1. Featured Articles

    1-21 of 21
    1. Group refractive index and group velocity dispersion measurement by complex master slave interferometry

      Group refractive index and group velocity dispersion measurement by complex master slave interferometry

      This paper demonstrates that the complex master slave interferometry ( CMSI ) method used in spectral domain interferometry ( SDI ) can efficiently be used for accurate refractive index and group velocity dispersion measurements of optically transparent samples. For the first time, we demonstrate the relevance of the phase information delivered by CMSI for dispersion evaluations with no need to linearize data. The technique proposed here has been used to accurately measure the group refractive index and the group velocity dispersion of a strong dispersive sample (SF6 glass), and a weak dispersive one (distilled water). The robustness of the technique is demonstrated through the ...

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    2. Masters of Science in Optical Coherence Tomography at the University of Kent

      Masters of Science in Optical Coherence Tomography at the University of Kent

      Optical Coherence Tomography (OCT) is having a dramatic impact on the diagnosis and management of eye disease, and offers a wide range of career prospects in research and industry. Come and study the principles of spectral and time domain interferometry, and learn how progress in the fibre optics and laser industry has shaped OCT technology. In this one-year programme, students will develop an experimental project under the supervision of one of the four academics of the Applied Optics Group (AOG) which has long and extensive experience in OCT. Projects can be selected from a wide range of areas, including tissue ...

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    3. Post-doctoral Research Fellow Position and 2 PhD Studentships in Ophthalmic Imaging at the Nicolaus Copernicus University, Torun, Poland

      Post-doctoral Research Fellow Position and 2 PhD Studentships in Ophthalmic Imaging at the Nicolaus Copernicus University, Torun, Poland

      The Bio-Optics & Optical Engineering Lab at the Nicolaus Copernicus University invites applications for the positions in a project entitled Lenticular and vitreal light scattering and refraction for tomorrow's eye diagnostics financed by the Foundation for Polish Science (Programme TEAM) from the Smart Growth Operational Programme funds (PO IR) in 2014-2020. We are seeking young researchers for the following positions: Post-doctoral Research Fellow, and PhD students (2x). The project aims at the development and clinical validation of novel imaging-based tools to extract spatially resolved information on the light scattering and refraction in the ocular structures and media. The project addresses ...

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    4. Clinically applicable deep learning for diagnosis and referral in retinal disease

      Clinically applicable deep learning for diagnosis and referral in retinal disease

      The volume and complexity of diagnostic imaging is increasing at a pace faster than the availability of human expertise to interpret it. Artificial intelligence has shown great promise in classifying two-dimensional photographs of some common diseases and typically relies on databases of millions of annotated images. Until now, the challenge of reaching the performance of expert clinicians in a real-world clinical pathway with three-dimensional diagnostic scans has remained unsolved. Here, we apply a novel deep learning architecture to a clinically heterogeneous set of three-dimensional optical coherence tomography scans from patients referred to a major eye hospital. We demonstrate performance in ...

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    5. Now DeepMind's AI can spot eye disease just as well as your doctor

      Now DeepMind's AI can spot eye disease just as well as your doctor

      When Pearse Keane started using optical coherence tomography (OCT) scanners to peer to the back of a person's eye in Los Angeles a decade ago, the machines were relatively crude. "The devices were lower resolution, they had much slower image acquisition speeds," says Keane, a consultant ophthalmic surgeon at Moorfields Eye Hospital and researcher at University College, London. From 2007, Keane spent two years studying scans from OCT machines learning to diagnose eye conditions in patients and pick out the minute details which make up sight-threatening diseases. "It was very time consuming, laborious work," Keane says. OCT scans use ...

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    6. Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography

      Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography

      We investigate the origin of high frequency noise in Fourier domain mode locked (FDML) lasers and present an extremely well dispersion compensated setup which virtually eliminates intensity noise and dramatically improves coherence properties. We show optical coherence tomography (OCT) imaging at 3.2 MHz A-scan rate and demonstrate the positive impact of the described improvements on the image quality. Especially in highly scattering samples, at specular reflections and for strong signals at large depth, the noise in optical coherence tomography images is significantly reduced. We also describe a simple model that suggests a passive physical stabilizing mechanism that leads to ...

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    7. OCT-Guided Laser Therapy for Patients With Recurrent Respiratory Papillomatosis

      OCT-Guided Laser Therapy for Patients With Recurrent Respiratory Papillomatosis

      Importance Recurrent respiratory papillomatosis (RRP) is a viral-induced disease caused by human papillomavirus and the second leading cause of dysphonia in children; however, neither a cure nor a definitive surgical treatment is currently available for RRP. Although laser therapy is often used in the treatment of RRP, the lack of real-time laser-tissue interaction feedback undermines the ability of physicians to provide treatments with low morbidity. Therefore, an intraoperative tool to monitor and control laser treatment depth is needed. Objective To investigate the potential of combining optical coherence tomography (OCT) with laser therapy for patient-tailored laryngeal RRP treatments. Design, Setting, and ...

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    8. Comparative study on the detection of early dental caries using thermo-photonic lock-in imaging and optical coherence tomography

      Comparative study on the detection of early dental caries using thermo-photonic lock-in imaging and optical coherence tomography

      Early detection of dental caries is known to be the key to the effectiveness of therapeutic and preventive approaches in dentistry. However, existing clinical detection techniques, such as radiographs, are not sufficiently sensitive to detect and monitor the progression of caries at early stages. As such, in recent years, several optics-based imaging modalities have been proposed for the early detection of caries. The majority of these techniques rely on the enhancement of light scattering in early carious lesions, while a few of them are based on the enhancement of light absorption at early caries sites. In this paper, we report ...

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    9. Mechanical/Optical Engineering Position at OCT Medical Imaging Inc.

      Mechanical/Optical Engineering Position at OCT Medical Imaging Inc.

      Job Description This opening is for a senior mechanical engineer who will be responsible for the design and development and manufacturing of several intravascular catheters and pullback devices used in intravascular imaging. Senior mechanical engineer will develop disposable devices following FDA regulatory standards, by working in coordination with regulatory professionals, optical engineers and software professionals in the company. Moreover, senior mechanical engineer will, maintain history files of product designs, and make changes by working in close coordination with end-users as needed. This position requires a bachelor’s degree in mechanical engineering with 10 years’ experience in medical device industry or ...

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    10. Postdoc Position in Biomedical Optics and Photonics at University of Western Australia

      Postdoc Position in Biomedical Optics and Photonics at University of Western Australia

      Now available is a position for a Postdoc in Biomedical Optics, Biophotonics, Photonics or Optical Microscopy | Ref: 502043 | SCHOOL OF ELECTRICAL, ELECTRONIC & COMPUTER ENGINEERING OPTICAL+BIOMEDICAL ENGINEERING LABORATORY Two year appointment Salary range: Level A $68,452 – $97,497 p.a. or Level B $97,310 – $115,350 p.a. (dependent on qualifications and experience) Postdoc in Biomedical Optics/Biophotonics/Photonics/Optical Microscopy (Australia) The University of Western Australia (UWA) is ranked amongst the top 100 universities in the world and a member of the prestigious Australian Group of Eight research-intensive universities. With an enviable research track record, vibrant campus ...

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    11. Non-Destructive Classification of Diversely Stained Capsicum annuum Seed Specimens of Different Cultivars Using Near-Infrared Imaging Based Optical Intensity Detection

      Non-Destructive Classification of Diversely Stained Capsicum annuum Seed Specimens of Different Cultivars Using Near-Infrared Imaging Based Optical Intensity Detection

      The non-destructive classification of plant materials using optical inspection techniques has been gaining much recent attention in the field of agriculture research. Among them, a near-infrared (NIR) imaging method called optical coherence tomography (OCT) has become a well-known agricultural inspection tool since the last decade. Here we investigated the non-destructive identification capability of OCT to classify diversely stained (with various staining agents) Capsicum annuum seed specimens of different cultivars. A swept source (SS-OCT) system with a spectral band of 1310 nm was used to image unstained control C. annuum seeds along with diversely stained Capsicum seeds, belonging to different cultivar ...

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    12. Microscale light management and inherent optical properties of intact corals studied with optical coherence tomography

      Microscale light management and inherent optical properties of intact corals studied with optical coherence tomography

      Coral reefs are highly productive photosynthetic systems and coral optics studies suggest that such high efficiency is due to optimised light scattering by coral tissue and skeleton. Here, we characterise the inherent optical properties, i.e., the scattering coefficient, μ s , and the anisotropy of scattering, g , of 8 intact coral species using optical coherence tomography (OCT). Specifically, we describe light scattering by coral skeletons, coenoarc tissues, polyp tentacles and areas covered by fluorescent pigments (FP). Our results reveal that light scattering between coral species ranges from μ s = 3 mm -1 ( Stylophora pistillata ) to μ s = 25 mm -1 ( Echinopora lamelosa ). For ...

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    13. Finite-difference time-domain analysis of increased penetration depth in optical coherence tomography by wavefront shaping

      Finite-difference time-domain analysis of increased penetration depth in optical coherence tomography by wavefront shaping

      Multiple scattering in turbid media inhibits optimal light focusing and thus limits the penetration depth in optical coherence tomography (OCT). However, the effects of multiple scattering in a turbid medium can be systematically controlled by shaping the incident wavefront. The authors utilize the reciprocity of Maxwell’s equations and finite-difference time-domain numerical analysis to investigate the ultimate performance bounds of wavefront shaping-OCT under ideal and realistic configurations and compare them with the conventional method. The results reveal that the optimized impinging wavefront significantly enhances the penetration depth of OCT.

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    14. Towards Robotic Eye Surgery: Marker-free, Online Hand-eye Calibration using Optical Coherence Tomography Images

      Towards Robotic Eye Surgery: Marker-free, Online Hand-eye Calibration using Optical Coherence Tomography Images

      Ophthalmic microsurgery is known to be a challenging operation, which requires very precise and dexterous manipulation. Image guided robot-assisted surgery (RAS) is a promising solution that brings significant improvements in outcomes and reduces the physical limitations of human surgeons. However, this technology must be further developed before it can be routinely used in clinics. One of the problems is the lack of proper calibration between the robotic manipulator and appropriate imaging device. In this work, we developed a flexible framework for hand-eye calibration of an ophthalmic robot with a microscope-integrated Optical Coherence Tomography (MI-OCT) without any markers. The proposed method ...

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    15. Axsun Technologies Announces Breakthrough Tunable VCSEL Platform for Optical Coherence Tomography (OCT) Imaging

      Axsun Technologies Announces Breakthrough Tunable VCSEL Platform for Optical Coherence Tomography (OCT) Imaging

      Axsun Technologies, Inc., a leading developer and supplier of MEMSbased optical engines for medical imaging, industrial spectroscopy, and optical telecommunications, today announced the development of a novel Tunable Vertical Cavity Surface Emitting Laser (Tunable VCSEL) platform for OCT imaging applications. Raising the bar on OCT imaging performance, Axsun’s new Tunable VCSEL platform leverages the company’s core strengths of high performance optical integration and cost-effective volume manufacturing. By integrating all the major tunable VCSEL components into a single compact butterfly package, the Axsun tunable VCSEL enables higher performance and flexibility, reliability and scalability with low power consumption. “While our ...

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    16. Impact and trends of intravascular imaging in diagnostic coronary angiography and percutaneous coronary intervention in inpatients in the United States

      Impact and trends of intravascular imaging in diagnostic coronary angiography and percutaneous coronary intervention in inpatients in the United States

      Background Intravascular imaging with intravascular ultrasound (IVUS) and optical coherence tomography (OCT) is an important adjunct to invasive coronary angiography. Objectives The primary objective was to examine the frequency of intravascular coronary imaging, trends in imaging use, and outcomes of patients undergoing angiography and/or percutaneous coronary intervention (PCI) in the United States. Methods Adult patients ≥18 years of age undergoing in‐hospital cardiac catheterization from January 2004 to December 2014 were identified from the National Inpatient Sample (NIS). International Classification of Diseases, Ninth Revision (ICD‐9) diagnosis and procedure codes were used to identify IVUS and OCT use during ...

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    17. Thorlabs Extends OCT Offering to Include 248 kHz A-Scan Rate Systems

      Thorlabs Extends OCT Offering to Include 248 kHz A-Scan Rate Systems

      Thorlabs announced today that it has expanded its well-established Ganymede™ OCT line to include two complete imaging systems offering an industry-leading A-scan rate of 248 kHz. With this new release, the GAN610C1 and GAN620C1 become the fastest commercially available Spectral-Domain OCT systems on the market, providing a new standard for high-speed, high-sensitivity 2D and 3D imaging of moving samples with reduced motion artifacts. As with Thorlabs’ previously released Ganymede™ and Telesto™ OCT systems, these new OCT systems are available in both general-purpose (GAN610) and high-resolution (GAN620 – 3 µm axial resolution) variants, each of which offers the same low roll-off and ...

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    18. Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

      Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

      Incorrect needle placement during an epidural block causes medical complications such as dural puncture or spinal cord injury. We propose a system combining an optical coherence tomography imaging probe with an automatic identification algorithm to objectively identify the epidural needle-tip position and thus reduce complications during epidural needle insertion. Eight quantitative features were extracted from each two-dimensional optical coherence tomography image during insertion of the needle tip from the skin surface to the epidural space. 847 in vivo optical coherence tomography images were obtained from three anesthetized piglets. The area under the receiver operating characteristic curve was used to quantify ...

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    19. Angiography Alone Versus Angiography Plus Optical Coherence Tomography to Guide Percutaneous Coronary Intervention: Outcomes From the Pan-London PCI Cohort

      Angiography Alone Versus Angiography Plus Optical Coherence Tomography to Guide Percutaneous Coronary Intervention: Outcomes From the Pan-London PCI Cohort

      Objectives This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). Background Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints . Methods This was a cohort study based on the Pan-London (United Kingdom) PCI registry, which includes 123,764 patients who underwent PCI in National Health Service hospitals in London between 2005 and 2015. Patients undergoing primary PCI or pressure wire use were excluded leaving 87,166 ...

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    20. Will Optical Coherence Tomography Become the Standard Imaging Tool for Percutaneous Coronary Intervention Guidance?

      Will Optical Coherence Tomography Become the Standard Imaging Tool for Percutaneous Coronary Intervention Guidance?

      Editorial Comment: In the last 3 decades, intravascular ultrasound (IVUS) and, more recently, optical coherence tomography (OCT) have been increasingly used to guide percutaneous coronary intervention (PCI). Although there are randomized trials, registries, and meta-analyses suggesting better outcomes using IVUS to guide PCI (1–3), data on the clinical impact of OCT are still missing. In the United Kingdom, consecutive data of all PCI procedures must be prospectively entered in the registry organized by the British Cardiovascular Interventional Society, endorsed by the United Kingdom Department of Health, with tracking of events based on the complete and unquestionable national statistics. One ...

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    1-21 of 21
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