1. Featured Articles

    1-14 of 14
    1. High-resolution polarization-sensitive optical coherence tomography for zebrafish muscle imaging

      High-resolution polarization-sensitive optical coherence tomography for zebrafish muscle imaging

      Zebrafish are an important animal model, whose structure and function information can be used to study development, pathologic changes and genetic mutations. However, limited by the penetration depth, the available optical methods are difficult to image the whole-body zebrafish in juvenile and adult stages. Based on a home-made high-resolution polarization-sensitive optical coherence tomography (PS-OCT) system, we finished in vivo volumetric imaging for zebrafish, and various muscles can be clearly discerned by scanning from dorsal, ventral, and lateral directions. Besides structure information, polarization properties extracted from PS-OCT images provide abundant function information to distinguish different muscles. Furthermore, we found local retardation ...

      Read Full Article
    2. 3D co-registration algorithm for catheter-based optical coherence tomography

      3D co-registration algorithm for catheter-based optical coherence tomography

      Applications of catheter-based optical coherence tomography (OCT) - originally developed for cardiovascular imaging - have expanded to other organ systems. However, currently available algorithms to co-register 3D OCT data to a second imaging modality were developed for cardiovascular applications and with it, are tailored to small tubular tissue structures. The available algorithms can often not be applied outside the cardiovascular system, e.g. when an OCT probe is introduced into the kidney, lungs, or wrist. Here, we develop a generic co-registration algorithm with potentially numerous applications. This algorithm only requires that the OCT probe is visible on the second imaging modality and ...

      Read Full Article
    3. The feasibility and utility of optical coherence tomography directed histopathology for surgical margin assessment of canine mast cell tumors

      The feasibility and utility of optical coherence tomography directed histopathology for surgical margin assessment of canine mast cell tumors

      Histopathologic surgical margin assessment in veterinary patients is an imprecise science with assessment limited to a small proportion of the surgical margin due to time and finances. Incomplete excision of canine mast cell tumors (MCTs) alters treatment recommendations and prognosis. Optical coherence tomography (OCT) is a novel imaging modality that has been reported in a single veterinary study for surgical margin assessment. Twenty‐five dogs with 34 MCTs were enrolled in a prospective pilot‐study to assess the imaging characteristics of canine MCTs with OCT and to evaluate the feasibility and utility of OCT‐guided histopathology. All dogs underwent routine ...

      Read Full Article
    4. Optical microangiography reveals temporal and depth-resolved hemodynamic change in mouse barrel cortex during whisker stimulation

      Optical microangiography reveals temporal and depth-resolved hemodynamic change in mouse barrel cortex during whisker stimulation

      Significance: Cerebral blood flow (CBF) regulation at neurovascular coupling (NVC) plays an important role in normal brain functioning to support oxygen delivery to activating neurons. Therefore, studying the mechanisms of CBF adjustment is crucial for the improved understanding of brain activity. Aim: We investigated the temporal profile of hemodynamic signal change in mouse cortex caused by neural activation and its variation over cortical depth. Approach: Following the cranial window surgery, intrinsic optical signal imaging (IOSI) was used to spatially locate the activated region in mouse cortex during whisker stimulation. Optical microangiography (OMAG), the functional extension of optical coherence tomography, was ...

      Read Full Article
    5. Monitoring fatigue damage in different CAD/CAM materials: A new approach with optical coherence tomography.

      Monitoring fatigue damage in different CAD/CAM materials: A new approach with optical coherence tomography.

      Purpose: To investigate fatigue damage over time, monolithic posterior computer-aided-designed/computer-aided-manufactured (CAD/CAM) crowns were artificially aged in a mouth-motion-simulator, and damage was monitored with optical coherence tomography (OCT). Methods: Forty-eight crowns were milled of six different CAD/CAM-materials (n=8), including 3Y-TZP (Lava Plus,‘3Y’), 4Y-PSZ (Pritidentamultidisc,‘4Y’), 5Y-PSZ (Prettauanterior,‘5Y’), zirconia-reinforced lithium silicate (CeltraDuo,‘ZLS’), hybrid ceramic (Vita Enamic,‘VE’),and resin composite (BrilliantCrios,‘COM’), and were adhesively luted on CAD/CAM-milled human molars. Specimens were artificially aged in a mouth-motion-simulator (50-500N, 2Hz, 37°C) for a period of 1 million cycles. Before loading and every 250,000 ...

      Read Full Article
    6. HP-OCT™ wins Victorian AEEA award – nominated for Sir William Hudson award

      HP-OCT™ wins Victorian AEEA award – nominated for Sir William Hudson award

      Cylite Pty Ltd, a developer and manufacturer of 4 th Generation OCT systems for Ophthalmology and Optometry, is thrilled to announce it has won the Australian Engineering Excellence Award Victoria. The Australian Engineering Excellent Awards first began in 1988, after a decade of celebrating local projects through an Engineers Australia office. Brought to the national stage, an excellence award recognises outstanding achievement in engineering and the invaluable contribution that engineering makes to the economy, community and environment. Winning projects exhibit excellence, distinction, merit, perfection and quality. Kylee Hall, Cylite’s VP Sales and Marketing Manager commented, ”It is such an ...

      Read Full Article
      Mentions: Cylite
    7. Postdoctoral Scholar in High Resolution Retinal Imaging at The Ohio State University

      Postdoctoral Scholar in High Resolution Retinal Imaging at The Ohio State University

      A NIH funded Post Doctoral Scholar position is available in the laboratory of Drs. Nathan Doble and Stacey Choi in the College of Optometry/Department of Ophthalmology and Visual Science at The Ohio State University (OSU). The successful candidate will work within a highly collaborative research environment focused on the development and use of novel high-resolution optical instrumentation for the study of retinal structure and function. The candidate will be expected to assist with construction and validation of novel instrumentation as well as the collection and analysis of the experimental data; preparation of research results for publication and talks; writing ...

      Read Full Article
    8. Semi-automated registration and segmentation for gingival tissue volume measurement on 3D OCT images

      Semi-automated registration and segmentation for gingival tissue volume measurement on 3D OCT images

      The change in gingival tissue volume may be used to indicate changes in gingival inflammation, which may be useful for the clinical assessment of gingival health. Properly quantifying gingival tissue volume requires a robust technique for accurate registration and segmentation of longitudinally captured 3-dimensional (3D) images. In this paper, a semi-automated registration and segmentation method for micrometer resolution measurement of gingival-tissue volume is proposed for 3D optical coherence tomography (OCT) imaging. For quantification, relative changes in gingiva tissue volume are measured based on changes in the gingiva surface height using the tooth surface as a reference. This report conducted repeatability ...

      Read Full Article
    9. Pet laser pointers have enough power to “blast away” cells in the back of the eye

      Pet laser pointers have enough power to “blast away” cells in the back of the eye

      Laser pointers used to exercise pets may seem like safe and simple low-powered devices, but an Ohio teen learned the hard way that staring at the narrow beam can cause permanent eye damage. His minimal vision loss tells some of the story, but a high-resolution optical imaging device developed by Ohio State University researchers showed in stark detail that cells in the boy’s retinas are missing – “blasted away” by the laser, his ophthalmologist explained. This area of the eye is home to photoreceptors, light-sensitive cells (often referred to as rods and cones) that allow us to “see.” These cells ...

      Read Full Article
    10. Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples

      Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples

      Significance: To advance our understanding of the contrast observed when imaging with polarization-sensitive optical coherence tomography (PS-OCT) and its correlation with oral cancerous pathologies, a detailed comparison with histology provided via ex vivo fixed tissue is required. The effects of tissue fixation, however, on such polarization-based contrast have not yet been investigated. Aim: A study was performed to assess the impact of tissue fixation on depth-resolved (i.e., local) birefringence measured with PS-OCT. Approach: A PS-OCT system based on depth-encoded polarization multiplexing and polarization-diverse detection was used to measure the Jones matrix of a sample. A wide variety of ex ...

      Read Full Article
    11. Industrialization Potential of Optics in Biomedicine (On-Line Conference October 7 & 8, 2020)

      Industrialization Potential of Optics in Biomedicine (On-Line Conference October 7 & 8, 2020)

      The conference will be focused on the past, current and the future developments of optical biomedical imaging techniques. The program of the i-POB conference will provide companies with an opportunity to share the experience and tribulations of taking a new discovery to the market with researchers that are successful in the process of implementing new technologies. The event will include opportunities for interaction between, scientist, innovators and entrepreneurs, including education on how to successfully run projects, start the company and enter to the global market. The meeting will be especially instructive for junior researchers and inventors interested in the development ...

      Read Full Article
    12. Correlative infrared optical coherence tomography and hyperspectral chemical imaging

      Correlative infrared optical coherence tomography and hyperspectral chemical imaging

      Optical coherence tomography (OCT) is a high-resolution three-dimensional imaging technique that enables nondestructive measurements of surface and subsurface microstructures. Recent developments of OCT operating in the mid-infrared (MIR) range (around 4 µm) lifted fundamental scattering limitations and initiated applied material research in formerly inaccessible fields. The MIR spectral region, however, is also of great interest for spectroscopy and hyperspectral imaging, which allow highly selective and sensitive chemical studies of materials. In this contribution, we introduce an OCT system (dual-band, central wavelengths of 2 µm and 4 µm) combined with MIR spectroscopy that is implemented as a raster scanning chemical imaging ...

      Read Full Article
    13. The optoretinogram reveals the primary steps of phototransduction in the living human eye

      The optoretinogram reveals the primary steps of phototransduction in the living human eye

      Photoreceptors initiate vision by converting photons to electrical activity. The onset of the phototransduction cascade is marked by the isomerization of photopigments upon light capture. We revealed that the onset of phototransduction is accompanied by a rapid (<5 ms), nanometer-scale electromechanical deformation in individual human cone photoreceptors. Characterizing this biophysical phenomenon associated with phototransduction in vivo was enabled by high-speed phase-resolved optical coherence tomography in a line-field configuration that allowed sufficient spatiotemporal resolution to visualize the nanometer/millisecond-scale light-induced shape change in photoreceptors. The deformation was explained as the optical manifestation of electrical activity, caused due to rapid charge displacement ...

      Read Full Article
    14. In vivo SS-OCT imaging of crystalline lens sutures

      In vivo SS-OCT imaging of crystalline lens sutures

      We demonstrate in vivo three-dimensional (3-D) visualization of crystalline lens sutures in healthy eyes using swept source optical coherence tomography (SS-OCT). Volumetric data sets of the crystalline lenses were acquired and processed to obtain enhanced contrast projection images and to extract suture patterns in both anterior and posterior lens. The results presented different types of the sutures including Y-sutures, simple and complex star sutures. Age-related changes in suture arrangement were characterized quantitatively. Crystalline lens suture imaging with SS-OCT might be a useful tool in fundamental studies on development and ageing of human lens.

      Read Full Article
    1-14 of 14
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles