1. Featured Articles

    1-22 of 22
    1. PhD Position Available in Lübeck: Development of an Ultra-Wideband FDML-Laser

      PhD Position Available in Lübeck: Development of an Ultra-Wideband FDML-Laser

      We offer a three year PhD student position for an Early Stage Researcher (ESR) on laser development in biomedical optics. The position is part of a Marie Skłodowska-Curie Innovative Training Network (ITN) within the EU Horizon 2020 Framework Programme. It will be within the project NETLAS (https://cordis.europa.eu/project/id/860807), which focuses on innovative solutions for fast, narrow linewidth, phase stable and wide tuning bandwidth swept sources as well as on their application in biomedical optics - especially for optical coherence tomography (OCT). 

      The position is in the group of Robert Huber at the University of Lübeck ...

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    2. Postdoctoral positions in Biophotonics and Biomedical Informatics and Data Science at University of Houston

      Postdoctoral positions in Biophotonics and Biomedical Informatics and Data Science at University of Houston

      Applications are invited for a postdoctoral research associate position in the Biomedical Optics Laboratory ( http://bol.egr.uh.edu ) at the University of Houston, TX. The position is supported by National Library of Medicine (NLM) Training Program in Biomedical Informatics and Data Science fellowships. The NLM Training Program in Biomedical Informatics and Data Science is an innovative, inter-disciplinary, and multi-institutional training program that trains at the interface between the computational /mathematical sciences and biological sciences/biomedicine to face the biggest challenges in biomedical informatics and data science today. Our accomplished training faculty, history of collaboration, and the combined resources of ...

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    3. Quantification of plant morphology and leaf thickness with optical coherence tomography

      Quantification of plant morphology and leaf thickness with optical coherence tomography

      Optical coherence tomography (OCT) can be a valuable imaging tool for in vivo and label-free digital plant phenotyping. However, for imaging leaves, air-filled cavities limit the penetration depth and reduce the image quality. Moreover, up to now quantification of leaf morphology with OCT has been done in one-dimensional or two-dimensional images only, and has often been limited to relative measurements. In this paper, we demonstrate a significant increase in OCT imaging depth and image quality by infiltrating the leaf air spaces with water. In the obtained high-quality OCT images the top and bottom surface of the leaf are digitally segmented ...

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    4. Multimodal Imaging Crucial in Finding the Cause of Heart Attack in Women with Non-Obstructive Coronary Artery Disease - Nyu Langone Health

      Multimodal Imaging Crucial in Finding the Cause of Heart Attack in Women with Non-Obstructive Coronary Artery Disease - Nyu Langone Health

      N ew research presented today at the American Heart Association’s Scientific Sessions 2020 found that additional imaging tests can determine the underlying reason for heart attacks in most women without coronary artery narrowing . A correct diagnosis can guide appropriate medical treatment. Led by researchers and clinicians at NYU Grossman School of Medicine, the study examined women with MINOCA, or myocardial infarction with non-obstructive coronary arteries, a condition that accounts for 6 to 15 percent of heart attacks and is 3 times more common among women than men with heart attack. It determined that coronary optical coherence tomography (OCT) and ...

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    5. Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging

      Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging

      In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We demonstrate a detailed technical layout of the strategies necessary to achieve efficient coherent averaging. Since there are many new challenges specific to coherent averaging in swept source MHz-OCT, we analyze ...

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    6. Cylites HP-OCT™ takes out Engineering Australia’s highest honour – The Sir William Hudson Award

      Cylites HP-OCT™ takes out Engineering Australia’s highest honour – The Sir William Hudson Award

      Cylite Pty Ltd, a developer and manufacturer of 4 th Generation OCT systems for Ophthalmology and Optometry, is honoured to be awarded the Sir William Hudson Award. Australia's highest accolade for an engineering project. The judges citation read “this is a remarkable piece of equipment and demonstrates the profound impact biomedical engineering can have on society. By using 1000’s of light waves to create an accurate and almost instantaneous 3D image of the eye, the equipment streamlines the screening process that currently requires several individual diagnostic devices to build a clinical picture of the patient. This enables more ...

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      Mentions: Cylite
    7. Optical coherence tomography in the 2020s—outside the eye clinic

      Optical coherence tomography in the 2020s—outside the eye clinic

      Optical coherence tomography (OCT) is a paragon of success in the translation of biophotonics science to clinical practice. OCT systems have become ubiquitous in eye clinics but access beyond this is limited by their cost, size and the skill required to operate the devices. Remarkable progress has been made in the development of OCT technology to improve the speed of acquisition, the quality of images and into functional extensions of OCT such as OCT angiography. However, more needs to be done to radically improve the access to OCT by addressing its limitations and enable penetration outside of typical clinical settings ...

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    8. 8th OCT Angiography and advances in OCT Rome Congress December 18 &19. Virtual Congress “ICOOR 2020”

      8th OCT Angiography and advances in OCT Rome Congress December 18 &19. Virtual Congress “ICOOR 2020”

      More than 50 leading scholars will share their enthusiasm for OCT Angiography and OCT . Highlights of the Congress: scientific and technology session organized by James Fujimoto, Lumbroso Lecture by Larry Yannuzzi, five clinical sessions planned by David Sarraf. Look up the complete program at http://www.apmeetings.com/singolo_evento_sem.php?id=3&lang=en

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    9. Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT

      Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT

      Automatic quantification and visualization of 3-D collagen fiber architecture using Optical Coherence Tomography (OCT) has previously relied on polarization information and/or prior knowledge of tissue-specific fiber architecture. This study explores image processing, enhancement, segmentation, and detection algorithms to map 3-D collagen fiber architecture from OCT images alone. 3-D fiber mapping, histogram analysis, and 3-D tractography revealed fiber groupings and macro-organization previously unseen in uterine tissue samples. We applied our method on centimeter-scale mosaic OCT volumes of uterine tissue blocks from pregnant and non-pregnant specimens revealing a complex, patient-specific network of fibrous collagen and myocyte bundles.

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    10. Open Source Optical Coherence Tomography Software

      Open Source Optical Coherence Tomography Software

      Optical coherence tomography (OCT) is a non-invasive imaging technique that is often described as the optical equivalent to ultrasound imaging. The basic building block of OCT acquisitions is an optical interference pattern that can be processed into a depth profile, which is also called A-scan. Several adjacent A-scans can be merged into a cross-sectional image. Most research that incorporates OCT requires a software solution for processing of the acquired raw data. Here we present an open source software package for OCT processing with an easy to use graphical user interface. The implemented OCT processing pipeline enables A-scan processing rates in ...

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    11. Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway imaging

      Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway imaging

      Introduction: Bronchial thermoplasty (BT) is an endoscopic treatment for severe asthma that reduces airway smooth muscle (ASM) by radiofrequent energy. No diagnostic method is currently available to assess ASM, other than invasive, focal airway biopsies. Bronchoscopic standard optical coherence tomography (OCT) generates high resolution images of the airways. Polarization sensitive OCT (PS-OCT) provides tissue-specific contrast that might enable ASM detection and quantification. Aim: Use novel PS-OCT to detect ASM and determine changes in ASM before and after BT in severe asthma. Methods: Bronchoscopic PS-OCT was performed from distal to proximal airways in a severe asthma patient before and after BT ...

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    12. Thorlabs Adds 1060 nm Option to Swept Source OCT Portfolio

      Thorlabs Adds 1060 nm Option to Swept Source OCT Portfolio

      Thorlabs announced today that it has expanded its Swept Source OCT (SS-OCT) offering with the release of Atria™ systems centered at 1060 nm. These new systems, which integrate Thorlabs’ patented MEMS-VCSEL swept-wavelength technology, are available in 60 kHz (ATR206C1) and 200 kHz (ATR220C1) variants, including a version with an ultra-long imaging depth of 20 mm. The 1060 nm options offer the same low roll-off and high sensitivity performance found in the already well-established VEGA™ swept source OCT series. Also like the Vega series, the Atria’s MEMS-VCSEL swept source and imaging module are packaged into a single housing, with the ...

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      Mentions: Thorlabs
    13. In Vivo Cochlear imaging provides a tool to study endolymphatic hydrops

      In Vivo Cochlear imaging provides a tool to study endolymphatic hydrops

      Exposure to noise trauma, such as that from improvised explosive devices, can lead to sensorineural hearing loss and a reduced quality of life. In order to elucidate the mechanisms underlying noise-induced hearing loss, we have adapted optical coherence tomography (OCT) for real-time cochlear visua lization in live mice after blast exposure. We demonstrated that endolymphatic hydrops develops following blast injury, and that this phenomenon may be associated with glutamate excitotoxicity and cochlear synaptopathy. Additionally, osmotic stabilization of endolymphatic hydrops partially rescues cochlear synapses after blast trauma. OCT is thus a valuable research tool for investigating the mechanisms underlying acoustic trauma ...

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    14. Visible light OCT improves imaging through a highly scattering retinal pigment epithelial wall

      Visible light OCT improves imaging through a highly scattering retinal pigment epithelial wall

      Here we provide a counter-example to the conventional wisdom in biomedical optics that longer wavelengths aid deeper imaging in tissue. Specifically, we investigate visible light optical coherence tomography of Bruch’s membrane (BM) in the non-pathologic eyes of humans and two mouse strains. Surprisingly, we find that shorter visible wavelengths improve the visualization of BM in pigmented eyes, where it is located behind a highly scattering layer of melanosomes in the retinal pigment epithelium (RPE). Monte Carlo simulations of radiative transport suggest that, while absorption and scattering are higher at shorter wavelengths, detected multiply scattered light from the RPE is ...

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    15. Vision-Inspection-Synchronized Dual Optical Coherence Tomography for High-Resolution Real-Time Multidimensional Defect Tracking in Optical Thin Film Industry

      Vision-Inspection-Synchronized Dual Optical Coherence Tomography for High-Resolution Real-Time Multidimensional Defect Tracking in Optical Thin Film Industry

      Large-scale product inspection is an important aspect in thin film industry to identify defects with a high precision. Although vision line scan camera (VLSC)-based inspection has been frequently implemented, it is limited to surface inspections. Therefore, to overcome the conventional drawbacks, there is a need to extend inspection capabilities to internal structures. Considering that VLSC systems have access to rich information, such as color and texture, high-resolution real-time multimodal optical synchronization between VLSC and dual spectral domain optical coherence tomography (SD-OCT) systems was developed with a laboratory customized in-built automated defect-tracking algorithm for optical thin films (OTFs). Distinguishable differences ...

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    16. Spaceflight Associated Neuro-Ocular Syndrome (SANS): A Systematic Review and Future Directions

      Spaceflight Associated Neuro-Ocular Syndrome (SANS): A Systematic Review and Future Directions

      Purpose: To present a systematic review of the current body of literature surrounding spaceflight associated neuro-ocular syndrome (SANS) and highlight priorities for future research. Methods: Three major biomedical databases were searched with the following terms: ((neuro ocular) OR ((brain) AND (eye))) AND ((spaceflight) OR (astronaut) OR (microgravity)) AND (ENGLISH[Language]). Once duplicates were removed, 283 papers were left. Articles were excluded if they were not written in English or conference abstracts only. We avoided including review papers which did not provide any new information; however, two reviews on the pathophysiology of SANS were included for completeness. No limitations on date ...

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    17. Multi-directional Morphological Assessment of Single Bacterial Colonies Through Non-invasive Optical Imaging

      Multi-directional Morphological Assessment of Single Bacterial Colonies Through Non-invasive Optical Imaging

      A bacterium in bacterial colony is a basal component of bacterial studies and is therefore of considerable importance. The morphological characteristics of a single colony have been widely used as the standard to identify diverse bacterial species. However, the conventional methods for obtaining morphological information, such as microscopic techniques, cannot provide tomographic views. This study utilizes spectral-domain optical coherence tomography (SD-OCT) to observe both external and internal structures for single colonies. OCT imaging provided a clear top (projection) and lateral (cross-sectional) images, which can identify distinct features in the fifteen different bacterial species examined. Through the acquired OCT images, the ...

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    18. Research Center Pharmaceutical Engineering Awarded Two FDA Contracts for Next-Generation Pharma Technology

      Research Center Pharmaceutical Engineering Awarded Two FDA Contracts for Next-Generation Pharma Technology

      The Research Center Pharmaceutical Engineering GmbH (RCPE), a global leader in pharmaceutical engineering sciences, has been awarded FDA funding for two projects commencing in the 4th quarter of 2020. The projects will focus on utilising advanced technologies to improve production processes within Pharma. With an average of only 5 – 10 projects awarded to EU companies by the FDA each year, this development represents a landmark achievement for RCPE and reflects the potential impact of these projects within the global pharma industry. In partnership with major global pharma companies, including MSD and Pfizer, RCPE will use the FDA funding to investigate ...

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    19. Early vascular modifications after endoscopic endonasal pituitary surgery: The role of OCT-angiography

      Early vascular modifications after endoscopic endonasal pituitary surgery: The role of OCT-angiography

      Purpose The aim of the present study is to analyze the changes in retinal vessel density (VD), using Optical Coherence Tomography Angiography (OCT-A), in patients that received endoscopic endonasal approach for the removal of an intra-suprasellar pituitary adenoma compressing optic chiasm. Methods We evaluated the VD in Superficial Capillary Plexus (SCP), Deep Capillary Plexus (DCP), Radial Peripapillary Capillary (RPC) and the Foveal Avascular Zone (FAZ) area in a series of fourteen patients (7 males, 7 females, mean age 56 ± 13 years), as compared to healthy controls. We also detected the structural Spectral Domain (SD)-OCT parameters: Ganglion Cell Complex (GCC ...

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    20. Diagnosis of Occlusal Tooth Wear Using 3D Imaging of Optical Coherence Tomography Ex Vivo

      Diagnosis of Occlusal Tooth Wear Using 3D Imaging of Optical Coherence Tomography Ex Vivo

      The aim of this study was to assess the utility of 3D imaging of optical coherence tomography (OCT) for the diagnosis of occlusal tooth wear ex vivo. Sixty-three extracted human molars with or without visible tooth wear were collected to take digital intraoral radiography and 3D OCT images. The degree of tooth wear was evaluated by 12 examiners and scored using 4-rank scale: 1—slight enamel wear; 2—distinct enamel wear; 3—tooth wear with slight dentin exposure; 4—tooth wear with distinct involvement of dentin. The degree of tooth wear was validated by the histological view of confocal laser ...

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    21. Visualization of Bacterial Colonization and Cellular Layers in a Gut-on-a-Chip System Using Optical Coherence Tomography

      Visualization of Bacterial Colonization and Cellular Layers in a Gut-on-a-Chip System Using Optical Coherence Tomography

      Imaging of cellular layers in a gut-on-a-chip system has been confined to two-dimensional (2D)-imaging through conventional light microscopy and confocal laser scanning microscopy (CLSM) yielding three-dimensional- and 2D-cross-sectional reconstructions. However, CLSM requires staining and is unsuitable for longitudinal visualization. Here, we compare merits of optical coherence tomography (OCT) with those of CLSM and light microscopy for visualization of intestinal epithelial layers during protection by a probiotic Bifidobacterium breve strain and a simultaneous pathogen challenge by an Escherichia coli strain. OCT cross-sectional images yielded film thicknesses that coincided with end-point thicknesses derived from cross-sectional CLSM images. Light microscopy on histological ...

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    22. NinePoint Medical, Inc. filed a voluntary petition for relief under Chapter 11 of the United States Bankruptcy Code

      NinePoint Medical, Inc. filed a voluntary petition for relief under Chapter 11 of the United States Bankruptcy Code

      On October 16, 2020 (the "Petition Date"), NinePoint Medical, Inc. (the "Debtor") filed a voluntary petition for relief under Chapter 11 of the United States Bankruptcy Code. The Debtor’s bankruptcy case is pending under case no. 20-12618 in the U.S. Bankruptcy Court for the District of Delaware (the "Bankruptcy Court"). Additional information about the bankruptcy case may be obtained by visiting https://cases.stretto.com/ninepointmedical or calling 855.432.5929 (toll-free)

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    1-22 of 22
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