1. Featured Articles

    1-24 of 40 1 2 »
    1. Avinger Announces 30-Day VISION Trial Results at EuroPCR 2015

      Avinger Announces 30-Day VISION Trial Results at EuroPCR 2015

      Avinger, Inc., (Nasdaq: AVGR ) a developer and manufacturer of image-guided, catheter-based systems for the treatment of peripheral arterial disease (PAD) and pioneer of the lumivascular approach to treating vascular disease, today announced 30-day interim results for its VISION clinical study. VISION is designed to evaluate the safety and efficacy of the Pantheris™ system to perform directional atherectomy, while for the first time ever allowing physicians to use real-time intravascular imaging to aid in the removal of plaque from diseased lower extremity arteries. Results were presented by Arne Schwindt, M.D. of St. Franziskus Hospital in Muenster, Germany at the EuroPCR ...

      Read Full Article
    2. Demonstration of tolerance to dispersion of master/slave interferometry

      Demonstration of tolerance to dispersion of master/slave interferometry

      A theoretical model is developed for the Master/Slave interferometry (MSI) that is used to demonstrate its tolerance to dispersion left uncompensated in the interferometer when evaluating distances and thicknesses. In order to prove experimentally its tolerance to dispersion, different lengths of optical fiber are inserted into the interferometer to introduce dispersion. It is demonstrated that the sensitivity profile versus optical path difference is not affected by the length of fiber left uncompensated. It is also demonstrated that the axial resolution is constant within the axial range, close to the expected theoretical resolution determined by the optical source bandwidth. Then ...

      Read Full Article
    3. Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle

      Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle

      We evaluate strategies to maximize the field of view (FOV) of in vivo retinal OCT imaging of human eyes. Three imaging modes are tested: Single volume imaging with 85° FOV as well as with 100° and stitching of five 60° images to a 100° mosaic (measured from the nodal point). We employ a MHz-OCT system based on a 1060nm Fourier domain mode locked (FDML) laser with a depth scan rate of 1.68MHz. The high speed is essential for dense isotropic sampling of the large areas. Challenges caused by the wide FOV are discussed and solutions to most issues are ...

      Read Full Article
    4. Noninvasive cross-sectional observation of three-dimensional cell sheet-tissue-fabrication by optical coherence tomography

      Noninvasive cross-sectional observation of three-dimensional cell sheet-tissue-fabrication by optical coherence tomography

      Cell sheet engineering allows investigators/clinicians to prepare cell-dense three-dimensional (3-D) tissues, and various clinical trials with these fabricated tissues have already been performed for regenerating damaged tissues. Cell sheets are easily manipulated and 3-D tissues can be rapidly fabricated by layering the cell sheets. This study used optical coherence tomography (OCT) to noninvasively analyze the following processes: (1) adhesions between layered cell sheets, and (2) the beating and functional interaction of cardiac cell sheet-tissues for fabricating functional thicker 3-D tissues. The tight adhesions and functional couplings between layered cell sheets could be observed cross-sectionally and in real time. Importantly ...

      Read Full Article
      Mentions: Panasonic
    5. New Clinical Data Using the NvisionVLE® Imaging System to be Presented at Digestive Disease Week® 2015

      New Clinical Data Using the NvisionVLE® Imaging System to be Presented at Digestive Disease Week® 2015

      NinePoint Medical, Inc. , an emerging leader in the development of medical devices for advanced imaging, today announced that new clinical data relating to its proprietary NvisionVLE ® Imaging System, will be presented in a series of oral and poster presentations during Digestive Disease Week ® (DDW ® ) 2015. The annual meeting will take place May 16-19th in Washington, DC. The schedule for scientific presentations related to advanced optical coherence tomography (OCT) and the NvisionVLE ® Imaging System at DDW 2015 is provided below. SATURDAY, May 16, 2015 Three posters will be presented on Saturday, May 16 at 9:30am in Hall C of Walter ...

      Read Full Article
    6. Accuracy of intravascular ultrasound and optical coherence tomography in identifying functionally significant coronary stenosis according to vessel diameter: A meta-analysis of 2,581 patients and 2,807 lesions

      Accuracy of intravascular ultrasound and optical coherence tomography in identifying functionally significant coronary stenosis according to vessel diameter: A meta-analysis of 2,581 patients and 2,807 lesions

      Introduction Accuracy of intracoronary imaging to discriminate functionally significant coronary stenosis according to vessel diameter remains to be defined. Methods PubMed, Scopus, and Google Scholar were systematically searched for studies assessing diagnostic accuracy (area under the receiver operating characteristic curve [AUC], the primary end point) and sensitivity and specificity (the secondary end points) of minimal luminal area (MLA) or of minimal luminal diameter (MLD) derived from intravascular ultrasound (IVUS) or optical coherence tomography (OCT) to detect functionally significant stenosis as determined with fractional flow reserve (FFR). Results Fifteen studies were included, 2 with 110 patients analyzing only left main (LM ...

      Read Full Article
    7. Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos)

      Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos)

      Background Volumetric laser endomicroscopy (VLE) produces high-resolution, cross-sectional surface, and subsurface images for detecting neoplasia, targeting biopsies, and guiding real-time treatment. Objective To evaluate the safety and feasibility of the Nvision VLE system. Design Prospective, multicenter study. Setting Tertiary-care medical centers. Patients One hundred patients with suspected Barrett’s esophagus, including 52 patients with prior endotherapy. Interventions The first-generation Nvision VLE Imaging System, a balloon-centered, rotating optical probe provided images of the mucosa and submucosa through a 6-cm segment length and 360° scan of the distal esophagus. Main Outcome Measurements Acquisition of a complete, 6-cm scan from the distal esophagus ...

      Read Full Article
    8. Volumetric laser endomicroscopy in Barrett's esophagus: a feasibility study on histological correlation

      Volumetric laser endomicroscopy in Barrett's esophagus: a feasibility study on histological correlation

      Volumetric laser endomicroscopy (VLE) is a novel balloon-based optical coherence tomography (OCT) imaging technique that may improve detection of early neoplasia in Barrett's esophagus (BE). Most OCT studies lack a direct correlation between histology and OCT images. The aim is to investigate the optimal approach for achieving one-to-one correlation of ex-vivo VLE images of endoscopic resection (ER) specimens with histology. BE patients with and without early neoplasia underwent ER after delineating areas with electrocoagulation markers (ECM). After ER, specimens underwent additional ex-vivo marking with several different markers (ink, pin, Gold Probe) followed by ex-vivo VLE scanning. ER specimens were ...

      Read Full Article
    9. Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue

      Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue

      We report the development of a combined confocal Raman spectroscopy (CRS) and optical coherence tomography (OCT) instrument (CRS-OCT) capable of measuring analytes in targeted biological tissues with sub-100-micron spatial resolution. The OCT subsystem was used to measure depth-resolved tissue morphology and guide the acquisition of chemically-specific Raman spectra. To demonstrate its utility, the instrument was used to accurately measure depth-resolved, physiologically-relevant concentrations of Tenofovir, a microbicide drug used to prevent the sexual transmission of HIV, in ex vivo tissue samples.

      Read Full Article
    10. Tiny Camera Sees Inside Blood Vessels

      Tiny Camera Sees Inside Blood Vessels

      Ahead of any surgical procedure, doctors try to learn as much as possible about the state of the organs they plan to operate on. A new camera developed in the Netherlands can now make that easier - giving surgeons an incredibly detailed look inside blood vessels, all the way to the patient’s heart. Blockages in coronary arteries, caused by the buildup of plaque, are the main cause of heart attacks. In most cases, doctors treat the problem by widening the artery with a mechanical device called a stent, inserted at the end of a long thin wire-like catheter. But within ...

      Read Full Article
    11. Optical Coherence Elastography

      Optical Coherence Elastography

      S ince the days of Hippocrates, as early as 400 B.C.E., physicians have used palpation—probing by touch—to identify diseased tissue by variations in its mechanical properties. In the modern clinic, the uses of palpation range from assessment of skin lesions to the guidance of the surgical excision of tumors. Indeed, the usefulness of palpation has, over the past 25 years, given rise to a new family of imaging techniques—known as elastography—that map the spatial variation of the mechanical properties of diseased tissue, with greater accuracy and often much higher resolution than can be achieved ...

      Read Full Article
    12. Single input state, single-mode fiber-based polarization-sensitive optical frequency domain imaging by eigenpolarization referencing

      Single input state, single-mode fiber-based polarization-sensitive optical frequency domain imaging by eigenpolarization referencing

      Fiber-based polarization-sensitive optical frequency domain imaging is more challenging than free-space implementations. Using multiple input states, fiber-based systems provide sample birefringence information with the benefit of a flexible sample arm but come at the cost of increased system and acquisition complexity, and either reduce acquisition speed or require increased acquisition bandwidth. Here we show that with the calibration of a single polarization state, fiber-based configurations can approach the conceptual simplicity of traditional free-space configurations. We remotely control the polarization state of the light incident at the sample using the eigenpolarization states of a wave plate as a reference, and determine ...

      Read Full Article
    13. IN VIVO CHARACTERIZATION OF RETINAL VASCULARIZATION MORPHOLOGY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      IN VIVO CHARACTERIZATION OF RETINAL VASCULARIZATION MORPHOLOGY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To evaluate retinal vessel morphology using split-spectrum amplitude-decorrelation angiography with optical coherence tomography in healthy eyes. Methods: Fifty-two eyes of 26 healthy volunteers (age range from 35 to 48 years; mean age 41.94 years; SD: +/-4.13) were evaluated by optical coherence tomography angiography in the macular region. The protocol acquisition consisted of a 216 x 216 A-scan that was repeated 5 times in the same position, in 3 x 3 mm centered into the fovea. Results: All 52 eyes showed 2 separate vascular networks in the inner retina: the superficial network, located in the nerve fiber layer ...

      Read Full Article
    14. Multiple-reference optical coherence tomography for smartphone applications

      Multiple-reference optical coherence tomography for smartphone applications

      As a multifunctional clinical diagnostic and monitoring technique, optical coherence tomography (OCT) 1 has become a well-established tool in many areas, including ophthalmology, dermatology, gastrointestinal endoscopy, intravascular imaging, and oncology. OCT is a low-coherence, interferometric-based imaging modality that can be implemented using either time-domain (TD) or frequency-domain (FD) methods in which the interference signals generated by combining reference signals with light scattered by the target are detected. Early OCT systems are based on TD technology, and they use a bulky scanning reference arm optical delay to sequentially generate the axial scans (A-scans). TD systems require an inherently long acquisition time ...

      Read Full Article
    15. Impacts of lesion angle on incidence and distribution of acute vessel wall injuries and strut malapposition after drug-eluting stent implantation assessed by optical coherence tomography

      Impacts of lesion angle on incidence and distribution of acute vessel wall injuries and strut malapposition after drug-eluting stent implantation assessed by optical coherence tomography

      Aims To investigate the impact of lesion angle on the incidence and distribution of acute vessel wall injuries and incomplete stent apposition (ISA) following second-generation drug-eluting stent (DES) implantation using optical coherence tomography (OCT). Several ex vivo studies demonstrated that angled arterial walls are exposed to imbalanced mechanical stress from deployed stents. Methods and results We included 243 lesions treated with a single DES (148 everolimus-eluting stent and 95 zotarolimus-eluting stent). Angled lesions were defined as lesions with angle ≥45° on an angiogram ( n = 58). The vessel wall injuries and ISA were evaluated by OCT. The results were compared with ...

      Read Full Article
    16. Clinical OCT Angiography Atlas (Textbook)

      Clinical OCT Angiography Atlas (Textbook)

      Guide to the understanding and interpretation of Angio-OCT · Provides complete overview of technique and interpretation, including terminology · Describes use of OCT for diagnosis of ocular diseases and disorders in different parts of the eye, and future developments · Highly illustrated with more than 250 clinical images · Internationally recognised editor and author team comprising leading clinicians and researchers in ophthalmology and OCT imaging

      Read Full Article
    17. Dr. David Huang Joins the Research to Prevent Blindness (RPB) Scientific Advisory Board

      Dr. David Huang Joins the Research to Prevent Blindness (RPB) Scientific Advisory Board

      David Huang, MD, PhD, Peterson Professor of Ophthalmology and Professor of Biomedical Engineering at Oregon Health & Science University, has joined the Research to Prevent Blindness (RPB) Scientific Advisory Board. This will enhance the ability of RPB to evaluate imaging and engineering based grant applications. For information on RPB grant program, please see https://www.rpbusa.org/rpb/grants/grants/

      Read Full Article
    18. Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography

      Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography

      Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth-resolved cross-sectional images. In this study, OCT was used to detect changes in the optical properties of cortical tissue in vivo in mice during the induction of global (pentylenetetrazol) and focal (4-aminopyridine) seizures. Through the use of a confidence interval statistical method on depth-resolved volumes of attenuation coefficient, we demonstrated localization of regions exhibiting both significant positive and negative changes in attenuation coefficient, as well as differentiating between global and focal seizure propagation.

      Read Full Article
    19. Molecular imaging needles: dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue

      Molecular imaging needles: dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue

      Molecular imaging using optical techniques provides insight into disease at the cellular level. In this paper, we report on a novel dual-modality probe capable of performing molecular imaging by combining simultaneous three-dimensional optical coherence tomography (OCT) and two-dimensional fluorescence imaging in a hypodermic needle. The probe, referred to as a molecular imaging (MI) needle, may be inserted tens of millimeters into tissue. The MI needle utilizes double-clad fiber to carry both imaging modalities, and is interfaced to a 1310-nm OCT system and a fluorescence imaging subsystem using an asymmetrical double-clad fiber coupler customized to achieve high fluorescence collection efficiency. We ...

      Read Full Article
    20. Study shows new technology may improve management of leading causes of blindness

      Study shows new technology may improve management of leading causes of blindness

      Research published today in the Proceedings of the National Academy of Sciences (PNAS) demonstrates that technology invented by researchers at Oregon Health & Science University's Casey Eye Institute can improve the clinical management of the leading causes of blindness. Optical coherence tomography (OCT) angiography could largely replace current dye-based angiography in the management of these diseases. OHSU researchers found that OCT angiography has considerable advantages over conventional techniques for the diagnosis and management of macular degeneration, diabetic eye disease and glaucoma, the leading causes of blindness in the United States. "This is a significant breakthrough technology that could fundamentally change ...

      Read Full Article
    21. Heidelberg Engineering Announces 85,000 Hz OCT2; Next Generation SPECTRALIS OCT Module

      Heidelberg Engineering Announces 85,000 Hz OCT2; Next Generation SPECTRALIS OCT Module

      Heidelberg Engineering announces significant improvements to the SPECTRALIS ® OCT2 Module. The OCT2 Module brings the next generation OCT technology to the SPECTRALIS diagnostic imaging platform. It combines a high scan rate with Heidelberg Engineering’s proprietary TruTrack Active Eye Tracking, to provide unmatched image quality and significantly improved acquisition speed. New applications such as OCT Angiography* will build on the OCT2 Module. Since its debut at the 2014 American Academy of Ophthalmology in Chicago, the OCT2 Module is an option for all new SPECTRALIS models. In addition, a large number of SPECTRALIS devices in use, depending on their technical specifications ...

      Read Full Article
    22. Senior Systems Engineer Opening at NinePoint Medical

      Senior Systems Engineer Opening at NinePoint Medical

      The Company NinePoint Medical is positioned to improve patient care through the development of medical devices that enable high-resolution in-vivo imaging. Using advanced optical technologies, NinePoint Medical empowers treating physicians and pathologists to image cross-sectionally and visualize features at and below the tissue surface. Job Summary We are looking for a talented Senior Systems Engineer who will be responsible for developing future medical device platforms, and supporting existing technologies. Key Responsibilities: Execution of diverse tasks related to the development of complete integrated systems (console & optical probes): from concept and development through commercialization. Define, develop, and document system- and subsystem-level requirements ...

      Read Full Article
    23. An efficient phase analysis-based wavenumber linearization scheme for swept source optical coherence tomography systems

      An efficient phase analysis-based wavenumber linearization scheme for swept source optical coherence tomography systems

      This letter reports an efficient phase analysis-based direct time domain resampling scheme for swept source-based optical coherence tomography (SS-OCT) systems. The unwrapped phase values, representing non-linear frequency sweeping of the laser, are extracted from the calibration signal generated by a Mach–Zehnder interferometer. Equidistant wavenumber spaces are calculated by normalizing obtained phase values followed by scaling to the maximum number of sampling points. The non-uniform fractional time index values corresponding to the uniformly distributed phase values are computed directly from the linearizer coordinates in order to eliminate the use of the polynomial fitting approach that is used in existing phase-based ...

      Read Full Article
    1-24 of 40 1 2 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles