1. Featured Articles

    1-16 of 16
    1. Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice

      Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice

      We report the use of an electrically tunable lens (ETL) in a 1.3 μm spectral-domain optical coherence tomography (SD-OCT) system to overcome the depth of focus (DOF) limitation in conventional OCT systems for OCT angiography (OCTA) in a mouse cerebral cortex. The ETL provides fast and dynamic control of the axial focus of the probe beam along the entire range of the mouse cortex, upon which we performed cerebral blood flow imaging of all cortical layers by stitching the OCTA images automatically captured at six focal depths. Capillary vasculature and axial blood flow velocity were revealed in distinctive cortical ...

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    2. Metasurface-based focus-tunable mirror

      Metasurface-based focus-tunable mirror

      Varifocal mirrors, which have various applications in optical coherent tomography and three-dimensional displays, are traditionally based on the fluid pressure or mechanical pusher to deform the mirror. The limitations of conventional varifocal mirrors are obvious, such as the heavy size of the device and constraints of tunability, due to their mechanical pressure control elements. The reprogrammable metasurface, a new flat photonic device with multifunction in an ultrathin dimension, paves the way towards an ultrathin and lightweight mirror with precise phase profile. Here, an active reconfigurable metasurface is proposed to achieve the manipulation of the wavefront. The meta-atom in the metasurface ...

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    3. Marie Curie Early Stage Researcher “NExt generation of Tunable LASers for Optical Coherence Tomography”

      Marie Curie Early Stage Researcher “NExt generation of Tunable LASers for  Optical Coherence Tomography”

      School of Physical Sciences Location: Canterbury Salary: £32,500 Grade: Marie Curie Post Type: Full Time Contract Type: Fixed Term - 36 Months Release Date: Thursday 10 October 2019 Closing Date: 23.59 hours GMT on Monday 30 December 2019 (unless otherwise stated) Reference: STM-074-19 We are recruiting for three PhD Studentships in the fields of Optics and Laser Physics, with emphasis on optical coherence tomography for a period of 36 months with a start date anytime between 1st February 2020 and 31 January 2021, within the Applied Optics Group, School of Physical Sciences. These are supported by the Marie Curie ...

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    4. Scientific Reports Journal Collection on "Quantitative and Computational Techniques in Optical Coherence Tomography" open for submission

      Scientific Reports Journal Collection on "Quantitative and Computational Techniques in Optical Coherence Tomography" open for submission

      Scientific Reports , a Nature Research journal, is welcoming original primary research articles for a special Guest Edited Collection on ‘Quantitative and computational techniques in optical coherence tomography’ (https://www.nature.com/srep/guestedited#optical-coherence-tomography ). This Collection seeks to bring together original Articles which exploit realistic mathematical models of OCT image formation to obtain insight not otherwise available from raw OCT images. This includes research using techniques such as parametric attenuation imaging, local birefringence retrieval, full-wave modelling, computational adaptive optics, flow and displacement measurement, elastography and inverse scattering. Submissions are welcome on a rolling basis. For information regarding Scientific Reports' policies ...

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    5. A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head

      A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head

      Optical coherence tomography (OCT) has become an established clinical routine for the in vivo imaging of the optic nerve head (ONH) tissues, that is crucial in the diagnosis and management of various ocular and neuro-ocular pathologies. However, the presence of speckle noise affects the quality of OCT images and its interpretation. Although recent frame-averaging techniques have shown to enhance OCT image quality, they require longer scanning durations, resulting in patient discomfort. Using a custom deep learning network trained with 2,328 ‘clean B-scans’ (multi-frame B-scans; signal averaged), and their corresponding ‘noisy B-scans’ (clean B-scans + Gaussian noise), we were able to ...

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    6. VISE affiliates awarded $1.8 million grant to improve surgical guidance during eye surgery

      VISE affiliates awarded $1.8 million grant to improve surgical guidance during eye surgery

      A team of Vanderbilt University engineers and clinicians have won a five-year $1.8 million National Eye Institute grant to develop and translate novel intraoperative imaging technologies to the ophthalmic surgical suite to enable real-time surgical guidance. “Our group has spent quite a few years working on developing the underlying imaging technology,” said Yuankai Kenny Tao, assistant professor of biomedical engineering and a faculty researcher in the Vanderbilt Institute for Surgery and Engineering, is the principal investigator. “This grant will support our translational efforts and allow us to identify ophthalmic surgeries that will directly benefit from real-time guidance and to ...

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    7. Advances In Intraoperative OCT

      Advances In Intraoperative OCT

      Over the past decade, there have been major advances in the field of intraoperative optical coherence tomography. From the development of the portable OCT probe to the first microscope-integrated system, intraoperative OCT has evolved from a research idea to a clinically viable technology. Advances such as heads-up visualization and microscope-integration, as well as the results from large clinical studies, have pushed the field forward. While the feasibility and potential utility of intraoperative optical coherence tomography has been demonstrated both in clinical studies and in real-world usage, several areas of enhancement are needed to enable iOCT to be part of a ...

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    8. Co-cultured microfluidic model of the airway optimized for microscopy and micro-optical coherence tomography imaging

      Co-cultured microfluidic model of the airway optimized for microscopy and micro-optical coherence tomography imaging

      We have developed a human bronchial epithelial (HBE) cell and endothelial cell co-cultured microfluidic model to mimic the in vivo human airway. This airway-on-a-chip was designed with a central epithelial channel and two flanking endothelial channels, with a three-dimensional monolayers of cells growing along the four walls of the channel, forming central clear lumens. These cultures mimic airways and microvasculature in vivo . The central channel cells are grown at air-liquid interface and show features of airway differentiation including tight-junction formation, mucus production, and ciliated cells. Combined with novel micro-optical coherence tomography, this chip enables functional imaging of the interior of ...

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    9. Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring

      Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring

      The success of reef-building corals for >200 million years has been dependent on the mutualistic interaction between the coral host and its photosynthetic endosymbiont dinoflagellates (family Symbiodiniaceae) that supply the coral host with nutrients and energy for growth and calcification. While multiple light scattering in coral tissue and skeleton significantly enhance the light microenvironment for Symbiodiniaceae, the mechanisms of light propagation in tissue and skeleton remain largely unknown due to a lack of technologies to measure the intrinsic optical properties of both compartments in live corals. Here we introduce ISOCT (inverse spectroscopic optical coherence tomography), a non-invasive approach to measure ...

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    10. Fractional Flow Reserve or Optical Coherence Tomography to Guide Management of Angiographically-Intermediate Coronary Stenosis: A Single-Center Trial

      Fractional Flow Reserve or Optical Coherence Tomography to Guide Management of Angiographically-Intermediate Coronary Stenosis: A Single-Center Trial

      Background Fractional flow reserve (FFR) and optical coherence tomography (OCT) may help both in assessment of angiographically-intermediate coronary lesions (AICL) and in percutaneous coronary interventions (PCI) optimization. Objectives: To compare OCT-guidance and FFR-guidance in patients with AICL in a single-center, prospective, 1:1 randomized trial (acronym: FORZA, NCT01824030 ). Methods Patients with AICL were randomized to FFR or OCT. In the FFR arm, PCI was performed if FFR was ≤0.80. In the OCT arm, PCI was performed if area stenosis was ≥75% or 50%-75% with minimal lumen area <2.5 mm 2 or plaque rupture. Angina (evaluated by Seattle ...

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      Mentions: Rocco Vergallo
    11. Fully Automatic Artificial Intelligence Diagnostic Model Of Coronary Artery Lesions Using Oct Imaging

      Fully Automatic Artificial Intelligence Diagnostic Model Of Coronary Artery Lesions Using Oct Imaging

      Background Coronary artery disease leads to progression of pathological formations in arterial wall layers, which may be followed by acute coronary syndrome. Optical Coherence Tomography has high resolution to visualize intracoronary wall structure. In this study, we aimed to design a computer aided diagnostic model providing clinicians with an operator-independent diagnosis of coronary lesions. Jump to Section Background Methods and Results Conclusion Methods and Results 45 OCT pullbacks obtained from different pediatric patients using ILUMIEN OCT system with ∼100 images per pullback are used in this study. Our proposed coronary diagnostic model starts with evaluating the structural changes of the ...

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    12. OCT-Based Tooth Scan and Reconstruction

      OCT-Based Tooth Scan and Reconstruction

      Digital dental reconstruction can be a more efficient and effective mechanism for artificial crown construction and period inspection. However, optical methods cannot reconstruct those portions under gums, and X-ray-based methods have high radiation to limit their applied frequency. Optical coherence tomography (OCT) can harmlessly penetrate gums using low-coherence infrared rays, and thus, this work designs an OCT-based framework for dental reconstruction using optical rectification, fast Fourier transform, volumetric boundary detection, and Poisson surface reconstruction to overcome noisy imaging. Additionally, in order to operate in a patient’s mouth, the caliber of the injector is small along with its short penetration ...

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    13. Intravascular optical coherence tomography method for automated detection of macrophage infiltration within atherosclerotic coronary plaques

      Intravascular optical coherence tomography method for automated detection of macrophage infiltration within atherosclerotic coronary plaques

      Background and aims Significant macrophages infiltration in advanced atherosclerotic plaques promotes acute coronary events. Hence, the clinical imaging of macrophage content in coronary atherosclerotic plaques could potentially aid in identifying patients most at risk of future acute coronary events. The aim of this study was to introduce and validate a simple intravascular optical coherence tomography (IV-OCT) image processing method for automated, accurate and fast detection of macrophage infiltration within coronary atherosclerotic plaques. Methods This method calculates the ratio of the normalized-intensity standard deviation (NSD) values estimated over two axially-adjacent regions of interest in an IV-OCT cross-sectional image (B-scan). When applied ...

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      Mentions: Javier A. Jo
    14. Postdoctoral Research Associate - Biomedical Optics and Functional Imaging Laboratory at University of Illinois at Chicago

      Postdoctoral Research Associate - Biomedical Optics and Functional Imaging Laboratory at University of Illinois at Chicago

      A postdoctoral position is available in the Biomedical Optics and Functional Imaging group with Dr. Xincheng Yao ( yaolab.bioe.uic.edu ) within the Department of Bioengineering, University of Illinois at Chicago. Dr. Yao’s Biomedical Optics and Functional Imaging Laboratory is housed in the Lions of Illinois Eye Research Institute (LIERI), within the same building with UIC Retina Clinic. In collaboration with experienced ophthalmologists and vision scientists, our lab is focusing on new development of ophthalmic instrumentation and imaging technology to advance retinal study, disease diagnosis and treatment evaluation. Our current research includes ultra-wide field fundus photography, functional optical coherence ...

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      Mentions: Xincheng Yao
    15. VIS-OCT Opens Eyes to New Approaches

      VIS-OCT Opens Eyes to New Approaches

      First reported in 1991 by Huang and colleagues 1 , OCT has become an important imaging tool for ophthalmology following innovations over the past three decades. OCT noninvasively provides 3D in vivo optical biopsy with microscopic resolution in the eye at a depth range up to the choroid 2 . Besides 3D anatomical imaging, OCT can also provide functional information. The most notable functional extension is OCT angiography (OCTA), which can map the microvasculature in the eye without contrast agent and is being investigated in clinical ophthalmology.

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    16. OCT and Ophthalmology in the Age of Artificial Intelligence, Tuesday Oct 8, 2019 1:00P EDT

      OCT and Ophthalmology in the Age of Artificial Intelligence, Tuesday Oct 8, 2019 1:00P EDT

      This webinar will provide an executive overview for leaders in imaging and ophthalmology on how artificial intelligence (AI) is transforming the field of medical imaging. Presenter Nishant Mohan will provide a hands-on demonstration of how to develop a deep-learning AI system from scratch, giving attendees critical insight into how to use this powerful tool. Separating the hype from reality, Mohan will discuss essential concepts behind the revolutionizing power of AI. In addition, he will present critical factors in the ecosystem that is driving AI technology and major AI platforms. He will provide specific examples of the application of AI in ...

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    1-16 of 16
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