1. Featured Articles

    1-11 of 11
    1. Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis

      Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis

      In this paper, we report what we believe is a novel technique to overcome the depth-of-focus (DOF) limitation in optical coherence tomography (OCT). Using confocal optics on a sample arm, we scanned the illumination beam across the under-filled objective lens pupil plane by steering the beam at the pinhole using a microcylindrical lens. The detected interferometric signals from multiple distinctive apertures were digitally refocused, which is analogous to synthetic aperture radar (SAR). Using numerical simulations and imaging experiments, we verified that this technique can maintain a diffraction-limited transverse resolution along a DOF that is ∼ 10 ∼10 times larger than the ...

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    2. Investigating the influence of organic matter composition on biofilm volumes in reverse osmosis using optical coherence tomography

      Investigating the influence of organic matter composition on biofilm volumes in reverse osmosis using optical coherence tomography

      Biofouling, a critical issue in membrane filtration, is influenced by several factors such as membrane characteristics and feed water quality. The organic matter (OM) composition is known to significantly influence biofilm formation, but few studies on this subject have been reported. Optical coherence tomography (OCT) allows direct monitoring of biofilm development on the membrane surface without the need for membrane autopsy. The purposes of the present study are 1) to quantify biofouling formation on a membrane surface using OCT; 2) to monitor the temporal variation of OM composition during membrane formation; and 3) to investigate the variation of OM composition ...

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    3. Compact Optical Delay Line for More Efficient OCT Imaging from Gooch & Housego

      Compact Optical Delay Line for More Efficient OCT Imaging from Gooch & Housego

      Systems Technology Groups presents the G&H small form factor (SFF) delay line. The delay line was specifically designed for the exacting requirements of optical coherence tomography (OCT). OCT is an imaging modality, mainly used in biomedical applications. By using OCT, it is possible to take real-time, high resolution 3D images in a non-invasive manner. OCT is a technique that utilises optical interferometry in which one interferometer arm is the reference optical path and the other is the optical path to the sample being imaged. The technique relies on the precise length alignment between the paths of the two interfering ...

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      Mentions: Gooch & Housego
    4. Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo

      Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo

      Swept-source optical coherence tomography (SS-OCT) shows potential for the in vivo quantitative evaluation of micro-structural enamel surface phenomena occurring during early erosive demineralization. This randomized controlled single-blind cross-over clinical study aimed to evaluate the use of SS-OCT for detecting optical changes in the enamel of 30 healthy volunteers subjected to orange juice rinsing (erosive challenge) in comparison to mineral water rinsing (control), according to wiped and non-wiped enamel surface states. Participants were randomly allocated to 60 min of orange juice rinsing (pH 3.8) followed by 60 min of water rinsing (pH 6.7) and vice versa, with a 2-week ...

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    5. Pharmaceutical film coating catalogue for spectral-domain optical coherence tomography

      Pharmaceutical film coating catalogue for spectral-domain optical coherence tomography

      Optical coherence tomography (OCT) has recently been demonstrated to measure the film coating thickness of pharmaceutical tablets and pellets directly. The results enable the analysis of inter- and intra-tablet coating variability at an off-line and in-line setting. To date, only a few coating formulations have been tried and there is very little information on the applicability of OCT to other coatings. As it is well documented that optical methods including OCT are prone to scattering leading to limited penetration, some pharmaceutical coatings may not be measurable altogether. This study presents OCT measurements of 22 different common coatings for the assessment ...

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    6. Introduction to the feature issue on the 25 year anniversary of optical coherence tomography

      Introduction to the feature issue on the 25 year anniversary of optical coherence tomography

      This feature issue commemorates the approximately 25 year history of Optical Coherence Tomography (OCT), one of the most successful biophotonic technologies. While OCT has technological origins traceable to ultrafast laser development and fiber optic system test instrumentation of the 1980’s, innovations in low coherence interferometry for optical ranging and imaging for biomedical applications in the U.S., Europe and Japan by the early 1990’s led to coinage of the now widely known term OCT in 1991 [1]. As discussed in the following cited Invited Review and Invited Research articles in this issue, remarkable strides have since been made ...

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    7. Speckle-modulating optical coherence tomography in living mice and humans

      Speckle-modulating optical coherence tomography in living mice and humans

      Optical coherence tomography (OCT) is a powerful biomedical imaging technology that relies on the coherent detection of backscattered light to image tissue morphology in vivo . As a consequence, OCT is susceptible to coherent noise (speckle noise), which imposes significant limitations on its diagnostic capabilities. Here we show speckle-modulating OCT (SM-OCT), a method based purely on light manipulation that virtually eliminates speckle noise originating from a sample. SM-OCT accomplishes this by creating and averaging an unlimited number of scans with uncorrelated speckle patterns without compromising spatial resolution. Using SM-OCT, we reveal small structures in the tissues of living animals, such as ...

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    8. Effects of statins on plaque rupture assessed by optical coherence tomography in patients presenting with acute coronary syndromes: insights from the optical coherence tomography (OCT)-FORMIDABLE registry

      Effects of statins on plaque rupture assessed by optical coherence tomography in patients presenting with acute coronary syndromes: insights from the optical coherence tomography (OCT)-FORMIDABLE registry

      Aims Chronic pre-treatment with statins may reduce mortality and morbidity in patients experiencing acute coronary syndromes (ACS), but mechanisms accounting for these findings are not completely understood. Methods and results The optical coherence tomography (OCT)-Formidable registry retrospectively enrolled 285 consecutive patients with ACS undergoing OCT in 9 European centres. Mean age was 60.4 ± 12.8 years, 148 (51.9%) patients had hyperlipemia, 45 (15.8%) diabetes mellitus and 142 (49.8%) presented with ST Segment Elevation Myocardial Infarction (STEMI). Patients were stratified according to statin prescription: 150 (52.6%) were on chronic pre-treatment with statins before ACS and ...

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    9. Zeiss Acquisition of Insight Ophthalmic Laser Engines for 19.1M Euros

      Zeiss Acquisition of Insight Ophthalmic Laser Engines for 19.1M Euros

      On 24 February 2017 a contract was concluded between Carl Zeiss Meditec, Inc., Dublin USA, and Insight Photonics Solutions, Inc. (hereinafter “Insight”), which domiciled in Lafayette, USA, pertaining to the acquisition of 52 percent of the shares in Ophthalmic Laser Engines, LLC, Lafayette, USA (hereinafter referred to as “OLE”). The main aim of acquiring these shares is to develop and produce an akinetic swept source laser for ophthalmology, and the associated OCT system elements. Departing from the voting rights distribution, a profit distribution of 30% for Insight was agreed until 31 December 2022, which allocated as a performance-related component to ...

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    10. U.S. Engineers James G. Fujimoto and Eric A. Swanson, and German Physicist Robert Huber Win European Inventor Award 2017

      U.S. Engineers James G. Fujimoto and Eric A. Swanson, and German Physicist Robert Huber Win European Inventor Award 2017

      Exceptional inventors from Austria, Belgium, France, Germany, Italy, Morocco, the Netherlands, Spain, and the US receive European Inventor Award 2017 at ceremony in Venice ... U.S. Engineers James G. Fujimoto and Eric A. Swanson, and German Physicist Robert Huber Win in the "Non-EPO Countries" category. For more information see http://www.prweb.com/releases/2017/06/prweb14416991.htm.

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    11. Spectral Domain Optical Coherence Tomography in Macular Disease (Textbook)

      Spectral Domain Optical Coherence Tomography in Macular Disease (Textbook)

      . This book aims to build concepts and create a solid foundation in the field of optical coherence tomography (OCT) for the general ophthalmologists as well as for the resident trainees and fellows. The chapters are written by leading international authorities in a style comprehensible to a broad audience. Numerous clinical pictures and SD-OCT scans help elucidate various clinical entities.OCT is the optical analog of ultrasound imaging and has emerged as a powerful imaging technique that enables non-invasive, in-vivo, high-resolution, cross-sectional imaging in retinal tissue. A new generation spectral domain optical coherence tomography (SD-OCT) technology has now been developed, representing ...

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    1-11 of 11
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