1. Featured Articles

    1-17 of 17
    1. Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation

      Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation

      Optical coherence tomography (OCT) is a non-invasive technique for cross-sectional imaging. It is particularly advantageous for applications where conventional microscopy is not able to image deeper layers of samples in a reasonable time, e.g. in fast moving, deeper lying structures. However, at infrared and optical wavelengths, which are commonly used, the axial resolution of OCT is limited to about 1  μ m, even if the bandwidth of the light covers a wide spectral range. Here, we present extreme ultraviolet coherence tomography (XCT) and thus introduce a new technique for non-invasive cross-sectional imaging of nanometer structures. XCT exploits the nanometerscale coherence ...

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    2. A Case Series of Dural Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Association of Outcomes with Optical Coherence Tomography

      A Case Series of Dural Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Association of Outcomes with Optical Coherence Tomography

      Purpose/Aim : Pseudotumor cerebri, or idiopathic intracranial hypertension (IIH), is characterized by increased intracranial pressure of unknown etiology. A subset of patients has shown benefit from endovascular dural venous sinus stenting (DVSS). We sought to identify a population of IIH patients who underwent DVSS to assess outcomes. Materials and Methods : A retrospective study was performed to identify IIH patients with dural sinus stenosis treated with DVSS. Outcome measures included dural sinus pressure gradients, peripapillary retinal nerve fiber layer thickness using optical coherence tomography, and improvement in symptoms. Results : Seventeen patients underwent DVSS. Average pre- and post-intervention pressure gradients were 23 ...

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    3. Functional optical coherence tomography of rat olfactory bulb with periodic odor stimulation

      Functional optical coherence tomography of rat olfactory bulb with periodic odor stimulation

      In rodent olfactory bulb (OB), optical intrinsic signal imaging (OISI) is commonly used to investigate functional maps to odorant stimulations. However, in such studies, the spatial resolution in depth direction (z-axis) is lost because of the integration of light from different depths. To solve this problem, we propose functional optical coherence tomography (fOCT) with periodic stimulation and continuous recording. In fOCT experiments of in vivo rat OB, propionic acid and m-cresol were used as odor stimulus presentations. Such a periodic stimulation enabled us to detect the specific odor-responses from highly scattering brain tissue. Swept source OCT operating at a wavelength ...

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    4. Compact Imaging/NUI Galway Research Featured At Global Photonics Conference in San Francisco

      Compact Imaging/NUI Galway Research Featured  At Global Photonics Conference in San Francisco

      Researchers and technologists from Compact Imaging, Inc. (CI) and their research collaboration partner NUI Galway, who together are developing miniature optical sensors that noninvasively image and measure subsurface characteristics of human tissue, will have featured roles at the annual SPIE/Photonics West Conference, scheduled for February 13-18 at the Moscone Center in San Francisco. Prof. Martin J. Leahy, PhD, a key advisor to the Company and Chair of the Applied Physics Department at NUI Galway, will serve as a Conference chair and will present a significant paper on Compact Imaging’s innovative OCT technology, MRO™ (Multiple Reference OCT), titled, “The ...

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    5. Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm –1 ; 3.85 mm –1 ; p < 0.0001) for all patients combined. The area under the ROC curve was 0.64. In order to circumvent the effect of histopathology mismatching, we performed a sub-analysis on only OCT data in which tumor ...

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    6. Complex master slave interferometry

      Complex master slave interferometry

      A general theoretical model is developed to improve the novel Spectral Domain Interferometry method denoted as Master/Slave (MS) Interferometry. In this model, two functions, g and h are introduced to describe the modulation chirp of the channeled spectrum signal due to nonlinearities in the decoding process from wavenumber to time and due to dispersion in the interferometer. The utilization of these two functions brings two major improvements to previous implementations of the MS method. A first improvement consists in reducing the number of channeled spectra necessary to be collected at Master stage. In previous MSI implementation, the number of ...

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    7. St. Jude Medical Announces Launch of OPTIS Mobile System in Europe and Japan

      St. Jude Medical Announces Launch of OPTIS Mobile System in Europe and Japan

      St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced the launch of the company’s OPTIS™ Mobile System in Japan and Europe. The diagnostic system is designed to couple state-of-the-art optical coherence tomography (OCT) and angiography co-registration with fractional flow reserve (FFR) technology into one portable system for hospitals with multiple catheterization labs. OPTIS Mobile Integrated Lab (Photo: Business Wire) Driven by a global increase in vascular disease and enabled by advances in technology, the catheterization lab allows physicians to use minimally invasive percutaneous coronary intervention (PCI) procedures that give patients an alternative to open heart ...

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      Mentions: St. Jude Medical
    8. Post-Doc Position for biomedical engineer / vision scientist in the UC Davis EyePod - Small Animal Retinal Imaging Laboratory at University of California, Davis

      Post-Doc Position for biomedical engineer / vision scientist in the UC Davis EyePod - Small Animal Retinal Imaging Laboratory at University of California, Davis

      Applications are invited for a post-doctoral research associate position in the UC Davis EyePod Small Animal Imaging Laboratory in the Department of Cell Biology and Human Anatomy at the UC Davis Main Campus. The goal of our research is to develop and translate the next generation in vivo cellular resolution multimodal retinal imaging instruments and data analysis tools and to apply them to disease mechanisms and therapeutic interventions that can be investigated in the eye. The ideal candidate will have strong skills in some combination of retinal/microscopic imaging modalities, including but not limited to adaptive optics (AO), OCT, SLO ...

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    9. Optovue Releases AngioAnalytics, World's First OCTA Blood Vessel Measurement Technology

      Optovue Releases AngioAnalytics, World's First OCTA Blood Vessel Measurement Technology

      Optovue , the global leader in the development and commercialization of optical coherence tomography angiography (OCTA), today announced commercial availability of AngioAnalytics™*, the next generation of its OCTA technology available on the AngioVue™ ** Imaging System, for use outside of the U.S. This new capability enables clinicians to quantify the density of blood flow in the retina, the light-sensitive portion of the eye, to help manage diseases that cause progressive blindness such as diabetic retinopathy or acute macular degeneration. Optovue also announced it will host an educational symposium at the World Ophthalmology Congress ( WOC 2016 ) entitled, "The Transformative Power of Quantitative ...

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    10. Use of intravascular ultrasound vs. optical coherence tomography for mechanism and patterns of in-stent restenosis among bare metal stents and drug eluting stents

      Use of intravascular ultrasound vs. optical coherence tomography for mechanism and patterns of in-stent restenosis among bare metal stents and drug eluting stents

      This article is a perspective responses to the “Mechanisms and Patterns of Intravascular Ultrasound In-Stent Restenosis Among Bare Metal Stents and First- and Second-Generation Drug-Eluting Stents” by Goto et al ., The above mentioned article outlines the use of intravascular ultrasound (IVUS) in visualizing the patterns and mechanisms of in-stent restenosis (ISR) post percutaneous coronary intervention (PCI). Although IVUS is an appropriate method of choice for this scenario, IVUS has certain limitations which can be overcome by using optical coherent tomography (OCT). OCT is not only able to overcome IVUS’s limitations but is also able to provide additional information to ...

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    11. Automated imaging technologies for the diagnosis of glaucoma: a comparative diagnostic study for the evaluation of the diagnostic accuracy, performance as triage tests and cost-effectiveness (GATE study

      Automated imaging technologies for the diagnosis of glaucoma: a comparative diagnostic study for the evaluation of the diagnostic accuracy, performance as triage tests and cost-effectiveness (GATE study

      Background Many glaucoma referrals from the community to hospital eye services are unnecessary. Imaging technologies can potentially be useful to triage this population. Objectives To assess the diagnostic performance and cost-effectiveness of imaging technologies as triage tests for identifying people with glaucoma. Design Within-patient comparative diagnostic accuracy study. Markov economic model comparing the cost-effectiveness of a triage test with usual care. Setting Secondary care. Participants Adults referred from the community to hospital eye services for possible glaucoma. Interventions Heidelberg Retinal Tomography (HRT), including two diagnostic algorithms, glaucoma probability score (HRT-GPS) and Moorfields regression analysis (HRT-MRA); scanning laser polarimetry [glaucoma diagnostics ...

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    12. Determination of a material characteristic with the use of second-order photon correlation

      Determination of a material characteristic with the use of second-order photon correlation

      An optical system and method for characterizing an object is provided. The system includes at least one light source configured to direct photons toward an object and an interferometer configured to receive photons from the object. The system also includes at least one detector system adapted to detect an optical signal at an output of the interferometer and to remove, from the detected optical signal, a signal portion representing first order photon correlations, when present. The system also includes a processor configured to receive data relating to second-order correlated photons from said at least one detector system, each photon or ...

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    13. Customized Tool for the Validation of Optical Coherence Tomography in Differentiation of Prostate Cancer

      Customized Tool for the Validation of Optical Coherence Tomography in Differentiation of Prostate Cancer

      Objective: To design and demonstrate a customized tool to generate histologic sections of the prostate that directly correlate with needle-based optical coherence tomography pullback measurements. Materials and Methods: A customized tool was created to hold the prostatectomy specimens during optical coherence tomography measurements and formalin fixation. Using the tool, the prostate could be sliced into slices of 4 mm thickness through the optical coherence tomography measurement trajectory. In this way, whole-mount pathology slides were produced in exactly the same location as the optical coherence tomography measurements were performed. Full 3-dimensional optical coherence tomography pullbacks were fused with the histopathology slides ...

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    14. Review of optical coherence tomography based angiography in neuroscience

      Review of optical coherence tomography based angiography in neuroscience

      The brain is a complex ecosystem, consisting of multiple layers and tissue compartments. To facilitate the understanding of its function and its response to neurological insults, a fast in vivo imaging tool with a micron-level resolution, which can provide a field of view at a few millimeters, is desirable. Optical coherence tomography (OCT) is a noninvasive method for imaging three-dimensional biological tissues with high resolution ( ∼ 10    μ m ∼10  μm ) and without a need for contrast agents. Recent development of OCT-based angiography has started to shed some new light on cerebral hemodynamics in neuroscience. We give an overview of the recent ...

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    15. Optical coherence tomography system mass-producible on a silicon photonic chip

      Optical coherence tomography system mass-producible on a silicon photonic chip

      Miniaturized integrated optical coherence tomography (OCT) systems have the potential to unlock a wide range of both medical and industrial applications. This applies in particular to multi-channel OCT schemes, where scalability and low cost per channel are important, to endoscopic implementations with stringent size demands, and to mechanically robust units for industrial applications. We demonstrate that fully integrated OCT systems can be realized using the state-of-the-art silicon photonic device portfolio. We present two different implementations integrated on a silicon-on-insulator (SOI) photonic chip, one with an integrated reference path (OCT int ) for imaging objects in distances of 5 mm to 10 ...

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    16. Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Purpose To compare the diagnostic imaging ability of three different optical coherence tomography (OCT) devices in non-melanoma skin cancer (NMSC). Methods Thirty actinic keratoses (AKs) and 27 basal cell carcinomas (BCCs) of 29 patients were examined with three different OCT devices, VivoSight ® , Callisto ® and Skintell ® . Results Complete data sets were available for 16 BCCs and 10 AKs of 18 patients. All OCT devices were able to discriminate BCCs and AKs significantly from perilesional normal skin due to lower signal intensities as well as a thicker stratum corneum and epidermis in AKs. A significant decrease in the signal intensity and thickness ...

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    17. Optical Coherence Tomography Industry Has Provided Well Over 20,000 Person-Years of Direct Employment

      Optical Coherence Tomography Industry Has Provided Well Over 20,000 Person-Years of Direct Employment

      The field of Optical Coherence Tomography (OCT) has grown dramatically since its discovery in the early 1990’s. The commercialization and growth of OCT which has occurred over the past 25 years has been highly impactful, scientifically, clinically, and economically. Many factors have helped drive this success starting with the clinical need for new cost-effective high-resolution minimally-invasive imaging solutions for various diagnostic and therapeutic applications. But equally important to this success has been the worldwide ecosystem consisting of the intertwined role of scientists, engineers, clinicians, professional societies, government agencies, government funding, regulatory bodies, entrepreneurs, venture capitalists, and small and large ...

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    1-17 of 17
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