1. Featured Articles

    25-48 of 87 « 1 2 3 4 »
    1. Real-time processing for frequency domain optical imaging based on field programmable gated arrays

      Real-time processing for frequency domain optical imaging based on field programmable gated arrays

      Fequency domain optical imaging (OFDI) provides high resolution and sensitivity. However, the speed of the data processing program in C language limits its application. A real-time imaging system of OFDI based on field programmable gate arrays (FPGAs) is proposed. It adopts a high-speed digitizer board PXI14400 from Signatec for interferometric data acquisition. The acquired data is processed in the user defined FPGA on board in real-time with a pipeline data processing algorithm. The algorithm eliminates the complex conjugate ambiguity, overcomes the swept laser source’s nonlinearity in k -space, and allows the data to be processed continuously. We also provide ...

      Read Full Article
      Mentions: Signatec
    2. Surface imaging of metallic material fractures using optical coherence tomography

      Surface imaging of metallic material fractures using optical coherence tomography

      We demonstrate the capability of optical coherence tomography (OCT) to perform topography of metallic surfaces after being subjected to ductile or brittle fracturing. Two steel samples, OL 37 and OL 52, and an antifriction Sn–Sb–Cu alloy were analyzed. Using an in-house-built swept source OCT system, height profiles were generated for the surfaces of the two samples. Based on such profiles, it can be concluded that the first two samples were subjected to ductile fracture, while the third one was subjected to brittle fracture. The OCT potential for assessing the surface state of materials after fracture was evaluated by ...

      Read Full Article
    3. Optical coherence tomography for coronary imaging

      Optical coherence tomography for coronary imaging

      Optical coherence tomography (OCT) is a novel invasive imaging technique that produces high resolution intracoronary images. Its general principle of operation is similar to IVUS, however OCT uses infrared light, not ultrasound. In the last years, the need for more precise information regarding coronary artery disease to achieve optimal treatment has seen intravascular imaging becoming an area of primary importance in interventional cardiology. OCT in this area has grown and is spreading. It benefits both therapeutic and research purposes and is also proving able to fill gaps in conventional invasive coronary imaging.

      Read Full Article
    4. Advanced Optical Coherence Tomography Applications for the Retina Specialist (CME Webinar Seires)

      Advanced Optical Coherence Tomography Applications for the Retina Specialist (CME Webinar Seires)

      Advances in retinal pharmacology have significantly improved outcomes for patients with a range of chronic retinal conditions, including age-related macular degeneration, macular edema, retinal vascular disorders and diseases of the vitreomacular interface. Maximizing the efficacy of available treatments requires the appropriate use of optical coherence tomography (OCT) to diagnose these conditions and to monitor the efficacy of treatment. In this webinar series, leading clinicians and researchers will discuss the role of OCT in detecting structural changes associated with a range of retinal diseases and provide clinical pearls on using tools such as thickness maps, automated change analysis and angiography in ...

      Read Full Article
    5. Treatment of coronary bifurcation lesions with the Absorb bioresorbable vascular scaffold in combination with the Tryton dedicated coronary bifurcation stent: evaluation using two- and three-dimensional optical coherence tomography

      Treatment of coronary bifurcation lesions with the Absorb bioresorbable vascular scaffold in combination with the Tryton dedicated coronary bifurcation stent: evaluation using two- and three-dimensional optical coherence tomography

      Aims: The Tryton bifurcation stent has been developed to improve clinical outcomes after treatment of bifurcation lesions. Limited data are available on the use of the Absorb bioresorbable vascular scaffold (BVS) in bifurcation lesions with side branches >2 mm. We present here the acute procedural results and midterm clinical follow-up of the first-in-man combined use of the Tryton stent and the Absorb scaffold for the treatment of complex bifurcation lesions. Methods and results: Ten patients treated with the Tryton stent in combination with Absorb BVS were included in the current report. Offline two- and three-dimensional optical coherence tomography (OCT) analyses ...

      Read Full Article
    6. Sina Farsiu: Biomedical Engineer Processes an Avalanche of Images

      Sina Farsiu: Biomedical Engineer Processes an Avalanche of Images

      Sina Farsiu wants to figure out how to peer into your soul . . . or at least your brain. An expert in designing computer image processing algorithms, Farsiu is an assistant professor of ophthalmology at Duke Medicine who recently accepted a primary appointment in the Pratt biomedical engineering department with the hopes of strengthening collaborations across the university. “When President Bush said he looked Vladimir Putin in the eye and got a sense of his soul, he was actually on to something,” said Farsiu, who has a long history of collaborating with peers in Duke’s engineering school. “The retina is part ...

      Read Full Article
    7. Automated classification of optical coherence tomography images for the diagnosis of oral malignancy in the hamster cheek pouch

      Automated classification of optical coherence tomography images for the diagnosis of oral malignancy in the hamster cheek pouch

      Most studies evaluating the potential of optical coherence tomography (OCT) for the diagnosis of oral cancer are based on visual assessment of OCT B-scans by trained experts. Human interpretation of the large pool of data acquired by modern high-speed OCT systems, however, can be cumbersome and extremely time consuming. Development of image analysis methods for automated and quantitative OCT image analysis could therefore facilitate the evaluation of such a large volume of data. We report automated algorithms for quantifying structural features that are associated with the malignant transformation of the oral epithelium based on image processing of OCT data. The ...

      Read Full Article
    8. A survey of current and anticipated use of standard and specialist equipment by UK optometrists

      A survey of current and anticipated use of standard and specialist equipment by UK optometrists

      Purpose To investigate current and anticipated use of equipment and information technology (IT) in community optometric practice in the UK, and to elicit optometrists' views on adoption of specialist equipment and IT. Methods An anonymous online questionnaire was developed, covering use of standard and specialist diagnostic equipment, and IT. The survey was distributed to a random sample of 1300 UK College of Optometrists members. Results Four hundred and thirty-two responses were received (response rate = 35%). Enhanced (locally commissioned) or additional/separately contracted services were provided by 73% of respondents. Services included glaucoma repeat measures (30% of respondents), glaucoma referral refinement ...

      Read Full Article
    9. Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

      Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

      Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy increased from 15% to 91% and the coefficient of variation (CV) decreased 9.3-fold;in vivo mouse brain validation showed that CV decreased 4.4-/10.8- fold for venular ...

      Read Full Article
    10. This is Your Brain's Blood Vessels on Cocaine

      This is Your Brain's Blood Vessels on Cocaine

      New imaging technique shows how cocaine shuts down blood flow in mouse brains A new method for measuring and imaging how quickly blood flows in the brain could help doctors and researchers better understand how drug abuse affects the brain, which may aid in improving brain-cancer surgery and tissue engineering, and lead to better treatment options for recovering drug addicts. The new method, developed by a team of researchers from Stony Brook University in New York, USA and the U.S. National Institutes of Health, was published today in The Optical Society’s ( OSA ) open-access journal Biomedical Optics Express . The ...

      Read Full Article
    11. Ultra-compact silicon photonic integrated interferometer for swept-source optical coherence tomography

      Ultra-compact silicon photonic integrated interferometer for swept-source optical coherence tomography

      We demonstrate an ultra-compact silicon integrated photonic interferometer for swept-source optical coherence tomography (SS-OCT). The footprint of the integrated interferometer is only 0.75 × 5     mm 2 . The design consists of three 2 × 2 splitters, a 13 cm physical length (50.4 cm optical length) reference arm, and grating couplers. The photonic integrated circuit was used as the interferometer of an SS-OCT system. The sensitivity of the system was measured to be − 62     dB with 115 μW power delivered to the sample. Using the system, we demonstrate cross-sectional OCT imaging of a layered tissue phantom. We also discuss potential improvements ...

      Read Full Article
    12. Scalable multiplexing for parallel imaging with interleaved optical coherence tomography

      Scalable multiplexing for parallel imaging with interleaved optical coherence tomography

      We demonstrate highly parallel imaging with interleaved optical coherence tomography (iOCT) using an in-house-fabricated, air-spaced virtually-imaged phased array (VIPA). The air-spaced VIPA performs spectral encoding of the interferograms from multiple lateral points within a single sweep of the source and allows us to tune and balance several imaging parameters: number of multiplexed points, ranging depth, and sensitivity. In addition to a thorough discussion of the parameters and operating principles of the VIPA, we experimentally demonstrate the effect of different VIPA designs on the multiplexing potential of iOCT. Using a 200-kHz light source, we achieve an effective A-scan rate of 3 ...

      Read Full Article
    13. True color scanning laser ophthalmoscopy and optical coherence tomography handheld probe

      True color scanning laser ophthalmoscopy and optical coherence tomography handheld probe

      Scanning laser ophthalmoscopes (SLOs) are able to achieve superior contrast and axial sectioning capability compared to fundus photography. However, SLOs typically use monochromatic illumination and are thus unable to extract color information of the retina. Previous color SLO imaging techniques utilized multiple lasers or narrow band sources for illumination, which allowed for multiple color but not “true color” imaging as done in fundus photography. We describe the first “true color” SLO, handheld color SLO, and combined color SLO integrated with a spectral domain optical coherence tomography (OCT) system. To achieve accurate color imaging, the SLO was calibrated with a color ...

      Read Full Article
    14. Coherent signal composition and global phase determination in signal multiplexed polarization sensitive optical coherence tomography

      Coherent signal composition and global phase determination in signal multiplexed polarization sensitive optical coherence tomography

      We present an analysis of the structural image information acquired with polarization sensitive optical coherence tomography (PS-OCT). In PS-OCT a total of four channels of data are acquired: two orthogonal polarization state components for each of two incident polarization states by which the sample is interrogated. Up to recently, the structural information of the sample was obtained by incoherent summation of these four channels. The four channels can be represented as a Jones matrix for each data point acquired from a sample. We show that the Signal to Noise ratio of the structural information can be improved by 2.3 ...

      Read Full Article
    15. Three-dimensional optical coherence micro-elastography of skeletal muscle tissue

      Three-dimensional optical coherence micro-elastography of skeletal muscle tissue

      In many muscle pathologies, impairment of skeletal muscle function is closely linked to changes in the mechanical properties of the muscle constituents. Optical coherence micro-elastography (OCME) uses optical coherence tomography (OCT) imaging of tissue under a quasi-static, compressive mechanical load to map variations in tissue mechanical properties on the micro-scale. We present the first study of OCME on skeletal muscle tissue. We show that this technique can resolve features of muscle tissue including fibers, fascicles and tendon, and can also detect necrotic lesions in skeletal muscle from the mdx mouse model of Duchenne muscular dystrophy. In many instances, OCME provides ...

      Read Full Article
    16. University of Washington Received a 2014 NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 3D Pathology of Pancreas

      University of Washington Received a 2014 NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 3D Pathology of Pancreas

      University of Washington Received a 2014 NIH Grant For $232,550 for Needle Biopsy Preservation and Preparation for Rapid 3D Pathology of Pancreas. The principal investigator is Eric Seibel. The program began in 2014 and ends in 2017. Below is a summary of the proposed work. There are over three million needle biopsies performed every year in the USA, typically for the diagnosis of breast, prostate, thyroid, lung, liver, and pancreatic cancers. Because needle biopsies are less invasive than surgical biopsies, they are much more cost-effective. However, a major limitation for all needle biopsies are that the pathologist or cytologist ...

      Read Full Article
    17. Utilizing Optical Coherence Tomography in the Nondestructive and Noncontact Measurement of Egg Shell Thickness

      Utilizing Optical Coherence Tomography in the Nondestructive and Noncontact Measurement of Egg Shell Thickness

      The goal of this study was to measure the thickness of egg shells without any contact and by utilizing a nondestructive method that sends infrared light beam on the egg. We obtain measurement resolutions on the order of 7  μ m up to a penetration depth of 1.7 mm from the actual surface of the egg shell. The measurement results we obtained show that optical coherence tomography can be used to accurately determine the egg shell thickness. Scanning the light beam over the surface allows for measuring the egg profile and monitoring the variations of shell thickness. Since this information ...

      Read Full Article
    18. Postdoctoral Opening at Biophotonics Laboratory at Yale University

      Postdoctoral Opening at Biophotonics Laboratory at Yale University

      There is an immediate opening at Yale University for a postdoctoral associate to work on a newly-funded research project entitled “Massively parallel interferometric confocal microscopy using degenerate lasers.” The postdoctoral associate will be supervised by Michael A. Choma, MD, PhD (Yale Diagnostic Radiology) in collaboration with Hui Cao, PhD (Yale Applied Physics). The postdoctoral associate will work in a highly collaborative and interdisciplinary environment to develop next-generation laser technologies to enable new kinds of biomedical optical imaging systems. We are particularly interested in candidates who have experience in designing and building solid-state lasers, but candidates with excellent skills in designing ...

      Read Full Article
    19. Fiber-optic catheter-based polarization-sensitive OCT for radio-frequency ablation monitoring

      Fiber-optic catheter-based polarization-sensitive OCT for radio-frequency ablation monitoring

      An all-fiber optic catheter-based polarization-sensitive optical coherence tomography system is demonstrated. A novel multiplexing method was used to illuminate the sample, splitting the light from a 58.5 kHz Fourier-domain mode-locked laser such that two different polarization states, alternated in time, are generated by two semiconductor optical amplifiers. A 2.3 mm forward-view cone-scanning catheter probe was designed, fabricated, and used to acquire sample scattering intensity and phase retardation images. The system was first verified with a quarter-wave plate and then by obtaining intensity and phase retardation images of high-birefringence plastic, human skin in vivo , and untreated and thermally ablated ...

      Read Full Article
    20. Optical biopsy approaches in Barrett’s esophagus with next-generation optical coherence tomography

      Optical biopsy approaches in Barrett’s esophagus with next-generation optical coherence tomography

      During endoscopic surveillance and treatment in Barrett’s esophagus, the endoscopist may use a combination of tools to assist in targeting biopsies and endoscopic resections in order to diagnose and treat Barrett’s esophagus–associated neoplasia. There is a concern for subepithelial metaplasia or neoplasia in both naïve and previously treated Barrett’s esophagus. Tools to characterize so-called buried disease may allow for improved detection of occult disease. Optical biopsy with volumetric laser endomicroscopy, or VLE, is based on optical coherence tomography.

      Read Full Article
    21. High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s

      High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s

      We present a 1300 nm OCT system for volumetric real-time live OCT acquisition and visualization at 1 billion volume elements per second. All technological challenges and problems associated with such high scanning speed are discussed in detail as well as the solutions. In one configuration, the system acquires, processes and visualizes 26 volumes per second where each volume consists of 320 x 320 depth scans and each depth scan has 400 usable pixels. This is the fastest real-time OCT to date in terms of voxel rate. A 51 Hz volume rate is realized with half the frame number. In both ...

      Read Full Article
    22. Optical Coherence Tomography angiography reveals laminar microvascular hemodynamics in the rat somatosensory cortex during activation

      Optical Coherence Tomography angiography reveals laminar microvascular hemodynamics in the rat somatosensory cortex during activation

      The BOLD (blood-oxygen-level dependent) fMRI (functional Magnetic Resonance Imaging) signal is shaped, in part, by changes in red blood cell (RBC) content and flow across vascular compartments over time. These complex dynamics have been challenging to characterize directly due to a lack of appropriate imaging modalities. In this study, making use of infrared light scattering from RBCs, depth-resolved Optical Coherence Tomography (OCT) angiography was applied to image laminar functional hyperemia in the rat somatosensory cortex. After defining and validating depth-specific metrics for changes in RBC content and speed, laminar hemodynamic responses in microvasculature up to cortical depths of > 1 mm ...

      Read Full Article
    23. Senior Scientist Position Open at Carl Zeiss Meditec in Dublin California

      Senior Scientist Position Open at Carl Zeiss Meditec in Dublin California

      The Senior Scientist is responsible for the initiation, design, development, and implementation of scientific research projects to explore technology for future platform concepts and support the development and execution of product roadmaps. Will investigate the feasibility of applying scientific principles and concepts to potential inventions and products. Maintains substantial knowledge of state-of the-art principles and theories and may contribute to scientific literature and conferences. May participate in development of intellectual property and visit clinical sites and interact with the market to provide inputs to the R&D teams about various possible system design improvements. May identify and work with external ...

      Read Full Article
    24. Novel endoscopic diagnosis for bladder cancer

      Novel endoscopic diagnosis for bladder cancer

      A dvances in endoscopic imaging technology may improve sensitivity for the detection of bladder cancer and provide a more complete understanding of the urothelial landscape, and it also may lead to improved short-term and long-term cancer control. Fluorescence cystoscopy requires intravesical administration of a photosensitizing agent (5-aminolevulinic acid or hexaminolevulinate), and imaging with a blue-light endoscopy system demonstrably improves the detection of papillary and flat bladder lesions compared with conventional white-light cystoscopy. Prospective phase 3 clinical trials have demonstrated improved diagnostic ability, enhanced tumor resection, and a small but significant reduction in recurrence-free survival. Optical coherence tomography delineates subsurface microarchitecture ...

      Read Full Article
    25-48 of 87 « 1 2 3 4 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles