1. Featured Articles

    1-14 of 14
    1. Longitudinal optical coherence tomography to visualize the in vivo response of middle ear biofilms to antibiotic therapy

      Longitudinal optical coherence tomography to visualize the in vivo response of middle ear biofilms to antibiotic therapy

      Studying the impact of antibiotic treatment on otitis media (OM), the leading cause of primary care office visits during childhood, is critical to develop appropriate treatment strategies. Tracking dynamic middle ear conditions during antibiotic treatment is not readily applicable in patients, due to the limited diagnostic techniques available to detect the smaller amount and variation of middle ear effusion (MEE) and middle ear bacterial biofilm, responsible for chronic and recurrent OM. To overcome these challenges, a handheld optical coherence tomography (OCT) system has been developed to monitor in vivo response of biofilms and MEEs in the OM-induced chinchilla model, the ...

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    2. Rupture detection during needle insertion using complex OCT data and CNNs

      Rupture detection during needle insertion using complex OCT data and CNNs

      Objective: Soft tissue deformation and ruptures complicate needle placement. However, ruptures at tissue inter- faces also contain information which helps physicians to navigate through different layers. This navigation task can be challenging, whenever ultrasound (US) image guidance is hard to align and externally sensed forces are superimposed by friction. Methods: We propose an experimental setup for reproducible needle insertions, applying optical coherence tomography (OCT) directly at the needle tip as well as external US and force measurements. Processing the complex OCT data is challenging as the penetration depth is limited and the data can be difficult to interpret. Using a ...

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    3. Prevalence of subclinical retinal ischemia in patients with cardiovascular disease – a hypothesis driven study

      Prevalence of subclinical retinal ischemia in patients with cardiovascular disease – a hypothesis driven study

      Background Cardiovascular disease is the leading cause of mortality and disability worldwide. A noninvasive test that can detect underlying cardiovascular disease has the potential to identify patients at risk prior to the occurrence of adverse cardiovascular events. We sought to determine whether an easily observed imaging finding indicative of retinal ischemia, which we term ‘ retinal ischemic perivascular lesions’ (RIPLs), could serve as a biomarker for cardiovascular disease. Methods We reviewed optical coherence tomography (OCT) scans of individuals, with no underlying retinal pathology, obtained at UC San Diego Health from July 2014 to July 2019. We identified 84 patients with documented ...

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    4. Heart Disease is in the Eye of the Beholder

      Heart Disease is in the Eye of the Beholder

      In a new study from Shiley Eye Institute at UC San Diego Health, researchers have identified a potential new marker that shows cardiovascular disease may be present in a patient using an optical coherence tomography (OCT) scan — a non-invasive diagnostic tool commonly used in ophthalmology and optometry clinics to create images of the retina. The finding suggests it may be possible to detect heart disease during an eye examination. In the paper published March 2, 2021 in EClinical Medicine by The Lancet , the research team examined lesions of the retina, the inner-most, light-sensitive layer of the eye, to determine if ...

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    5. Postdoctoral Research Fellowship position in the Center for Ophthalmic Optics and Lasers, Casey Eye Institute, Oregon Health & Science University

      Postdoctoral Research Fellowship position  in the Center for Ophthalmic Optics and Lasers, Casey Eye Institute, Oregon Health & Science University

      A postdoctoral research fellowship position is immediately available in the Center for Ophthalmic Optics and Lasers www.COOLLab.net , Casey Eye Institute, Oregon Health & Science University. The fellowship will focus on interdisciplinary project in the field of optical imaging, image analysis, and glaucoma diagnosis. Ph.D. in Biomedical Engineering, Electrical Engineering, Computing Science, Optics, or a related field is required. Demonstrated excellence in one or more of the following areas is preferred: expertise in optical coherence tomography, image processing, artificial intelligence and machine learning, statistical analysis, C++/Matlab/R programming for data analysis. Please Contact Dr. Ou Tan ( tano@ohsu ...

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    6. PhD studentship in AI-Enabled OCT at Liverpool University, UK

      PhD studentship in AI-Enabled OCT at  Liverpool University, UK

      An EPSRC funded PhD studentship is available in the Laboratory of Professor Shen of Department of Electrical Engineering and Electronics, Liverpool University, UK. This project aims to develop artificial intelligence (AI)-enabled OCT techniques for imaging the corneal nerves in a non-contact manner. The candidate will be expected to refine and optimise the novel OCT instrumentation to achieve the required resolution and speed for imaging corneal nerves. The successful PhD candidate will benefit from working with a multidisciplinary team covering areas of imaging technology, AI and computer science, tissue engineering and medicine. Applicants should have (or expect to obtain by ...

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    7. Postdoc Position for Biomedical Engineer / Vision Scientist in the UC Davis EyePod - Small Animal Ocular Imaging Laboratory at University of California, Davis

      Postdoc Position for Biomedical Engineer / Vision Scientist in the UC Davis EyePod - Small Animal Ocular Imaging Laboratory at University of California, Davis

      Applications are invited for a post-doctoral research associate position in the UC Davis EyePod Small Animal Ocular Imaging Laboratory affiliated with Center for Vision Science ( http://cvs.ucdavis.edu ) at the UC Davis Main Campus. The goal of our research is to develop and translate the next generation in vivo cellular resolution multimodal retinal imaging instruments and data analysis tools from basic science to clinics and to apply them to in vivo study of disease mechanisms and therapeutic interventions. The ideal candidate will have strong skills in some combination of retinal/microscopic imaging modalities, including OCT, SLO, multispectral imaging, fluorescence ...

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    8. Remote monitoring with Home OCT

      Remote monitoring with Home OCT

      In this video, Anat Loewenstein, MD, MHA, speaks about a Home OCT device. This technology has been tested in studies, and patients have been given the chance to try it at home, following a few, simple instructions. Some of them also speak here. Home monitoring is one of the most promising new frontiers in healthcare, leading to: reduced number of patient visits reduced patient burden increased safety in the time of COVID-19 more frequent, consistent gathering and assessment of data timely, personalized treatment schedules

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      Mentions: Notal Vision
    9. Myths Associated With Optical Coherence Tomography for Glaucoma

      Myths Associated With Optical Coherence Tomography for Glaucoma

      D onald C. Hood, PhD, is the James F. Bender Professor of Psychology and Professor of Ophthalmic Sciences at Columbia University in New York, New York. His work has focused on improving the utility of optical coherence tomography (OCT) imaging in glaucoma treatment. He lectures on the lessons he has learned about the use of OCT, and how these lessons can aid the clinician in understanding and diagnosing glaucoma. Here, Glaucoma Physician talks with Dr. Hood about myths he believes glaucoma specialists hold about OCT for glaucoma. Q: How is OCT currently used in glaucoma management? A: Optical coherence tomography ...

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    10. Susana Marcos to lead Center for Visual Science

      Susana Marcos to lead Center for Visual Science

      Internationally recognized pioneer in vision science and its applications is named the next director of one of the University’s most highly regarded research centers. (Courtesy of Susana Marcos) Susana Marcos, an internationally recognized expert in the optics of the eye and the interactions of light with the retina, will become the David R. Williams Director of the Center for Visual Science at the University of Rochester . Her appointment will take effect July 1. The named position is endowed with a $2 million gift from John and Barbara Bruning. John, a member of the University’s Board of Trustees and ...

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    11. Material-specific imaging of nanolayers using extreme ultraviolet coherence tomography

      Material-specific imaging of nanolayers using extreme ultraviolet coherence tomography

      Scientific and technological progress depend substantially on the ability to image on the nanoscale. In order to investigate complex, functional, nanoscopic structures like, e.g., semiconductor devices, multilayer optics, or stacks of 2D materials, the imaging techniques not only have to provide images but should also provide quantitative information. We report the material-specific characterization of nanoscopic buried structures with extreme ultraviolet coherence tomography. The method is demonstrated at a laser-driven broadband extreme ultraviolet radiation source, based on high-harmonic generation. We show that, besides nanoscopic axial resolution, the spectral reflectivity of all layers in a sample can be obtained using algorithmic ...

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    12. A sharper look at the interior of semiconductors

      A sharper look at the interior of semiconductors

      Images provide information—what we can observe with our own eyes enables us to understand. Constantly expanding the field of perception into dimensions that are initially hidden from the naked eye, drives science forward. Today, increasingly powerful microscopes let us see into the cells and tissues of living organisms, into the world of microorganisms as well as into inanimate nature. But even the best microscopes have their limits. "To be able to observe structures and processes down to the nanoscale level and below, we need new methods and technologies," says Dr. Silvio Fuchs from the Institute of Optics and Quantum ...

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    13. Integrated Quad-Scanner Strategy-Based Optical Coherence Tomography for the Whole-Directional Volumetric Imaging of a Sample

      Integrated Quad-Scanner Strategy-Based Optical Coherence Tomography for the Whole-Directional Volumetric Imaging of a Sample

      Whole-directional scanning methodology is required to observe distinctive features of an entire physical structure with a three dimensional (3D) visualization. However, the implementation of whole-directional scanning is challenging for conventional optical coherence tomography (OCT), which scans a limited portion of the sample by utilizing unidirectional and bidirectional scanning methods. Therefore, in this paper an integrated quad-scanner (QS) strategy-based OCT method was implemented to obtain the whole-directional volumetry of a sample by employing four scanning arms installed around the sample. The simultaneous and sequential image acquisition capabilities are the conceptual key points of the proposed QS-OCT method, and were implemented using ...

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    14. Forensic Problems, Optical Solutions

      Forensic Problems, Optical Solutions

      Since first hitting the scene in 1991, optical coherence tomography (OCT) has become a leviathan among biomedical imaging techniques, due to the method’s nondestructive ability to resolve layers of tissue. In ophthalmology, especially, OCT has been revolutionary, imaging retinal layers noninvasively through an approximately one-inch-thick watery window—the human eye. Now, U.K. researchers in applied optics, forensic science and the document-examination industry have joined forces to apply OCT to the high-resolution subsurface analysis of multilayered identification documents (Sci. Justice, doi: 10.1016/j.scijus.2020.12.001 ). The method can reportedly detect forged passports or national ID cards ...

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    1-14 of 14
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