1. Featured Articles

    1-22 of 22
    1. Unstable Angina Caused by Honeycomb-Like Coronary Lesion Identified with Use of Optical Coherence Tomography

      Unstable Angina Caused by Honeycomb-Like Coronary Lesion Identified with Use of Optical Coherence Tomography

      A 67-year-old man had angina and dyspnea for several weeks during exercise and rest, and he came to our hospital for coronary angiography. He had mild ST-segment variability, without necrosis markers. Cardiac ultrasonograms revealed moderate mitral regurgitation, preserved ejection fraction, and a posterior-wall infarction scar despite no history of infarction. Coronary angiograms, which revealed no obvious culprit lesion, showed mild focal stenosis in the proximal right coronary artery, distal chronic occlusion of a small left circumflex coronary artery, and mild stenosis and haziness in the mid left anterior descending coronary artery (LAD) (Fig. 1). Suspecting thrombus in the mid LAD ...

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    2. Biophotonics and Imaging Graduate Summer School to be held on August 2020 at National University of Ireland, Galway

      Biophotonics and  Imaging  Graduate  Summer  School to be held on August 2020 at National University of Ireland, Galway

      Dates: August 25th - 29th 2020 This is our eight Biophotonics and Imaging Graduate Summer School. It is an important opportunity for graduate students in 2020 to access the kind of close contact with leading professors that only this kind of environment facilitates. Tutors for BIGSS 2020 will include: Martin Booth (Oxford): Advanced Microscopy Steve Jacques (Washington): Tissue Optics Caroline Boudoux (Montreal): Endoscopy David Sampson (Surrey): OCT Sarah Bohndiek (Cambridge): Photoacoustics Arjun Yodh (U. Penn): Brain-Neurophotonics Brian Wilson (Toronto): Photo Medicine, Radiation Medicine and Nano Medicine Wei Chen (Oklahoma): Photoimmunology

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    3. Galahad project completes development of high-resolution OCT

      Galahad project completes development of high-resolution OCT

      EU-funded research aims to improve retinal imaging for early screening of glaucoma. Galahad in use Galahad , a Horizon 2020 research project developing an OCT platform for improved early screening of glaucoma, has successfully completed its work, according to project coordinators Gooch & Housego ( G&H ). Launched in 2016 , Galahad - from Glaucoma Advanced, LAbel-free High resolution Automated OCT Diagnostics - has now reached the end of its three-year €4-million program to develop ultra-high resolution polarization-sensitive optical coherence tomography (UHR-PS-OCT). Ten European partners made up the consortium. "Over the last 36 months the project has had a major impact on the development of UHR-PS-OCT ...

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    4. En‐face optical coherence tomography for the detection of cancer in prostatectomy specimens: quantitative analysis in 20 patients

      En‐face optical coherence tomography for the detection of cancer in prostatectomy specimens: quantitative analysis in 20 patients

      The increase histopathological evaluation of prostatectomy specimens rises the workload on pathologists. Automated histopathology systems, preferably directly on unstained specimens, would accelerate the pathology workflow. In this study, we investigate the potential of quantitative analysis of Optical Coherence Tomography (OCT) to separate benign from malignant prostate tissue automatically. Twenty fixated prostates were cut, from which 54 slices were scanned by OCT. Quantitative OCT metrics (attenuation coefficient, residue, goodness‐of‐fit) were compared for different tissue types, annotated on the histology slides. To avoid misclassification, the poor‐quality slides, and edges of annotations were excluded. Accurate registration of OCT data with ...

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    5. Conavi Medical and Japan Lifeline Announce MHLW Approval of Novasight Hybrid Intravascular Imaging System for Japanese Market

      Conavi Medical and Japan Lifeline Announce MHLW Approval of Novasight Hybrid Intravascular Imaging System for Japanese Market

      Conavi Medical Inc. and Japan Lifeline are pleased to announce that they have received regulatory approval from the Ministry of Health, Labor and Welfare (MHLW) in Japan for the Novasight Hybrid TM intravascular imaging system. The Novasight Hybrid system is the world’s first clinical system capable of providing both intravascular ultrasound (IVUS) and optical coherence tomography (OCT) on a single imaging catheter. The system also has Health Canada approval and FDA 510(k) clearance in the USA. Japan Lifeline is the exclusive distributor for this technology in Japan. Dr. Brian Courtney, Conavi Medical’s Chief Executive Officer, comments that ...

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    6. Three-dimensional detection and quantification of defects in SiC by optical coherence tomography

      Three-dimensional detection and quantification of defects in SiC by optical coherence tomography

      Silicon carbide (SiC) is widely used in high power electronic devices. However, defects on the SiC significantly reduce the yield and decrease the performance of SiC. Accurate detection of the defects is essential in the process control. We demonstrated a noninvasive three-dimensional (3D) defect detection method for SiC using optical coherence tomography (OCT). Defects including the triangular defects, hexagonal voids, grain boundaries, and carrot defects were inspected and analyzed on SiC wafers. The 3D images of defects acquired with OCT provided detailed information on the 3D structures and dimensions of defects, and the locations and orientations of the defects inside ...

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      Mentions: Pei Ma
    7. Post Doc Position for Optical Coherence Tomography at the Medical University Vienna

      Post Doc Position for Optical Coherence Tomography at the Medical University Vienna

      A PostDoc position is available from March 1, 2020 at the Center for Medical Physics and Biomedical Engineering, Medical University of Vienna. We offer a research position in the field of biomedical imaging with strong interdisciplinary collaboration. Our research group is developing novel coherent biomedical imaging methods based on parallel OCT and digital adaptive optics to overcome the conventional resolution limits and to pave the way from pure structural to functional tissue and cell metabolic imaging. This involves profound knowledge of theoretical and experimental optics, system engineering, data and image processing, as well as hands-on experience in modern biomedical optics ...

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    8. Optical coherence tomography as a noninvasive 3D real time imaging tool for the rapid evaluation of phenotypic variations in insect embryonic development

      Optical coherence tomography as a noninvasive 3D real time imaging tool for the rapid evaluation of phenotypic variations in insect embryonic development

      Noninvasive visualization of embryos at different development stages is crucial for the understanding of the basic developmental biology. It is therefore desirable to have an imaging tool capable of rapidly evaluating the effects of gene manipulation or genome editing in developing embryos for the studies of gene functions and genetic engineering. Here, we propose and demonstrate a novel use of optical coherence tomography (OCT) to noninvasively exam the embryonic development of the migratory locusts in real time with 3‐dimensional (3D) view capability. In particular, we obtain the sufficiently high spatial resolution tomographic 2D and 3D images of live locust ...

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    9. Dual-mode line-field confocal optical coherence tomography for ultrahigh-resolution vertical and horizontal section imaging of human skin in vivo

      Dual-mode line-field confocal optical coherence tomography for ultrahigh-resolution vertical and horizontal section imaging of human skin in vivo

      Line-field confocal optical coherence tomography (LC-OCT) is a recently introduced technique for ultrahigh-resolution vertical section (B-scan) imaging of human skin in vivo . This work presents a new implementation of the LC-OCT technique to obtain horizontal section images (C-scans) in addition to B-scans. C-scan imaging is achieved with this dual-mode LC-OCT system using a mirror galvanometer for lateral scanning along with a piezoelectric chip for modulation of the interferometric signal. A quasi-identical spatial resolution of ∼ 1 µm is measured for both B-scans and C-scans. The images are acquired in both modes at a rate of 10 frames per second. The horizontal ...

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    10. Applicability of optical coherence tomography in blue‐fronted parrots (Amazona aestiva)

      Applicability of optical coherence tomography in blue‐fronted parrots (Amazona aestiva)

      Objective Optical coherence tomography (OCT) measurement of adult blue‐fronted parrots ( Amazona aestiva ), free from infectious, inflammatory or neoplastic systemic diseases and from any ophthalmological illness, aim at its characterization, as well as to standardize the examination technique for the species. Procedure Pupillary dilation was achieved with rocuronium bromide (5 mg/mL) at 0, 2, 15, 17, 30, and 32 minutes. The animals were sedated with midazolam maleate (0.5 mg/kg/IM) and anesthetized with propofol (5.0 mg/kg/IV). Measurements were made to evaluate the thickness of the total retina (TR), sensorineural retinal (SR), and ganglion cell ...

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    11. Highly Stable All-Fiber-Ring Short-Cavity Continuously Tuned Swept Source

      Highly Stable All-Fiber-Ring Short-Cavity Continuously Tuned Swept Source

      In this study, we present a swept source that can intelligently control its sweeping speed while satisfying the commercial stability and miniaturization standards. The source’s central wavelength of the output spectrum is 1300 nm and spectral width is greater than 100 nm. Meanwhile, the scan frequency can be adjusted to range from 20 to 100 kHz, and the stability degree of the optical capacity is less than 0.34%. Additionally, this study establishes a numerical model for the swept-source optical coherence tomography (SS–OCT) system and introduces a numerical simulation of the signal produced during the OCT imaging process ...

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    12. OCT Cost Effective, Useful Pre-Cataract Surgery

      OCT Cost Effective, Useful Pre-Cataract Surgery

      An estimated 64.4% of patients were willing to pay for the extra imaging step. For patients considering cataract surgery with a multifocal intraocular lens (IOL), optical coherence tomography (OCT) done prior to the procedure may increase the overall cost, but it also could be beneficial in detecting other macular pathologies and improving quality of life, a study in Ophthalmology reports. Based on their analysis, researchers found approximately 20.5% of patients undergoing cataract surgery may have macular pathologies, of which 11% may not be found during the initial clinical exam. The investigation’s base case was a 67-year-old male ...

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    13. Optical Vaginal Biopsy Using Optical Coherence Tomography

      Optical Vaginal Biopsy Using Optical Coherence Tomography

      Objective Optical coherence tomography is a noninvasive technology that visualizes tissue microstructure with high spatial resolution. We designed a novel vaginal system that demonstrates a clear distinction between vaginal tissues planes. In this study, we sought to compare vaginal tomographic images of premenopausal, perimenopausal, and postmenopausal women, demonstrate feasibility of tracking vaginal tissue changes after treatment with fractional-pixel CO 2 laser therapy, and obtain a histologic correlation of these findings. Methods Enrolled subjects underwent imaging and were divided into 3 groups based on menopausal status. Women with genitourinary syndrome of menopause who received fractional-pixel CO 2 laser therapy were assessed ...

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    14. Optical Microscopy and Coherence Tomography of Cancer in Living Subjects

      Optical Microscopy and Coherence Tomography of Cancer in Living Subjects

      Intravital microscopy (IVM) and optical coherency tomography (OCT) are two powerful optical imaging tools that allow visualization of dynamic biological activities in living subjects with subcellular resolutions. Recent advances in labeling and label-free techniques empower IVM and OCT for a wide range of preclinical and clinical cancer imaging, providing profound insights into the complex physiological, cellular, and molecular behaviors of tumors. Preclinical IVM and OCT have elucidated many otherwise inscrutable aspects of cancer biology, while clinical applications of IVM and OCT are revolutionizing cancer diagnosis and therapies. We review important progress in the fields of IVM and OCT for cancer ...

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    15. Genetically Encodable Contrast Agents for Optical Coherence Tomography

      Genetically Encodable Contrast Agents for Optical Coherence Tomography

      Optical coherence tomography (OCT) has gained wide adoption in biological research and medical imaging due to its exceptional tissue penetration, 3D imaging speed and rich contrast. However, OCT plays a relatively small role in molecular and cellular imaging due to the lack of suitable biomolecular contrast agents. In particular, while the green fluorescent protein has provided revolutionary capabilities to fluorescence microscopy by connecting it to cellular functions such as gene expression, no equivalent reporter gene is currently available for OCT. Here we introduce gas vesicles, a class of naturally evolved gas-filled protein nanostructures, as genetically encodable OCT contrast agents. The ...

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    16. PhotoniCare's TOMi Scope takes Top Prize at SPIE and Photonics Media Prism Awards

      PhotoniCare's TOMi Scope takes Top Prize at SPIE and Photonics Media Prism Awards

      PhotoniCare, Inc., a company dedicated to revolutionizing healthcare by providing physicians with better diagnostic tools, today announced the company’s TOMi ™ Scope was awarded best healthcare product at the 12th Annual Prism Awards in San Francisco. The Prism Awards is an annual international competition that honors the best new optics and photonics products on the market. Since 2008, SPIE, along with media partner Photonics Media, has presented awards to companies and individuals that are creating products that make a difference, solve problems, and improve life through photonics. The Prism Awards reflect the exponential growth, exciting developments, and rich technical innovations ...

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    17. Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

      Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

      Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity associated findings collectively define the “Spaceflight Associated Neuro-ocular Syndrome” (SANS). We compare and contrast prior published work on SANS by the National Aeronautics and Space Administration’s (NASA) Space Medicine Operations Division with retrospective and prospective studies from other research groups. In this manuscript, we update and review the clinical manifestations of SANS including: unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and focal areas of ischemic retina (i.e., cotton wool spots). We ...

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    18. Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop

      Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop

      Non-muscle-invasive bladder cancer affects millions of people worldwide, resulting in significant discomfort to the patient and potential death. Today, cystoscopy is the gold standard for bladder cancer assessment, using white light endoscopy to detect tumor suspected lesion areas, followed by resection of these areas and subsequent histopathological evaluation. Not only does the pathological examination take days, but due to the invasive nature, the performed biopsy can result in significant harm to the patient. Nowadays, optical modalities, such as optical coherence tomography (OCT) and Raman spectroscopy (RS), have proven to detect cancer in real time and can provide more detailed clinical ...

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    19. Postdoctoral opening in quantitative retinal imaging and analysis at University of Illinois at Chicago

      Postdoctoral opening in quantitative retinal imaging and analysis at University of Illinois at Chicago

      A postdoctoral position is available in the Biomedical Optics and Functional Imaging group ( https://yaolab.bioe.uic.edu ) within the Department of Bioengineering, University of Illinois at Chicago. Our research lab is working on ultra-wide field fundus photography, functional optical coherence tomography (OCT), super-resolution ophthalmoscopy, retinal image analysis and classification. The postdoctoral fellow will be responsible for quantitative analysis of OCT/OCTA and machine learning based image classification. This position will be supported by a NIH project entitled differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathy . The successful candidate should have a Ph.D. degree in ...

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    20. Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice

      Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice

      Airway mucus obstruction is a hallmark of chronic lung diseases such as cystic fibrosis, asthma and COPD, and the development of more effective mucus mobilizing therapies remains an important unmet need for patients with these muco-obstructive lung diseases. However, methods for sensitive visualization and quantitative assessment of immediate effects of therapeutic interventions on mucus clearance in vivo are lacking. In this study, we determined if newly developed high-speed microscopic optical coherence tomography (mOCT) is sensitive to detect and compare in vivo effects of inhaled isotonic saline, hypertonic saline and bicarbonate on mucus mobilization and clearance in Scnn1b -transgenic mice with ...

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    21. Acucela Meets with NASA and TRISH for Phase 1 Update for SS-OCT Project

      Acucela Meets with NASA and TRISH for Phase 1 Update for SS-OCT Project

      Acucela Inc. (“Acucela”), a clinical-stage ophthalmology company and wholly-owned subsidiary of Kubota Pharmaceutical Holdings Co., Ltd. (Tokyo 4596), announced today that the company was invited to meet with NASA and the Translational Research Institute for Space Health (TRISH) *1 to present on January 30, 2020 the status of its Swept Source-OCT *2 (“SS-OCT”) device being developed for NASA’s Deep Space missions. The purpose of the meeting was to review and discuss progress of this Phase 1 project with the engineers, basic and medical scientists and program managers from NASA and TRISH. Additionally, a demonstration of the Phase 1 device ...

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    22. New OCT Image Analysis Capabilities From Wasatch Photonics

      New OCT Image Analysis Capabilities From Wasatch Photonics

      Wasatch Photonics is pleased to announce the expansion of our WP OCT Software and software development kits with new features to facilitate the translation of images into actionable information. These OCT image analysis capabilities lower the barrier to use for OCT by non-experts, and offer the potential for automated analysis of images in real time. The new features include image enhancement, layer segmentation, and classification functions based on powerful machine learning algorithms, and may be accessed from our user-friendly OCT image acquisition software or via our software development kits (SDKs). To help you see the possibilities, we have trained our ...

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    1-22 of 22
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