1. Featured Articles

    1-12 of 12
    1. Massachusetts General Hosptial Receives NIH Grant for Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy

      Massachusetts General Hosptial Receives NIH Grant for Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy

      Massachusetts General Hosptial Received a 2022 NIH Grant for $643,503 for Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy. The principal investigator is Guillermo Tearney. Below is a summary of the proposed study. Esophageal adenocarcinoma (EAC) is a deadly cancer that is preceded by a metaplastic change called Barrett's esophagus (BE). It has long been thought that endoscopic screening for BE followed by endoscopic surveillance can significantly decrease the mortality of EAC. This unfortunately has not borne out as the cost and inconvenience of conscious sedation prohibits endoscopy from being used as a population-based ...

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    2. In situ volumetric imaging and analysis of FRESH 3D bioprinted constructs using optical coherence tomography

      In situ volumetric imaging and analysis of FRESH 3D bioprinted constructs using optical coherence tomography

      As 3D bioprinting has grown as a fabrication technology, so too has the need for improved analytical methods to characterize engineered constructs. This is especially challenging for engineered tissues composed of hydrogels and cells, as these materials readily deform when trying to assess print fidelity and other properties non-destructively. Establishing that the 3D architecture of the bioprinted construct matches its intended anatomic design is critical given the importance of structure-function relationships in most tissue types. Here we report development of a multimaterial bioprinting platform with integrated optical coherence tomography (OCT) for in situ volumetric imaging, error detection, and 3D reconstruction ...

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    3. Leica Microsystems's EnFocus Intraoperative Optical Coherence Tomography Development Team Wins Optica’s 2022 Paul F. Forman Team Engineering Excellence Award

      Leica Microsystems's EnFocus Intraoperative Optical Coherence Tomography Development Team Wins Optica’s 2022 Paul F. Forman Team Engineering Excellence Award

      Advancing Optics and Photonics Worldwide, is pleased to announce that Leica Microsystems's EnFocus Intraoperative Optical Coherence Tomography Development Team , has received the 2022 Paul F. Forman Team Engineering Excellence Award . The team is recognized, “for developing an optically brilliant, latency-free intrasurgical optical coherence tomography microscope that fully integrates into the ophthalmic surgical workflow, allowing a surgeon to see more and do more to preserve patient sight.” The 2022 award will be presented during Frontiers in Optics + Laser Science ( FiO LS ). A list of the team members is available below. “Optica is proud to honor this diverse team for their ...

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      Mentions: Leica
    4. Optical Interference Measurement using High-Coherence Wavelength Swept Light Sources

      Optical Interference Measurement using High-Coherence Wavelength Swept Light Sources

      Conventional contact measurement is replacing product shape inspection by non-contact optical measurement as part of the evolution of “smart factories”. Optical measurement includes various non-contact and non-destructive optical interferometry methods. Conventional methods feature accuracies ranging from nm to µm-order levels, but measurement distances are short, and high measurement accuracy is difficult to achieve due to meter-level measurement distances for targets with large surface areas. Our Wavelength swept light source with high coherence length supports accurate measurement over distances of several meters. This article explains the basic principles of OFDR as a typical optical interferometry measurement method and discusses the results ...

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    5. High-depth-resolution imaging of dispersive samples using quantum optical coherence tomography

      High-depth-resolution imaging of dispersive samples using quantum optical coherence tomography

      Quantum optical coherence tomography (QOCT) is a promising approach to overcome the degradation of the resolution in optical coherence tomography (OCT) due to dispersion. Here, we report on an experimental demonstration of QOCT imaging in the high-resolution regime. We achieved a depth resolution of 2.5

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    6. Image-based cross-calibration method for multiple spectrometer-based OCT

      Image-based cross-calibration method for multiple spectrometer-based OCT

      A fast and practical computational cross-calibration of multiple spectrometers is described. A signal correlation matrix (CM) can be constructed from paired B-scans in a multiple-spectrometer optical coherence tomography (OCT), where the wavelength-corresponding pixels are indicated by high cross correlation. The CM can be used to either guide the physical alignment of spectrometers or to numerically match the spectra in the post-process. The performance is comparable to the previously reported optimization approach, as demonstrated by the mirror tests, qualitative comparison of OCT and optical coherence tomography angiography (OCTA) images, and quantitative comparison of image metrics. © 2022 Optica Publishing Group under the ...

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    7. Dr Michael Chiang Chronicles the NEI's Research Into AI, Telemedicine in Ophthalmology

      Dr Michael Chiang Chronicles the NEI's Research Into AI, Telemedicine in Ophthalmology

      Advances in imaging and data science are changing the nature of retina practice, and retina specialists need to stay on top of these, said Michael F. Chiang, MD, director of the National Eye Institute (NEI), who also discussed some of the current research the agency is conducting into artificial intelligence (AI) and telemedicine.

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    8. Minimally Invasive Polarization Sensitive Optical Coherence Tomography (PS-OCT) for assessing Pre-OA, a pilot study on technical feasibility

      Minimally Invasive Polarization Sensitive Optical Coherence Tomography (PS-OCT) for assessing Pre-OA, a pilot study on technical feasibility

      Efforts to develop chondroprotective approaches to halt osteoarthritis (OA) progression have recently increased. Current imaging techniques are critical in managing advanced OA, but greater resolution is needed to identify reversible stages (pre-OA). Optical coherence tomography (OCT) is a micron scale imaging technology widely used in ophthalmology, cardiology, and neurology. We previously demonstrated that polarization sensitive OCT (PS-OCT) can identify pre-OA in vitro, in animals, and in open surgical fields. This feasibility study examines performing intraarticular PS-OCT using a flexible endocatheter introduced through a stiff 18-gauge spinal needle. Results are critical for designing larger clinical trials examining minimally invasive PS-OCT's ...

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    9. Mouse embryo phenotyping with optical coherence tomography

      Mouse embryo phenotyping with optical coherence tomography

      With the explosion of gene editing tools in recent years, there has been a much greater demand for mouse embryo phenotyping, and traditional methods such as histology and histochemistry experienced a methodological renaissance as they became the principal tools for phenotyping. However, it is important to explore alternative phenotyping options to maximize time and resources and implement volumetric structural analysis for enhanced investigation of phenotypes. Cardiovascular phenotyping, in particular, is important to perform in vivo due to the dramatic structural and functional changes that occur in heart development over relatively short periods of time. Optical coherence tomography (OCT) is one ...

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    10. The Use of Optical Coherence Tomography for Gross Examination and Sampling of Fixed Breast Specimens: A Pilot Study

      The Use of Optical Coherence Tomography for Gross Examination and Sampling of Fixed Breast Specimens: A Pilot Study

      Abstract Thorough gross examination of breast cancer specimens is critical in order to sample relevant portions for subsequent microscopic examination. This task would benefit from an imaging tool which permits targeted and accurate block selection. Optical coherence tomography (OCT) is a non-destructive imaging technique that visualizes tissue architecture and has the potential to be an adjunct at the gross bench. Our objectives were: (1) to familiarize pathologists with the appearance of breast tissue entities on OCT; and (2) to evaluate the yield and quality of OCT images of unprocessed, formalin-fixed breast specimens for the purpose of learning and establishment of ...

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    11. Superior Imaging Performance of All-Fiber, Two-Focusing-Element Microendoscopes

      Superior Imaging Performance of All-Fiber, Two-Focusing-Element Microendoscopes

      All-fiber-optic imaging microendoscopes are emerging as an important tool in bioimaging studies, including those conducted with optical coherence tomography, but physical limitations constrain the achievable beam characteristics of designs using a single focusing element. These constraints are especially relevant for applications that require a long working distance, high resolution, and/or minimal probe diameter. Through detailed analysis based on ABCD matrix modelling, we show that side-viewing probes combining a graded-index (GRIN) fiber with a ball lens – GRIN-ball-lens probes (GBLPs) – offer superior performance over a range of numerical apertures and pave the way for a broader range of imaging applications. The ...

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    12. Optical coherence tomography—in situ and high-speed 3D imaging for laser materials processing

      Optical coherence tomography—in situ and high-speed 3D imaging for laser materials processing

      Exploiting Fourier-domain optical coherence tomography, a high-speed and real-time inspection of multi-photon 3D laser printing has been reported. We expect that this technique can be further extended to single shot compressive 3D imaging for studying the ultrafast dynamics of laser-matter interaction. Femtosecond lasers are essential tools for micro/nanoscale surface patterning 1 , as well as 3D lithography and printing 2 , 3 . Aiming for highly precision laser engineering, in situ and high-speed monitoring is of significance. While the wide-field microscopy enables a convenient in situ monitoring, it is limited to 2D imaging. The other advanced imaging methods, such as scanning electron ...

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    1-12 of 12
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