1. Featured Articles

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    1. Research Engineer/Software Programmer Position at Doheny Eye Institute UCLA

      Research Engineer/Software Programmer Position at Doheny Eye Institute UCLA

      GOAL: Develop graphical user interface (GUI) tools in Windows and web-based applications. RESEARCH LABORATORY: Doheny Image Analysis Laboratory (DIAL) at Doheny Eye Institute/University of California, Los Angeles PROJECT DESCRIPTION: We are a rapidly growing and interdisciplinary group to investigate new approaches for image segmentation, registration, visualization, and analysis in various multimodal ophthalmic images at Doheny Eye Institute, standing among the top recipients of medical research grants from the National Institutes of Health, which fund 80% of all vision research in America. We are particularly interested in the development of graphical user interface tools for Windows and web-based applications including ...

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    2. Case Western Reserve University Posdoctoral Fellow Positions Open

      Case Western Reserve University Posdoctoral Fellow Positions Open

      The Jenkins lab at Case Western Reserve University (Deparments of Pediatrics and Biomedical Engineering) is looking for sharp, enthusiastic, well-trained individuals for postdoctoral fellow positions. Project opportunities include the development of optical pacing, optical inhibition (blocking action potential propagation), and optical imaging (e.g. OCT) technology for cardiovascular and neural applications. Applicants are expected to have earned a Ph.D. in biomedical engineering or a related field. Specific experience in building optical imaging systems or infrared stimulation is especially preferred, but the primary qualifications are outstanding technical proficiency and research skill. Successful applicants will be expected to work in an ...

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    3. Dynamic light scattering arising from flowing Brownian particles: analytical model in optical coherence tomography conditions

      Dynamic light scattering arising from flowing Brownian particles: analytical model in optical coherence tomography conditions

      The statistical model of scattered by flowing Brownian particles coherent radiation is suggested. The model includes the random Doppler shifts caused by particle Brownian motion and the speckle fluctuations caused primarily by the flow motion of particles. Analytical expressions are obtained for the correlation function, power spectrum, and spectral width of scattered radiation in the imaging geometry typically used in optical coherence tomography (OCT). It is shown that the spectral density has the Voigt shape, a well-known spectral profile from atomic and molecular spectroscopy. The approach enables the choice of the experimental regimes for the measurement of Brownian particle motion ...

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    4. Law Firm Launches Investigation of the Board of Directors of Volcano Corporation Regarding the Fairness of the Sale of the Company to Royal Philips

      Law Firm Launches Investigation of the Board of Directors of Volcano Corporation Regarding the Fairness of the Sale of the Company to Royal Philips

      Levi & Korsinsky is investigating the Board of Directors of Volcano Corporation ("Volcano" or "the Company") (Nasdaq: VOLC ) for possible breaches of fiduciary duty and other violations of state law in connection with the sale of the Company to Royal Philips . Click here to learn more about the investigation: http://zlk.9nl.com/volcano-volc . Under the terms of the transaction, Volcano shareholders will receive $18.00 in cash for each share of Volcano stock they own. The investigation concerns whether the Board of Volcano breached their fiduciary duties to stockholders by failing to adequately shop the Company before agreeing to enter ...

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    5. Philips to acquire Volcano to expand global leadership position in image-guided therapy market

      Philips to acquire Volcano to expand global leadership position in image-guided therapy market

      Royal Philips (NYSE: PHG; AEX: PHIA) and Volcano Corporation (NASDAQ:VOLC), a global leader in catheter-based imaging and measurement solutions for cardiovascular applications, today announced that they have entered into a definitive merger agreement. Pursuant to the agreement, Philips will commence a tender offer to acquire all of the issued and outstanding shares of Volcano for USD 18.00 per share, or a total equity purchase price of USD 1 billion (approx. EUR 800 million), to be paid in cash upon completion. The board of directors of Volcano has unanimously approved the transaction and recommends the offer to its shareholders ...

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    6. Two-dimensional micro-displacement measurement for laser coagulation using optical coherence tomography

      Two-dimensional micro-displacement measurement for laser coagulation using optical coherence tomography

      To improve the reproducibility of photocoagulation, the ability to quantitatively monitor the thermal change of laser-irradiated retinal tissue is required. Recently, optical coherence tomography has enabled non-invasive and non-contact monitoring of the tissue structural changes during laser irradiation. To further improve the capability of this technique, a method is proposed to measure tissue displacement by simultaneously using Doppler phase shifts and correlation coefficients. The theoretical approach for this method is described, and its performance is experimentally confirmed and evaluated. Finally, lateral and axial displacements in the laser-irradiated retinal tissues of an enucleated porcine eye are observed. The proposed method is ...

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    7. MEMS scanning micromirror for optical coherence tomography

      MEMS scanning micromirror for optical coherence tomography

      This paper describes an endoscopic-inspired imaging system employing a micro-electromechanical system (MEMS) micromirror scanner to achieve beam scanning for optical coherence tomography (OCT) imaging. Miniaturization of a scanning mirror using MEMS technology can allow a fully functional imaging probe to be contained in a package sufficiently small for utilization in a working channel of a standard gastroesophageal endoscope. This work employs advanced image processing techniques to enhance the images acquired using the MEMS scanner to correct non-idealities in mirror performance. The experimental results demonstrate the effectiveness of the proposed technique.

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    8. Postdoctoral research fellowships and studentship (optical coherence tomography) at Nanyang Technological University

      Postdoctoral research fellowships and studentship (optical coherence tomography) at Nanyang Technological University

      One PhD fellowship and 2 research staff position are available in the area of optical imaging at the Nanyang Technological University in the School of Electrical and Electronic Engineering. Successful candidates will join leading efforts in the development and application of new optical imaging techniques such as next-generation optical coherence tomography (OCT) imaging, endoscopic microscopy, and application of the new techniques in the research areas such as early cancer diagnosis. Liu group is supported by more than US$7M research funding in three main research directions: subcellular resolution transendoscopic OCT, submicrometer resolution ophthalmic OCT, and OCT nano-imaging. Requirements for graduate ...

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    9. Ultrawide-field parallel spectral domain optical coherence tomography for nondestructive inspection of glass

      Ultrawide-field parallel spectral domain optical coherence tomography for nondestructive inspection of glass

      Aiming at the requirements of real-time inspection in material industry, an ultrawide-field parallel SD-OCT system capable of visualizing cross-sectional image of internal structures by a single shot of a 2-D CMOS camera is developed. To achieve ultrawide-field parallel detection, one meniscus lens with negative dioptric is introduced as an additional relay lens and imaging optics including sample arm, relay lenses and spectrometer are optimized as a whole for desirable imaging quality. The developed system has an ultrawide-field of 35 mm and an axial range of 8 mm in air. The maximum on-axis sensitivity and the axial resolution are experimentally determined ...

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    10. Postdoctoral Research Fellowships (Optical Coherence Tomography) Wellman Center for Photomedicine Massachusetts General Hospital

      Postdoctoral Research Fellowships (Optical Coherence Tomography) Wellman Center for Photomedicine Massachusetts General Hospital

      A Postdoctoral research fellowship in the area of optical coherence tomography (OCT) is available in the Tearney Lab at the Massachusetts General Hospital (MGH) in the Wellman Center for Photomedicine. This appointment will be made at the rank of postdoctoral fellow at Harvard Medical School. MGH’s role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for developing and translating new OCT technologies with applications in basic and clinical research. The fellowship will focus on the development and clinical application of advanced OCT imaging devices, including endoscopic ...

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    11. Feasibility of Optical Coronary Tomography in Quantitative Measurement of Coronary Arteries With Lipid-Rich Plaque

      Feasibility of Optical Coronary Tomography in Quantitative Measurement of Coronary Arteries With Lipid-Rich Plaque

      Background: The aim of the present study was to evaluate the feasibility of optical coherence tomography (OCT) for measurement of vessel area in coronary arteries with lipid-rich plaque as compared with intravascular ultrasound (IVUS). Methods and Results: We investigated 80 coronary artery segments with lipid-rich plaque on OCT and non-attenuated plaque on IVUS. According to the lipid arc on OCT, the plaques were classified into 4 groups: group 1, lipid arc ≤90°; group 2, 90°<lipid arc≤180°; group 3, 180°<lipid arc≤270°; group 4, lipid arc >270°. Vessel circular arcs that could not be identified due to OCT ...

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    12. Mechanical Engineering Position Opening at Diagnostic Photonics In Chicago IIllinois

      Mechanical Engineering Position Opening at Diagnostic Photonics In Chicago IIllinois

      Mechanical Engineer Job Description Diagnostic Photonics is seeking a Mechanical Engineer to design and develop a next-generation surgical imaging system to assist surgeons in identifying cancer. They will work with a small, dynamic, and dedicated team to redefine the way cancer is treated. The Mechanical Engineer will be responsible for the mechanical aspects of system design definition, design implementation, and overall development support. Specific tasks will vary with the development cycle and will including the following activities and associated skills/experiences: System Mechanical Definition and Design Interact with physicians, clinical staff, and optical engineers to define the system mechanical design ...

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    13. Two postdoctoral Positions in Biomedical Optics Instrumentation and Retinal Imaging At the University of Illinois at Chicago

      Two postdoctoral Positions in Biomedical Optics Instrumentation and Retinal Imaging At the University of Illinois at Chicago

      Two postdoctoral positions are available in the Biomedical Optics and Functional Imaging Laboratory, Department of Bioengineering, University of Illinois at Chicago. The first position will be responsible for advanced development of biomedical optics instruments. We have been working on functional OCT , confocal and super-resolution microscopy, etc. for optical imaging of retinal morphology and physiology. The successful candidate should have a Ph.D. degree in Optical Engineering, Electrical Engineering, Applied Physics or a related discipline. Experience with optical instrument construction is essential. Proficiency in Labview and Matlab programming is expected. Hand-on experience in one or more of the following areas is ...

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      Mentions: Xincheng Yao
    14. Current OCT Approaches Do Not Reliably Identify TCFAs

      Current OCT Approaches Do Not Reliably Identify TCFAs

      It is now clearly established that Thin-Capped Fibroatheromas (TCFAs) lead to most Acute Coronary Syndromes (ACSs). The ability to selectively intervene on TCFAs predisposed to rupture and ACSs would dramatically alter the practice of cardiology. While the ability of OCT to identify thin walled plaques at micron scale resolutions has represented a major advance, it is a misconception that it can reliably identify TCFAs. One major reason is that the ‘diffuse border’ criteria currently used to determine ‘lipid plaque’ is almost undoubtedly from high scattering in the intima and not because of core composition (necrotic core). A second reason is ...

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    15. In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis

      In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis

      Background and Objective Development of miniaturized imaging systems with molecular probes enables examination of molecular changes leading to initiation and progression of colorectal cancer in an azoxymethane (AOM)-induced mouse model of the disease. Through improved and novel studies of animal disease models, more effective diagnostic and treatment strategies may be developed for clinical translation. We introduce use of a miniaturized multimodal endoscope with lavage-delivered fluorescent probes to examine dynamic microenvironment changes in an AOM-treated mouse model. Study Design/Materials and Methods The endoscope is equipped with optical coherence tomography (OCT) and laser induced fluorescence (LIF) imaging modalities. It is ...

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    16. Simultaneous dual-band optical coherence tomography for endoscopic applications

      Simultaneous dual-band optical coherence tomography for endoscopic applications

      Dual-band optical coherence tomography (OCT) can greatly enhance the imaging contrast with potential applications in functional (spectroscopic) analysis. A new simultaneous dual-band Fourier domain mode-locked swept laser configuration for dual-band OCT is reported. It was based on a custom-designed dual-channel driver to synchronize two different wavelength bands at 1310 and 1550 nm, respectively. Two lasing wavelengths were swept simultaneously from 1260 to 1364.8 nm for the 1310-nm band and from 1500 to 1604 nm for the 1550-nm band at an A-scan rate of 45 kHz. Broadband wavelength-division multiplexing was utilized to couple two wavelength bands into a common catheter ...

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    17. Functional optical coherence tomography reveals transient phototropic change of photoreceptor outer segments

      Functional optical coherence tomography reveals transient phototropic change of photoreceptor outer segments

      Dynamic near infrared microscopy has revealed transient retinal phototropism (TRP) correlated with oblique light stimulation. Here, by developing a hybrid confocal microscopy and optical coherence tomography (OCT), we tested sub-cellular source of the TRP in living frog retina. Dynamic confocal microscopy and OCT consistently revealed photoreceptor outer segments as the anatomic source of the TRP. Further investigation of the TRP can provide insights in better understanding of Stiles–Crawford effect (SCE) on rod and cone systems, and may also promise an intrinsic biomarker for early detection of eye diseases that can produce photoreceptor dysfunction.

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    18. In Search of the Vulnerable Plaque Is There Any Light at the End of the Catheter?

      In Search of the Vulnerable Plaque Is There Any Light at the End of the Catheter?

      Plaque destabilization with consequent rupture (or erosion) and superimposed thrombosis is the proximate cause of acute coronary syndromes (ACS). Although ACS treatment has advanced considerably in the past decade, the ability to detect, predict, and prevent plaque vulnerability remains elusive. Several imaging tools have been developed to characterize morphological determinants of plaque vulnerability 1 . Among these, intravascular ultrasound (IVUS) is useful for characterizing stenosis severity, plaque burden (PB), remodeling, and calcification but has low resolution and limited ability to detect plaque erosion, rupture, and thrombus. Optical coherence tomography (OCT) can characterize plaques but possesses poor penetration, thereby limiting assessment of ...

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      Mentions: Jagat Narula
    19. Dispersion cancellation in high-resolution two-photon interference

      Dispersion cancellation in high-resolution two-photon interference

      The dispersion cancellation observed in Hong-Ou-Mandel (HOM) interference between frequency-entangled photon pairs has been the basis of quantum optical coherence tomography and quantum clock synchronization. Here we explore the effect of phase dispersion on ultranarrow HOM dips. We show that the higher-order dispersion, the linewidth of the pump laser, and the spectral shape of the parametric fluorescence have a strong effect on the dispersion cancellation in the high-resolution regime with several experimental verifications. Perfect dispersion cancellation with a linewidth of 3 μ m is also demonstrated through 25 mm of water.

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    20. STACCATO (Assessment of Stent sTrut Apposition and Coverage in Coronary ArTeries with Optical coherence tomography in patients with STEMI, NSTEMI and stable/unstable angina undergoing everolimus vs. biolimus A9-eluting stent implantation): a randomised co

      STACCATO (Assessment of Stent sTrut Apposition and Coverage in Coronary ArTeries with Optical coherence tomography in patients with STEMI, NSTEMI and stable/unstable angina undergoing everolimus vs. biolimus A9-eluting stent implantation): a randomised co

      Aims: To compare tissue coverage in coronary lesions stented with durable fluoropolymer-coated everolimus-eluting stents (EES) vs. biodegradable polymer-coated biolimus A9-eluting stents (BES). Methods and results: Sixty-four patients (64 lesions) with de novo coronary artery lesions were randomised to percutaneous treatment with XIENCE® EES (Abbott Vascular, Santa Clara, CA, USA) vs. BioMatrix™ BES (Biosensors, Morges, Switzerland). The primary endpoint was the percentage of uncovered struts, as assessed with OCT, at nine months. The average percentage of uncovered struts was significantly lower with EES (4.3±4.8% vs. 8.7±7.8% with BES, p=0.019). There was no difference ...

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    21. Dual optical modality endoscopic imaging of cancer development in the mouse colon

      Dual optical modality endoscopic imaging of cancer development in the mouse colon

      Background and Objective We utilize a miniature, dual-modality endoscope that combines fluorescence-based surface magnifying chromoendoscopy (SMC) and optical coherence tomography (OCT) to follow the anatomical changes that occur during adenoma development in the mouse colon. Materials and Methods Twenty-five mice were treated with the carcinogen azoxymethane (AOM) to induce tumor development in the distal colon, or were treated with saline as control, and were imaged over six months. OCT detects adenoma number with high sensitivity and specificity and can measure lesion size. In methylene blue-lavaged colons, SMC detects changes in the colonic crypts. SMC images of control mouse colons exhibit ...

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    22. Imaging of cardiovascular development in Mammalian embryos using optical coherence tomography (Book Chapter)

      Imaging of cardiovascular development in Mammalian embryos using optical coherence tomography (Book Chapter)

      The cardiovascular system is the first functional organ system to develop within the mammalian embryo. During the early stages of cardiovascular development, the heart and blood vessels undergo rapid growth and remodeling required for embryo viability, proper morphogenesis, and the function of all organ systems. Live imaging of these dynamic events in early mouse embryos is critical to understanding when and how these morphological changes occur during normal development and how mutations and pharmacological agents affect cardiovascular structure and function in vivo. The use of optical coherence tomography (OCT) allows for rapid, three-dimensional structural and functional imaging of mouse embryos ...

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    23. OCT Assessment of the Long-Term Vascular Healing Response 5 Years After Everolimus-Eluting Bioresorbable Vascular Scaffold

      OCT Assessment of the Long-Term Vascular Healing Response 5 Years After Everolimus-Eluting Bioresorbable Vascular Scaffold

      Background Although recent observations suggest a favorable initial healing process of the everolimus-eluting bioresorbable vascular scaffold (BVS), little is known regarding long-term healing response. Objectives This study assessed the in vivo vascular healing response using optical coherence tomography (OCT) 5 years after elective first-in-man BVS implantation. Methods Of the 14 living patients enrolled in the Thoraxcenter Rotterdam cohort of the ABSORB A study, 8 patients underwent invasive follow-up, including OCT, 5 years after implantation. Advanced OCT image analysis included luminal morphometry, assessment of the adluminal signal-rich layer separating the lumen from other plaque components, visual and quantitative tissue characterization, and ...

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    24. NinePoint Medical Appoints Christopher von Jako, Ph.D., to Chief Executive Officer

      NinePoint Medical Appoints Christopher von Jako, Ph.D., to Chief Executive Officer

      NinePoint Medical, Inc., an emerging leader in the development of medical devices for advanced optical imaging, today announced the appointment of Christopher von Jako, Ph.D., as president and chief executive officer. Dr. von Jako brings to NinePoint Medical more than 20 years of experience in the global medical device industry and has demonstrated success leading and growing the value of organizations with early-stage commercial products. “Chris is a passionate and technology-minded individual who deeply understands the dynamics of today’s medical device field,” said Tom Miller, chairman of NinePoint’s board of directors. “We believe his commercial insights and ...

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