capable of providing microstructural images of coronary atherosclerotic lesions, it is limited in its capability to ascertain the compositional/molecular features of plaque. A recent study in cadaver coronary plaque showed that endogenous NIRAF is elevated in necrotic core lesions. The combination of these 2 technologies in 1 device may therefore provide synergistic data to aid in the diagnosis of coronary pathology in vivo. Methods We developed ...

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    6. Fourth international meeting on OCT Angiography, advances in OCT, and “en face” OCT will be held in Rome December 16 and 17 2016.

      Fourth international meeting on OCT Angiography, advances in OCT, and “en face” OCT will be held in Rome December 16 and 17 2016.

      The Fourth international meeting on OCT Angiography, advances in OCT, and “en face” OCT will be held in Rome December 16 and 17 2016. This organization committee includes: Bruno Lumbroso, David Huang,Gabriel Coscas, Jay Duker, K. Bailey Freund, Yali Jia, Richard Rosen,Phil Rosenfeld, David Sarraf, Eric Souied, Richard Spaide, Giovanni Staurenghi, Nadia Waheed. President of Honor: James Fujimoto Coordinators: Amani Fawzi, Martine Mauget Faysse, Andre Romano, Marco Rispoli. For more information www.apmeetings.com .

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    7. Repeatability and agreement in optical biometry of a new swept-source optical coherence tomography–based biometer versus partial coherence interferometry and optical low-coherence reflectometry

      Repeatability and agreement in optical biometry of a new swept-source optical coherence tomography–based biometer versus partial coherence interferometry and optical low-coherence reflectometry

      Purpose To estimate the repeatability of biometric parameters obtained with a new swept-source biometer and to compare the agreement with that of partial coherence interferometry (PCI) and optical low-coherence reflectometry (OLCR). Setting Department of Ophthalmology, Helios Hospital Erfurt, Erfurt, Julius-Maximilians University, Würzburg, and Philipps University, Marburg, Germany. Design Prospective comparative multicenter clinical study. Methods Biometry was taken with the use of 3 different biometers: the IOLMaster 700 swept-source biometer, the PCI-based IOLMaster 500, and the OCLR-based Lenstar LS 900. Axial length (AL), anterior chamber depth (ACD), and spherical equivalent (SE) were compared between swept-source and PCI biometry and central ...

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    8. Clinical monitoring of smooth surface enamel lesions using CP-OCT during nonsurgical intervention

      Clinical monitoring of smooth surface enamel lesions using CP-OCT during nonsurgical intervention

      Introduction Studies have shown that cross-polarization optical coherence tomography (CP-OCT) can be used to image the internal structure of carious lesions in vivo . The objective of this study was to show that CP-OCT can be used to monitor changes in the internal structure of early active carious lesions on smooth surfaces during non-surgical intervention with fluoride. Methods Lesions on the smooth surfaces of teeth were imaged using CP-OCT on 17 test subjects. Lesion structural changes were monitored during fluoride varnish application at 6-week intervals for 30 weeks. The lesion depth ( L d ), integrated reflectivity (Δ R ), and surface zone thickness ( S ...

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    9. Longitudinal, 3D Imaging of Collagen Remodeling in Murine Hypertrophic Scars In Vivo Using Polarization-Sensitive Optical Frequency Domain Imaging

      Longitudinal, 3D Imaging of Collagen Remodeling in Murine Hypertrophic Scars In Vivo Using Polarization-Sensitive Optical Frequency Domain Imaging

      Hypertrophic scars (HTS), frequently seen after traumatic injuries and surgery, remain a major clinical challenge because of the limited success of existing therapies. A significant obstacle to understanding HTS etiology is the lack of tools to monitor scar remodeling longitudinally and noninvasively. We present an in vivo, label-free technique using polarization-sensitive optical frequency domain imaging for the 3D, longitudinal assessment of collagen remodeling in murine HTS. In this study, HTS was induced with a mechanical tension device for 4–10 days on incisional wounds and imaged up to 1 month after device removal; an excisional HTS model was also imaged ...

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    10. Avinger Announces FDA Clearance and U.S. Launch of Breakthrough Treatment for Patients with Peripheral Artery Disease

      Avinger Announces FDA Clearance and U.S. Launch of Breakthrough Treatment for Patients with Peripheral Artery Disease

      Avinger, Inc. (NASDAQ: AVGR), a leading developer of innovative treatments for peripheral artery disease (PAD), today announced that the company has received 510(k) clearance from the United States Food and Drug Administration (FDA) for an enhanced version of its Pantheris™ lumivascular atherectomy system, the first-ever image-guided atherectomy device for the treatment of PAD. Avinger will commence U.S. commercialization of this enhanced version of Pantheris immediately, which features improved ergonomics, physician controls and manufacturability “I am excited and eager to commercially launch the most recent version of Pantheris. I offer a special thanks to all the patients and investigators ...

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    11. Usefulness of Frequency Domain Optical Coherence Tomography Compared with Intravascular Ultrasound as a Guidance for Percutaneous Coronary Intervention

      Usefulness of Frequency Domain Optical Coherence Tomography Compared with Intravascular Ultrasound as a Guidance for Percutaneous Coronary Intervention

      Objectives To compare outcomes and rates of optimal stent placement between optical coherence tomography (OCT) and intravascular ultrasound (IVUS) guided percutaneous coronary intervention (PCI). Background Unlike IVUS-guided PCI, rates of clinical outcomes and optimal stent placement have not been well characterized for OCT-guided PCI. Methods The study enrolled 290 patients who underwent implantation of a second generation drug eluting stent under OCT (122 patients) or IVUS (168 patients) guidance. The two groups were compared after adjusting for baseline differences using 1:1 propensity score matching (PSM) (114 patients in each group). Optimal stent placement was defined as achieving an adequate ...

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    12. Optical Coherence Tomography Industry Has Provided Well Over 20,000 Person-Years of Direct Employment

      Optical Coherence Tomography Industry Has Provided Well Over 20,000 Person-Years of Direct Employment

      The field of Optical Coherence Tomography (OCT) has grown dramatically since its discovery in the early 1990’s. The commercialization and growth of OCT which has occurred over the past 25 years has been highly impactful, scientifically, clinically, and economically. Many factors have helped drive this success starting with the clinical need for new cost-effective high-resolution minimally-invasive imaging solutions for various diagnostic and therapeutic applications. But equally important to this success has been the worldwide ecosystem consisting of the intertwined role of scientists, engineers, clinicians, professional societies, government agencies, government funding, regulatory bodies, entrepreneurs, venture capitalists, and small and large ...

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    13. Incidence and Clinical Significance of Poststent Optical Coherence Tomography Findings: One-Year Follow-Up Study From a Multicenter Registry

      Incidence and Clinical Significance of Poststent Optical Coherence Tomography Findings: One-Year Follow-Up Study From a Multicenter Registry

      Background— Optical coherence tomography (OCT) was recently introduced to optimize percutaneous coronary intervention. However, the exact incidence and significance of poststent OCT findings are unknown. Methods and Results— A total of 900 lesions treated with 1001 stents in 786 patients who had postprocedure OCT imaging were analyzed to evaluate the incidence of poststent OCT findings and to identify the OCT predictors for device-oriented clinical end points, including cardiac death, target vessel–related myocardial infarction, target lesion revascularization, and stent thrombosis. Patients were followed up to 1 year. Stent edge dissection was detected in 28.7% of lesions, and incomplete stent ...

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    14. Novel microscope-integrated stereoscopic display for intrasurgical optical coherence tomography

      Novel microscope-integrated stereoscopic display for intrasurgical optical coherence tomography

      The first generation of intrasurgical optical coherence tomography (OCT) systems displayed OCT data onto a separate computer monitor, requiring surgeons to look away from the surgical microscope. In order to provide real-time OCT feedback without requiring surgeons to look away during surgeries, recent prototype research and commercial intrasurgical OCT systems have integrated heads-up display (HUD) systems into the surgical microscopes to allow the surgeons to access the OCT data and the surgical field through the oculars concurrently. However, all current intrasurgical OCT systems with a HUD are only capable of imaging through one ocular limiting the surgeon’s depth perception ...

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