1. Featured Articles

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    1. Convective Nozaki-Bekki holes in a long cavity OCT laser

      Convective Nozaki-Bekki holes in a long cavity OCT laser

      We show, both experimentally and theoretically, that the loss of coherence of a long cavity optical coherence tomography (OCT) laser can be described as a transition from laminar to turbulent flows. We demonstrate that in this strongly dissipative system, the transition happens either via an absolute or a convective instability depending on the laser parameters. In the latter case, the transition occurs via formation of localised structures in the laminar regime, which trigger the formation of growing and drifting puffs of turbulence. Experimentally, we demonstrate that these turbulent bursts are seeded by appearance of Nozaki-Bekki holes, characterised by the zero ...

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    2. Research Associate in Biophotonics Openings at the Univesity of Sheffield (2 openings)

      Research Associate in Biophotonics Openings at the Univesity of Sheffield (2 openings)

      University of Sheffield - Faculty of Engineering, Department of Electronic and Electrical Engineering Location: Sheffield Salary: £31,302 to £36,261 Grade 7 per annum Hours: Full Time Contract Type: Fixed-Term/Contract Placed On: 22nd May 2019 Closes: 20th June 2019 Job Ref: UOS022704 Contract Type: Fixed term for 36 months, with a start date on or after 1st July 2019. Are you interested in working for a world top 100 University? We have two exciting opportunities in the Department of Electronic and Electrical Engineering for people with a passion for research at the medicine/engineering interface, looking to use their ...

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    3. Depth-resolved birefringence imaging of collagen fiber organization in the human oral mucosa in vivo

      Depth-resolved birefringence imaging of collagen fiber organization in the human oral mucosa in vivo

      Stromal collagen organization has been identified as a potential prognostic indicator in a variety of cancers and other diseases accompanied by fibrosis. Changes in the connective tissue are increasingly considered for grading dysplasia and progress of oral squamous cell carcinoma, investigated mainly ex vivo by histopathology. In this study, polarization-sensitive optical coherence tomography (PS-OCT) with local phase retardation imaging is used for the first time to visualize depth-resolved (i.e., local) birefringence of healthy human oral mucosa in vivo . Depth-resolved birefringence is shown to reveal the expected local collagen organization. To demonstrate proof-of-principle, 3D image stacks were acquired at labial ...

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    4. Upper limit for angular compounding speckle reduction

      Upper limit for angular compounding speckle reduction

      Angular compounding is a technique for reducing speckle noise in optical coherence tomography that is claimed to significantly improve the signal-to-noise ratio (SNR) of images without impairing their spatial resolution. Here, we examine how focal point movements caused by optical aberrations in an angular compounding system may produce unintended spatial averaging and concomitant loss of spatial resolution. Experimentally, we accounted for such aberrations by aligning our system and measuring distortions in images and found that when the distortions were corrected, the speckle reduction by angular compounding was limited. Our theoretical analysis using Monte Carlo simulations indicates that “pure” angular compounding ...

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    5. GGold Nanobipyramids as Second Near Infrared Optical Coherence Tomography Contrast Agents for Multiplexed In Vivo Lymphangiography

      GGold Nanobipyramids as Second Near Infrared Optical Coherence Tomography Contrast Agents for Multiplexed In Vivo Lymphangiography

      Developing contrast-enhanced optical coherence tomography (OCT) techniques is important for specific imaging of tissue lesions, molecular imaging, cell-tracking, and highly sensitive microangiography and lymphangiography. Multiplexed OCT imaging in the second near infrared (NIR-II) window is highly desirable since it allows simultaneous imaging and tracking of multiple biological events in high resolution with deeper tissue penetration in vivo. Here we demonstrate that gold nanobipyramids can function as OCT multiplexing contrast agents, allowing the visualization of two separate lymphatic flows occurring simultaneously from different drainage basins into the same lymph node in a live mouse. Contrast-enhanced multiplexed lymphangiography of a melanoma tumor ...

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    6. Post-Doctoral Research Opening in the Department of Physics at University of Coimbra, Portugal

      Post-Doctoral Research Opening in the Department of Physics at University of Coimbra, Portugal

      We opened a tender for selecting a Post-Doctoral Researcher with a contract for an open-ended period of time. We are looking for someone with a Doctoral degree in Biomedical Engineering, Physics Engineering, Physics, Electrotechnical Engineering or a closely related area, knowledge in optoelectronic instrumentation, photonics, optics and electronics and knowledge in programming. The position concerns the ElastoOCT project - Optical Coherence Elastography for imaging retina mechanical properties – and is available at the University of Coimbra, Portugal. The aim of the project is to develop and build an optical coherence elastography system for retinal imaging, with ultrasound excitation and measurement of induced ...

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    7. The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

      The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

      Objective To demonstrate the safety and feasibility of clinical in vivo needle‐based optical coherence tomography (OCT) imaging of the prostate. Materials and Methods Two patients with prostate cancer underwent each two percutaneous in vivo needle‐based OCT measurements before transperineal template mapping biopsy. The OCT probe was introduced via a needle and positioned under ultrasound guidance. To test the safety, adverse events were recorded during and after the procedure. To test the feasibility, OCT and US images were studied during and after the procedure. Corresponding regions for OCT and biopsy were determined. A uropathologist evaluated and annotated the histopathology ...

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    8. Expert consensus published on use of imaging to guide heart attack treatment

      Expert consensus published on use of imaging to guide heart attack treatment

      Imaging provides a more precise diagnosis of a heart attack that can be used to individualise treatment. That’s the main message of an expert consensus paper published today 1 in European Heart Journal, a journal of the European Society of Cardiology (ESC), and presented at EuroPCR in Paris, France. 2 Heart attacks are diagnosed and treated using coronary angiography, an invasive procedure which provides an X-ray outline of the arteries supplying blood to the heart. Invasive imaging of the arteries gives more detail but there has been controversy over when to use it. This document seeks to resolve that ...

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    9. Research Scientist for Optical Diagnostic at Carestream Dental

      Research Scientist for Optical Diagnostic at Carestream Dental

      We are seeking a Research Scientist for Optical Diagnostics to be part of an innovative research team (based in Rochester, New York) that develops new optical devices for improving measurements and diagnoses in dentistry. Position Description: Research Scientist who will research and develop new optical technologies for dental measurements and diagnostics Conceptualize and demonstrate new applications of optics and photonics in solving problems in modern dentistry and advancing the field Design, implement, and develop experimental and prototype systems and perform clinical evaluation Collaborate with a multi-disciplinary team to translate technology solution into commercial product H-1B Candidates are welcome to apply ...

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    10. Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Intervent

      Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Intervent

      This consensus document is the second of two reports summarizing the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on the clinical use of intracoronary imaging including intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near infrared spectroscopy (NIRS)-IVUS. Beyond guidance of stent selection and optimization of deployment, invasive imaging facilitates angiographic interpretation and may guide treatment in acute coronary syndrome. Intravascular imaging can provide additional important diagnostic information when confronted with angiographically ambiguous lesions and allows assessment of plaque morphology enabling identification of vulnerability characteristics. This second document focuses on useful ...

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    11. Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study

      Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study

      Objective To determine the optimal thresholds for intereye differences in retinal nerve fiber and ganglion cell + inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multicenter international study at 11 sites, optical coherence tomography was measured for patients and healthy controls as part of the International Multiple Sclerosis Visual System Consortium. High‐ and low‐contrast acuity were also collected in a subset ...

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    12. PhD Studentship Opening at The University of Liverpool

      PhD Studentship Opening at The University of Liverpool

      PhD studentship in the development of optical coherence tomography (OCT) and artificial intelligence (AI) for precisely and automatically measurement of the corneal power. Successful students will receive a studentship of tuition fees paid at the Home/EU rate for 3.5 years and a stipend of £15,009 per annum for 3.5 years. In addition, students will have access to a research support fund of £1,000 per annum for purchasing equipment, consumables and conference costs co-managed by the academic supervisor. The project is supported by the University of Liverpool Doctoral Network in Future Digital Health, which is directed ...

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    13. Postdoctoral Positions Immediately Open at Boston University School of Medicine, Boston Medical Center

      Postdoctoral Positions Immediately Open at Boston University School of Medicine, Boston Medical Center

      Postdoctoral positions immediately open at Boston University School of Medicine, Boston Medical Center. About the position : We are looking for highly motivated individuals to join the lab, to develop novel optical imaging techniques for ophthalmic and endoscopic applications. Candidates with experiences on ophthalmic imaging, endoscopy, optical coherence tomography, fiber sensing and imaging system will be highly competitive. The position will require PhD degree on scientific discipline, for example, electrical engineering, computer science, biomedical engineering etc. The position also requires good communication skill, willingness for collaboration, and is expected to independently publish scientific papers. Please contact the PI, Dr. Ji Yi ...

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    14. Avinger Announces Successful Treatment of 1,000th Patient with Next-Generation Pantheris Device

      Avinger Announces Successful Treatment of 1,000th Patient with Next-Generation Pantheris Device

      Avinger, Inc. (AVGR), a commercial-stage medical device company marketing the first and only intravascular image-guided, catheter-based system for diagnosis and treatment of patients with Peripheral Artery Disease (PAD), today announced that physicians in 78 clinical sites have successfully treated more than 1,000 patients with the next-generation Pantheris image-guided atherectomy system. The next-generation Pantheris was launched on a limited basis in the U.S. following receipt of 510(k) clearance by the U.S. Food and Drug Administration (FDA) in late May 2018 and features a number of improvements intended to augment the performance and reliability of the product. Importantly ...

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      Mentions: FDA Avinger
    15. Ping An completes multi-center clinical trials for world's first intelligent OCT retinal disease screening system

      Ping An completes multi-center clinical trials for world's first intelligent OCT retinal disease screening system

      Ping An Insurance (Group) Company of China, Ltd. is pleased to announce that its technology arm, Ping An Technology, has completed a prospective multi-center clinical trial for the world's first intelligent optical coherence tomography (OCT) retinal disease screening system. The screening system is jointly developed by Ping An Technology and US-based Optovue, Inc. It is the first artificial intelligence (AI) imaging and screening system in the world that seamlessly integrates an OCT retinal imaging device and AI lesion detection software. The clinical trial was conducted at three well-known research institutions, the Eye and ENT Hospital of Fudan University in ...

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    16. In vivo volumetric imaging by crosstalk-free full-field OCT

      In vivo volumetric imaging by crosstalk-free full-field OCT

      Cellular resolution imaging of biological structures has always been a challenge due to strong scattering that limits the achievable transverse resolution or imaging penetration depth. Recently, a major advancement toward high-resolution and volumetric imaging was achieved by implementing a parallel detection (i.e., full field) into Fourier-domain optical coherence tomography. The drawback of using parallel detection is that scattered light can travel laterally and get mapped improperly at a camera creating optical crosstalk, which severely impairs the interpretation of subcellular images and limits its use in medical diagnostics. In this work, we demonstrate for what we believe is the first ...

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    17. EXALOS Introduces RGB Modules for Augmented Reality and Head-up Display Applications

      EXALOS Introduces RGB Modules for Augmented Reality and Head-up Display Applications

      Schlieren, Switzerland, May 6 th , 2019. EXALOS, the world’s leading developer of visible Superluminescent Light Emitting Diodes (SLEDs), has expanded its product porfolio with the introduction of a compact RGB SLED module that will enable the advancement of micro-display architectures for augmented reality (AR) and head-up displays (HUDs). The RGB module constitutes three SLED chips housed in a 14-pin butterfly package (20.8 mm x 1.7 mm) with a total output power of about 30 mW (~ 10 mW/color), which corresponds to a total luminous flux of 5 lm. The individual chips (635 nm (R), 510 nm (G ...

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      Mentions: Exalos Kevin Hsu
    18. NinePoint Medical Announces Publication of 1000 Patient Registry Study

      NinePoint Medical Announces Publication of 1000 Patient Registry Study

      NinePoint Medical, Inc, a transformative medical device company pioneering the use of Optical Coherence Tomography (OCT) for gastrointestinal applications, today announced the publication of their 1000 patient Volumetric Laser Endomicroscopy (VLE) Registry study focused on Barrett’s Esophagus. The 18 site study, published in Diseases of the Esophagus , enrolled 1000 patients between 2014 and 2016 for imaging using the NvisionVLE® Imaging System. The study was designed to determine usage patterns of VLE in clinical practice and to estimate quantitative and qualitative performance metrics, with this publication focused on Barrett’s Esophagus. All enrolled patients were examined with standard upper endoscopy ...

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    19. Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography

      Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography

      Optical coherence tomography angiography (OCTA) provides in-vivo images of microvascular perfusion in high resolution. For its application to basic and clinical research, an automatic and robust quantification of the capillary architecture is mandatory. Only this makes it possible to reliably analyze large amounts of image data, to establish biomarkers, and to monitor disease developments. However, due to its optical properties, OCTA images of skin often suffer from a poor signal-to-noise ratio and contain imaging artifacts. Previous work on automatic vessel segmentation in OCTA mostly focuses on retinal and cerebral vasculature. Its applicability to skin and, furthermore, its robustness against imaging ...

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    20. High frequency optical coherence tomography assessment of homogenous neck coverage by intrasaccular devices predicts successful aneurysm occlusion

      High frequency optical coherence tomography assessment of homogenous neck coverage by intrasaccular devices predicts successful aneurysm occlusion

      Background High frequency optical coherence tomography (HF-OCT) is a novel intravascular imaging technology developed for use in the cerebral vasculature. We hypothesize that HF-OCT characterization of intrasaccular device neck coverage can prognosticate exclusion of the aneurysm from the circulation. Methods Bifurcation and sidewall aneurysms were made in six dogs. Seven aneurysms were treated with next generation intrasaccular devices (NGID) and four with traditional platinum coils. HF-OCT was performed to interrogate gaps in the neck coverage, coil herniation, or acute thrombus formation. Animals were re-imaged at 7, 30, 90, and 180  days following aneurysm embolization. An automated image processing method segmented ...

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    21. Permanent Professor Position available at University of Lubeck

      Permanent Professor Position available at University of Lubeck

      The Institute of Biomedical Optics at the Department of Computer Science/Engineering and Department of Natural Sciences (STEM) at the Universität zu Lübeck invites applications for a permanent University Professorship (W2) in Biomedical Optics and Photonics commencing as soon as possible. Conditions of the appointment are in accordance with the Higher Education Act (Hochschulgesetz) of Schleswig Holstein. Details will be explained on request. The successful candidate will represent the respective field in research and teaching. The overall focus of the professorship lies on novel physics approaches in optics and their development to the point of application in the ...

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    22. Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry

      Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry

      Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan was performed. The objective of this registry was to determine usage patterns of VLE in clinical practice and to estimate quantitative and qualitative performance metrics as they are applied to Barrett's esophagus (BE) management. All procedures utilized the NvisionVLE Imaging System (NinePoint Medical, Bedford, MA) which was used by investigators to identify the tissue types present, along with focal areas of concern. Following the VLE ...

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    23. Ultralow-voltage electrothermal MEMS based fiber-optic scanning probe for forward-viewing endoscopic OCT

      Ultralow-voltage electrothermal MEMS based fiber-optic scanning probe for forward-viewing endoscopic OCT

      We report an ultralow-voltage, electrothermal (ET) micro-electro-mechanical system (MEMS) based probe for forward-viewing endoscopic optical coherence tomography (OCT) imaging. The fully assembled probe has a diameter of 5.5 mm and a length of 55 mm, including the imaging optics and a 40 mm long fiber-optic cantilever attached on a micro-platform of the bimorph ET MEMS actuator. The ET MEMS actuator provides a sufficient mechanical actuation force as well as a large vertical displacement, achieving up to a 3 mm optical scanning range with only a 3

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    24. PhotoniCare Inc. Announces Initiation of a Multi-Site Registered Clinical Study in Patients Undergoing Surgery for Chronic Middle Ear Infection

      PhotoniCare Inc. Announces Initiation of a Multi-Site Registered Clinical Study in Patients Undergoing Surgery for Chronic Middle Ear Infection

      PhotoniCare Inc., a medical device company headquartered in Champaign, Illinois, announces successful initiation of a multi-site registered clinical study to evaluate the imaging capabilities and image analysis performance of the PhotoniCare TOMi Scope. Children’s National Health System (Washington, D.C.) is the first initiated of two clinical sites involved in this registered multi-site clinical study, along with Carle Foundation Hospital (Urbana, Illinois). The study is led by Dr. Diego Preciado, Children’s National, and Dr. Ryan Porter, Carle Hospital, along with a team of recognized otitis media experts at both clinical sites. This multi-center study plans to enroll a ...

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