1. Featured Articles

    1-24 of 43 1 2 »
    1. Two-grating Talbot bands spectral-domain interferometer

      Two-grating Talbot bands spectral-domain interferometer

      A configuration for Talbot bands is presented in which two tilted gratings replace the splitter normally used for recombining the signals from the two interferometer arms. The two optical beams from the interferometer are launched by two fiber leads tightly brought together in the front focal plane of a collimating lens. As the tips of the two fibers are slightly off-axis, the emergent beams after the collimating lens are not parallel. In combination with the two tilted gratings, the nonparallel launching of the two beams leads to a total elimination of mirror terms even when the two beams overlap on ...

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    2. Automated choroidal neovascularization detection algorithm for optical coherence tomography angiography

      Automated choroidal neovascularization detection algorithm for optical coherence tomography angiography

      Optical coherence tomography angiography has recently been used to visualize choroidal neovascularization (CNV) in participants with age-related macular degeneration. Identification and quantification of CNV area is important clinically for disease assessment. An automated algorithm for CNV area detection is presented in this article. It relies on denoising and a saliency detection model to overcome issues such as projection artifacts and the heterogeneity of CNV. Qualitative and quantitative evaluations were performed on scans of 7 participants. Results from the algorithm agreed well with manual delineation of CNV area.

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    3. First Annual OCT Angiography Summit Signals a New Era in Imaging Technology

      First Annual OCT Angiography Summit Signals a New Era in Imaging Technology

      OCT Angiography: The Next Game Changer in OCT Scientists, clinicians and engineers from throughout the world gathered in Portland, Oregon, USA for the first annual OCT Angiography Summit meeting. Participants spent the day sharing their knowledge and discussing applications of a breakthrough imaging technology that may someday transform the way we diagnose and care for patients with the most common causes of blindness, namely macular degeneration, glaucoma and diabetes. Currently, these innovations are being applied in ophthalmology and are proving to be a superior alternative to dye-based methods for visualizing and measuring blood flow in the back of the eye ...

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    4. Swept-Source OCT: Patent License Agreement between Massachusetts General Hospital and Heidelberg Engineering

      Swept-Source OCT: Patent License Agreement between Massachusetts General Hospital and Heidelberg Engineering

      Heidelberg Engineering has entered into a patent license agreement with Massachusetts General Hospital (MGH) in Boston. The agreement grants global and exclusive rights to 77 basic patents and patent applications which relate to swept-source OCT technology and its application in ophthalmology. Spectral domain OCT has become indispensable to eye care professionals worldwide to diagnose and follow-up patients with diseases of the posterior segment of the eye, such as age-related macular degeneration, diabetic retinopathy, or glaucoma. Swept-source OCT technology has specific characteristics which are ideal to acquire comprehensive information about a wide variety of properties of the anterior part of the ...

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    5. Optical identification based on time domain optical coherence tomography

      Optical identification based on time domain optical coherence tomography

      We present a novel method for optical identification, i.e., authenticating valuable documents such as a passport, credit cards, and bank notes, using optical coherence tomography (OCT). An OCT system can capture three-dimensional (3D) images and visualize the internal structure of an object. In our work, as an object, we consider a multilayered optical identification tag composed of a limited number of thin layers (10–100 μm thick). The thickness, width, and location of the layers in the tag encode a unique identification information. Reading of the tag is done using a time domain OCT (TD-OCT) system. Typically, a TD-OCT ...

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    6. Degree of polarization (uniformity) and depolarization index: unambiguous depolarization contrast for optical coherence tomography

      Degree of polarization (uniformity) and depolarization index: unambiguous depolarization contrast for optical coherence tomography

      The degree of polarization (uniformity) has attracted increased interest as a functional contrast in optical coherence tomography (OCT). However, its computation from a single polarization state suggests an ambiguity that is strongly dependent on a sample’s orientation. We here propose an improved metric to present depolarization with respect to the optical system rather than the propagating field. Using numerical simulations and optical frequency domain imaging, we evaluate the conventional DOP(U) for different polarization states and compare its performance with the unambiguous depolarization index.

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    7. OCT Medical Imaging Inc. Receives fast-track SBIR funding for “Clinical evaluation and development of a diagnostic multi-modal intravascular imaging system

      OCT Medical Imaging Inc. Receives fast-track SBIR funding for “Clinical evaluation and development of a diagnostic multi-modal intravascular imaging system

      Dr. Ram Ramalingam CEO of OCT Medical Imaging Inc., (OCTMI), a privately held medical device company announced that it has received a fast-tract Small Business Innovation Research (SBIR) grant from SBIR funding as National Heart Lung Blood institute (NHLBI) for “Clinical evaluation and development of a diagnostic multi-modal intravascular imaging system”. This fast-track SBIR grant worth 2.9 million dollar with potential support for two and half-year will be led by Dr. Ram Ramalingam, Co-founder of OCTMI and will involve clinicians from Columbia University Medical School (CUMS) and University of California Irvine Medical School (UCIMS), Orange, California. This milestone based ...

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    8. Post Doctoral Opening In Novel Optical Microscopy Technologies for Neuroscience Applications at Northwestern University

      Post Doctoral Opening In Novel Optical Microscopy Technologies for Neuroscience Applications at Northwestern University

      We have an immediate opening at Northwestern University (Evanston, IL) for one post-doctoral position to develop novel optical microscopy technologies for neuroscience applications. We especially encourage applicants with extensive instrumentation experiences in optics, two-photon, super-resolution or light-sheet microscopy. The successful candidate will be based in the Department of Neurobiology (Kozorovitskiy lab), also working closely with the laboratories of Hao F. Zhang (Department of Biomedical Engineering) and Gregory Schwartz (Department of Ophthalmology). Please submit CV, a cover letter and names and contact information of three references to Y. Kozorovitskiy and H. F. Zhang ( yevgenia.kozorovitskiy@northwestern.edu , hfzhang@northwestern.edu ).

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    9. Subsurface ablation of atherosclerotic plaque using ultrafast laser pulses

      Subsurface ablation of atherosclerotic plaque using ultrafast laser pulses

      We perform subsurface ablation of atherosclerotic plaque using ultrafast pulses. Excised mouse aortas containing atherosclerotic plaque were ablated with ultrafast near-infrared (NIR) laser pulses. Optical coherence tomography (OCT) was used to observe the ablation result, while the physical damage was inspected in histological sections. We characterize the effects of incident pulse energy on surface damage, ablation hole size, and filament propagation. We find that it is possible to ablate plaque just below the surface without causing surface damage, which motivates further investigation of ultrafast ablation for subsurface atherosclerotic plaque removal.

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    10. Observation of white spot lesions using swept source optical coherence tomography (SS-OCT): in vitro and in vivo study

      Observation of white spot lesions using swept source optical coherence tomography (SS-OCT): in vitro and in vivo study

      This study aimed to assess swept source optical coherence tomography (SS-OCT) for in vitro and in vivo detection of enamel white spot lesion (WSL). WSLs without surface breakdown on 33 extracted human posterior teeth were non-invasively scanned using SSOCT. The teeth were then cross-sectioned and imaged under confocal laser scanning microscope (CLSM) and light microscopy (LM). SS-OCT cross-sectional images were compared with CLSM and LM. WSL shapes in SS-OCT images closely corresponded to those of LM. There were significant correlations ( p <0.001) in WSLs depth between SS-OCT and LM (r=0.92), SS-OCT and CLSM (r=0.80) and ...

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    11. Experimental investigation of intravascular OCT for imaging of intracranial aneurysms

      Experimental investigation of intravascular OCT for imaging of intracranial aneurysms

      Purpose Rupture risk assessment of an intracranial aneurysm (IA) is an important factor for indication of therapy. Until today, there is no suitable objective prediction method. Conventional imaging modalities cannot assess the IA’s vessel wall. We investigated the ability of intravascular optical coherence tomography (OCT) as a new tool for the characterization and evaluation of IAs. Materials and methods An experimental setup for acquisition of geometrical aneurysm parameters was developed. Object of basic investigation was a silicone phantom with six IAs from patient data. For structural information, three circle of Willis were dissected and imaged postmortem. All image data ...

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    12. Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Objective: We used optical coherence tomography (OCT) to assess the impact of thrombus aspiration before angioplasty on poststenting tissue protrusions in patients undergoing a primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Methods and results: A total of 188 patients with STEMI who underwent thrombus-aspiration PCI (n=113) or standard PCI (n=75) were examined in this study. OCT was performed immediately after primary PCI to assess lesion morphology in the stented segment. The minimum stent area was similar between the thrombus-aspiration PCI group and the standard PCI group [7.4 interquartile range (IQR): 5.8-9.4 ...

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    13. Postdoctoral Researcher in Photonics Technologies for Miniature Biometric and Healthcare Instrumentation at the National University of Ireland, Galway

      Postdoctoral Researcher in Photonics Technologies for Miniature Biometric and Healthcare Instrumentation at the National University of Ireland, Galway

      Postdoctoral Researcher in Photonics technologies for miniature biometric and healthcare instrumentation ‘Multiple-Reference Optical Coherence Tomography’ (MR-OCT) Tissue Optics and Microcirculation imaging Laboratory School of Physics National University of Ireland, Galway Ref. No. NUIG 095-15 Applications are invited from suitably qualified candidates for a full-time, fixed term position as a photonics technology postdoctoral research scientist with the Tissue Optics and Microcirculation Imaging Facility Laboratory (TOMI) at the National University of Ireland, Galway. This position is funded by a mix of commercial and public funding. The position is available from the 1st of September 2015 on a two year fixed term contract ...

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    14. Post-doctoral Research Fellowship at Yale in Cardiovascular Molecular and Translational Imaging

      Post-doctoral Research Fellowship at Yale in Cardiovascular Molecular and Translational Imaging

      Post-doctoral research fellowship immediately available at Yale on NIH funded T32 training grant focused on providing multi-disciplinary multi-modality training in molecular and translational cardiovascular imaging for highly qualified fellows holding either a MD or/and PhD, in preparation for academic careers as independent investigators in the highly clinically relevant field of cardiovascular imaging. Post-doctoral fellowship training will be 2-3 years in duration. There are three primary research focuses in the post-doctoral training, 1) cardiovascular molecular imaging, 2) cardiovascular imaging technologies and analyses, and 3) translational cardiovascular imaging. Applicants will have full access to resources available through the Yale Translational Research ...

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    15. Acquisition of Spin-out Company Bioptigen to Bring Duke Imaging Technology to New Markets

      Acquisition of Spin-out Company Bioptigen to Bring Duke Imaging Technology to New Markets

      In June 2015, microscopy and imaging systems company Leica Microsystems acquired Bioptigen Inc., a company born from Duke's Pratt School of Engineering. Formed in 2004, Bioptigen has become a leader in optical coherence tomography (OCT), an imaging technique that uses light to capture extremely high-resolution, three-dimensional pictures of the eye. Bioptigen was the brainchild of Duke’s Michael J. Fitzpatrick Professor of Engineering Joseph Izatt and CEO Eric Buckland. Since its launch, the company secured more than 60 issued patents in OCT technology, many of which were licensed from intellectual property developed by Izatt, his students, and collaborators at ...

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    16. Recent development of optical coherence tomography for preoperative diagnosis of esophageal malignancies

      Recent development of optical coherence tomography for preoperative diagnosis of esophageal malignancies

      Endoscopic diagnosis with histological evidence is necessary to decide the best strategy for treating esophageal squamous cell carcinoma and Barrett’s-associated neoplasia, and the recent development of endoscopic technologies have made possible real-time information of malignant hallmarks. We focused on the development of optical coherence tomography (OCT), the only technology that can depict real-time cross-sectional images with high resolution. With the improvements in image resolution, acquisition rate and demonstrable area of three-dimensional devices with Doppler capability, OCT imaging was shown to enable visualization of structural/ functional alterations in the mucosal/submucosal tissue of the esophagus, resulting in more accurate preoperative ...

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    17. Illuminating Culprit Plaque Histology by Optical Coherence Tomography : Shedding New Light on Old Insights

      Illuminating Culprit Plaque Histology by Optical Coherence Tomography : Shedding New Light on Old Insights

      Coronary atherosclerosis continues to be major cause of death in the developed world ( (1) ). Although we have known for at least a century that fissures and ruptures of coronary arteries are the cause of coronary thrombosis and, in the last 2 decades, that plaque erosion and calcified nodule are additional causes of thrombosis, our ability to use this knowledge in a real-time fashion to affect the treatment of patients with acute coronary syndromes (ACS) has been limited ( (2) ). Although angiography-guided percutaneous coronary intervention (PCI) has become the standard of care for treatment of ACS, it provides little understanding of culprit ...

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      Mentions: Emory University
    18. Long Range Optical Coherence Tomography of the Neonatal Upper Airway for Early Diagnosis of Intubation-related Subglottic Injury

      Long Range Optical Coherence Tomography of the Neonatal Upper Airway for Early Diagnosis of Intubation-related Subglottic Injury

      Subglottic edema and acquired subglottic stenosis are potentially airway -compromising sequelae in neonates following endotracheal intubation . At present, no imaging modality is capable of in vivo diagnosis of subepithelial airway wall pathology as signs of intubation - related injury . OBJECTIVES: To use Fourier domain long - range optical coherence tomography (LR-OCT) to acquire micrometer-resolution images of the airway wall of intubated neonates in a neonatal intensive care unit (NICU) setting and to analyze images for histopathology and airway wall thickness. METHODS: LR-OCT of the neonatal laryngotracheal airway was performed a total of 94 times on 72 subjects (age 1-175 days, total intubation ...

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    19. Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Stud

      Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Stud

      Background A multicenter, prospective, blinded study was performed to test the feasibility of using a handheld optical imaging probe for the intraoperative assessment of final surgical margins during breast-conserving surgery (BCS) and to determine the potential impact on patient outcomes. Methods Forty-six patients with early-stage breast cancer (one with bilateral disease) undergoing BCS at two study sites, the Johns Hopkins Hospital and Anne Arundel Medical Center, were enrolled in this study. During BCS, cavity-shaved margins were obtained and the final margins were examined ex vivo in the operating room with a probe incorporating optical coherence tomography (OCT) hardware and interferometric ...

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    20. Wavelength shifting of intra-cavity photons: Adiabatic wavelength tuning in rapidly wavelength-swept lasers

      Wavelength shifting of intra-cavity photons: Adiabatic wavelength tuning in rapidly wavelength-swept lasers

      We analyze the physics behind the newest generation of rapidly wavelength tunable sources for optical coherence tomography (OCT), retaining a single longitudinal cavity mode during operation without repeated build up of lasing. In this context, we theoretically investigate the currently existing concepts of rapidly wavelength-swept lasers based on tuning of the cavity length or refractive index, leading to an altered optical path length inside the resonator. Specifically, we consider vertical-cavity surface-emitting lasers (VCSELs) with microelectromechanical system (MEMS) mirrors as well as Fourier domain mode-locked (FDML) and Vernier-tuned distributed Bragg reflector (VT-DBR) lasers. Based on heuristic arguments and exact analytical solutions ...

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    21. Wide-field in vivo oral OCT imaging

      Wide-field in vivo oral OCT imaging

      We have built a polarization-sensitive swept source Optical Coherence Tomography (OCT) instrument capable of wide-field in vivo imaging in the oral cavity. This instrument uses a hand-held side-looking fiber-optic rotary pullback catheter that can cover two dimensional tissue imaging fields approximately 2.5 mm wide by up to 90 mm length in a single image acquisition. The catheter spins at 100 Hz with pullback speeds up to 15 mm/s allowing imaging of areas up to 225 mm 2 field-of-view in seconds. A catheter sheath and two optional catheter sheath holders have been designed to allow imaging at all locations ...

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    22. Perimeter Medical Imaging Closes Oversubscribed $5 Million Series A Financing Round Led By Roadmap Capital

      Perimeter Medical Imaging Closes Oversubscribed $5 Million Series A Financing Round Led By Roadmap Capital

      Perimeter Medical Imaging, Inc., a developer of real time imaging systems for in-surgery tissue assessment, is pleased to announce the closing of their $5 million Series A financing. The round was led by Roadmap Capital with participation from EPIC Capital, NorthView Ventures and Pathfinder Asset Management. Funds will support the completion of their current clinical study at Princess Margaret Cancer Centre as well as product development and FDA regulatory clearance for their first tissue imaging product. Perimeter’s ground-breaking new Optical Tissue Imaging System (OTIS™) is an intraoperative medical imaging tool that provides clinicians with the ability to visualize the ...

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    23. Wideband Electrically Pumped 1050-nm MEMS-Tunable VCSEL for Ophthalmic Imaging

      Wideband Electrically Pumped 1050-nm MEMS-Tunable VCSEL for Ophthalmic Imaging

      In this paper, we present a 1050-nm electrically pumped microelectromechanically tunable vertical cavity surface emitting laser (MEMS-VCSEL) with a record dynamic tuning bandwidth of 63.8 nm, suitable for swept-source optical coherence tomography (SS-OCT) imaging. These devices provide reduced cost and complexity relative to previously demonstrated optically pumped devices by obviating the need for a pump laser and associated hardware. We demonstrate ophthalmic SS-OCT imaging with the electrically-pumped MEMS-VCSEL at a 400 kHz axial scan rate for wide-field imaging of the in vivo human retina over a 12 mm × 12 mm field and for OCT angiography of the macula over ...

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    24. Recent advances in clinical application of optical coherence tomography of human skin

      Recent advances in clinical application of optical coherence tomography of human skin

      Optical coherence tomography (OCT) is an emerging noninvasive imaging method that uses infrared light and interferometric techniques. The method has become increasingly popular in skin research as well as daily dermatology practice. In the present brief review, we focused on recent (2009–2014) OCT studies on the human skin, which included a reasonable sample size and statistics. Twenty-five papers were selected and briefly described OCT of epidermal thickness, skin appendages, wound healing, extracellular matrix and skin fibrosis, vascular malformations, and skin tumors such as basal cell carcinoma, actinic keratoses, and malignant melanoma

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      Mentions: Thilo Gambichler
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