1. Featured Articles

    25-32 of 32 « 1 2
    1. Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue

      Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue

      Accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high re-excision rates without resorting to the removal of excess healthy tissue. Optical coherence micro-elastography (OCME) is a three-dimensional, high-resolution imaging technique that is sensitive to micro-scale variations of the mechanical properties of tissue. As tumor modifies the mechanical properties of breast tissue, OCME has the potential to identify, on the micro-scale, involved regions of fresh, unstained tissue. OCME is based on ...

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    2. Detection of buried Barrett’s glands after radiofrequency ablation with volumetric laser endomicroscopy

      Detection of buried Barrett’s glands after radiofrequency ablation with volumetric laser endomicroscopy

      Background and Aims The prevalence and clinical relevance of buried Barrett’s glands (BB) after radiofrequency ablation (RFA) in Barrett’s esophagus (BE) are debated. Recent optical coherence tomography studies demonstrated a high prevalence of BBs. Direct histological correlation, however, has been lacking. Volumetric laser endomicroscopy (VLE) is a second-generation optical coherence tomography system capable of scanning a large surface of the esophageal wall layers with low-power microscopy resolution. The aim was to evaluate whether post-RFA subsquamous glandular structures (SGSs), detected with VLE, actually correspond to BBs by pursuing direct histological correlation with VLE images. Methods In vivo VLE was ...

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    3. St. Jude Medical Announces Launch of the First International Trial to Compare OCT-Guided Stent Implantation to IVUS or Angiography-Guided PCI

      St. Jude Medical Announces Launch of the First International Trial to Compare OCT-Guided Stent Implantation to IVUS or Angiography-Guided PCI

      St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced the launch of the ILUMIEN III clinical trial, a prospective, international, randomized trial evaluating the clinical benefits of the company’s optical coherence tomography (OCT) guidance during stent implantation. The ILUMIEN III study will compare OCT-guided stent implantation to implantation guided by intravascular ultrasound (IVUS) or angiography alone, diagnostic tools that offer less resolution than OCT during intravascular assessments and percutaneous coronary intervention (PCI). The ILUMIEN III study is the largest multicenter randomized study to date to compare PCI outcomes associated with all three imaging tools. By ...

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    4. Optovue Introduces AngioVue OCTA in Glaucoma

      Optovue Introduces AngioVue OCTA in Glaucoma

      Optovue, a pioneer in optical coherence tomography angiography (OCTA) and leader in commercialization of the technology, announced that it has expanded the application of its OCT Angiography technology into glaucoma. After a successful introduction of the revolutionary AngioVue Imaging System to retina last year, Optovue has worked to develop clinical applications in glaucoma as well.

      The use of the AngioVue Imaging System in glaucoma was introduced at a highly successful symposium at the 6th World Glaucoma Congress in Hong Kong. The Optovue-hosted event featured presentations on the clinical applications of OCTA in glaucoma research using the company's AngioVue OCTA ...

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    5. High-resolution three-dimensional in vivo imaging of mouse oviduct using optical coherence tomography

      High-resolution three-dimensional in vivo imaging of mouse oviduct using optical coherence tomography

      The understanding of the reproductive events and the molecular mechanisms regulating fertility and infertility in humans relies heavily on the analysis of the corresponding phenotypes in mouse models. While molecular genetic approaches provide significant insight into the molecular regulation of these processes, the lack of live imaging methods that allow for detailed visualization of the mouse reproductive organs limits our investigations of dynamic events taking place during the ovulation, the fertilization and the pre-implantation stages of embryonic development. Here we introduce an in vivo three-dimensional imaging approach for visualizing the mouse oviduct and reproductive events with micro-scale spatial resolution using ...

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    6. Computational high-resolution optical imaging of the living human retina

      Computational high-resolution optical imaging of the living human retina

      High-resolution in vivo imaging is of great importance for the fields of biology and medicine. The introduction of hardware-based adaptive optics (HAO) has pushed the limits of optical imaging, enabling high-resolution near diffraction-limited imaging of previously unresolvable structures 1 , 2 . In ophthalmology, when combined with optical coherence tomography, HAO has enabled a detailed three-dimensional visualization of photoreceptor distributions 3 , 4 and individual nerve fibre bundles 5 in the living human retina. However, the introduction of HAO hardware and supporting software adds considerable complexity and cost to an imaging system, limiting the number of researchers and medical professionals who could benefit ...

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    7. Optical Coherence Tomography: Technology and Applications Second Edition (Textbook)

      Optical Coherence Tomography: Technology and Applications Second Edition (Textbook)

      New medical imaging technologies can improve the diagnosis and clinical management of many diseases. Furthermore, advanced imaging also contributes to a better understanding of pathogenesis and therefore to the development of new pharmaceuticals and novel therapies. Thus, imaging plays a critical role in modern medical research and clinical practice. Noninvasive or minimally invasive imaging techniques have revolutionized diagnostic medicine during the last decades, e.g., X-ray computed tomography (CT), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), radioisotope imaging (position emission tomography (PET)), single-photon emission computed tomography (SPECT), and diffuse optical tomography (DOT). These techniques permit three-dimensional visualization; however ...

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    8. Barrett's Esophagus: Advanced Imaging Options For Early Cancer Detection

      Barrett's Esophagus: Advanced Imaging Options For Early Cancer Detection

      This Video describes the basic approach to endoscopic inspection of Barrett's esophagus. It Focuses on new imaging technologies that increase our ability to detect precancerous or cancerous changes and thus allow us to better target treatment to these areas. For more information on Barrett's Esophagus, visit: http://www.mayoclinic.org/diseases-co...

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