1. Featured Articles

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    1. Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Objective: We used optical coherence tomography (OCT) to assess the impact of thrombus aspiration before angioplasty on poststenting tissue protrusions in patients undergoing a primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Methods and results: A total of 188 patients with STEMI who underwent thrombus-aspiration PCI (n=113) or standard PCI (n=75) were examined in this study. OCT was performed immediately after primary PCI to assess lesion morphology in the stented segment. The minimum stent area was similar between the thrombus-aspiration PCI group and the standard PCI group [7.4 interquartile range (IQR): 5.8-9.4 ...

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    2. Postdoctoral Researcher in Photonics technologies for miniature biometric and healthcare instrumentation at the National University of Ireland

      Postdoctoral Researcher in Photonics technologies for miniature biometric and healthcare instrumentation at the National University of Ireland

      Postdoctoral Researcher in Photonics technologies for miniature biometric and healthcare instrumentation ‘Multiple-Reference Optical Coherence Tomography’ (MR-OCT) Tissue Optics and Microcirculation imaging Laboratory School of Physics National University of Ireland, Galway Ref. No. NUIG XX-15 Applications are invited from suitably qualified candidates for a full-time, fixed term position as a photonics technology postdoctoral research scientist with the Tissue Optics and Microcirculation Imaging Facility Laboratory (TOMI) at the National University of Ireland, Galway. This position is funded by a mix of commercial and public funding. The position is available from the 1st of September 2015 on a two year fixed term contract ...

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    3. Post-doctoral Research Fellowship at Yale in Cardiovascular Molecular and Translational Imaging

      Post-doctoral Research Fellowship at Yale in Cardiovascular Molecular and Translational Imaging

      Post-doctoral research fellowship immediately available at Yale on NIH funded T32 training grant focused on providing multi-disciplinary multi-modality training in molecular and translational cardiovascular imaging for highly qualified fellows holding either a MD or/and PhD, in preparation for academic careers as independent investigators in the highly clinically relevant field of cardiovascular imaging. Post-doctoral fellowship training will be 2-3 years in duration. There are three primary research focuses in the post-doctoral training, 1) cardiovascular molecular imaging, 2) cardiovascular imaging technologies and analyses, and 3) translational cardiovascular imaging. Applicants will have full access to resources available through the Yale Translational Research ...

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    4. Acquisition of Spin-out Company Bioptigen to Bring Duke Imaging Technology to New Markets

      Acquisition of Spin-out Company Bioptigen to Bring Duke Imaging Technology to New Markets

      In June 2015, microscopy and imaging systems company Leica Microsystems acquired Bioptigen Inc., a company born from Duke's Pratt School of Engineering. Formed in 2004, Bioptigen has become a leader in optical coherence tomography (OCT), an imaging technique that uses light to capture extremely high-resolution, three-dimensional pictures of the eye. Bioptigen was the brainchild of Duke’s Michael J. Fitzpatrick Professor of Engineering Joseph Izatt and CEO Eric Buckland. Since its launch, the company secured more than 60 issued patents in OCT technology, many of which were licensed from intellectual property developed by Izatt, his students, and collaborators at ...

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    5. Recent development of optical coherence tomography for preoperative diagnosis of esophageal malignancies

      Recent development of optical coherence tomography for preoperative diagnosis of esophageal malignancies

      Endoscopic diagnosis with histological evidence is necessary to decide the best strategy for treating esophageal squamous cell carcinoma and Barrett’s-associated neoplasia, and the recent development of endoscopic technologies have made possible real-time information of malignant hallmarks. We focused on the development of optical coherence tomography (OCT), the only technology that can depict real-time cross-sectional images with high resolution. With the improvements in image resolution, acquisition rate and demonstrable area of three-dimensional devices with Doppler capability, OCT imaging was shown to enable visualization of structural/ functional alterations in the mucosal/submucosal tissue of the esophagus, resulting in more accurate preoperative ...

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    6. Illuminating Culprit Plaque Histology by Optical Coherence Tomography : Shedding New Light on Old Insights

      Illuminating Culprit Plaque Histology by Optical Coherence Tomography : Shedding New Light on Old Insights

      Coronary atherosclerosis continues to be major cause of death in the developed world ( (1) ). Although we have known for at least a century that fissures and ruptures of coronary arteries are the cause of coronary thrombosis and, in the last 2 decades, that plaque erosion and calcified nodule are additional causes of thrombosis, our ability to use this knowledge in a real-time fashion to affect the treatment of patients with acute coronary syndromes (ACS) has been limited ( (2) ). Although angiography-guided percutaneous coronary intervention (PCI) has become the standard of care for treatment of ACS, it provides little understanding of culprit ...

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      Mentions: Emory University
    7. Long Range Optical Coherence Tomography of the Neonatal Upper Airway for Early Diagnosis of Intubation-related Subglottic Injury

      Long Range Optical Coherence Tomography of the Neonatal Upper Airway for Early Diagnosis of Intubation-related Subglottic Injury

      Subglottic edema and acquired subglottic stenosis are potentially airway -compromising sequelae in neonates following endotracheal intubation . At present, no imaging modality is capable of in vivo diagnosis of subepithelial airway wall pathology as signs of intubation - related injury . OBJECTIVES: To use Fourier domain long - range optical coherence tomography (LR-OCT) to acquire micrometer-resolution images of the airway wall of intubated neonates in a neonatal intensive care unit (NICU) setting and to analyze images for histopathology and airway wall thickness. METHODS: LR-OCT of the neonatal laryngotracheal airway was performed a total of 94 times on 72 subjects (age 1-175 days, total intubation ...

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    8. Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Stud

      Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Stud

      Background A multicenter, prospective, blinded study was performed to test the feasibility of using a handheld optical imaging probe for the intraoperative assessment of final surgical margins during breast-conserving surgery (BCS) and to determine the potential impact on patient outcomes. Methods Forty-six patients with early-stage breast cancer (one with bilateral disease) undergoing BCS at two study sites, the Johns Hopkins Hospital and Anne Arundel Medical Center, were enrolled in this study. During BCS, cavity-shaved margins were obtained and the final margins were examined ex vivo in the operating room with a probe incorporating optical coherence tomography (OCT) hardware and interferometric ...

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    9. Wavelength shifting of intra-cavity photons: Adiabatic wavelength tuning in rapidly wavelength-swept lasers

      Wavelength shifting of intra-cavity photons: Adiabatic wavelength tuning in rapidly wavelength-swept lasers

      We analyze the physics behind the newest generation of rapidly wavelength tunable sources for optical coherence tomography (OCT), retaining a single longitudinal cavity mode during operation without repeated build up of lasing. In this context, we theoretically investigate the currently existing concepts of rapidly wavelength-swept lasers based on tuning of the cavity length or refractive index, leading to an altered optical path length inside the resonator. Specifically, we consider vertical-cavity surface-emitting lasers (VCSELs) with microelectromechanical system (MEMS) mirrors as well as Fourier domain mode-locked (FDML) and Vernier-tuned distributed Bragg reflector (VT-DBR) lasers. Based on heuristic arguments and exact analytical solutions ...

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    10. Wide-field in vivo oral OCT imaging

      Wide-field in vivo oral OCT imaging

      We have built a polarization-sensitive swept source Optical Coherence Tomography (OCT) instrument capable of wide-field in vivo imaging in the oral cavity. This instrument uses a hand-held side-looking fiber-optic rotary pullback catheter that can cover two dimensional tissue imaging fields approximately 2.5 mm wide by up to 90 mm length in a single image acquisition. The catheter spins at 100 Hz with pullback speeds up to 15 mm/s allowing imaging of areas up to 225 mm 2 field-of-view in seconds. A catheter sheath and two optional catheter sheath holders have been designed to allow imaging at all locations ...

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    11. Perimeter Medical Imaging Closes Oversubscribed $5 Million Series A Financing Round Led By Roadmap Capital

      Perimeter Medical Imaging Closes Oversubscribed $5 Million Series A Financing Round Led By Roadmap Capital

      Perimeter Medical Imaging, Inc., a developer of real time imaging systems for in-surgery tissue assessment, is pleased to announce the closing of their $5 million Series A financing. The round was led by Roadmap Capital with participation from EPIC Capital, NorthView Ventures and Pathfinder Asset Management. Funds will support the completion of their current clinical study at Princess Margaret Cancer Centre as well as product development and FDA regulatory clearance for their first tissue imaging product. Perimeter’s ground-breaking new Optical Tissue Imaging System (OTIS™) is an intraoperative medical imaging tool that provides clinicians with the ability to visualize the ...

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    12. Wideband Electrically Pumped 1050-nm MEMS-Tunable VCSEL for Ophthalmic Imaging

      Wideband Electrically Pumped 1050-nm MEMS-Tunable VCSEL for Ophthalmic Imaging

      In this paper, we present a 1050-nm electrically pumped microelectromechanically tunable vertical cavity surface emitting laser (MEMS-VCSEL) with a record dynamic tuning bandwidth of 63.8 nm, suitable for swept-source optical coherence tomography (SS-OCT) imaging. These devices provide reduced cost and complexity relative to previously demonstrated optically pumped devices by obviating the need for a pump laser and associated hardware. We demonstrate ophthalmic SS-OCT imaging with the electrically-pumped MEMS-VCSEL at a 400 kHz axial scan rate for wide-field imaging of the in vivo human retina over a 12 mm × 12 mm field and for OCT angiography of the macula over ...

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    13. Recent advances in clinical application of optical coherence tomography of human skin

      Recent advances in clinical application of optical coherence tomography of human skin

      Optical coherence tomography (OCT) is an emerging noninvasive imaging method that uses infrared light and interferometric techniques. The method has become increasingly popular in skin research as well as daily dermatology practice. In the present brief review, we focused on recent (2009–2014) OCT studies on the human skin, which included a reasonable sample size and statistics. Twenty-five papers were selected and briefly described OCT of epidermal thickness, skin appendages, wound healing, extracellular matrix and skin fibrosis, vascular malformations, and skin tumors such as basal cell carcinoma, actinic keratoses, and malignant melanoma

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      Mentions: Thilo Gambichler
    14. Serving unmet needs with OCT Webcast with Dr. Mark Brezinski

      Serving unmet needs with OCT Webcast with Dr. Mark Brezinski

      To view this webcast click HERE . This webcast was originally broadcast on July 16, 2015 and is now available for on demand viewing. What Steve Jobs referred to as “the unmet need” is a barrier to effective treatment, scientific discovery—and equipment sales. Traditionally, developers (engineers) strive for precision, elegance, and maximum theoretical performance (e.g. resolution), whereas the end user (physician or researcher) often has very different requirements. Unfortunately, efforts to bridge this gap can easily become confused. In this webcast, biophotonics pioneer Mark Brezinski MD explores unmet needs in biomedicine, using examples in OCT to illustrate how developers ...

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    15. Utility of Optical Coherence Tomography Imaging with Angiographic Co-registration for the Guidance of Percutaneous Coronary Intervention

      Utility of Optical Coherence Tomography Imaging with Angiographic Co-registration for the Guidance of Percutaneous Coronary Intervention

      Intracoronary optical coherence tomography (OCT) is a light-based imaging modality able to visualise with high resolution (~10 μm) the vascular morphology and the acute and chronic effects of intervention with intracoronary devices. 1,2 OCT could therefore find application in the guidance of percutaneous coronary intervention (PCI), allowing a thorough preprocedural lesion assessment, which enables accurate device sizing, selection of the vessel segment requiring treatment, and, thus, efficient planning of the implantation strategy (see Table 1 ). 3 Moreover, it can be used for the assessment of the acute procedural result, allowing the estimation of stent expansion and vessel injury. Consequently ...

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    16. A Micromotor Catheter for Intravascular Optical Coherence Tomography

      A Micromotor Catheter for Intravascular Optical Coherence Tomography

      We have developed a new form of intravascular optical coherence tomography (IV-OCT) that allows the extremely fast acquisition of high-resolution images of the coronary arteries. This process leads to much better image quality by eliminating cardiac motion artefacts and undersampling. It relies on a catheter that incorporates a synchronous micromotor with a diameter of 1.0 mm and a rotational speed of up to 5600 revolutions per second, enabling an IV-OCT frame rate of 5.6 kHz. This speed is matched by a wavelength-swept laser that generates up to 2.8 million image lines per second. With this setup, our ...

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    17. Prostate cancer diagnosis: the feasibility of needle-based optical coherence tomography

      Prostate cancer diagnosis: the feasibility of needle-based optical coherence tomography

      The objective of this study is to demonstrate the feasibility of needle-based optical coherence tomography (OCT) and functional analysis of OCT data along the full pullback trajectory of the OCT measurement in the prostate, correlated with pathology. OCT images were recorded using a commercially available C7-XR™ OCT Intravascular Imaging System interfaced to a C7 Dragonfly™ intravascular 0.9-mm-diameter imaging probe. A computer program was constructed for automated image attenuation analysis. First, calibration of the OCT system for both the point spread function and the system roll-off was achieved by measurement of the OCT signal attenuation from an extremely weakly scattering ...

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    18. Finding a needle in a haystack: use of volumetric laser endomicroscopy in targeting focal dysplasia in long-segment Barrett’s esophagus

      Finding a needle in a haystack: use of volumetric laser endomicroscopy in targeting focal dysplasia in long-segment Barrett’s esophagus

      A 64-year-old man underwent esophagoscopy 15 months earlier, which diagnosed long-segment Barrett’s esophagus. Examination of random biopsy specimens yielded a diagnosis of intestinal metaplasia, with 1 biopsy specimen as indefinite for dysplasia. Two subsequent esophagoscopies were performed 6 months apart, and random biopsy specimens were negative for dysplasia. The patient was referred for volumetric laser endomicroscopy (VLE) (NVisionVLE, NinePoint Medical, Cambridge, Mass). At esophagoscopy, high-definition white-light endoscopy showed a 7-cm segment of flat salmon-colored mucosa (Prague class C6M7) ( A ).

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    19. Catheter-based intraluminal optical coherence tomography: mcomparison with digital light microscopy of ureter wall morphometry in porcine specimens

      Catheter-based intraluminal optical coherence tomography: mcomparison with digital light microscopy of ureter wall morphometry in porcine specimens

      OBJECTIVE: Reproducibility and agreement of width estimates for urothelium, lamina propria, and muscle layer of normal porcine ureter wall ex vivo were compared between catheter-mounted, intraluminal cross-sectional optical coherence tomography (OCT), as a new destruction-free optical imaging method that could be applied clinically to examine the upper urinary tract from within if found to reliably delineate its different anatomical layers, and whole-mount low-power digital light microscopy (DLM). MATERIALS AND METHODS: Eleven ex-vivo-specimens of porcine ureter were flushed with normal saline solution prior to OCT (catheter diameter, 0.014 inch, wavelength, 1300 ± 20 nm, LightLab Imaging, Inc., Westford, MA, USA) at ...

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      Mentions: St. Jude Medical
    20. Incidence and Clinical Significance of Post-Stent OCT Findings: One Year Follow-Up Study From a Multicenter Registry

      Incidence and Clinical Significance of Post-Stent OCT Findings: One Year Follow-Up Study From a Multicenter Registry

      Background —Optical coherence tomography (OCT) was recently introduced to optimize percutaneous coronary intervention. However, the exact incidence and significance of post-stent OCT findings are unknown. Methods and Results —A total of 900 lesions treated with 1001 stents in 786 patients who had post-procedure OCT imaging were analyzed to evaluate the incidence of post-stent OCT findings and to identify the OCT predictors for device-oriented clinical endpoints (DoCE), including cardiac death, target vessel-related myocardial infarction, target lesion revascularization (TLR) and stent thrombosis. Patients were followed up to 1 year. Stent edge dissection was detected in 28.7% of lesions and incomplete stent ...

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    21. Serving Unmet Needs with Optical Coherence Tomography WebCast with Dr. Mark Brezinski

      Serving Unmet Needs with Optical Coherence Tomography WebCast with Dr. Mark Brezinski

      What Steve Jobs referred to as “the unmet need” is a barrier to effective treatment, scientific discovery—and equipment sales. Traditionally, developers (engineers) strive for precision, elegance, and maximum theoretical performance (e.g. resolution), whereas the end user (physician or researcher) often has very different requirements. Unfortunately, efforts to bridge this gap can easily become confused. In this webcast, biophotonics pioneer Mark Brezinski MD explores unmet needs in biomedicine, using examples in OCT to illustrate how developers and end users can effectively collaborate. You'll come away with a better understanding of actual clinical needs, how biophotonics developers can fulfill ...

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    22. Impact of Side Branch Modeling on Computation of Endothelial Shear Stress in Coronary Artery Disease Coronary Tree Reconstruction by Fusion of 3D Angiography and OCT

      Impact of Side Branch Modeling on Computation of Endothelial Shear Stress in Coronary Artery Disease Coronary Tree Reconstruction by Fusion of 3D Angiography and OCT

      Background Computational fluid dynamics allow virtual evaluation of coronary physiology and shear stress (SS). Most studies hitherto assumed the vessel as a single conduit without accounting for the flow through side branches. Objectives This study sought to develop a new approach to reconstruct coronary geometry that also computes outgoing flow through side branches in hemodynamic and biomechanical calculations, using fusion of optical coherence tomography (OCT) and 3-dimensional (3D) angiography. Methods Twenty-one patients enrolled in the DOCTOR (Does Optical Coherence Tomography Optimize Revascularization) fusion study underwent OCT and 3D-angiography of the target vessel (9 left anterior descending, 2 left circumflex, 10 ...

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    23. Postdoctoral Positions in Biomedical Optics and Optical Coherence Tomography at the Center for Ophthalmic Optics & Lasers, Oregon Health & Science University

      Postdoctoral Positions in Biomedical Optics and Optical Coherence Tomography at the Center for Ophthalmic Optics & Lasers, Oregon Health & Science University

      Postdoctoral research opportunities are available in the area of biomedical optics at the Center for Ophthalmic Optics & Lasers ( www.COOLLab.net ) in the Casey Eye Institute, Oregon Health & Science University (OHSU). The COOL laboratory is a multidisciplinary team that incorporates optical scientists, image processing experts, ophthalmologists, statisticians, managers, and technicians. The group collaborates with several institutions to develop novel OCT technology, develop diagnostic and surgical planning software, and conduct clinical trials. The laboratory is well supported by the National Institutes of Health ( http://www.octnews.org/articles/2920025/optical-coherence-tomography-used-500m-of-federall/ ) and industry, and has brought many novel diagnostic technology into clinical ...

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