1. Featured Articles

    25-48 of 78 « 1 2 3 4 »
    1. Automated peroperative assessment of stents apposition from OCT pullbacks

      Automated peroperative assessment of stents apposition from OCT pullbacks

      This study׳s aim was to control the stents apposition by automatically analyzing endovascular optical coherence tomography (OCT) sequences. Lumen is detected using threshold, morphological and gradient operators to run a Dijkstra algorithm. Wrong detection tagged by the user and caused by bifurcation, struts’presence, thrombotic lesions or dissections can be corrected using a morphing algorithm. Struts are also segmented by computing symmetrical and morphological operators. Euclidian distance between detected struts and wall artery initializes a stent׳s complete distance map and missing data are interpolated with thin-plate spline functions. Rejection of detected outliers, regularization of parameters by generalized cross-validation ...

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    2. Real-time OCT guidance of an ablation laser for advancement in the fight of atherosclerotic cardio-vascular disease

      Real-time OCT guidance of an ablation laser for advancement in the fight of atherosclerotic cardio-vascular disease

      Real-time OCT guidance of an ablation laser has now been developed for use in the treatment of atherosclerotic cardio-vascular disease. DWH Systems, Inc. of Seminole Florida working with ELAN Vascular Technologies has developed a system whereby three OCT imaging heads monitor a femtosecond ablation laser in real-time, to perform micro ablation on the outer surface of diseased arteries. OCT is used first to acquire a 3D, C-scan map of the diseased portion of an artery then develops an ablation map for the system to follow. As ablation is performed, OCT again monitors the lasers cutting process from multiple angles in ...

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    3. James Fujimoto Awarded the Honorary Doctorate Degree at the Nicolaus Copernicus University

      James Fujimoto Awarded the Honorary Doctorate Degree at the Nicolaus Copernicus University

      On February 19 th , the birthday of Nicolaus Copernicus, Professor James G. Fujimoto was awarded the Honorary Doctorate Degree at the Nicolaus Copernicus University in Poland. Professor Fujimoto was awarded the University’s highest academic distinction, Doctor Honoris Causa, by Rector Andrzej Tretyn and Dean Andrzej Kowalczyk in recognition of his contribution to the fields of biomedical optics and medicine, his training and mentoring of young scientists, and his service to the international scientific community. Presentation of the Honorary Doctorate to Prof. Fujimoto by Dean Andrzej Kowalczyk (left) and Rector Andrzej Tretyn (right), photo by Andrzej Romański. The Copernicus University ...

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    4. Compensation of spectral and RF errors in swept-source OCT for high extinction complex demodulation

      Compensation of spectral and RF errors in swept-source OCT for high extinction complex demodulation

      We provide a framework for compensating errors within passive optical quadrature demodulation circuits used in swept-source optical coherence tomography (OCT). Quadrature demodulation allows for detection of both the real and imaginary components of an interference fringe, and this information separates signals from positive and negative depth spaces. To achieve a high extinction (∼60 dB) between these positive and negative signals, the demodulation error must be less than 0.1% in amplitude and phase. It is difficult to construct a system that achieves this low error across the wide spectral and RF bandwidths of high-speed swept-source systems. In a prior work ...

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    5. Sensing of Tooth Microleakage Based on Dental Optical Coherence Tomography

      Sensing of Tooth Microleakage Based on Dental Optical Coherence Tomography

      This study describes microleakage sensing based on swept-source optical coherence tomography (SS-OCT). With a handheld scanning probe, the SS-OCT system can provide portable real-time imaging for clinical diagnosis. Radiography is the traditional clinical imaging instrument used for dentistry; however, it does not provide good contrast images between filling material and the enamel of treated teeth with microleakage. The results of this study show that microleakage can be detected with oral probing using SS-OCT in vivo . The calculated microleakage length was 401  μ m and the width is 148  μ m, which is consistent with the related histological biopsy measurements. The diagnosis of ...

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    6. Optical coherence tomography appraisal of residual thrombus burden in patients with ST-segment elevation myocardial infarction undergoing intraprocedural versus post-stenting prolonged bivalirudin infusion. Rationale and design of the MATRIX (Minimizing A

      Optical coherence tomography appraisal of residual thrombus burden in patients with ST-segment elevation myocardial infarction undergoing intraprocedural versus post-stenting prolonged bivalirudin infusion. Rationale and design of the MATRIX (Minimizing A

      Aims: Residual thrombus accumulation around stent struts has been observed after the end of primary PCI and may represent a risk factor for acute stent thrombosis. The aim of this study is to test whether a strategy of prolonged bivalirudin infusion may reduce thrombosis of stent struts as compared to an intraprocedural only administration in subjects undergoing primary PCI. Methods and results: One hundred and sixty patients will be selected from the MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and angioX) study with all the following inclusion criteria: a) STEMI patients undergoing primary PCI with stent implantation, b ...

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    7. Imaging endocervical mucus anatomy and dynamics in macaque female reproductive track using optical coherence tomography

      Imaging endocervical mucus anatomy and dynamics in macaque female reproductive track using optical coherence tomography

      Background: Endocervical mucus acts as an important barrier to block human immunodeficiency virus (HIV) infection and other sexually transmitted diseases (STDs). Disruption of the mucus layer increases the risk of infection for females. An effective method to image the mucus properties can serve as a pre-screening step to risk-stratify the susceptible population. Methods: We proposed to use optical coherence tomography (OCT) to quantitatively measure the thickness of endocervical mucus. We used a home-built bench-top OCT system to monitor the dynamic change in mucus thickness of a cultivated sample. We also fabricated a prototype endoscopic OCT probe to demonstrate potential in ...

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    8. Line-field parallel swept source MHz OCT for structural and functional retinal imaging

      Line-field parallel swept source MHz OCT for structural and functional retinal imaging

      We demonstrate three-dimensional structural and functional retinal imaging with line-field parallel swept source imaging (LPSI) at acquisition speeds of up to 1 MHz equivalent A-scan rate with sensitivity better than 93.5 dB at a central wavelength of 840 nm. The results demonstrate competitive sensitivity, speed, image contrast and penetration depth when compared to conventional point scanning OCT. LPSI allows high-speed retinal imaging of function and morphology with commercially available components. We further demonstrate a method that mitigates the effect of the lateral Gaussian intensity distribution across the line focus and demonstrate and discuss the feasibility of high-speed optical angiography ...

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    9. Assessment of natural enamel lesions with optical coherence tomography in comparison with microfocus x-ray computed tomography

      Assessment of natural enamel lesions with optical coherence tomography in comparison with microfocus x-ray computed tomography

      A technology to characterize early enamel lesions is needed in dentistry. Optical coherence tomography (OCT) is a noninvasive method that provides high-resolution cross-sectional images. The aim of this study is to compare OCT with microfocus x-ray computed tomography ( μ CT ) for assessment of natural enamel lesions in vitro . Ten human teeth with visible white spot-like changes on the enamel smooth surface and no cavitation (ICDAS code 2) were subjected to imaging by μCT (SMX-100CT, Shimadzu) and 1300-nm swept-source OCT (Dental SS-OCT, Panasonic Health Care). In μ CT , the lesions appeared as radiolucent dark areas, while in SS-OCT, they appeared as areas of ...

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    10. Depth-encoded synthetic aperture optical coherence tomography of biological tissues with extended focal depth

      Depth-encoded synthetic aperture optical coherence tomography of biological tissues with extended focal depth

      Optical coherence tomography (OCT) has proven to be able to provide three-dimensional (3D) volumetric images of scattering biological tissues for in vivo medical diagnostics. Unlike conventional optical microscopy, its depth-resolving ability (axial resolution) is exclusively determined by the laser source and therefore invariant over the full imaging depth. In contrast, its transverse resolution is determined by the objective’s numerical aperture and the wavelength which is only approximately maintained over twice the Rayleigh range. However, the prevailing laser sources for OCT allow image depths of more than 5 mm which is considerably longer than the Rayleigh range. This limits high ...

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    11. Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas

      Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas

      Representative magnetomotive signal (green) using targeted and non-targeted magnetomotive microspheres in atherosclerotic diseased rabbit aortas. We report the development of an intravascular magnetomotive optical coherence tomography (IV-MM-OCT) system used with targeted protein microspheres to detect early-stage atherosclerotic fatty streaks/plaques. Magnetic microspheres (MSs) were injected in vivo in rabbits, and after 30 minutes of in vivo circulation, excised ex vivo rabbit aorta samples specimens were then imaged ex vivo with our prototype IV-MM-OCT system. The alternating magnetic field gradient was provided by a unique pair of external custom-built electromagnetic coils that modulated the targeted magnetic MSs. The results showed a ...

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    12. Michelson Diagnostics closes £2.5 million First Tranche of £4.0 million Series B fundraising Smith & Nephew as Cornerstone Investor

      Michelson Diagnostics closes £2.5 million First Tranche of £4.0 million Series B fundraising Smith & Nephew as Cornerstone Investor

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, is pleased to announce that it has closed the £2.5 million First Tranche of its Series B financing. This was led by strategic investor, global medical technology business Smith & Nephew and included new investor Kent County Council as well as existing investors. The £2.5 million investment will be used to expand the Michelson Diagnostics’ commercial presence in Germany; launch the Company’s next generation VivoSight OCT tissue-imaging system; complete the ongoing US multi-centre clinical biopsy avoidance study and explore further applications of ...

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    13. Current and evolving uses of optical coherence tomography in the genitourinary tract

      Current and evolving uses of optical coherence tomography in the genitourinary tract

      Optical coherence tomography is an emerging imaging modality that provides high-resolution, real-time, cross-sectional visualization of urologic tissue with promising results. Early studies have demonstrated detailed, accurate histologic information of tissues sampled. Optical coherence tomography (OCT) has also been applied in evaluating malignancy of the bladder, prostate, and kidney. In the bladder, it can assist in the identification, biopsy, and intraoperative resection of lesions suspicious for bladder cancer. Intraoperative use of OCT during radical prostatectomy can improve visualization of the neurovascular bundle and surgical margins. Several small, ex vivo studies have also shown promising results in the ability of OCT to ...

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    14. OCT for the Identification of Vulnerable Plaque in Acute Coronary Syndrome

      OCT for the Identification of Vulnerable Plaque in Acute Coronary Syndrome

      After 2 decades of development and use in interventional cardiology research, optical coherence tomography (OCT) has now become a core intravascular imaging modality in clinical practice. Its unprecedented spatial resolution allows visualization of the key components of the atherosclerotic plaque that appear to confer “vulnerability” to rupture—namely the thickness of the fibrous cap, size of the necrotic core, and the presence of macrophages. The utility of OCT in the evaluation of plaque composition can provide insights into the pathophysiology of acute coronary syndrome and the healing that occurs thereafter. A brief summary of the principles of OCT technology and ...

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    15. Wideband Electrically-Pumped 1050 nm MEMS-Tunable VCSEL for Ophthalmic Imaging

      Wideband Electrically-Pumped 1050 nm MEMS-Tunable VCSEL for Ophthalmic Imaging

      In this paper, we present a 1050 nm electricallypumped micro-electro-mechanically-tunable vertical-cavitysurface- emitting-laser (MEMS-VCSEL) with a record dynamic tuning bandwidth of 63.8 nm, suitable for swept source optical coherence tomography (SS-OCT) imaging. These devices provide reduced cost & complexity relative to previously demonstrated optically pumped devices by obviating the need for a pump laser and associated hardware. We demonstrate ophthalmic SS-OCT imaging with the electrically-pumped MEMS-VCSEL at a 400 kHz axial scan rate for wide field imaging of the in vivo human retina over a 12 mm × 12 mm field and for OCT angiography of the macula over 6 mm × 6 ...

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    16. Polarization sensitive optical frequency domain imaging system for endobronchial imaging

      Polarization sensitive optical frequency domain imaging system for endobronchial imaging

      A polarization sensitive endoscopic optical frequency domain imaging (PS-OFDI) system with a motorized distal scanning catheter is demonstrated. It employs a passive polarization delay unit to multiplex two orthogonal probing polarization states in depth, and a polarization diverse detection unit to detect interference signal in two orthogonal polarization channels. Per depth location four electro-magnetic field components are measured that can be represented in a complex 2x2 field matrix. A Jones matrix of the sample is derived and the sample birefringence is extracted by eigenvalue decomposition. The condition of balanced detection and the polarization mode dispersion are quantified. A complex field ...

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    17. ARVO to host Imaging in the Eye Conference in May 2015

      ARVO to host Imaging in the Eye Conference in May 2015

      The Association for Research in Vision and Ophthalmology (ARVO) will be hosting its annual Imaging in the Eye Conference on Saturday, May 2, 2015 in Denver, CO. This one-day conference takes place the day before the ARVO Annual Meeting. The conference brings together leading basic researchers, clinicians and engineers in the ophthalmic imaging field. Attendees can meet colleagues who are specialists in technology development, small animal imaging, image processing, translational research, clinical studies and clinical care in this rapidly changing area of research. The Imaging Conference highlights advances in many imaging techniques including optical coherence tomography (OCT), adaptive optics (AO ...

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    18. Voxeleron Releases Orion, Advanced OCT Analysis Software

      Voxeleron Releases Orion, Advanced OCT Analysis Software

      Orion™ is an application that offers fully-automated, rapid and accurate segmentation of seven layers in OCT images of the human retina. Currently for research use only, the award-winning software is platform independent - meaning it processes data from different OCT devices - and is now available following extensive beta testing. “We used Orion to process a considerable amount of data and found it to be a very useful research tool. The analysis tools that come with some of the OCT devices do not offer the functionality we need to do some of our fundamental clinical research, so Orion is a very powerful ...

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    19. Santec offers Electrically Pumped Tunable VCSEL HSL-1

      Santec offers Electrically Pumped Tunable VCSEL HSL-1

      Product Name: Tunable VCSEL Production code: HSL-1 Santec, a leading manufacturer of tunable lasers, optical instruments, and fiber-optic components, introduces the latest addition to its range of tunable lasers for spectroscopy and optical coherence tomography (OCT). The HSL-1 is based on advanced electrically pumped VCSEL (Vertical Cavity Surface Emitting Laser) technology. An attractive laser for SS-OCT applications the HSL-1 takes advantage of a number of features intrinsic to VCSELs to deliver best-in-class performance, including long coherence length, variable scan speed and low signal noise. The HSL-1 has been designed with system integration in mind; a compact, efficient package the laser ...

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      Mentions: Santec
    20. OFS Developes Optical Coherence Tomography Probes for Cardiovascular and GI Applications

      OFS Developes Optical Coherence Tomography  Probes for Cardiovascular and GI Applications

      OFS has been a part of the expanding adaptation of optical coherence tomography (OCT)—dominant in ophthalmology—using miniature optical fiber probes to see deep inside the body. The growth of applications, including cardiology, oncology, and gastroenterology, demonstrate the viability of the technology and the ultimate aim of improving our standard of healthcare. Optical Fiber Probes Supporting the adoption of OCT, OFS has developed the technology platform needed to build high quality optical fiber probes, with flexible tip lensing designs for b

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    21. Eye Health in Microgravity

      Eye Health in Microgravity

      OT’s Ryan O’Hare reports on NASA’s efforts to study the effects of space flight on the eye health of astronauts and why a trip to Mars could leave you needing a pair of reading glasses ORBITING THE Earth once every 90 minutes, at 431km above the planet’s surface, the International Space Station (ISS) is an ideal environment for studying the physiological effects of space travel. It’s far enough away to experience the vacuum of space but close enough to deliver supplies and equipment, and crucially, its velocity enables the crew to largely escape the pull ...

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    22. Three-dimensional Imaging and Analysis of Human Cartilage Degeneration Using Optical Coherence Tomography

      Three-dimensional Imaging and Analysis of Human Cartilage Degeneration Using Optical Coherence Tomography

      Optical Coherence Tomography (OCT) is an evolving imaging technology allowing non-destructive imaging of cartilage tissue at near-histological resolution. This study investigated the diagnostic value of real time 3-D OCT in comparison to conventional 2-D OCT in the comprehensive grading of human cartilage degeneration. Fifty-three human osteochondral samples were obtained from eight total knee arthroplasties. OCT imaging was performed by either obtaining a single two-dimensional cross-sectional image ( 2-D OCT ) or by collecting 100 consecutive parallel 2-D OCT images to generate a volumetric data set of 8 mm X 8 mm (3-D OCT ). OCT images were assessed qualitatively according to a modified ...

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    23. Assessment of a scoring system for Basal Cell Carcinoma with multi-beam optical coherence tomography

      Assessment of a scoring system for Basal Cell Carcinoma with multi-beam optical coherence tomography

      Background Multi-beam optical coherence tomography (OCT) is a novel method of non-invasive skin imaging allowing the evaluation of tissue at high level of lateral and axial resolution. It permits the horizontal and vertical evaluation of the extent of diseases. Objective Herein, we aimed to validate diagnosing basal cell carcinoma (BCC) by OCT using a newly developed scoring system (‘Berlin Score’-BS). This was based on the predetermined criteria such as dark border underneath the tumour and ovoid structures. Their frequency and distribution in subtypes of BCC were evaluated. Methods The study was conducted in two phases, in which the experience ...

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    24. Intravascular Ultrasound Versus Optical Coherence Tomography for Coronary Artery Imaging – Apples and Oranges?

      Intravascular Ultrasound Versus Optical Coherence Tomography for Coronary Artery Imaging – Apples and Oranges?

      Intravascular imaging has advanced our understanding of coronary artery disease and facilitated decision-making in percutaneous coronary intervention (PCI). In particular, intravascular ultrasound (IVUS) has contributed significantly to modern PCI techniques. The recent introduction of optical coherence tomography (OCT) has further expanded this field due to its higher resolution and rapid image acquisition as compared with IVUS. Furthermore, OCT allows detailed planning of interventional strategies and optimisation before stent deployment, particularly with complex lesions. However, to date it is unclear whether OCT is superior to IVUS as an intracoronary imaging modality with limited data supporting OCT use in routine clinical practice ...

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    25-48 of 78 « 1 2 3 4 »
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