1. Featured Articles

    1-9 of 9
    1. Toward clinical elastography of dermal tissues: A medical device to probe skin’s elasticity through suction, with subsurface imaging via optical coherence tomography

      Toward clinical elastography of dermal tissues: A medical device to probe skin’s elasticity through suction, with subsurface imaging via optical coherence tomography

      ABSTRACT The mechanical behavior of dermal tissues is unarguably recognized for its diagnostic ability and in the last decades received a steadily increasing interest in dermatology practices. Among the various methods to investigate the mechanics of skin in clinical environments, suction-based ones are especially noteworthy, thanks to their qualities of minimal invasiveness and relative simplicity of setups and data analysis. In such experiments, structural visualization of the sample is highly desirable, both in its own right and because it enables elastography. The latter is a technique that combines the knowledge of an applied mechanical stimulus and the visualization of the ...

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    2. A Method for the Assessment of Textile Pilling Tendency Using Optical Coherence Tomography

      A Method for the Assessment of Textile Pilling Tendency Using Optical Coherence Tomography

      Pilling is caused by friction pulling and fuzzing the fibers of a material. Pilling is normally evaluated by visually counting the pills on a flat fabric surface. Here, we propose an objective method of pilling assessment, based on the textural characteristics of the fabric shown in optical coherence tomography (OCT) images. The pilling layer is first identified above the fabric surface. The percentage of protruding fiber pixels and Haralick’s textural features are then used as pilling descriptors. Principal component analysis (PCA) is employed to select strongly correlated features and then reduce the feature space dimensionality. The first principal component ...

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    3. Real-time retinal layer segmentation of OCT Volumes with GPU and Deep learning

      Real-time retinal layer segmentation of OCT Volumes with GPU and Deep learning

      Segmentation of retinal layers in optical coherence tomography (OCT) is an essential step in OCT image analysis for screening, diagnosis, and assessment of retinal disease progression. Real-time segmentation together with high-speed OCT volume acquisition allows rendering of en face OCT of arbitrary retinal layers, which can be used to increase the yield rate of high-quality scans, provide real-time feedback during image-guided surgeries, and compensate aberrations in adaptive optics (AO) OCT without using wavefront sensors. We demonstrate here unprecedented real-time OCT segmentation of eight retinal layer boundaries achieved by 3 levels of optimization: 1) a modified, low complexity, neural network structure ...

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    4. Frequency-doubled FDML-MOPA laser in the visible

      Frequency-doubled FDML-MOPA laser in the visible

      Wavelength-swept lasers enable high-speed measurements in absorption spectroscopy, Raman spectroscopy, nonlinear Raman hyperspectral microscopy, rapid confocal microscopy, short impulse generation, and most importantly for high-speed optical coherence tomography, with speeds up to video-rate volumetric imaging. Recently, we introduced a pulsed wavelength-swept laser based on the Fourier domain mode-locked (FDML) laser principle combined with a master-oscillator power amplifier (MOPA) architecture. The high peak powers reached with this laser enabled rapid two-photon microscopy and two-photon fluorescence lifetime microscopy and high-speed light detection and ranging measurements. Here, we present the extension of this laser into the visible wavelength range by frequency doubling the ...

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    5. Post-doctoral Scholar Position in OCT Endoscopy at the University of North Carolina at Chapel Hill

      Post-doctoral Scholar Position in OCT Endoscopy at the University of North Carolina at Chapel Hill

      The Coherence Imaging Laboratory at the University of North Carolina at Chapel Hill seeks a highly motivated Postdoc to perform research in optical coherence tomography (OCT) imaging. Research activities will include the development and application of our endoscopic OCT imaging systems for upper airway imaging, and its application for assessment of airway injury and upper airway disorders. Candidates are required to have demonstrated expertise with imaging hardware and hardware design, with particular consideration given to candidates with experience using fiber optics, fabricating fiber optic tips, using and setting up interferometers or similar optical systems, and setting up data acquisition systems ...

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    6. The analysis of prostate tissue by optical coherence tomography (Thesis)

      The analysis of prostate tissue by optical coherence tomography (Thesis)

      The prostate is the gland located around the urethra beneath the bladder that produces most of the sperm fluid (figure 1). Prostate cancer (PCa) accounted for almost 1 in 5 new cancer diagnoses in males in the USA in 2017, and 1 in 8 men will develop invasive cancer in the prostate in their lifetime [1]. Prostate cancer is the second most common cancer in men (after skin cancer) and the second most common cause of cancer-related death (after lung cancer). Advances in screening, diagnosis, and treatment have led to an overall survival increase from 69% in 1991-1995 to 89 ...

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    7. Sensorless adaptive-optics optical coherence tomographic angiography

      Sensorless adaptive-optics optical coherence tomographic angiography

      Optical coherence tomographic angiography (OCTA) can image the retinal blood flow but visualization of the capillary caliber is limited by the low lateral resolution. Adaptive optics (AO) can be used to compensate ocular aberrations when using high numerical aperture (NA), and thus improve image resolution. However, previously reported AO-OCTA instruments were large and complex, and have a small sub-millimeter field of view (FOV) that hinders the extraction of biomarkers with clinical relevance. In this manuscript, we developed a sensorless AO-OCTA prototype with an intermediate numerical aperture to produce depth-resolved angiograms with high resolution and signal-to-noise ratio over a 2 × 2 ...

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    8. Wasatch Photonics adds 1600 nm OCT spectrometer for deep tissue imaging

      Wasatch Photonics adds 1600 nm OCT spectrometer for deep tissue imaging

      Wasatch Photonics has expanded its Cobra OCT spectrometer product line with a new 1600 nm OCT spectrometer for deep-tissue, SD-OCT imaging. The Cobra 1600 builds on the company’s existing line of more than 25 off-the-shelf OCT spectrometer models at visible, 800 nm, 1050 nm, and 1300 nm wavelengths, with camera speeds up to 250 kHz. Addition of a 1600 nm model offers greater depth penetration with high contrast for highly scattering tissues and materials, with applications in cardiology, neurology, dermatology, dentistry, and non-destructive testing. The Cobra 1600 OCT spectrometer utilizes a 240 nm bandwidth centered at 1570 nm to ...

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    9. New Research Finds Abbott's Optical Coherence Tomography Imaging Changed Treatment Decisions in 88% of Artery Blockages

      New Research Finds Abbott's Optical Coherence Tomography Imaging Changed Treatment Decisions in 88% of Artery Blockages

      Abbott (NYSE: ABT ) today announced new data from the company's LightLab Initiative that showed optical coherence tomography (OCT) imaging significantly changes how physicians decide to treat a vessel compared to traditional angiography by providing physicians improved visualization within a patient's blood vessels. Data from the study revealed physicians altered their treatment strategy in 88% of coronary artery blockages based on new information provided by OCT. Using laser technology, OCT captures high-resolution images inside a patient's arteries, displaying the type and severity of disease in the vessel, as well as enabling more accurate measurements to determine how the ...

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    1-9 of 9
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