1. Featured Articles

    1-24 of 100 1 2 3 4 5 »
    1. Pediatric Sleep-Related Breathing Disorders: Advances in imaging and computational modeling.

      Pediatric Sleep-Related Breathing Disorders: Advances in imaging and computational modeling.

      We understand now that sleep of sufficient length and quality is required for good health. This is particularly true for infants and children, who have the added physiologic task of growth and development, as compared to their adult counterparts. Sleep-related breathing disorders (SRBDs) are common in childhood and if unrecognized and not treated can result in significant morbidity. For example, children with obstructive sleep apnea (OSA) can exhibit behavioral, mood, and learning difficulties. If left untreated, alterations in the function of the autonomic nervous system and a chronic inflammatory state result, contributing to the risk of heart disease, stroke, glucose ...

      Read Full Article
    2. Probing biological nanotopology via diffusion of weakly constrained plasmonic nanorods with optical coherence tomography

      Probing biological nanotopology via diffusion of weakly constrained plasmonic nanorods with optical coherence tomography

      Biological materials exhibit complex nanotopology , i.e., a composite liquid and solid phase structure that is heterogeneous on the nanoscale. The diffusion of nanoparticles in nanotopological environments can elucidate biophysical changes associated with pathogenesis and disease progression. However, there is a lack of methods that characterize nanoprobe diffusion and translate easily to in vivo studies. Here, we demonstrate a method based on optical coherence tomography (OCT) to depth-resolve diffusion of plasmon-resonant gold nanorods (GNRs) that are weakly constrained by the biological tissue. By using GNRs that are on the size scale of the polymeric mesh, their Brownian motion is minimally ...

      Read Full Article
    3. Endoscopy for diagnosis and treatment in esophageal cancers: high-technology assessment

      Endoscopy for diagnosis and treatment in esophageal cancers: high-technology assessment

      The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the endoscopic tools to recognize squamous cell dysplasia; confocal laser endomicroscopy for Barrett's esophagus; confocal microscopy in the cancer patient; optical coherence tomography in the assessment of subsquamous Barrett's metaplasia; endoscopic mucosal resection for high-grade dysplasia in Barrett's esophagus; HALO in the treatment of squamous dysplasia; and the use of fluorescence in situ hybridization to detect dysplasia and adenocarcinoma in patients with Barrett's esophagus.

      Read Full Article
    4. Rescuing US biomedical research from its systemic flaws

      Rescuing US biomedical research from its systemic flaws

      The long-held but erroneous assumption of never-ending rapid growth in biomedical science has created an unsustainable hypercompetitive system that is discouraging even the most outstanding prospective students from entering our profession—and making it difficult for seasoned investigators to produce their best work. This is a recipe for long-term decline, and the problems cannot be solved with simplistic approaches. Instead, it is time to confront the dangers at hand and rethink some fundamental features of the US biomedical research ecosystem.

      Read Full Article
    5. Glenn vs. The Volcano

      Glenn vs. The Volcano

      Today saw a "volley across the bow" between Volcano Corporation (Nasdaq: VOLC), a major manufacturer of IVUS, FFR and iFR technologies, and Engaged Capital LLC, an investment firm which holds over two million shares, or 5.1%, of Volcano stock. Engaged founder Glenn W. Welling sent a letter to Volcano demanding that the company begin a search for a new CEO and find a buyer for the company (press release printed below). The letter was prompted by the fact that Volcano's stock price has dropped by more than half over the past year. Engaged has been in discussions with ...

      Read Full Article
    6. Bioptigen to Receive Grants Totaling $1.72 Million from the National Eye Institute for Development of Intraoperative SD-OCT

      Bioptigen to Receive Grants Totaling $1.72 Million  from the National Eye Institute for Development of Intraoperative SD-OCT

      Bioptigen announced today that the U.S. National Eye Institute, has allocated a total of $1.72 Million in grants to Bioptigen Inc. for development of microscope integrated intraoperative OCT technology. Presently, perioperative OCT imaging is performed using a hand-held probe, or by mounting such a probe to the surgical microscope. Under the new NEI grant, Bioptigen will advance development of a novel intraoperative OCT system integrated directly into the optical train of the surgical microscope. "The work advanced under these grants will bring surgeons one step closer to realizing the full value of intraoperative OCT," said Dr. Eric Buckland ...

      Read Full Article
    7. Engaged Capital Sends Letter to the Board of Volcano Corporation

      Engaged Capital Sends Letter to the Board of Volcano Corporation

      Engaged Capital, an investment firm specializing in small and mid-cap North American equities and beneficial owner of approximately 2,638,403 shares of the common stock of Volcano Corporation (“VOLC” or the “Company”) (Nasdaq:VOLC), today sent an open letter http://engagedcapital.com/press/VOLCBODLetter.pdf to the Company’s Board of Directors (the “Board”), filed with the U.S. Securities and Exchange Commission. “It is time for new leadership. We urge the Board to immediately commence a parallel process to evaluate strategic alternatives and conduct a search for CEO candidates with a history of driving profitability and extracting value ...

      Read Full Article
    8. Quantitative technique for robust and noise-tolerant speed measurements based on speckle decorrelation in optical coherence tomography

      Quantitative technique for robust and noise-tolerant speed measurements based on speckle decorrelation in optical coherence tomography

      Intensity-based techniques in optical coherence tomography (OCT), such as those based on speckle decorrelation, have attracted great interest for biomedical and industrial applications requiring speed or flow information. In this work we present a rigorous analysis of the effects of noise on speckle decorrelation, demonstrate that these effects frustrate accurate speed quantitation, and propose new techniques that achieve quantitative and repeatable measurements. First, we derive the effect of background noise on the speckle autocorrelation function, finding two detrimental effects of noise. We propose a new autocorrelation function that is immune to the main effect of background noise and permits quantitative ...

      Read Full Article
    9. In-situ biofilm characterization in membrane systems using Optical Coherence Tomography: Formation, structure, detachment and impact of flux change

      In-situ biofilm characterization in membrane systems using Optical Coherence Tomography: Formation, structure, detachment and impact of flux change

      Biofouling causes performance loss in spiral wound nanofiltration (NF) and reverse osmosis (RO) membrane operation for process and drinking water production. The development of biofilm formation, structure and detachment was studied in-situ, non-destructively with Optical Coherence Tomography (OCT) in direct relation with the hydraulic biofilm resistance and membrane performance parameters: transmembrane pressure drop (TMP) and feed-channel pressure drop (FCP). The objective was to evaluate the suitability of OCT for biofouling studies, applying a membrane biofouling test cell operated at constant crossflow velocity (0.1 m s -1 ) and permeate flux (20 L m -2 h -1 ). In time, the biofilm ...

      Read Full Article
    10. A feasibility study of full-field optical coherence tomography for rapid evaluation of EUS-guided microbiopsy specimens

      A feasibility study of full-field optical coherence tomography for rapid evaluation of EUS-guided microbiopsy specimens

      Background Rapid on-site evaluation of cytologic specimens is a way of determining the adequacy of fine-needle aspiration (FNA). However, alternatives may be useful when the presence of a cytotechnologist and/or pathologist is not possible. Objective To evaluate the feasibility of using full-field optical coherence tomography (FFOCT) for FNA specimen quality assessment. Design FFOCT images were acquired on gastric, pancreatic, pelvic, and lymph-node formalin-fixed FNA specimens and were compared with histology of the same samples. Setting Pathology suite in a hospital. Patients Fourteen patients undergoing gastric, pancreatic, pelvic, or lymph-node EUS-guided FNA biopsy. Interventions FFOCT imaging on formalin-fixed samples before ...

      Read Full Article
    11. Hybrid single-source online Fourier transform coherent anti-Stokes Raman scattering/optical coherence tomography

      Hybrid single-source online Fourier transform coherent anti-Stokes Raman scattering/optical coherence tomography

      We demonstrate a multimodal optical coherence tomography (OCT) and online Fourier transform coherent anti-Stokes Raman scattering (FTCARS) platform using a single sub-12 femtosecond (fs) Ti:sapphire laser enabling simultaneous extraction of structural and chemical (“morphomolecular”) information of biological samples. Spectral domain OCT prescreens the specimen providing a fast ultrahigh ( 4 × 12     μ m axial and transverse) resolution wide field morphologic overview. Additional complementary intrinsic molecular information is obtained by zooming into regions of interest for fast label-free chemical mapping with online FTCARS spectroscopy. Background-free CARS is based on a Michelson interferometer in combination with a highly linear piezo stage, which allows ...

      Read Full Article
    12. Full-Field Optical Coherence Tomography of Human Donor and Pathological Corneas

      Full-Field Optical Coherence Tomography of Human Donor and Pathological Corneas

      Purpose : To evaluate the performance of a full-field optical coherence tomography (FF-OCT) system in the study of human donor and pathological corneas and assess its suitability for use in eye banks. Methods : Our study was carried out using an FF-OCT system developed for non-invasive imaging of tissue structures in depth with ultrahigh resolution (1 µm in all directions). Images were acquired from eight stored human donor corneas (either edematous or after deswelling) and five surgical specimens of corneas with various diseases (bullous keratopathy, lattice corneal dystrophy, stromal scar after keratitis, keratoconus and Fuchs dystrophy). They were compared with standard histology ...

      Read Full Article
    13. Capabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques

      Capabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques

      Serious concerns exist about the Review by Otsuka et al . (Clinical classification of plaque morphology in coronary disease. Nat. Rev. Cardiol. 11, 379–389; 2014 ), 1 some of which are discussed in this Correspondence. The concerns are predominately about the authors' understanding of the principles and application of optical coherence tomography (OCT),

      Read Full Article
    14. Automated identification of basal cell carcinoma by polarization-sensitive optical coherence tomography

      Automated identification of basal cell carcinoma by polarization-sensitive optical coherence tomography

      We report an automated classifier to detect the presence of basal cell carcinoma in images of mouse skin tissue samples acquired by polarization-sensitive optical coherence tomography (PS-OCT). The sensitivity and specificity of the classifier based on combined information of the scattering intensity and birefringence properties of the samples are significantly higher than when intensity or birefringence information are used alone. The combined information offers a sensitivity of 94.4% and specificity of 92.5%, compared to 78.2% and 82.2% for intensity-only information and 85.5% and 87.9% for birefringence-only information. These results demonstrate that analysis of the ...

      Read Full Article
    15. 3D Polymer Weld Seam Characterization Based on Optical Coherence Tomography for Laser Transmission Welding Applications

      3D Polymer Weld Seam Characterization Based on Optical Coherence Tomography for Laser Transmission Welding Applications

      Laser transmission welding is an established single-stage plastic joining process, which enables hermetically sealed joints under the workpiece surface. The process requires joining partners with proper degrees of transmission and absorption to the processing wavelength. For reaching a stable process an in-process quality assurance is very valuable. Current monitoring systems have a limited usage, as no quantitative information of the weld itself is obtained without its destruction. In medical and pharmaceutical applications a weld with leakage is e.g. unacceptable. The main objective of this paper is the presentation of the optical coherence tomography as a tool for the quality ...

      Read Full Article
    16. In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography

      In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography

      Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.

      Read Full Article
    17. Orion is in Beta - Voxeleron prepares the release of their advanced OCT analysis software

      Orion is in Beta - Voxeleron prepares the release of their advanced OCT analysis software

      Orion™, Voxeleron’s advanced optical coherence tomography (OCT) analysis software, is currently being beta tested at a number of sites in the USA and Europe in preparation for release. Orion™ is an application that offers fully-automated, rapid and accurate segmentation of seven layers in OCT images of the human retina. Following the successful release of InSight , Voxeleron’s animal OCT package, Orion™ establishes Voxeleron as leaders in the development of OCT image analysis software. "The Orion software gives us the ability to measure the thickness of the nuclear layers in isolation, so is a welcome addition to our quantification tools ...

      Read Full Article
    18. Two-dimensional optical coherence tomography for real-time structural dynamical characterization

      Two-dimensional optical coherence tomography for real-time structural dynamical characterization

      We present a two-dimensional optical coherence vibration tomography (2DOCVT) system with an ultra-precision displacement resolution of ~0.1 nm that is capable of in site real-time absolute displacement measurement of structural line vibrations. Experimental results of sinusoidal, sweep and impulse vibrations were reported. The key figures of merit such as the 2DOCVT system could obtain fast line vibration measurement without scanning and it also could be used to capture structural modal parameters in one single impulse excitation measurement without any vibration excitation input information, making it attractive for the application in low-frequency vibration measurement and response-only modal analysis.

      Read Full Article
    19. Detection of plasmonic nanoparticles with full field-OCT: optical and photothermal detection

      Detection of plasmonic nanoparticles with full field-OCT: optical and photothermal detection

      Detecting the signal backscattered by nanoparticles immersed in highly scattering media such as biological tissue remains a challenge. In this article we report on the use of Full Field OCT (FF-OCT) to slice in depth in phantoms and in tissues in order a) to selectively observe the particles through the backscattered light at suitable wavelengths, and b) to detect the effects of the time-dependent response to full field optical heating through the strong absorption cross-section of these plasmonic nanoparticles. The analysis of the thermal wave behavior leads to the localization of the heat sources even when FF-OCT signals cannot reach ...

      Read Full Article
    20. St. Jude Medical Announces Launch of OPTIS Integrated System

      St. Jude Medical Announces Launch of OPTIS Integrated System

      The OPTIS™ Integrated System combines OCT imaging with angiography to provide more detailed, on-demand coronary assessment for more accurate PCI guidanc e St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced the company has secured CE Mark and FDA clearance for the new OPTIS Integrated System. The system is a departure from traditional, mobile cart-based diagnostic tools and advances percutaneous coronary intervention (PCI) optimization via direct installation into a hospital’s cardiac catheterization laboratory, fully integrating optical coherence tomography (OCT) and fractional flow reserve (FFR) into PCI workflow. The approval of the OPTIS Integrated system marks ...

      Read Full Article
    21. Quantitative measurements of strain and birefringence with common-path polarization-sensitive optical coherence tomography

      Quantitative measurements of strain and birefringence with common-path polarization-sensitive optical coherence tomography

      We demonstrate the first system for optical coherence tomography (OCT) that enables simultaneous measurement of quantitative birefringence and strain in biological samples using a common-path configuration. Owing to its superior phase stability, common-path polarization sensitive optical coherence tomography (CoPPSe-OCT) achieves a sub-nanometer displacement sensitivity of 0.52 nm at an SNR of 48 dB. We utilize CoPPSe-OCT to measure reflectance, birefringence, and strain for distinguishing burnt regions in a birefringent biological sample (chicken breast muscle).

      Read Full Article
    22. In vivo functional microangiography by visible-light optical coherence tomography

      In vivo functional microangiography by visible-light optical coherence tomography

      Although hemoglobin oxygen saturation (sO 2 ) in the microvasculature is an essential physiological parameter of local tissue functions, non-invasive measurement of microvascular sO 2 is still challenging. Here, we demonstrated that visible-light optical coherence tomography (vis-OCT) can simultaneously provide three-dimensional anatomical tissue morphology, visualize microvasculature at the capillary level, and measure sO 2 from the microvasculature in vivo . We utilized speckle contrast caused by the moving blood cells to enhance microvascular imaging. We applied a series of short-time inverse Fourier transforms to obtain the spectroscopic profile of blood optical attenuation, from which we quantified sO 2 . We validated the sO ...

      Read Full Article
    23. Point-of-care and point-of-procedure optical imaging technologies for primary care and global health

      Point-of-care and point-of-procedure optical imaging technologies for primary care and global health

      Leveraging advances in consumer electronics and wireless telecommunications, low-cost, portable optical imaging devices have the potential to improve screening and detection of disease at the point of care in primary health care settings in both low- and high-resource countries. Similarly, real-time optical imaging technologies can improve diagnosis and treatment at the point of procedure by circumventing the need for biopsy and analysis by expert pathologists, who are scarce in developing countries. Although many optical imaging technologies have been translated from bench to bedside, industry support is needed to commercialize and broadly disseminate these from the patient level to the population ...

      Read Full Article
    24. Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images

      Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images

      We present a novel fully automated algorithm for the detection of retinal diseases via optical coherence tomography (OCT) imaging. Our algorithm utilizes multiscale histograms of oriented gradient descriptors as feature vectors of a support vector machine based classifier. The spectral domain OCT data sets used for cross-validation consisted of volumetric scans acquired from 45 subjects: 15 normal subjects, 15 patients with dry age-related macular degeneration (AMD), and 15 patients with diabetic macular edema (DME). Our classifier correctly identified 100% of cases with AMD, 100% cases with DME, and 86.67% cases of normal subjects. This algorithm is a potentially impactful ...

      Read Full Article
    1-24 of 100 1 2 3 4 5 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles