1. Featured Articles

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    1. Spectrally encoded coherence tomography and reflectometry: Simultaneous en face and cross‐sectional imaging at 2 gigapixels per second

      Spectrally encoded coherence tomography and reflectometry: Simultaneous en face and cross‐sectional imaging at 2 gigapixels per second

      Non‐invasive biological imaging is crucial for understanding in vivo structure and function. Optical coherence tomography (OCT) and reflectance confocal microscopy are two of the most widely used optical modalities for exogenous contrast‐free, high‐resolution, three‐dimensional imaging in non‐fluorescent scattering tissues. However, sample motion remains a critical barrier to raster‐scanned acquisition and reconstruction of wide‐field anatomically accurate volumetric datasets. We introduce spectrally encoded coherence tomography and reflectometry (SECTR), a high‐speed, multimodality system for simultaneous OCT and spectrally encoded reflectance (SER) imaging. SECTR utilizes a robust system design consisting of shared optical relays, scanning mirrors ...

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    2. Vying for Dominance: Swept-Source vs. Spectral-Domain OCT

      Vying for Dominance: Swept-Source vs. Spectral-Domain OCT

      Optical coherence tomography (OCT) is among the most widely used in vivo optical diagnostic techniques. This high-resolution 3D imaging modality, with market size approaching $1 billion, has established itself as an indispensable tool for ophthalmology and is seeing growing acceptance in interventional cardiology, dermatology and nondestructive testing. OCT combines micron-level resolution with high speed and penetration up to 2 to 3 mm in the scattering tissue. In addition, instrumentation is relatively inexpensive and portable when compared to other 3D medical imaging modalities, such as MRI and CT. Figure 1. An example of using SS-OCT for studying therapeutic potential of allogeneic ...

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    3. Multiple Research Scientist and Postdoctoral Positions in Endoscopic Instrumentation Department of Biomedical Engineering, Texas A&M University, College Station-Texas

      Multiple Research Scientist and Postdoctoral Positions in Endoscopic Instrumentation Department of Biomedical Engineering, Texas A&M University, College Station-Texas

      The Laboratory for Optical Diagnosis and Imaging ( http://biomed.tamu.edu/LODI ) in the Department of Biomedical Engineering at Texas A&M University invites applications for multiple research scientist and postdoctoral positions in the area of endoscopic instrumentation development. Ideal candidates should have expertise in optical design, data acquisition instrumentation and software development, and substantial demonstrated experience in optical imaging and/or spectroscopic instrumentation design and implementation. Experience in fluorescence lifetime imaging microscopy (FLIM) and/or optical coherence tomography (OCT) is highly desirable. Successful applicants will join a dynamic, multidisciplinary and international team focused on developing and clinically validating optical ...

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    4. Announcing the 6th Meeting on OCT Angiography, “en face OCT”, and structural OCT, December 14 2018, Rome

      Announcing the 6th Meeting on OCT Angiography, “en face OCT”, and structural OCT, December 14 2018, Rome

      The 6th international Congreass on OCT Angiography and Advances in OCT will be held in Rome Congress on December 2018 and will be the world largest event in this field. We expect 1500 ophthalmologists, 250 talks, speakers from over 45 countries. The congress will cover the technologic, scientific and clinical sides of OCT Angiography and OCT, our 6 th Meeting will present the latest innovations and controversies in this area. S peakers are leading researchers and prominent experts. 50 scientific, technological and clinical sessions will cover all aspects of OCT and OCTA from basic science to practical applications. Participate at ...

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      Mentions: Bruno Lumbroso
    5. Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye

      Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye

      Imaging of the human retina with high resolution is an essential step towards improved diagnosis and treatment control. In this paper, we introduce a compact, clinically user-friendly instrument based on swept source optical coherence tomography (SS-OCT). A key feature of the system is the realization of two different operation modes. The first operation mode is similar to conventional OCT imaging and provides large field of view (FoV) images (up to 45° × 30°) of the human retina and choroid with standard resolution. The second operation mode enables it to optically zoom into regions of interest with high transverse resolution using adaptive ...

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    6. Magnetomotive Displacement of the Tympanic Membrane using Magnetic Nanoparticles: Toward Enhancement of Sound Perception

      Magnetomotive Displacement of the Tympanic Membrane using Magnetic Nanoparticles: Toward Enhancement of Sound Perception

      Objective: A novel hearing-aid scheme using magnetomotive nanoparticles (MNPs) as transducers in the tympanic membrane (TM) is proposed, aiming to noninvasively and directly induce a modulated vibration on the TM. Methods: In this feasibility study, iron-oxide (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles were applied on ex vivo rat TM tissues and allowed to diffuse over ~2 hr. Subsequently, magnetic force was exerted on the MNP-laden TM via a programmable electromagnetic solenoid to induce the magnetomotion. Optical coherence tomography (OCT), along with its phase-sensitive measurement capabilities, was utilized to visualize and quantify the nanometer-scale vibrations generated on the ...

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    7. Circumferential-scanning endoscopic optical coherence tomography probe based on a circular array of six 2-axis MEMS mirrors

      Circumferential-scanning endoscopic optical coherence tomography probe based on a circular array of six 2-axis MEMS mirrors

      We present a novel circumferential-scan endoscopic optical coherence tomography (OCT) probe by using a circular array of six electrothermal microelectromechanical (MEMS) mirrors and six C-lenses. The MEMS mirrors have a 0.5 mm × 0.5 mm mirror plate and a chip size of 1.5 mm × 1.3 mm. Each MEMS mirror can scan up to 45° at a voltage of less than 12 V. Six of those mirrors have been successfully packaged to a probe head; full circumferential scans have been demonstrated. Furthermore, each scan unit is composed of a MEMS mirror and a C-lens and the six scan ...

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      Mentions: Huikai K. Xie
    8. Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models

      Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models

      Lung cancer survival is poor, and radiation therapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to acute radiation-induced esophageal damage (ARIED). We investigated the feasibility of optical coherence tomography (OCT) for minimally invasive imaging of the esophagus with high resolution (10  μm) to detect ARIED in mice. Thirty mice underwent cone-beam computed tomography imaging for initial setup assessment and dose planning followed by a single-dose delivery of 4.0, 10.0, 16.0, and 20.0 Gy on 5.0-mm spots, spaced 10.0 mm apart in the esophagus. They were repeatedly imaged using ...

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    9. Teledyne SP Devices Announces Peer-to-Peer Streaming Support

      Teledyne SP Devices Announces Peer-to-Peer Streaming Support

      Teledyne SP Devices today announced the release of peer-to-peer data transfer firmware and software. With this solution data can be transferred from a digitizer to a peripheral device at astonishing peak rates of up to 6.8 GBytes/s. Many modern data acquisition systems produce vast amounts of data which needs to be processed. The data rates are often extremely high and therefore application-specific processing requires high-performance processing units such as field-programmable gate arrays (FPGAs) or graphics processing units (GPUs). Both methods have advantages but the latter offers cost-efficient processing capabilities and is programmed in CUDA™ or OpenCL™ supporting parallel ...

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    10. Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

      Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

      The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging + sensing imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass to enable temperature measurements. The high refractive index of the tellurite glass enables a common-path interferometer configuration for OCT, allowing easy exchange of probes for biomedical applications. The simultaneous imaging ...

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    11. PhD Scholarship: Multimodal optical coherence tomography / multi-spectral photo-acoustic imaging at University of Kent

      PhD Scholarship: Multimodal optical coherence tomography / multi-spectral photo-acoustic imaging at University of Kent

      Supervisor: Adrian Bradu A funded PhD position is available in the field of Biomedical Imaging. Optical coherence tomography (OCT) and photo-acoustic (PA) imaging are hot topics in the biomedical imaging field. They can offer structural and functional information of biological tissues with excellent resolution and high contrast. Both techniques have the potential to be applied to the early detection of cancer or examining vascular and skin diseases. By measuring back-scattered photons and a loading mechanism, the tissue mechanical properties can be reconstructed using OCT. At the same time, using PA measurements, it is also possible to reconstruct the mechanical properties ...

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    12. Abbott Initiates Groundbreaking Study to Assess Superiority of High-Resolution Imaging Versus Standard-of-Care Angiography in Treating Coronary Artery Disease

      Abbott Initiates Groundbreaking Study to Assess Superiority of High-Resolution Imaging Versus Standard-of-Care Angiography in Treating Coronary Artery Disease

      Abbott (NYSE: ABT) today announced the initiation of a clinical trial evaluating long-term outcomes of patients who undergo stent implantation guided by high-resolution light-based imaging technology—called optical coherence tomography (OCT)—compared to a common X-ray-guided technique called angiography. The trial (ILUMIEN IV) is the first large-scale randomized global study using Abbott's OCT imaging in patients with high-risk, complex coronary artery disease. Patients in the study will be randomized to either OCT-guided or traditional angiography to guide placement of one or more XIENCE everolimus-eluting coronary stents. The first patient was enrolled by Franco Fabbiocchi, M.D., director of Invasive ...

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      Mentions: FDA
    13. Pixel-Reassigned Spectral-Domain Optical Coherence Tomography

      Pixel-Reassigned Spectral-Domain Optical Coherence Tomography

      A novel method of pixel reassignment (PRA) is proposed to achieve transverse superresolution in the confocal microscopy. Inspired by it, for the first time, we report a pixel-reassigned spectral-domain optical coherence tomography (OCT) with ∼ 1.5 times transverse resolution improvement both in numerical simulations and imaging experiments. PRA is implemented by transversely shifting the detection fiber from the on-axis position to five off-axis positions, capturing cross-sectional images at each shifting step of the detection fiber and digitally reassigning them together to give a sharper image with moderately extended depth of focus and enhanced intensity. So, we believe that the PRA ...

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    14. Applications Engineer Opening at Michelson Diagnostics

      Applications Engineer Opening at Michelson Diagnostics

      Job Opportunity Applications Engineer Michelson Diagnostics Ltd (MDL), the leading Optical Coherence Tomography (OCT) company specialising in dermatology imaging, requires an Applications Engineer, to work with its customers and research partners in developing applications for its range of innovative multi-beam OCT products. The Applications Engineer will be based at MDL’s Maidstone office, but will be expected to travel as well. Key tasks for the Applications Engineer will include: Liaison with customers to find out, understand and interpret their needs in terms of OCT imaging; Assisting customers with interpretation and analysis of OCT images; Identifying, developing, validating and supporting new ...

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    15. Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy

      Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy

      One major hallmark of Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA) is the deposition of extracellular senile plaques and vessel wall deposits composed of amyloid-beta (A β ). In AD, degeneration of neurons is preceded by the formation of A β plaques, which show different morphological forms. Most of them are birefringent owing to the parallel arrangement of amyloid fibrils. Here, we present polarization sensitive optical coherence microscopy (PS-OCM) for imaging mature neuritic A β plaques based on their birefringent properties. Formalin-fixed, post-mortem brain samples of advanced stage AD patients were investigated. In several cortical brain regions, neuritic A β plaques were successfully ...

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    16. Ocular fundus pulsations within the posterior rat eye: Chorioscleral motion and response to elevated intraocular pressure

      Ocular fundus pulsations within the posterior rat eye: Chorioscleral motion and response to elevated intraocular pressure

      A multi-functional optical coherence tomography (OCT) approach is presented to determine ocular fundus pulsations as an axial displacement between the retina and the chorioscleral complex in the albino rat eye. By combining optical coherence elastography and OCT angiography (OCTA), we measure subtle deformations in the nanometer range within the eye and simultaneously map retinal and choroidal perfusion. The conventional OCT reflectivity contrast serves as a backbone to segment the retina and to define several slabs which are subsequently used for quantitative ocular pulsation measurements as well as for a qualitative exploration of the multi-functional OCT image data. The proposed concept ...

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    17. In vivo high-resolution cortical imaging with extended-focus optical coherence microscopy in the visible-NIR wavelength range

      In vivo high-resolution cortical imaging with extended-focus optical coherence microscopy in the visible-NIR wavelength range

      Visible light optical coherence tomography has shown great interest in recent years for spectroscopic and high-resolution retinal and cerebral imaging. Here, we present an extended-focus optical coherence microscopy system operating from the visible to the near-infrared wavelength range for high axial and lateral resolution imaging of cortical structures in vivo . The system exploits an ultrabroad illumination spectrum centered in the visible wavelength range (λ c   =  650  nm, Δλ  ∼  250  nm) offering a submicron axial resolution (∼0.85  μm in water) and an extended-focus configuration providing a high lateral resolution of ∼1.4  μm maintained over ∼150  μm in depth in water. The ...

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    18. Ugly ducklings—the dark side of plastic materials in contact with potable water

      Ugly ducklings—the dark side of plastic materials in contact with potable water

      Bath toys pose an interesting link between flexible plastic materials, potable water, external microbial and nutrient contamination, and potentially vulnerable end-users. Here, we characterized biofilm communities inside 19 bath toys used under real conditions. In addition, some determinants for biofilm formation were assessed, using six identical bath toys under controlled conditions with either clean water prior to bathing or dirty water after bathing. All examined bath toys revealed notable biofilms on their inner surface, with average total bacterial numbers of 5.5 × 10 6  cells/cm 2 (clean water controls), 9.5 × 10 6  cells/cm 2 (real bath toys ...

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    19. New software allows DMA of data from AlazarTech waveform digitizers to GPU at up to 6.9 GB/s with very low latency

      New software allows DMA of data from AlazarTech waveform digitizers to GPU at up to 6.9 GB/s with very low latency

      AlazarTech, a manufacturer of high-performance, low-cost PC-Based Instruments, today announced the release of ATS-GMA™, a software library that allows users to DMA data from its PCI Express waveform digitizers to AMD Radeon™ Pro Graphical Processing Units (GPUs) at rates up to 6.9 GB/s with latency as low as 100 μs. Though the powerful processing capabilities and high-speed graphical memory bus make GPUs perfectly suited for signal processing applications, direct DMA from hardware devices to the GPU’s on-board memory can be problematic. In the case of a waveform digitizer, users must manually copy data returned from the waveform ...

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    20. Wide-field quantitative micro-elastography of human breast tissue

      Wide-field quantitative micro-elastography of human breast tissue

      Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 × 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing a mastectomy. We present wide-field optical coherence tomography (OCT) images, qualitative (strain) micro-elastograms and quantitative (elasticity) micro-elastograms, acquired in 10 minutes. We demonstrate that wide-field quantitative micro-elastography can extend the range of tumors visible using OCT-based ...

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    21. Incremental yield of dysplasia detection in Barrett’s esophagus using volumetric laser endomicroscopy with and without laser marking compared with a standardized random biopsy protocol

      Incremental yield of dysplasia detection in Barrett’s esophagus using volumetric laser endomicroscopy with and without laser marking compared with a standardized random biopsy protocol

      Background and Aims Volumetric laser endomicroscopy (VLE) is a new wide-field advanced imaging technology for Barrett’s esophagus (BE). No data exist on incremental yield of dysplasia detection. Our aim is to report the incremental yield of dysplasia detection in BE using VLE. Methods This is a retrospective study from a prospectively maintained database from 2011 to 2017 comparing the dysplasia yield of 4 different surveillance strategies in an academic BE tertiary care referral center. The groups were (1) random biopsies (RB), (2) Seattle protocol random biopsies (SP), (3) VLE without laser marking (VLE), and (4) VLE with laser marking ...

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    22. Research Associate / Postdoctoral Fellow in High Resolution Optical Imaging of the Anterior Segment at Indian University

      Research Associate / Postdoctoral Fellow in High Resolution Optical Imaging of the Anterior Segment at Indian University

      The Corneal Imaging Laboratory at Indiana University School of Optometry is looking to fill a postdoctoral fellow or research associate position in the field of optical coherence tomography, interferometry and fluorescence microscopy. The successful candidate will join a vibrant team of scientists and engineers, developing cutting-edge optical systems and specifically high resolution optical coherence tomography (OCT) for corneal imaging in healthy and disease conditions. Qualifications for the position include a PhD and strong experimental background in OCT, optical instrumentation, or a related area. Experience with optical system design and construction, digital image acquisition and processing (e.g., in Matlab, Labview ...

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    23. Optical Design Engineering Opening at Volk Optical

      Optical Design Engineering Opening at Volk Optical

      About us: Volk Optical, Inc. (Mentor, OH) is the leading design, development and manufacturing company for ophthalmic lenses and portable imaging devices. The company’s products include portable diagnostic ophthalmic imaging systems (Volk iNview and Pictor Plus), as well as a full line of reusable and single-use diagnostic, laser and surgical lenses. The Product Development team at Volk is a group of motivated and dynamic team-players who embrace a culture of openness, free exchange of ideas, fast-paced development, entrepreneurial mindset and can-do attitude. We are passionate about developing new ideas, products and solutions to fulfill Volk’s purpose of eradicating ...

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      Mentions: Utkarsh Sharma
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