1. Featured Articles

    1-11 of 11
    1. Automated assessment of breast cancer margin in optical coherence tomography images via pre‐trained convolutional neural network

      Automated assessment of breast cancer margin in optical coherence tomography images via pre‐trained convolutional neural network

      The benchmark method for the evaluation of breast cancers involves microscopic testing of a hematoxylin and eosin (H&E) stained tissue biopsy. Resurgery is required in 20‐30% of cases because of incomplete excision of malignant tissues. Therefore, a more accurate method is required to detect the cancer margin to avoid the risk of recurrence. In the recent years, convolutional neural networks (CNNs) has achieved excellent performance in the field of medical images diagnosis. It automatically extracts the features from the images and classifies them. In the proposed study, we apply a pre‐trained Inception‐v3 CNN with reverse active ...

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      Mentions: UCLA
    2. Quantitative Articular Cartilage Sub-Surface Defect Assessment Using Optical Coherence Tomography: An In-Vitro Study

      Quantitative Articular Cartilage Sub-Surface Defect Assessment Using Optical Coherence Tomography: An In-Vitro Study

      Assessment of structural cartilage damage is of high scientific and clinical interest. Optical Coherence Tomography (OCT) is a light-based cross-sectional imaging modality that allows the real-time assessment of articular cartilage at near-histological resolution. Algorithm routines for the detection, parameterization and quantification of sub-surface defects as assessed by OCT were implemented and validated in this study. Standard defects of 0.9 mm, 1.1 mm and 1.3 mm diameter were created in the sub-surface regions of macroscopically intact human articular cartilage samples (n = 60 defects of variable sizes in n = 20 samples). Subsequently, samples were scanned by 3D OCT and ...

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    3. Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment

      Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment

      Purpose . Initial studies have shown that optical coherence tomography (OCT) is an effective margin-evaluation tool for breast-conserving surgery, but methods for the interpretation of breast OCT images have not been directly studied. In this work, breast pathologies were assessed with a handheld OCT probe. OCT images and corresponding histology were used to develop guidelines for the identification of breast tissue features in OCT images. Methods . Mastectomy and breast-conserving surgery specimens from 26 women were imaged with a handheld OCT probe. During standard pathology specimen dissection, representative 1-cm × 1-cm tissue regions were grossly identified, assessed with OCT, inked for orientation and ...

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    4. Altris.AI – The New Era of Retinal Diagnosis is Coming

      Altris.AI – The New Era of Retinal Diagnosis is Coming

      Altris.AI (Altris, Inc) announced it has signed an agreement with a South Korean ophthalmic and optical medical equipment manufacturer Huvitz Co., Ltd. aimed at the development of customized deep learning solutions for retinal diseases detection unique for Huvitz HOCT-1/1F device, All-in-One PC integrated 3D Optical Coherence Tomography (OCT) and Fundus Camera. Altris.AI’s OCT and Fundus algorithms have been trained using anonymized OCT retinal scans as well as Fundus images collected during more than 12 years, and are able to detect more than 50 retinal diseases and conditions. Currently, Altris.AI’s solution is available in web ...

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      Mentions: Huvitz
    5. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Position description: A full-time Postdoctoral Associate position in Biophotonics / Biomedical Optical Imaging is available at Lehigh University starting ASAP . The primary purpose of this position will be for a highly motivated individual to develop advanced optical imaging techniques for novel biomedical applications in vitro and/or in vivo . Compensation is commensurate with experience. Qualifications: Ph.D. in Electrical Engineering, Physics, Applied Physics, Biomedical Engineering / Bioengineering or related fields. Hands-on experience with optical coherence tomography (OCT), including spectral-domain and swept-source OCT, is preferred. Good publication record and communication skills. Research areas: The candidate is expected to work on one of the ...

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    6. Changes in volume of various retinal layers over time in early and intermediate age-related macular degeneration

      Changes in volume of various retinal layers over time in early and intermediate age-related macular degeneration

      Purpose To evaluate longitudinally volume changes in inner and outer retinal layers in early and intermediate age-related macular degeneration (AMD) compared to healthy control eyes using optical coherence tomography (OCT). Methods 71 eyes with AMD and 31 control eyes were imaged at two time points: baseline and after 2 years. Automated OCT layer segmentation was performed using Orion TM . This software is able to measure volumes of retinal layers with distinct boundaries including Retinal Nerve Fibre Layer (RNFL), Ganglion Cell-Inner Plexiform Layer (GCIPL), Inner Nuclear Layer (INL), Outer Plexiform Layer (OPL), Outer Nuclear Layer (ONL), Photoreceptors (PR) and Retinal Pigment ...

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    7. Non invasive optical cellular imaging in humans

      Non invasive optical cellular imaging in humans

      One of the most appealing and still unsolved problems in biological and medical imaging is the possibility of noninvasive visualization of tissue in vivo with an accuracy of microscopic examination. A major difficulty to solve in biomedical imaging is a degradation of image quality caused by the presence of optical inhomogeneity of tissue. Is there any chance to develop a microscopic method that allows non-invasive observation of cells in living tissue? Classical optical microscopy requires first to retrieve, then to process and finally to stain the sample, which is usually not possible to be performed in vivo. One of the ...

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    8. Advances in Optical Coherence Tomography

      Advances in Optical Coherence Tomography

      Optical coherence tomography (OCT) is a high-resolution, three-dimensional, noninvasive imaging technique. It is often called an optical ultrasound because it relies on time-of-flight information, similar to ultrasound imaging, to obtain subsurface information. The success of this technique has been fueled by a unique combination of technical and commercial factors, which include major investment in lasers, optical fibers, and sensors for telecommunications. That OCT is benefitting from these advances is proven in its applications across the health care industry. With close to a billion-dollar market size, OCT is seeing increased acceptance in areas such as interventional cardiology, dermatology, and ophthalmology, and ...

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    9. Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications

      Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications

      Development of low-cost and portable optical coherence tomography (OCT) systems is of global interest in the OCT research community. Such systems enable utility broadly throughout a clinical facility, or in remote areas that often lack clinical infrastructure. We report the development and validation of a low-cost, portable briefcase spectral-domain optical coherence tomography (SD-OCT) system for point-of-care diagnostics in primary care centers and/or in remote settings. The self-contained briefcase OCT contains all associated optical hardware, including light source, spectrometer, hand-held probe, and a laptop. Additionally, this system utilizes unique real-time mosaicking of surface video images that are synchronized with rapid ...

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    10. Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging

      Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging

      Comprehensive imaging of both the structural and biochemical characteristics of atherosclerotic plaque is essential for the diagnosis and study of coronary artery disease because both a plaque’s morphology and its biochemical composition affect the level of risk it poses. Optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIm) are promising optical imaging methods for characterizing coronary artery plaques morphologically and biochemically, respectively. In this study, we present a hybrid intravascular imaging device, including a custom-built OCT/FLIm system, a hybrid optical rotary joint, and an imaging catheter, to visualize the structure and biochemical composition of the plaque in an ...

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    11. Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography

      Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography

      Background  This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barrett’s esophagus and dysplasia. Methods  74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barrett’s esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barrett’s esophagus and a history of dysplasia and 30 with NDBE. The associations between irregular mucosal patterns on en face OCT, absence of mucosal layering, surface signal > subsurface, and > 5 atypical glands on cross-sectional OCT vs. histology and treatment history were ...

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    1-11 of 11
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