1. Featured Articles

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    1. Associations between the Framingham Risk Score and coronary plaque characteristics as assessed by three-vessel optical coherence tomography

      Associations between the Framingham Risk Score and coronary plaque characteristics as assessed by three-vessel optical coherence tomography

      Objectives: This study sought to explore the association between the Framingham Risk Score (FRS) and coronary plaque characteristics assessed by optical coherence tomography (OCT) imaging. Background: Clinical prediction models are useful for identifying high-risk patients. However, coronary events often occur in individuals estimated to be at low risk. Methods: A total of 254 patients with coronary artery disease who underwent three-vessel OCT were divided into tertiles according to FRS. Nonculprit plaque characteristics were compared among the three groups. Results: A total of 663 plaques were analyzed. FRS was significantly associated with calcification [37% (low FRS) vs. 46% (intermediate FRS) vs ...

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    2. Perimeter Medical Imaging Receives FDA Clearance for OTISTM Optical Tissue Imaging System

      Perimeter Medical Imaging Receives FDA Clearance for OTISTM Optical Tissue Imaging System

      Perimeter Medical Imaging, Inc., an innovative medical imaging company whose mission is to revolutionize tissue removal surgery for surgeons and patients, today announced receipt of U.S. Food and Drug Administration (FDA) 510(k) clearance for its OTIS TM 1.0 Optical Coherence Tomography System. The OTIS™ provides high-resolution, real-time imaging of the periphery of excised tissue, enabling clinicians to visualize sub-surface structures up to 2 mm below the surface. These sub-surface structures would otherwise not be evident until days – and often weeks – later when conventional histology slides are available for review. Dr. Ted James, Medical Director of Skin & Soft ...

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    3. Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

      Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

      Although retinal vasculitis is common in multiple sclerosis (MS), it is not known if MS is associated with quantitative abnormalities in retinal blood vessels (BVs). Optical coherence tomography (OCT) is suitable for examining the integrity of the anterior visual pathways in MS. In this paper we have compared the size and number of retinal blood vessels in patients with MS, with and without a history of optic neuritis (ON), and control subjects from the cross-sectional retinal images from OCT. Blood vessel diameter (BVD), blood vessel number (BVN), and retinal nerve fiber layer thickness (RNFL T ) were extracted from OCT images ...

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    4. Medical Marvel: Duke’s GPU-Powered Imaging Wins $150,000 Global Impact Award

      Medical Marvel: Duke’s GPU-Powered Imaging Wins $150,000 Global Impact Award

      Duke University researchers have received NVIDIA’s $150,000 Global Impact Award for their work using GPU-powered imaging techniques that give surgeons a 3D, stereoscopic live feed while performing highly sensitive ocular microsurgery. Nearly 30 applications from 13 nations were submitted for the annual award, which recognizes researchers using NVIDIA technology for groundbreaking work that addresses social, humanitarian and environmental problems. The Duke team, led by engineering professor Joseph Izatt , are using GPUs to transform how optical microsurgery is conducted. State-of-the-art microscopes produce 3D images of the eye every few microseconds to give surgeons immediate feedback during operations. Global Impact ...

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    5. Postdoctoral Research Fellowship in ophthalmic adaptive optics optical coherence tomography imaging at Duke University

      Postdoctoral Research Fellowship in ophthalmic adaptive optics optical coherence tomography imaging at Duke University

      Immediate opening at Duke University Biomedical Engineering Department for a Postdoctoral Research Associate interested in development of novel fast and high-resolution ophthalmic adaptive optics (AO) and Optical Coherence Tomography (OCT) imaging systems. Postdoc will be supervised by Prof. Joseph A. Izatt ( http://bme.duke.edu/faculty/joseph-izatt ) in collaboration with Prof. Sina Farsiu ( http://people.duke.edu/~sf59/ ). Multiple previous PhD students and postdocs from this team are now faculty members in top universities around the world. Requirement: PhD in EE, BME, or CS. The candidate must have a demonstrated strong background in optical design and photonics imaging as evidenced ...

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    6. Optical teardown of a Kindle Paperwhite display by OCT.

      Optical teardown of a Kindle Paperwhite display by OCT.

      An optical teardown, or reverse engineering, of an Amazon Kindle Paperwhite electrophoretic display was performed by Optical Coherence Tomography at 1060 nm. The display incorporates an optical diffuser, lightguide and scattering layers for white light illumination, capacitive touch sensing, and an electrophoretic display. All these layers can be imaged by OCT as well as the thin film transistor array on the back side for driving the pixels. Phase sensitive OCT is used to measure motion of the pigment particles as the display changes between black and white.

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    7. An Elastic Second Skin

      An Elastic Second Skin

      We report the synthesis and application of an elastic, wearable crosslinked polymer layer (XPL) that mimics the properties of normal, youthful skin. XPL is made of a tunable polysiloxane-based material that can be engineered with specific elasticity, contractility, adhesion, tensile strength and occlusivity. XPL can be topically applied, rapidly curing at the skin interface without the need for heat- or light-mediated activation. In a pilot human study, we examined the performance of a prototype XPL that has a tensile modulus matching normal skin responses at low strain (<40%), and that withstands elongations exceeding 250%, elastically recoiling with minimal strain-energy loss ...

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    8. SNR of swept SLEDs and swept lasers for OCT

      SNR of swept SLEDs and swept lasers for OCT

      A back-to-back comparison of a tunable narrow-band-filtered SLED (TSLED) and a swept laser are made for OCT applications. The two sources are similar in terms of sweep speed, tuning range and coherence length. A fundamental issue with a TSLED is that the RIN is proportional to 1/linewidth, meaning that the longer the coherence length, the higher the RIN and clock jitter. We show that the TSLED has an SNR limit that causes noise streaks at points of high reflection in images. The laser, which is shot noise limited, does not exhibit this effect. We add noise terms proportional to ...

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    9. Two Imaging Catheters Unite to Better Detect Dangerous Plaques in Arteries

      Two Imaging Catheters Unite to Better Detect Dangerous Plaques in Arteries

      Collaboration between two National Institute of Biomedical Imaging and Bioengineering (NIBIB)-funded labs has revealed a promising new method for identifying atherosclerotic plaques, the encased deposits in arteries that restrict blood flow and can lead to heart attack or stroke. The technique combines two different types of imaging, allowing for an unprecedented combination of depth and detail. The hybrid technology will provide doctors with a better diagnostic tool for identifying particularly problematic plaques. Heart disease is the leading cause of death worldwide. The majority of deaths from heart disease are caused by the rupture of a plaque lining an artery ...

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    10. NinePoint Medical Announces FDA 510(k) Clearance of a Real-Time Targeting Feature for the NvisionVLE® Imaging System and the First Clinical Cases in the U.S.

      NinePoint Medical Announces FDA 510(k) Clearance of a Real-Time Targeting Feature for the NvisionVLE® Imaging System and the First Clinical Cases in the U.S.

      NinePoint Medical, Inc., a transformative medical device company pioneering the use of a real-time imaging platform for gastrointestinal applications, announced today that it has received U.S. Food and Drug Administration (FDA) 510(k) clearance to market its Real-time Targeting™ feature for its flagship product, the NvisionVLE ® Imaging System. In addition, the first procedures with this new system were performed at Beth Israel Deaconess Medical Center in Boston, Massachusetts. The NvisionVLE Imaging System employs proprietary Optical Coherence Tomography (OCT) technology allowing physicians to perform a Volumetric Laser Endomicroscopy (VLE) procedure that produces real-time, high-resolution cross-sectional images. This system enables gastroenterologists ...

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    11. Polarization sensitive optical coherence microscopy for brain imaging

      Polarization sensitive optical coherence microscopy for brain imaging

      Optical coherence tomography (OCT) and optical coherence microscopy (OCM) have demonstrated the ability to investigate cyto- and myelo-architecture in the brain. Polarization-sensitive OCT provides sensitivity to additional contrast mechanisms, specifically the birefringence of myelination and, therefore, is advantageous for investigating white matter fiber tracts. In this Letter, we developed a polarization-sensitive optical coherence microscope (PS-OCM) with a 3.5 μm axial and 1.3 μm transverse resolution to investigate fiber organization and orientation at a finer scale than previously demonstrated with PS-OCT. In a reconstructed mouse brain section, we showed that at the focal depths of 20–70 μm, the ...

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    12. OCT Laser Device Allows Visualization of Skin Without Biopsy

      OCT Laser Device Allows Visualization of Skin Without Biopsy

      The annual incidence of skin cancer is more than breast, colon, lung, and prostate cancer combined. Of the 7 most common skin cancers in the US melanoma is the only one whose incidence is increasing. The highest risk group for skin cancer are fair skin, adults with a history of sun exposure.

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    13. OCT Postdoctoral Research Fellowships in the The Tearney Lab Wellman Center for Photomedicine Massachusetts General Hospital

      OCT Postdoctoral Research Fellowships in the The Tearney Lab Wellman Center for Photomedicine Massachusetts General Hospital

      A Postdoctoral research fellowship in the area of optical coherence tomography (OCT) is available in the Tearney Lab at the Massachusetts General Hospital (MGH) in the Wellman Center for Photomedicine. This appointment will be made at the rank of postdoctoral fellow or instructor at Harvard Medical School, commensurate with the applicant’s experience. MGH’s role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for developing and translating new OCT technologies with applications in basic and clinical research. The fellowship will focus on high resolution OCT imaging ...

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    14. VivoSight OCT used to visualize vascular networks in melanoma and non-melanoma skin cancers

      VivoSight OCT used to visualize vascular networks in melanoma and non-melanoma skin cancers

      Maidstone, UK, 3rd May 2016 New results have been published in Dermatology Online demonstrating that Michelson Diagnostics’ VivoSight OCT scanner can be used to image the blood vessel networks grown by skin cancers, and showing that skin lesions could be differentiated using their characteristic vascular patterns. This new technology may become a powerful tool in the dermatologists’s toolkit for the diagnosis of skin cancer and other conditions. The paper, entitled “Speckle-variance optical coherence tomography: a novel approach to skin cancer characterization using vascular patterns” was by Dr Orit Markowitz and co-workers from SUNY Downstate Medical Center, New Your Harbor ...

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    15. Abbott Agrees to Buy St. Jude in $25 Billion Deal

      Abbott Agrees to Buy St. Jude in $25 Billion Deal

      Abbott Laboratories agreed to acquire St. Jude Medical Inc. in a cash-and-stock deal valued at $25 billion that would create one of the leading makers of heart-related devices. Under the deal, Abbott agreed to swap $46.75 in cash and 0.8708 shares for each St. Jude share. The offer values each St. Jude share at about $85, representing a 37% premium to the stock’s closing price Wednesday. Shares of Abbott fell 7% to $40.60 in early trading, while St. Jude rose 25% to $77.70. The companies said the deal merges St. Jude’s strong positions in ...

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      Mentions: St. Jude Medical
    16. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today several dual-probe catheters have been introduced including combined near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), that is already commercially available, IVUS-optical coherence tomography (OCT), the OCT-NIRS, the OCT-near infrared fluorescence (NIRF) molecular ...

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    17. Mount Sinai Health System Experts Share Skin Cancer Tips and Patient Stories for Skin Cancer Awareness Month and Melanoma Monday

      Mount Sinai Health System Experts Share Skin Cancer Tips and Patient Stories for Skin Cancer Awareness Month and Melanoma Monday

      Skin cancer is the most common form of cancer in the United States, with one in five Americans developing it over the course of their lives. It’s also one of the most preventable types of cancers. In recognition of May’s Skin Cancer Awareness Month and Melanoma Monday on May 2nd, Mount Sinai Health System experts are arming the public with vital tips on prevention and offering FREE skin cancer screenings. Experts Available for Interview • Mark G. Lebwohl , MD, Sol and Clara Kest Professor of Dermatology, Kimberly and Eric J. Waldman Professor and Chair of the Kimberly and Eric ...

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    18. Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model

      Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model

      It is known that the progression of oral cancer is accompanied by changes in both tissue biochemistry and morphology. A multimodal imaging approach combining functional and structural imaging modalities could therefore provide a more comprehensive prognosis of oral cancer. This idea forms the central theme of the current study, wherein this premise is examined in the context of a multimodal imaging system that combines fluorescence lifetime imaging (FLIM) and optical coherence tomography (OCT). Towards this end, in the first part of the present study, the diagnostic advantage obtained by using both fluorescence intensity and lifetime information is assessed. In the ...

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    19. Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy: a serial optical coherence tomography study

      Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy: a serial optical coherence tomography study

      Objective: Previous studies have suggested that intensive statin therapy, compared with moderate statin therapy, provided greater reduction of LDL and better protection against major cardiovascular events. However, the exact dose-dependent mechanism of plaque stabilization remains unclear. The aim of this study is to investigate the three-dimensional (3D) response of fibrous caps overlying lipid plaques to statin therapy. Methods: We applied a novel computer algorithm to investigate the fibrous cap 3D morphological change over time in patients with coronary artery disease. Patients were treated with either atorvastatin 20 mg/day (moderate intensity) or atorvastatin 60 mg/day (high intensity). Optical coherence ...

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    20. Novel microscope-integrated stereoscopic heads-up display for intrasurgical optical coherence tomography

      Novel microscope-integrated stereoscopic heads-up display for intrasurgical optical coherence tomography

      Intra-operative optical coherence tomography (OCT) requires a display technology which allows surgeons to visualize OCT data without disrupting surgery. Previous research and commercial intrasurgical OCT systems have integrated heads-up display (HUD) systems into surgical microscopes to provide monoscopic viewing of OCT data through one microscope ocular. To take full advantage of our previously reported real-time volumetric microscope-integrated OCT (4D MIOCT) system, we describe a stereoscopic HUD which projects a stereo pair of OCT volume renderings into both oculars simultaneously. The stereoscopic HUD uses a novel optical design employing spatial multiplexing to project dual OCT volume renderings utilizing a single micro-display ...

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    21. OCT Angiography: Technology and Applications Webcast April 26th 2016, 1:00 EST

      OCT Angiography: Technology and Applications Webcast April 26th 2016, 1:00 EST

      Optical Coherence Tomography (OCT) has become the most widely used optical technique for medical imaging over the last decade. The technology is standard of care for diagnosis and disease management for several ophthalmic conditions and represents a market of over 500 million US dollars per year. Like other established medical imaging technologies, OCT is making its move from structural to functional imaging with advent of OCT angiography. However, unlike most other techniques OCT angiography does not rely on external contrast agents, making it particularly useful. This presentation will discuss principles and technology behind OCT angiography. A brief history of development ...

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    22. 4D imaging of cardiac trabeculae contracting in vitro using gated OCT

      4D imaging of cardiac trabeculae contracting in vitro using gated OCT

      Cardiac trabeculae are widely used as experimental muscle preparations for studying heart muscle. However, their geometry (diameter, length, and shape) can vary not only amongst samples, but also within a sample, leading to inaccuracies in estimating their stress production, volumetric energy output, and/or oxygen consumption. Hence, it is desirable to have a system that can accurately image each trabecula in vitro during an experiment. To this end, we constructed an optical coherence tomography (OCT) system and implemented a gated imaging procedure to image actively contracting trabeculae and reconstruct their time-varying geometry. By imaging a single cross section while monitoring ...

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    23. Post-doctoral Associate Position in Biophotonics/Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics/Biomedical Optical Imaging at Lehigh University

      Position description: A full-time Postdoctoral Associate position in Biophotonics / Biomedical Optical Imaging is available at Lehigh University starting ASAP . The primary purpose of this position will be for a highly motivated individual to develop advanced optical imaging techniques for novel biomedical applications in vitro and/or in vivo . Compensation is commensurate with experience. Qualifications: Ph.D. in Electrical Engineering, Physics, Applied Physics, Biomedical Engineering / Bioengineering or related fields. Hands-on experience with optical coherence tomography (OCT), especially phase-sensitive Fourier-domain OCT, is preferred. Good publication record and communication skills. Strong programming skills (Matlab, Labview, C++ and GPU programming) are pluses. Research areas ...

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    24. Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications

      Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications

      Recent advances in optical coherence tomography (OCT)-based angiography have demonstrated a variety of biomedical applications in the diagnosis and therapeutic monitoring of diseases with vascular involvement. While promising, its imaging field of view (FOV) is however still limited (typically less than 9 mm 2 ), which somehow slows down its clinical acceptance. In this paper, we report a high-speed spectral-domain OCT operating at 1310 nm to enable wide FOV up to 750 mm 2 . Using optical microangiography (OMAG) algorithm, we are able to map vascular networks within living biological tissues. Thanks to 2,048 pixel-array line scan InGaAs camera operating ...

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