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    1. New World Resources and Perimeter Medical Imaging Provide Updates Regarding Their Amalgamation Transaction and Announce Amended and Restated Arrangement Agreement

      New World Resources and Perimeter Medical Imaging Provide Updates Regarding Their Amalgamation Transaction and Announce Amended and Restated Arrangement Agreement

      New World Resources Corp. (TSXV: NW) ("New World") and Perimeter Medical Imaging, Inc. ("Perimeter") are pleased to announce that they have now agreed to a completion goal of Q1 of 2020 for their amalgamation by way of plan of arrangement (the "Transaction"). The Transaction is an arm's length transaction and will result in a reverse take-over and change of control of New World by the shareholders of Perimeter. The resulting publicly traded company (the "Resulting Issuer") will be named Perimeter Medical Imaging AI, Inc. and its management team will be led by Will Rosellini and Perimeter's newly appointed ...

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    2. Artificial intelligence, the internet of things, and virtual clinics: ophthalmology at the digital translation forefront

      Artificial intelligence, the internet of things, and virtual clinics: ophthalmology at the digital translation forefront

      The advent of artificial intelligence (AI), big data, and the next-generation telecommunication network (5G) has generated enormous interest in digital health. Digital health comprises overlapping areas ranging from AI, the internet of things, electronic health, and telehealth to the analysis and use of big data. 1 With substantial innovation opportunities in digital health, WHO published a set of guidelines earlier this year, 1 advising potential researchers and innovators on how to harness this technology to create evidence-based interventions within real-world settings to improve patients' outcome. Here, we highlight some of the new developments in ophthalmology, focusing on AI and other ...

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    3. Stable multi-megahertz circular-ranging optical coherence tomography at 1.3 µm

      Stable multi-megahertz circular-ranging optical coherence tomography at 1.3 µm

      In Fourier-domain optical coherence tomography (OCT), the finite bandwidth of the acquisition electronics constrains the depth range and speed of the system. Circular-ranging (CR) OCT methods use optical-domain compression to surpass this limit. However, the CR-OCT system architectures of prior reports were limited by poor stability and were confined to the 1.55 µm wavelength range. In this work, we describe a novel CR-OCT architecture that is free from these limitations. To ensure stable operation, temperature sensitive optical modules within the system were replaced; the kilometer-length fiber spools used in the stretched-pulse mode-locked (SPML) laser was eliminated in favor of ...

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    4. Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability

      Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability

      It is a widely believed paradigm that intimal angiogenesis in coronary atherosclerosis contributes to plaque instability through both hemorrhagic plaque expansion and cholesterol deposition. 1 However, this article supports an alternative concept in which angiogenesis is actually essential for plaque stabilization and healing. 2 , 3 The prevailing paradigm has its origins primarily in histopathology work from the 1980s by Barger’s group reported by Kamat et al. 4 We argue that misinterpretation of their results has skewed the understanding of vulnerable plaque for >35 years. This misconception still endures in recent plaque angiogenesis reviews, affecting understanding of acute coronary syndromes ...

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    5. Optical coherence tomography in the assessment of cutaneous cancer margins of the face: an immediate ex vivo study

      Optical coherence tomography in the assessment of cutaneous cancer margins of the face: an immediate ex vivo study

      Background The assessment of cutaneous cancer margins intra-operatively or in the immediate postoperative phase can guide the operator into achieving clearer margins. Achieving a clear (tumour-free) margins following surgery is an essential factor that can reduce morbidity and disfigurement. The aim of present study was to determine the accuracy of optical coherence tomography in assessing cutaneous cancer margins of the face. Materials and Methods The excised tissue specimens that were examined, in this study, were acquired from 70 patients with 70 facial cancer lesions, with no nodal disease. Forty lesions were basal cell carcinomas (150 margins; 27 tumour positive) and ...

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    6. Duke University Engineering Professor Sina Farsiu Elected Fellow of the IEEE

      Duke University Engineering Professor Sina Farsiu Elected Fellow of the IEEE

      Sina Farsiu , the Paul Ruffin Scarborough Associate Professor of Engineering, and Jeffrey Krolik , professor of electrical and computer engineering, have been named fellows of the Institute of Electrical and Electronics Engineers (IEEE), the world's largest technical professional organization dedicated to advancing technology for the benefit of humanity. Each year, following a rigorous evaluation procedure, the IEEE Fellow Committee recommends a select group of recipients for elevation to IEEE fellow. Less than 0.1 percent of voting members are selected annually for this honor. With appointments in biomedical engineering, ophthalmology, electrical and computer engineering, and computer science, Farsiu was recognized ...

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    7. PhotoniCare Takes First Place at the 2019 HealthTECH Startup Competition

      PhotoniCare Takes First Place at the 2019 HealthTECH Startup Competition

      PhotoniCare took home first place at the 7th Annual Insight Product Development 2019 HealthTECH Startup Competition. The annual competition, sponsored by Insight Innovation Center – Chicago, MATTER, and iBIO, brings together a mix of healthcare industry and community stakeholders. The program aims to achieve the following goals: Improve lives by bringing innovative health solutions to patients Encourage entrepreneurship in the healthcare industry Grow the medical innovation ecosystem Connect investors and corporations with early-stage companies The competition included 10 finalists, selected based on a competitive application process, which came together on November 14th in Chicago, Illinois, to each give a five-minute startup ...

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      Mentions: PhotoniCare
    8. GaAs-Based InPBi Quantum Dots for High Efficiency Super-Luminescence Diodes

      GaAs-Based InPBi Quantum Dots for High Efficiency Super-Luminescence Diodes

      InPBi exhibits broad and strong photoluminescence at room temperature, and is a potential candidate for fabricating super-luminescence diodes applied in optical coherence tomography. In this paper, the strained InPBi quantum dot (QD) embedded in the AlGaAs barrier on a GaAs platform is proposed to enhance the light emission efficiency and further broaden the photoluminescence spectrum. The finite element method is used to calculate the strain distribution, band alignment and confined levels of InPBi QDs. The carrier recombinations between the ground states and the deep levels are systematically investigated. A high Bi content and a flat QD shape are found preferable ...

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    9. Postdoctoral Position Opening in High Resolution OCT at Nanyang Technological University

      Postdoctoral Position Opening in High Resolution OCT at Nanyang Technological University

      x The School of Electrical & Electronic Engineering at the Nanyang Technological University invites applications for a postdoctoral fellow position in the area of high resolution optical coherence tomography (OCT) devices. The successful candidate will work on a collaborative research project with a focus on micro-optical coherence tomography, synthetic aperture endoscopy, and point-of-care optical imaging devices. Specific requirements: A PhD’s degree in optical instrumentation, optics and optical technology, precision instrument or related fields; Extensive experiences in optical microscopic or endoscopic system design and alignment; Experiences in designing and development of opto-mechanical systems such as an OCT endoscope; Research track records ...

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    10. Identification of multi-dimensional thread geometry using depth-resolved swept-source optical coherence tomography for assessment of dental implant fabrication

      Identification of multi-dimensional thread geometry using depth-resolved swept-source optical coherence tomography for assessment of dental implant fabrication

      The geometrical characteristics of dental implants, such as thread depth and width, facing angle, pitch, and surface roughness, are important to assess their stability and osseointegration after implant surgery. Herein, we demonstrate the potential use of depth-resolved swept-source optical coherence tomography (SS-OCT) to assess the structural quality of widely used dental implants. The implemented SS-OCT system was centered at a wavelength of 1300 nm with a 100 nm full-width at half-maximum. Four dental implants with different structural formations fabricated using either titanium or ceramic were visualized. Qualitative assessments were performed using boundary flattening with an amplitude-profiling algorithm to emphasize and ...

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    11. Automated plaque characterization using deep learning on coronary intravascular optical coherence tomographic images

      Automated plaque characterization using deep learning on coronary intravascular optical coherence tomographic images

      Accurate identification of coronary plaque is very important for cardiologists when treating patients with advanced atherosclerosis. We developed fully-automated semantic segmentation of plaque in intravascular OCT images. We trained/tested a deep learning model on a folded, large, manually annotated clinical dataset. The sensitivities/specificities were 87.4%/89.5% and 85.1%/94.2% for pixel-wise classification of lipidous and calcified plaque, respectively. Automated clinical lesion metrics, potentially useful for treatment planning and research, compared favorably (<4%) with those derived from ground-truth labels. When we converted the results to A-line classification, they were significantly better (p < 0.05) than ...

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    12. Multiple PhD and postdoctoral positions in Optical Imaging and Biomechanics at University of Houston

      Multiple PhD and postdoctoral positions in Optical Imaging and Biomechanics at University of Houston

      The Biomedical Optics Laboratory ( http://bol.egr.uh.edu ) in Department of Biomedical Engineering at the University of Houston, TX invites applications for one or more pre- and post-doctoral positions in the area of optical imaging, photoacoustics, and biomechanics. Extensive experience in one of the following areas is required: optical coherence tomography (OCT), opto(photo)acoustics, light-sheet microscopy (instrumentation and software development), optical elastography/biomechanics, and Brillouin Spectroscopy. The successful applicants will join dynamic team to work on projects such as optical methods to study tissue (ocular, skin, heart) biomechanics and development of advanced optical methods for developmental biology. Excellent ...

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    13. Optical coherence tomography (OCT) in patients with acute respiratory failure on the ICU

      Optical coherence tomography (OCT) in patients with acute respiratory failure on the ICU

      Introduction: Differentiating ARDS from other forms of respiratory failure can be difficult. By advancing an optic fiber through a diagnostic bronchoscope, followed by an automatic pullback mechanism, OCT enables real-time 3D imaging of the alveolar compartment and peripheral airways. Aim: To investigate feasibility of bronchoscopic OCT, and to describe different OCT patterns of the alveolar compartment in mechanically ventilated patients. Methods: Observational study of OCT imaging in mechanically ventilated patients for non-resolving acute respiratory failure with an indication for diagnostic bronchoscopy. Results: 9 patients were included with clinical features of acute respiratory failure and bilateral pulmonary infiltrates not fully explained ...

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    14. Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty

      Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty

      Objective: Deep anterior lamellar keratoplasty (DALK) significantly reduces the post-transplantation morbidity in patients eligible for partial-thickness cornea grafts. The popular "big bubble" technique for DALK is so challenging, however, that a significant fraction of corneal pneumodissection attempts fail for surgeons without extensive DALK-specific experience, even with previous-generation cross-sectional optical coherence tomography (OCT) guidance. We seek to develop robotic, volumetric OCT-guided technology capable of facilitating or automating the difficult needle insertion step in DALK. Methods: Our system provides for real-time volumetric corneal imaging, segmentation, and tracking of the needle insertion to display feedback for surgeons and to generate needle insertion plans ...

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    15. Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital

      Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital

      Employer Description Until recently, visualizing the architectural and cellular morphology of human tissue has required histopathological examination. Samples would be excised from the patient, processed, sectioned, stained and viewed under a microscope. In addition to being invasive, time consuming and costly, the static nature of conventional pathology prohibits the study of biological dynamics and function. The Tearney Laboratory at Massachusetts General Hospital has led the way in transforming the current diagnostic paradigm through the invention and translation of new noninvasive, high-resolution optical imaging modalities that enable disease diagnosis from living patients without excising tissues from the body. Led by Guillermo ...

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    16. Australia’s Cylite promises the next generation OCT

      Australia’s Cylite promises the next generation OCT

      An Australian company is taking on the giants of ophthalmology with its own OCT device. LEWIS WILLIAMS looks at what the Cylite HP-OCT is doing different to set itself apart. When visiting trade displays at conferences, it is always wise to pay particular attention to the lower-key exhibits. That was certainly the case at the recent O=MEGA19 conference and trade exhibition held at Melbourne’s Convention and Exhibition Centre in July. There, on the Medmont stand, was an understated inclusion – an Australian designed and made optical coherence tomography (OCT) instrument. It is difficult to imagine a more unlikely or ...

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      Mentions: Cylite
    17. PhD Opening at Indiana University

      PhD Opening at Indiana University

      A PhD student position is available in Don Miller’s laboratory on advanced ophthalmic imaging at Indiana University ( www.opt.indiana.edu/dtmiller/Index.aspx ). The laboratory is looking for a highly motivated student in engineering, optical physics, or a related discipline with an interest to develop cutting-edge optical instrumentation to study noninvasively the retina at the cellular level. The laboratory’s primary focus is on the development and use of adaptive optics and optical coherence tomography, technologies the laboratory has been advancing for the past two decades. Some of our recent work can be found in PNAS: www.pnas ...

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    18. Non-contact characterization of compound optical elements using reflectance confocal microscopy, low-coherence interferometry, and computational ray-tracing

      Non-contact characterization of compound optical elements using reflectance confocal microscopy, low-coherence interferometry, and computational ray-tracing

      Advances in microscopy have enabled us to see at unprecedented depths and resolutions, even breaking the diffraction-limit by several fold. These improvements have come at the expense of system complexity with microscopes routinely employing multiple objective lenses and custom optical relays. Optimal system design is paramount for imaging performance, but research systems are limited by the use of commercial components because optical prescriptions are often inaccessible. System performance can be further degraded when these components are implemented in nonstandard configurations outside of manufacturer specifications. Here, we describe a method for characterization of compound optical elements including curvatures, material and air-gap ...

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      Mentions: Yuankai K. Tao
    19. Intravascular Polarimetry in Patients With Coronary Artery Disease

      Intravascular Polarimetry in Patients With Coronary Artery Disease

      Objectives The aims of this first-in-human pilot study of intravascular polarimetry were to investigate polarization properties of coronary plaques in patients and to examine the relationship of these features with established structural characteristics available to conventional optical frequency domain imaging (OFDI) and with clinical presentation. Background Polarization-sensitive OFDI measures birefringence and depolarization of tissue together with conventional cross-sectional optical frequency domain images of subsurface microstructure. Methods Thirty patients undergoing polarization-sensitive OFDI (acute coronary syndrome, n = 12; stable angina pectoris, n = 18) participated in this study. Three hundred forty-two cross-sectional images evenly distributed along all imaged coronary arteries were classified into ...

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    20. Researchers advance image-guided robotic surgical tools for delicate eye procedures

      Researchers advance image-guided robotic surgical tools for delicate eye procedures

      Molecular, gene and cell-based therapies targeting eye diseases could prevent and potentially reverse cell degeneration that leads to loss of sight. However, delivering injections safely and accurately into targeted ocular layers remain concerns that affect the advancement of life-changing new treatments. To address the safety and reliability challenges, researchers in the Vanderbilt Institute for Surgery and Engineering are joining their expertise to enable the use of optical coherence tomography (OCT) imaging for assistive robot control feedback aimed at enabling extreme precision subretinal drug delivery. Front, Mechanical Engineering Professor Nabil Simaan and Karen Joos, Joseph and Barbara Ellis Professor of Ophthalmology ...

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    21. Postdoctoral or Research Scientist Position in Biomedical Optics at Baylor College of Medicine

      Postdoctoral or Research Scientist Position in Biomedical Optics at Baylor College of Medicine

      A postdoctoral or research scientist position is available in Larina Lab in the Department of Molecular Physiology and Biophysics at the Baylor College of Medicine, Houston, TX to develop functional optical imaging methods toward investigation of developmental mechanisms. We are a dynamic highly collaborative team of optical engineers and biologists, investigating biomechanical aspects of biological processes in mouse models of human disorders. Our studies bring together optical system design, OCT, confocal/multiphoton microscopy, optogenetics, technology development in functional optical imaging and data processing (4D angiography, cilia beat mapping, cardiodynamic analysis, elastography), vital fluorescent reporters, genetic mouse models of human disorders ...

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    22. Intravascular Polarimetry for Tissue Characterization of Coronary Atherosclerosis

      Intravascular Polarimetry for Tissue Characterization of Coronary Atherosclerosis

      The microscopic tissue structure and organization influence the polarization of light. Intravascular polarimetry leverages this compelling intrinsic contrast mechanism by using polarization-sensitive optical frequency domain imaging to measure the polarization properties of the coronary arterial wall. Tissues rich in collagen and smooth muscle cells appear birefringent, while the presence of lipid causes depolarization, offering quantitative metrics related to the presence of important components of coronary atherosclerosis. Here, we review the basic principles, the interpretation of polarization signatures, and first clinical investigations of intravascular polarimetry and discuss how this extension of contemporary intravascular imaging may advance our knowledge and improve clinical ...

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    23. 3D cellular-resolution imaging in arteries using few-mode interferometry

      3D cellular-resolution imaging in arteries using few-mode interferometry

      Article Open Access Published: 21 November 2019 3D cellular-resolution imaging in arteries using few-mode interferometry Biwei Yin , Zhonglie Piao , Kensuke Nishimiya , Chulho Hyun , Joseph A. Gardecki , Adam Mauskapf , Farouc A. Jaffer & Guillermo J. Tearney Light: Science & Applications volume 8 , Article number: 104 ( 2019 ) Cite this article Article metrics 3 Altmetric Metrics details Abstract Cross-sectional visualisation of the cellular and subcellular structures of human atherosclerosis in vivo is significant, as this disease is fundamentally caused by abnormal processes that occur at this scale in a depth-dependent manner. However, due to the inherent resolution-depth of focus tradeoff of conventional focusing optics, today ...

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    24. Optical Technology Stepping Forward ― Utility of Intracoronary Optical Coherence Tomography ―

      Optical Technology Stepping Forward ― Utility of Intracoronary Optical Coherence Tomography ―

      I ntravascular optical coherence tomography (OCT) is a light-based imaging modality that enables detailed visualization of the intraluminal structures in coronary arteries. High-resolution (10–20μm) cross-sectional images are generated by measuring the echo time delay and intensity of light that is reflected or backscattered from the internal structures in tissues.1,2 OCT is clinically useful during percutaneous coronary intervention (PCI) to assess lesion severity, optimize stent implantation, and characterize atherosclerotic plaques, including the identification of thin-cap fibroatheroma (TCFA) and lipid-rich plaques, which are reportedly responsible for periprocedural complications. OCT can also be used to assess the mechanism for ...

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      Mentions: Toshiro Shinke
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