1. Featured Articles

    1-20 of 20
    1. Diagnosis of subglottic stenosis in a rabbit model using long-range optical coherence tomography

      Diagnosis of subglottic stenosis in a rabbit model using long-range optical coherence tomography

      Objectives/Hypothesis Current imaging modalities lack the necessary resolution to diagnose subglottic stenosis. The aim of this study was to use optical coherence tomography (OCT) to evaluate nascent subglottic mucosal injury and characterize mucosal thickness and structural changes using texture analysis in a simulated intubation rabbit model. Study Design Prospective animal study in rabbits. Methods Three-centimeter-long sections of endotracheal tubes (ETT) were endoscopically placed in the subglottis and proximal trachea of New Zealand White rabbits (n = 10) and secured via suture. OCT imaging and conventional endoscopic video was performed just prior to ETT segment placement (day 0), immediately after tube ...

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    2. Common-path optical coherence tomography using a microelectromechanical-system-based endoscopic probe

      Common-path optical coherence tomography using a microelectromechanical-system-based endoscopic probe

      This paper presents a common-path (CP) swept-source optical coherence tomography (SSOCT) system based on a special endoscopic probe design with an in-line internal reflection as the reference and a two-axis electrothermal microelectromechanical system mirror for image scanning. The rear surface of a gradient reflective index (GRIN) lens inside the probe is set as the reference reflection plane. The length of the GRIN lens is optimized to eliminate the artifacts in SSOCT images successfully. Doppler OCT is also demonstrated based on the CP endoscopic probe. The diameter of the probe is only 2.5 mm, so it can be easily inserted ...

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    3. Filtering for unwrapping noisy Doppler optical coherence tomography images for extended microscopic fluid velocity measurement range

      Filtering for unwrapping noisy Doppler optical coherence tomography images for extended microscopic fluid velocity measurement range

      In this Letter, we report the first application of two phase denoising algorithms to Doppler optical coherence tomography (DOCT) velocity maps. When combined with unwrapping algorithms, significantly extended fluid velocity dynamic range is achieved. Instead of the physical upper bound, the fluid velocity dynamic range is now limited by noise level. We show comparisons between physical simulated ideal velocity maps and the experimental results of both algorithms. We demonstrate unwrapped DOCT velocity maps having a peak velocity nearly 10 times the theoretical measurement range.

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    4. Hybrid averaging offers high-flow contrast by cost apportionment among imaging time, axial, and lateral resolution in optical coherence tomography angiography

      Hybrid averaging offers high-flow contrast by cost apportionment among imaging time, axial, and lateral resolution in optical coherence tomography angiography

      The current temporal, wavelength, angular, and spatial averaging approaches trade imaging time and resolution for multiple independent measurements that improve the flow contrast in optical coherence tomography angiography (OCTA). We find that these averaging approaches are equivalent in principle, offering almost the same flow contrast enhancement as the number of averages increases. Based on this finding, we propose a hybrid averaging strategy for contrast enhancement by cost apportionment. We demonstrate that, compared with any individual approach, the hybrid averaging is able to offer a desired flow contrast without severe degradation of imaging time and resolution. Making use of the extended ...

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    5. Estimation of Jones matrix, birefringence and entropy using Cloude-Pottier decomposition in polarization-sensitive optical coherence tomography

      Estimation of Jones matrix, birefringence and entropy using Cloude-Pottier decomposition in polarization-sensitive optical coherence tomography

      Estimation of polarimetric parameters has been a fundamental issue to assess biological tissues that have form birefringence or polarization scrambling in polarization-sensitive optical coherence tomography (PS-OCT). We present a mathematical framework to provide a maximum likelihood estimation of the target covariance matrix and its incoherent target decomposition to estimate a Jones matrix of a dominant scattering mechanism, called Cloude-Pottier decomposition, thereby deriving the phase retardation and the optic axis of the sample. In addition, we introduce entropy that shows the randomness of the polarization property. Underestimation of the entropy at a low sampling number is mitigated by asymptotic quasi maximum ...

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    6. Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography

      Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography

      Minimally-invasive microsurgery has resulted in improved outcomes for patients. However, operating through a microscope limits depth perception and fixes the visual perspective, which result in a steep learning curve to achieve microsurgical proficiency. We introduce a surgical imaging system employing four-dimensional (live volumetric imaging through time) microscope-integrated optical coherence tomography (4D MIOCT) capable of imaging at up to 10 volumes per second to visualize human microsurgery. A custom stereoscopic heads-up display provides real-time interactive volumetric feedback to the surgeon. We report that 4D MIOCT enhanced suturing accuracy and control of instrument positioning in mock surgical trials involving 17 ophthalmic surgeons ...

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    7. Optical Assessment of Soft Contact Lens Edge-Thickness

      Optical Assessment of Soft Contact Lens Edge-Thickness

      Purpose: To assess the edge shape of soft contact lenses using Gabor-Domain Optical Coherence Microscopy (GD-OCM) with a 2-μm imaging resolution in three dimensions and to generate edge-thickness profiles at different distances from the edge tip of soft contact lenses. Methods: A high-speed custom-designed GD-OCM system was used to produce 3D images of the edge of an experimental soft contact lens (Bausch + Lomb, Rochester, NY) in four different configurations: in air, submerged into water, submerged into saline with contrast agent, and placed onto the cornea of a porcine eyeball. An algorithm to compute the edge-thickness was developed and applied ...

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    8. Optical Coherence Tomography for Lesion Assessment

      Optical Coherence Tomography for Lesion Assessment

      Optical coherence tomography (OCT) is an intravascular imaging technology that employs an optical source for image acquisition, allowing high-resolution (10–20 μm) analysis of the coronary vasculature. The development of this imaging tool over the last decade, along with European CE Mark approval in March 2009 and US Food and Drug Administration approval in April 2010, has led to a dramatic increase in the number of operators and institutions using this technology. In many ways, early experience with this technology mimics the early experience with intravascular ultrasound (IVUS) 2 decades earlier, and as a still-emerging innovative imaging modality, much of ...

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      Mentions: St. Jude Medical
    9. Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

      Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

      Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an articulated probe to extract human cutaneous vasculature in vivo in various skin regions. OCT angiography supplements the microvasculature which PAT alone is unable to provide. Co-registered volumes for vessel network is further embedded in the morphologic image provided by OCT. This multi-modal system is therefore demonstrated as a valuable tool for comprehensive non-invasive ...

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    10. Postdoctoral Fellows Openings at Northwestern University

      Postdoctoral Fellows Openings at Northwestern University

      Functional Optical Imaging lab (FOIL) in the Department of Biomedical Engineering at Northwestern University develops optical imaging and sensing technologies for biomedical applications, including ophthalmology, vision science, neuroscience, HIV, and cancers. We are looking for two new postdoctoral fellows to join our extremely friendly, vibrant, productive, and collaborative group to develop novel optical microscopy technologies for ophthalmology and single-molecule imaging. We especially encourage applicants with extensive instrumentation and signal processing experiences in optical coherence tomography, ultra-fast optics, and super-resolution optical imaging. Experiences with small animal imaging, human retinal imaging, or cell culture and staining are also desired. The successful candidate ...

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    11. Postdoctoral Position in OCT at the University of Houston

      Postdoctoral Position in OCT at the University of Houston

      The Biomedical Optics Laboratory ( http://bol.egr.uh.edu ) in Department of Biomedical Engineering at the University of Houston, TX invites applications for one or more postdoctoral scholar positions in the area of system development and image/signal processing from optical coherence tomography (OCT) and optical coherence elastography (OCE). The successful applicants will join dynamic team to work in the area of OCT and OCE for projects such as high-resolution imaging of live embryonic development and biomechanics of tissues and cells. Excellent opportunities exist for collaboration with clinicians from Texas Medical Center. The initial appointment will be full-time, for a ...

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    12. Optics Augments Reality and Brings 3D Medicine into Focus

      Optics Augments Reality and Brings 3D Medicine into Focus

      Live 3D imaging is one of the hottest topics in optics today, transforming medical imaging capabilities and delivering the immersive experience behind augmented and virtual reality. During The Optical Society’s Light the Future centennial program in Heidelberg, Germany on 26 July, Dr. Joseph Izatt of Duke University and Microsoft’s Bernard Kress gave an insider’s look at how these technologies are advancing medicine and changing the future of how we interact with computers. Picking up where Ray Kurzweil left off in the previous Light the Future presentation about artificial intelligence and the continually shrinking scale of medicine, Izatt ...

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    13. Post Doc Position for in-vivo Biomicroscopy at the Medical University of Vienna

      Post Doc Position for in-vivo Biomicroscopy at the Medical University of Vienna

      An academic PostDoc position is available from September 1, 2016 at the Christian Doppler Laboratory for Innovative Optical Imaging and Its Translation to Medicine, Center for Medical Physics and Biomedical Engineering. We offer a research position in the field of biomedical imaging with strong interdisciplinary (door to door) collaboration with clinicians as well as biologists. Our research group is developing novel coherent biomedical imaging methods to overcome the conventional resolution limits and to pave the way from pure structural to functional tissue and cell metabolic imaging. This involves profound knowledge of theoretical and experimental optics, system engineering, data and image ...

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    14. Postdoctoral Research Fellowships in In Vivo Microscopy at Wellman Center for Photomedicine, Massachusetts General Hospital

      Postdoctoral Research Fellowships in In Vivo Microscopy at Wellman Center for Photomedicine,  Massachusetts General Hospital

      A Postdoctoral research fellowship in the area of In Vivo Microscopy is available in the Tearney Lab at the Massachusetts General Hospital (MGH) in the Wellman Center for Photomedicine. This appointment will be made at the rank of postdoctoral fellow at Harvard Medical School. MGH’s role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for developing and translating new in vivo microscopy technologies with applications in basic and clinical research. The fellowship will focus on the development and clinical application of advanced in vivo microscopy imaging ...

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    15. Avinger Offers A Better Mousetrap, But A Lot Of Challenges

      Avinger Offers A Better Mousetrap, But A Lot Of Challenges

      Summary: Adding high-quality imaging to mechanical atherectomy could be a powerful combination that finally ignites a $500 million-plus market that has long frustrated med-tech watchers. Avinger is short on cash and has a lot of spending to do to drive market share into the teens and beyond; dilution seems like a certainty today. An EV/revenue multiple between 4.5x and 5x supports a $7 FV today, and high-growth med-tech stocks can trade well above 5x forward revenue during the good times.

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    16. Visualization of prostatic nerves by polarization-sensitive optical coherence tomography

      Visualization of prostatic nerves by polarization-sensitive optical coherence tomography

      Preservation of prostatic nerves is critical to recovery of a man’s sexual potency after radical prostatectomy. A real-time imaging method of prostatic nerves will be helpful for nerve-sparing radical prostatectomy (NSRP). Polarization-sensitive optical coherence tomography (PS-OCT), which provides both structural and birefringent information of tissue, was applied for detection of prostatic nerves in both rat and human prostate specimens, ex vivo. PS-OCT imaging of rat prostate specimens visualized highly scattering and birefringent fibrous structures superficially, and these birefringent structures were confirmed to be nerves by histology or multiphoton microscopy (MPM). PS-OCT could easily distinguish these birefringent structures from surrounding ...

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      Mentions: Ki Hean Kim
    17. Loose powder detection and surface characterization in selective laser sintering via optical coherence tomography

      Loose powder detection and surface characterization in selective laser sintering via optical coherence tomography

      Defects produced during selective laser sintering (SLS) are difficult to non-destructively detect after build completion without the use of X-ray-based methods. Overcoming this issue by assessing integrity on a layer-by-layer basis has become an area of significant interest for users of SLS apparatus. Optical coherence tomography (OCT) is used in this study to detect surface texture and sub-surface powder, which is un-melted/insufficiently sintered, is known to be a common cause of poor part integrity and would prevent the use of SLS where applications dictate assurance of defect-free parts. To demonstrate the capability of the instrument and associated data-processing algorithms ...

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    18. The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy

      The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy

      Advanced imaging techniques used in the management of Barrett’s esophagus include electronic imaging enhancement (e.g. narrow band imaging, flexible spectral imaging color enhancement, and i-Scan), chromoendoscopy, and confocal laser endomicroscopy. Electronic imaging enhancement is used frequently in daily practice, but use of the other advanced technologies is not routine. High-definition white light endoscopy and random four quadrant biopsy remain the standard of care for evaluation of Barrett’s esophagus; this is largely due to the value of advanced imaging technologies not having been validated in large studies or in everyday practice. A new advanced imaging technology called volumetric ...

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    19. The Development, Commercialization, and Impact of Optical Coherence Tomography

      The Development, Commercialization, and Impact of Optical Coherence Tomography

      This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function – diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration ...

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    20. Key Developments for Partial Coherence Biometry and Optical Coherence Tomography in the Human Eye Made in Vienna

      Key Developments for Partial Coherence Biometry and Optical Coherence Tomography in the Human Eye Made in Vienna

      Purpose : To describe key developments of optical biometry and optical coherence tomography (OCT) for ophthalmic applications made by one of the pioneering research groups. Methods : Partial coherence interferometry (PCI) as the basic ranging technology for modern optical biometry and for OCT was introduced for biomedical applications in the 1980s. Later, Fourier domain (FD) OCT was introduced and demonstrated to provide superior sensitivity as compared to time domain OCT. Further developments comprised ultrahigh-resolution OCT and deep-penetration OCT at wavelengths of approximately 1050 nm. Important functional extensions comprise Doppler OCT/OCT angiography, polarization-sensitive OCT, and adaptive optics OCT. Results : High-precision PCI biometry ...

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    1-20 of 20
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