1. Featured Articles

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    1. Single input state polarization sensitive swept source optical coherence tomography based on an all single mode fiber interferometer

      Single input state polarization sensitive swept source optical coherence tomography based on an all single mode fiber interferometer

      We present a newly developed single mode fiber based swept source polarization sensitive optical coherence tomography system using a single input state at 1040 nm. Two non-polarizing fiber based beam splitters are combined to form a Mach-Zehnder interferometer, while two polarizing beam splitters are used to obtain a polarization sensitive detection. Both types of beam splitters solely feature conventional single mode fibers. Polarization control paddles are used to set and maintain the polarization states in the fibers of the interferometer and detection unit. By use of a special paddle alignment scheme we are able to eliminate any bulk optic wave ...

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    2. Intracoronary Optical Coherence Tomography: Insights from Clinical Research—What Do We Need to Learn?

      Intracoronary Optical Coherence Tomography: Insights from Clinical Research—What Do We Need to Learn?

      Optical coherence tomography (OCT) is a high-resolution technology for imaging of biological tissues that has shown tremendous potential for intracoronary use. Based on near-infrared light rather than ultrasound, catheter-based OCT provides cross-sectional images of the vessel wall and related devices in a histology-like manner. At present, OCT is primarily being used in research to better characterize and understand the pathophysiology of vulnerable plaques and to study the acute and long-term effects of coronary stent implantation. The present review provides the interventional cardiologist with a summary of the clinical research involving OCT, with an emphasis on specific challenges and how these ...

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      Mentions: Maria D. Radu
    3. Optical coherence tomography applied to tests of skin care products in humans – a case study

      Optical coherence tomography applied to tests of skin care products in humans – a case study

      Background/purpose When evaluating skin care products for human skin, quantitative test methods need to be simple, precise and reliable. Optical coherence tomography (OCT), provides high-resolution sectional images of translucent materials to a depth of a few millimeters, a technique usually applied to medical measurements in ophthalmology and dermatology. This study aimed to demonstrate the application of OCT as the main technique for monitoring changes in skin topography during tests of a wrinkle-reduction product in humans. Methods We used a commercial OCT apparatus to perform clinical examinations of skin roughness in treated and non-treated sites in the periorbital region of ...

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    4. ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance

      ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance

      Objectives The aim of this study was to compare the acute performance of the PLLA ABSORB bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) with second-generation metal drug-eluting stents (DES) in complex coronary artery lesions. Background Thick polymer-based BVS have different mechanical properties than thin second-generation DES. Data on the acute performance of BVS are limited to simple coronary lesions treated in trials with strict inclusion criteria. Methods Fifty complex coronary lesions (all type American College of Cardiology/American Heart Association B2-C) treated with a BVS undergoing a final optical coherence tomography (OCT) examination were compared with an equal ...

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    5. Postdoctoral Research Associate Opening at University of Liverpool

      Postdoctoral Research Associate Opening at University of Liverpool

      Postdoctoral Research Associate £31,644 - £36,661 pa Faculty of Science and Engineering, Institute of Electrical Engineering and Electronics, Department of Electrical Engineering and Electronics Location: University Campus Ref: R-585803/WWW Closing date for receipt of applications: Fri, 22 Aug 2014 17:00:00 BST To undertake a project “ I ntelligent Manufacturing of Pharmaceutical Film Coating Using Terahertz Pulsed Imaging, Optical Coherence Tomography and Numerical Modelling ” in collaboration with Cambridge University. You will primarily focus on the development and integration of an optical coherence tomography (OCT) sensor for online monitoring and quality control of pharmaceutical coating process. The duties include ...

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    6. Viewing Dentistry in a New Light

      Viewing Dentistry in a New Light

      Dental X-rays expose patients to radiation, require time to process, and can only “see” a limited amount inside the mouth. Now new optical techniques developed by UC San Francisco’s Daniel Fried , PhD, use light to take instantaneous digital images that can provide a better picture of our teeth and could one day zap cavities with pinpoint precision. Daniel Fried, PhD, speaks with Leon Chung, a dental research fellow in his lab. Photo by Susan Merrell Fried, a professor in the School of Dentistry’s Division of Biomaterials and Bioengineering in the Department of Preventive and Restorative Dental Sciences, is ...

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    7. Versatile Swept Source With Adjustable Coherence Length

      Versatile Swept Source With Adjustable Coherence Length

      An electronically controlled optical swept source at 1550 nm using mode locking in a dispersive ring cavity is described. Active mode-locking was achieved by directly modulating the current of a semiconductor optical amplifier (SOA) used as a gain medium. In the static regime, parameters such as linewidth, tuning bandwidth, and contrast were measured, whereas the axial range was determined dynamically. Two types of fiber, dispersion compensation and single mode, are employed in the laser ring cavity. It is demonstrated that the relative lengths of the two types of fiber have little effect on the linewidth, whereas more control on the ...

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    8. Real-time three-dimensional imaging of epidermal splitting and removal by high-definition optical coherence tomography

      Real-time three-dimensional imaging of epidermal splitting and removal by high-definition optical coherence tomography

      Background While real-time 3-D evaluation of human skin constructs is needed, only 2-D non-invasive imaging techniques are available. Objective Evaluation of the potential of High-Definition Optical Coherence Tomography (HD-OCT) for real-time 3-D assessment of the epidermal splitting and de-cellularisation. Methods Human skin samples were incubated with four different agents: Dispase II, NaCl 1M, Sodium Dodecyl Sulfate (SDS) and Triton X-100. Epidermal splitting, dermo-epidermal junction, acellularity and 3-D architecture of dermal matrices were evaluated by High-Definition Optical Coherence Tomography before and after incubation. Real-time 3-D HD-OCT assessment was compared with 2-D en face assessment by Reflectance Confocal Microscopy (RCM). (Immuno)histopathology ...

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    9. Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography

      Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography

      The presence of cholesterol crystals is a hallmark of atherosclerosis, but until recently, such crystals have been considered to be passive components of necrotic plaque cores. Recent studies have demonstrated that phagocytosis of cholesterol crystals by macrophages may actively precipitate plaque progression via an inflammatory pathway, emphasizing the need for methods to study the interaction between macrophages and crystalline cholesterol. In this study, we demonstrate the feasibility of detecting cholesterol in macrophages in situ using Micro-Optical Coherence Tomography (µOCT), an imaging modality we have recently developed with 1-µm resolution. Macrophages containing cholesterol crystals frequently demonstrated highly scattering constituents in ...

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    10. Micro-structural information of porous materials by optical coherence tomography

      Micro-structural information of porous materials by optical coherence tomography

      In this study we describe the use of Optical Coherence Tomography (OCT) to reveal microstructures and damages in porous media. An approach for establishing pore size and pore size distribution based upon OCT was developed. This approach was tested with oil source rock samples. Several sedimentary rock samples from Brazilian oil fields with porosity values ranging between 15% and 28% were evaluated, and the results agreed quite well with the traditional pycnometry method. In addition, pore size distribution for the samples in three dimensional planes were obtained. Finally, the experimental results proved that the OCT images with a suited digital ...

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    11. Generic pixel-wise speckle detection in Fourier-domain optical coherence tomography images

      Generic pixel-wise speckle detection in Fourier-domain optical coherence tomography images

      We present a generic phase-domain processing method for detecting speckles in Fourier-domain optical coherence tomography (OCT) images. The physics behind the interferometry is revisited and analytically along with simulation results it indicates that the speckle formation comes with phase distortion to the complex OCT signal. The first and the second derivatives of phase along the imaging depth are then calculated for speckle identification. The phase-domain processing method was applied to images acquired by both spectral-domain OCT and swept-source OCT systems, and the experimental results show that this method enables pixel-wise speckle identification.

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    12. Michelson Diagnostics to present at Fortbildungswoche, Munich

      Michelson Diagnostics to present at Fortbildungswoche, Munich

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces that leading experts in the use of optical technology in dermatology will be presenting the benefits of multi-beam OCT at the 24th Annual Education Week for Practical Dermatology and Venereology, known as Fortbildungswoche, in Munich, Germany, 19-25 July 2014. The conference session on ‘Evidence for OCT diagnostics’ will take place at 12:15-13:15, Forum 9, on Friday 25th July. The presentations include: Optical coherence tomography scientific fundamentals and applications, Dr. Martina Ulrich Optical coherence tomography for basal cell carcinoma, Prof. Dr ...

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    13. A Functional Anatomic Defect of the Cystic Fibrosis Airway

      A Functional Anatomic Defect of the Cystic Fibrosis Airway

      Rationale: The mechanisms underlying cystic fibrosis (CF) lung disease pathogenesis are unknown. Objective: To establish mechanisms linking anion transport with the functional microanatomy, we evaluated normal and CF piglet trachea, as well as adult swine trachea in the presence of selective anion inhibitors. Methods: We investigated airway functional microanatomy using micro-optical coherence tomography, a new imaging modality that concurrently quantifies multiple functional parameters of airway epithelium in a co-localized fashion. Main Results: Tracheal explants from wild type swine demonstrated a direct link between periciliary liquid (PCL) hydration and mucociliary transport (MCT) rates, a relationship frequently invoked but never experimentally confirmed ...

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    14. Invasive management without stents in selected acute coronary syndrome patients with a large thrombus burden: a prospective study of optical coherence tomography guided treatment decisions

      Invasive management without stents in selected acute coronary syndrome patients with a large thrombus burden: a prospective study of optical coherence tomography guided treatment decisions

      Aims: To assess whether a strategy of invasive management without stents in selected acute coronary syndrome (ACS) patients with a large thrombus burden (LTB) might be feasible and safe. Methods and results: We performed a prospective non-randomised observational cohort study of invasive treatment decisions guided by optical coherence tomography (OCT) in selected ACS patients with LTB. Among 852 ACS patients who had undergone invasive coronary angiography, 101 (11.8%) patients with large thrombus burden on initial angiography underwent thrombectomy to restore TIMI 3 flow without stenting. All of these patients then had repeat angiography with OCT (days 0-2 [Group 1 ...

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      Mentions: Francesco Prati
    15. Computer-Aided Image Analysis Algorithm to Enhance In Vivo Diagnosis of Plaque Erosion by Intravascular Optical Coherence Tomography

      Computer-Aided Image Analysis Algorithm to Enhance In Vivo Diagnosis of Plaque Erosion by Intravascular Optical Coherence Tomography

      Background —Recent reports show that plaque erosion can be diagnosed in vivo using optical coherence tomography (OCT) in patients with acute coronary syndromes (ACS). However, quantitative OCT image criteria for computer-aided diagnosis of plaque erosion have not been established. Methods and Results —A total of 42 patients with ACS caused by plaque erosion were included. Plaque erosion was identified according to the previously established OCT criteria. Both optical properties and morphological features of the focal eroded region as well as erosion-adjacent region were analyzed using a custom designed computer algorithm. Non-eroded fibrous plaques remote from the erosion site within the ...

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    16. Enhanced Vitreous Imaging in Healthy Eyes Using Swept Source Optical Coherence Tomography

      Enhanced Vitreous Imaging in Healthy Eyes Using Swept Source Optical Coherence Tomography

      Purpose To describe enhanced vitreous imaging for visualization of anatomic features and microstructures within the posterior vitreous and vitreoretinal interface in healthy eyes using swept-source optical coherence tomography (SS-OCT). The study hypothesis was that long-wavelength, high-speed, volumetric SS-OCT with software registration motion correction and vitreous window display or high-dynamic-range (HDR) display improves detection sensitivity of posterior vitreous and vitreoretinal features compared to standard OCT logarithmic scale display. Design Observational prospective cross-sectional study. Methods Multiple wide-field three-dimensional SS-OCT scans (500×500A-scans over 12×12 mm 2 ) were obtained using a prototype instrument in 22 eyes of 22 healthy volunteers. A registration ...

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    17. Dynamics of a short cavity swept source OCT laser

      Dynamics of a short cavity swept source OCT laser

      We investigate the behaviour of a short cavity swept source laser with an intra cavity swept filter both experimentally and theoretically. We characterise the behaviour of the device with real-time intensity measurements using a fast digital oscilloscope, showing several distinct regimes, most notably regions of mode-hopping, frequency sliding mode-locking and chaos. A delay differential equation model is proposed that shows close agreement with the experimental results. The model is also used to determine important quantities such as the minimum and maximum sweep speeds for the mode-locking regime. It is also shown that by varying the filter width the maximum sweep ...

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    18. Do you know where your fillers go? An ultrastructural investigation of the lips

      Do you know where your fillers go? An ultrastructural investigation of the lips

      Aim: To investigate the exact location and position of hyaluronic acid fillers in the perioral region by ultrasound and optical coherence tomography. Introduction: To date, there are few in vivo investigations in humans on the exact positioning of injectable hyaluronic acid fillers, and severe complications such as hematoma and thromboembolism are rarely addressed. Materials and methods: There were nine female patients investigated in this pilot study. All of them were periorally injected with hyaluronic acid. The exact product, amount, and locations, as well as the injection techniques, were recorded and compared. Before, immediately after, and 18 days after injection, photo ...

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    19. Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma

      Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma

      Purpose To compare optic disc perfusion between normal subjects and subjects with glaucoma using optical coherence tomography (OCT) angiography and to detect optic disc perfusion changes in glaucoma. Design Observational, cross-sectional study. Participants Twenty-four normal subjects and 11 patients with glaucoma were included. Methods One eye of each subject was scanned by a high-speed 1050-nm–wavelength swept-source OCT instrument. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to compute 3-dimensional optic disc angiography. A disc flow index was computed from 4 registered scans. Confocal scanning laser ophthalmoscopy (cSLO) was used to measure disc rim area, and stereo photography was used ...

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    20. Avinger Enrolls First PAD Patient in VISION Global Clinical Trial

      Avinger Enrolls First PAD Patient in VISION Global Clinical Trial

      Avinger Inc., pioneer of the lumivascular approach for treating vascular disease announced today that Dr. John Pigott of Jobst Vascular Institute, Toledo, OH, enrolled the first patient in VISION. VISION is a global IDE clinical trial, approved by the FDA to evaluate Avinger’s PantherisTM catheter for the treatment of Peripheral Artery Disease (PAD). It is estimated that PAD affects 12 million people in the US alone. The PantherisTM system combines directional atherectomy capabilities with real-time intravascular visualization to remove plaque from blocked arteries. The minimally invasive catheter is designed to remove plaque, while avoiding the disruption of normal arterial ...

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    21. Academic Post Doc Position in Biomedical Optics at the Medical University Vienna

      Academic Post Doc Position in Biomedical Optics at the Medical University Vienna

      An academic PostDoc position is available from September 1, 2014 in the Biomedical Optics Division, Center for Medical Physics and Biomedical Engineering . Depending on the candidates’ research record the position may be continued as tenure track after the first two to three years. We offer an academic position at an international highly recognized research institute in the field of biomedical imaging with strong interdisciplinary (door to door) collaboration with clinicians as well as biologists. Our research group is developing novel coherent biomedical imaging methods to overcome the conventional resolution limits and to pave the way from pure structural to functional ...

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    1-21 of 21
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