1. Featured Articles

    1-24 of 29 1 2 »
    1. Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Studies have proven the relationship between cutaneous vasculature abnormalities and dermatological disorders, but to image vasculature noninvasively in vivo , advanced optical imaging techniques are required. In this study, we imaged a palm of a healthy volunteer and three subjects with cutaneous abnormalities with photoacoustic tomography (PAT) and optical coherence tomography with angiography extension (OCTA). Capillaries in the papillary dermis that are too small to be discerned with PAT are visualized with OCTA. From our results, we speculate that the PA signal from the palm is mostly from hemoglobin in capillaries rather than melanin, knowing that melanin concentration in volar skin ...

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    2. Postdoctoral Associate: Biophotonics and Computer Vision Stanford University, Stanford, CA

      Postdoctoral Associate: Biophotonics and Computer Vision Stanford University, Stanford, CA

      The Stanford Biomedical Optics Group (http://sbo.stanford.edu), in close collaboration with clinical researchers in the School of Medicine (urology), seeks highly motivated postdoctoral candidates with excellent computer programming and image processing skills along with a good background in optics, microscopy or medical imaging and interest or experience in computer vision. Stanford University provides an outstanding environment for solid technical research with clinical impact. Applicants will work closely with clinical collaborators and will spend a significant amount of time observing and guiding clinical research activities while working on a heavily computer vision programming-oriented research project. Time permitting, candidate may ...

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    3. Identification of Volumetric Laser Endomicroscopy features predictive for early neoplasia in Barrett’s esophagus using high-quality histological correlation

      Identification of Volumetric Laser Endomicroscopy features predictive for early neoplasia in Barrett’s esophagus using high-quality histological correlation

      Background and aims volumetric laser endomicroscopy (VLE) provides a circumferential scan that enables the visualization of subsurface layers of the esophageal wall at 7 μm resolution. The aims of this study were to identify VLE features ofBarrett’s esophagus (BE) neoplasia and to develop a VLE prediction score. Methods A database of VLE images from endoscopic resection specimens, precisely correlated with histology, from BE patients +/- neoplasia was used. Features potentially predictive for early BE neoplasia were identified by unblinded evaluation of 25 VLE-histology images. In a learning phase, 20 VLE images with or without BE neoplasia were scored by 2 ...

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    4. Micro-optical coherence tomography of the mammalian cochlea

      Micro-optical coherence tomography of the mammalian cochlea

      The mammalian cochlea has historically resisted attempts at high-resolution, non-invasive imaging due to its small size, complex three-dimensional structure, and embedded location within the temporal bone. As a result, little is known about the relationship between an individual’s cochlear pathology and hearing function, and otologists must rely on physiological testing and imaging methods that offer limited resolution to obtain information about the inner ear prior to performing surgery. Micro-optical coherence tomography (μOCT) is a non-invasive, low-coherence interferometric imaging technique capable of resolving cellular-level anatomic structures. To determine whether μOCT is capable of resolving mammalian intracochlear anatomy, fixed guinea pig ...

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    5. Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

      Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

      Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a ...

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    6. Promising New Imaging Tool Allows Surgeons to Detect Malignant Tissue During Breast-Conserving Surgery for Breast Cancer

      Promising New Imaging Tool Allows Surgeons to Detect Malignant Tissue During Breast-Conserving Surgery for Breast Cancer

      Combining wide-field micro-elastography with Optical Coherence Tomography (OCT), an Australian research team have developed a new imaging tool to detect malignant tissue during surgery that offers the potential to dramatically reduce the number of reoperations for patients with breast cancer Every year, an estimated 1.6 million women are diagnosed with breast cancer worldwide. It is one of the most common forms of cancer to affect women, second only to skin cancer. It is also deadly, killing an estimated 522,000 women annually. The development of mammography technologies has aided in the detection of earlier stage breast cancers. As a ...

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    7. Automatic classification of atherosclerotic plaques imaged with intravascular OCT

      Automatic classification of atherosclerotic plaques imaged with intravascular OCT

      Intravascular optical coherence tomography (IV-OCT) allows evaluation of atherosclerotic plaques; however, plaque characterization is performed by visual assessment and requires a trained expert for interpretation of the large data sets. Here, we present a novel computational method for automated IV-OCT plaque characterization. This method is based on the modeling of each A-line of an IV-OCT data set as a linear combination of a number of depth profiles. After estimating these depth profiles by means of an alternating least square optimization strategy, they are automatically classified to predefined tissue types based on their morphological characteristics. The performance of our proposed method ...

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    8. Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography

      Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography

      We report the application of spectral-domain optical coherence tomography (SD-OCT) technology that enables real-time functional analysis of sorting microparticles and cells in an inertial microfluidic device. We demonstrated high-speed, high-resolution acquisition of cross-sectional images at a frame rate of 350 Hz, with a lateral resolution of 3 μm and an axial resolution of 1 μm within the microfluidic channel filled with water. We analyzed the temporal sequence of cross-sectional SD-OCT images to determine the position and diameter of microspheres in a spiral microfluidic channel under various flow rates. We used microspheres with known diameters to validate the sub-micrometer precision of ...

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      Mentions: Ji Yi Hao F. Zhang
    9. A Mosaicking Approach for In Vivo Thickness Mapping of the Human Tympanic Membrane Using Low Coherence Interferometry

      A Mosaicking Approach for In Vivo Thickness Mapping of the Human Tympanic Membrane Using Low Coherence Interferometry

      The thickness of the human tympanic membrane (TM) is known to vary considerably across different regions of the TM. Quantitative determination of the thickness distribution and mapping of the TM is of significant importance in hearing research, particularly in mathematical modeling of middle-ear dynamics. Change in TM thickness is also associated with several middle-ear pathologies. Determination of the TM thickness distribution could therefore also enable a more comprehensive diagnosis of various otologic diseases. Despite its importance, very limited data on human TM thickness distribution, obtained almost exclusively from ex vivo samples, are available in the literature. In this study, the ...

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    10. Wideband ultrafast fiber laser sources for OCT and metrology

      Wideband ultrafast fiber laser sources for OCT and metrology

      Fiber lasers, which use optical fibers as ideal waveguides, have been attracting a great deal of attention as stable, practical, and maintenance-free lasers. Using a combination of an ultrashort-pulse fiber laser and a nonlinear fiber, we can realize wideband highly functional ultrafast fiber laser sources. The generation of ultrashort pulses with wide wavelength tunability and supercontinua based on fiber lasers and nonlinear fibers has been demonstrated. These techniques are useful for laser applications, especially for imaging and metrology. In this topical review, the fundamentals of and recent progress in wideband ultrafast fiber laser sources and their applications are reviewed mainly ...

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    11. Jennifer Barton a Leader in Cancer research, Imaging Honored with 2016 SPIE President’s and Directors’ Awards

      Jennifer Barton a Leader in Cancer research, Imaging Honored with 2016 SPIE President’s and Directors’ Awards

      Jennifer Barton is the recipient of this year’s SPIE President’s Award and Majid Rabbani of the SPIE Directors’ award, Robert Lieberman, 2016 President of SPIE the international society for optics and photonics, announced at an awards banquet during SPIE Optics + Photonics 2016 in San Diego, California, on 31 August. Barton is interim director of the BIO5 Institute at the University of Arizona, which works to solve complex biology-based problems affecting humanity. She is also professor of biomedical engineering, electrical and computer engineering, optical sciences, and agricultural and bio-systems engineering at UA. Barton is known for her innovative use ...

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    12. Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography

      Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography

      Clinical manifestations of cystic fibrosis (CF) result from an increase in the viscosity of the mucus secreted by epithelial cells that line the airways. Particle-tracking microrheology (PTM) is a widely accepted means of determining the viscoelastic properties of CF mucus, providing an improved understanding of this disease as well as an avenue to assess the efficacies of pharmacologic therapies aimed at decreasing mucus viscosity. Among its advantages, PTM allows the measurement of small volumes, which was recently utilized for an in situ study of CF mucus formed by airway cell cultures. Typically, particle tracks are obtained from fluorescence microscopy video ...

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    13. Semi-automated ICRS scoring of equine articular cartilage lesions in optical coherence tomography images

      Semi-automated ICRS scoring of equine articular cartilage lesions in optical coherence tomography images

      Background Arthroscopic optical coherence tomography (OCT) is a promising tool for detailed evaluation of articular cartilage injuries. However, OCT-based articular cartilage scoring still relies on the operator's visual estimation. Objectives To test the hypothesis that semi-automated ICRS (International Cartilage Repair Society) scoring of chondral lesions seen in OCT images could enhance intra- and inter-observer agreement of the scoring and its accuracy. Study design Validation study, using equine cadaver tissue. Methods Osteochondral samples ( n = 99) were prepared from eighteen equine metacarpophalangeal joints and imaged using OCT. Custom-made software was developed for semi-automated ICRS scoring of cartilage lesions on OCT images ...

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    14. Compact Imaging to Demonstrate Sub-dermal Fingerprint for Presentation Attack Detection At GIS2016 in Tampa

      Compact Imaging to Demonstrate Sub-dermal Fingerprint for  Presentation Attack Detection At GIS2016 in Tampa

      Compact Imaging, Inc., a Silicon Valley company developing small, low-cost optical sensors for the rapidly growing biometric security, personal health monitoring and non-destructive testing (NDT) markets, today announced that it will demonstrate its MRO™ subsurface scanning technology at the Global Identity Summit 2016 (GIS2016), Sept. 19-22, in Tampa. Compact Imaging's breakthrough MRO™ (Multiple Reference OCT) technology brings non-invasive OCT (optical coherence tomography) depth scanning to high volume field applications that require small size and low cost, such as biometric collection systems. Previously, OCT had been limited by its large size, high cost and extreme complexity in clinical and laboratory ...

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    15. Call for Papers OPTICAL COHERENCE TOMOGRAPHY 25TH ANNIVERSARY FEATURE ISSUE

      Call for Papers OPTICAL COHERENCE TOMOGRAPHY 25TH ANNIVERSARY FEATURE ISSUE

      Since its first appearance approximately 25 years ago, Optical Coherence Tomography (OCT) has undergone multiple generations of rapid technology development and has become a standard of care diagnostic technology in several medical specialties. Many of these developments were first described in OSA journals and meetings. Biomedical Optics Express is recognizing this milestone by publishing a Feature Issue collection of contributed original papers describing novel technology development and applications, and invited review papers summarizing historical progress in particular sub- fields of technology and applications of OCT. For more information click HERE .

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    16. Wolfgang Drexler reviews latest imaging advances

      Wolfgang Drexler reviews latest imaging advances

      At Euretina 2016, Wolfgang Drexler, PhD, talks about current limitations and future developments of optical coherence tomography. Adaptive optics-enhanced OCT angiography, new widefield, high-speed and swept-source-based systems, Doppler technology, multiple beam approaches, absorption measurement techniques, as well as miniaturized handheld modalities are in the pipeline.

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    17. 3rd International Symposium on Optical Coherence Tomography for Non-Destructive Testing Linz Austria

      3rd International Symposium on Optical Coherence Tomography for Non-Destructive Testing Linz Austria

      3rd International Symposium on Optical Coherence Tomography for Non-Destructive Testing The symposium takes place on February 15 th - 16 th , 2017 at the Johannes Kepler University in Linz, Austria . The symposium is dedicated to present the latest scientific results, methodological and technological advancements related to optical coherence tomography in the field of non-destructive testing. It is intended as a get-together for people working in this field and aims at initiating new ideas and projects. Researchers from academia and industry are invited to participate and exchange their knowledge on optical coherence tomography. The accompanying exhibition provides an excellent contact platform and ...

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    18. Classification of basal cell carcinoma in human skin using machine learning and quantitative features captured by polarization sensitive optical coherence tomography

      Classification of basal cell carcinoma in human skin using machine learning and quantitative features captured by polarization sensitive optical coherence tomography

      We report the first fully automated detection of basal cell carcinoma (BCC), the most commonly occurring type of skin cancer, in human skin using polarization-sensitive optical coherence tomography (PS-OCT). Our proposed automated procedure entails building a machine-learning based classifier by extracting image features from the two complementary image contrasts offered by PS-OCT, intensity and phase retardation (PR), and selecting a subset of features that yields a classifier with the highest accuracy. Our classifier achieved 95.4% sensitivity and specificity, validated by leave-one-patient-out cross validation (LOPOCV), in detecting BCC in human skin samples collected from 42 patients. Moreover, we show the ...

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    19. Effective anti-thrombotic therapy without stenting: intravascular optical coherence tomography-based management in plaque erosion (the EROSION study)

      Effective anti-thrombotic therapy without stenting: intravascular optical coherence tomography-based management in plaque erosion (the EROSION study)

      Aims Plaque erosion, compared with plaque rupture, has distinctly different underlying pathology and therefore may merit tailored therapy. In this study, we aimed to assess whether patients with acute coronary syndrome (ACS) caused by plaque erosion might be stabilized by anti-thrombotic therapy without stent implantation. Methods and results This was a single-centre, uncontrolled, prospective, proof-of concept study. Patients with ACS including ST-segment elevation myocardial infarction were prospectively enrolled. If needed, aspiration thrombectomy was performed. Patients diagnosed with plaque erosion by optical coherence tomography (OCT) and residual diameter stenosis <70% on coronary angiogram were treated with anti-thrombotic therapy without stenting. OCT ...

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    20. Optical Coherence Tomography to Optimize Results of Percutaneous Coronary Intervention in Patients with Non-ST-Elevation Acute Coronary Syndrome: Results of the Multicenter, Randomized DOCTORS (Does Optical Coherence Tomography Optimize Results of Stentin

      Optical Coherence Tomography to Optimize Results of Percutaneous Coronary Intervention in Patients with Non-ST-Elevation Acute Coronary Syndrome: Results of the Multicenter, Randomized DOCTORS (Does Optical Coherence Tomography Optimize Results of Stentin

      BACKGROUND: No randomized study has investigated the value of optical coherence tomography (OCT) in optimizing the results of percutaneous coronary intervention (PCI) for non-ST-segment elevation acute coronary syndromes. METHODS: We conducted a multicenter, randomized study involving 240 patients with non-ST-segment elevation acute coronary syndromes to compare OCT-guided PCI (use of OCT pre- and post-PCI; OCT-guided group) to fluoroscopy-guided PCI (angiography-guided group). The primary end point was the functional result of PCI assessed by the measure of post PCI fractional flow reserve. Secondary end points included procedural complications and type 4a periprocedural myocardial infarction. Safety was assessed by the rate of ...

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    21. OSA Centennial Snapshots: OCT and the Flowering of Biophotonics

      OSA Centennial Snapshots: OCT and the Flowering of Biophotonics

      The birth, commercialization and ultimate impact of OCT stand out as landmark accomplishments even amid the abundant advances in biophotonics during the 1980s and 1990s. Twenty-five years ago this month, the editors of Science accepted for publication a research paper titled “Optical Coherence Tomography.” That three-word phrase (and its punchier abbreviation, OCT) heralded a revolution in ophthalmology—one that would spawn a billion-dollar-a-year market, and affect millions of people. 

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    22. Biophotonics: Pushes the Boundaries of Radiology

      Biophotonics: Pushes the Boundaries of Radiology

      Biophotonics — the development and application of optical techniques for the study of biological molecules, cells and tissue — is expanding the scope of radiology by bringing clinicians and researchers new tools for noninvasive imaging of cancer and other diseases. While the x-rays and gamma rays commonly used in imaging represent highenergy light sources, biophotonics typically relies on sources at the lower end of the energy spectrum like infrared, near infrared, visible and ultraviolet light. This lower energy light helps preserve the biological cells examined even as the optical equipment visualizes structures too small to be seen with x-ray, CT and MRI ...

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    23. Advanced OCT: Making Waves in the Market

      Advanced OCT: Making Waves in the Market

      Optical coherence tomography (OCT) is poised for further growth, thanks to a new wave of progress in applications with commercial potential. Here’s a cross-sectional survey of OCT advances making their way from concept to market. This year marks the 25th anniversary of the celebrated initial optical coherence tomography (OCT) paper in Science by OSA Fellow James Fujimoto’s group at the Massachusetts Institute of Technology (Cambridge, Mass., USA). Five years later, in 1996, OCT profoundly changed the realm of ophthalmology when Carl Zeiss Meditec (Dublin, Calif., USA) launched the first commercial OCT platform for retinal imaging. In only 20 ...

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