1. Featured Articles

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    1. Dragonfly OpStar OCT Catheter Recalled for Loose Marker Band

      Dragonfly OpStar OCT Catheter Recalled for Loose Marker Band

      Abbott has recalled its Dragonfly OpStar imaging catheter, used for imaging the coronary arteries with optical coherence tomography, due to the possibility that the marker band farthest from the tip of the catheter could become loose and harm the patient, the US Food and Drug Administration announced Thursday . The recall has been deemed Class I, the most serious type. The issue has been associated with five incidents and one injury, but no deaths. In two cases, the loose band separated completely from the catheter while it was in use. If that happens and the band remains behind in the patient ...

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      Mentions: Abbott FDA
    2. Pilot Study of Biopsy Scanner for Evaluation of Bronchoscopic Small Biopsy Specimens to Determine Adequacy

      Pilot Study of Biopsy Scanner for Evaluation of Bronchoscopic Small Biopsy Specimens to Determine Adequacy

      In this study, lymph node or lung nodule tissue will be collected by bronchoscopy as part of standard clinical care. The tissue is being collected to help make a diagnosis of a pulmonary condition. The same amount of tissue that is collected per standard of care for diagnosis will be collected during the study; no additional tissue is taken for this study. The biopsy sample will be analyzed by the Aquyre Biopsy Scanner which will provide images of unprocessed lung biopsy tissue taken during your procedure. A pathologist will also analyze the tissue sample in accordance with existing clinical guidelines ...

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    3. OncoRes Medical raises another $12.5M

      OncoRes Medical raises another $12.5M

      OncoRes Medical announced that it raised $12.5 million for its handheld imaging device for identifying cancer cells. Perth, Western Australia-based OncoRes designed its imaging system to facilitate real-time tumor assessment, helping surgeons more accurately identify and remove cancerous tissue, including for breast cancer . The company won FDA breakthrough device designation in October 2020 for the device aimed at enabling surgeons to remove all cancer on the first try, thus avoiding a second procedure. When the handheld probe is applied to a region of interest, it provides micro-scale maps of the stiffness of the tissue — a key differentiator from healthy ...

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      Mentions: FDA OncoRes Medical
    4. Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries

      Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries

      Photothermal optical coherence tomography (PT-OCT) is a functional extension of OCT with the ability to generate qualitative maps of molecular absorptions co-registered with the micron-resolution structural tomograms of OCT. Obtaining refined insight into chemical information from PT-OCT images, however, requires solid understanding of the multifactorial physics behind generation of PT-OCT signals and their dependence on system and sample parameters. Such understanding is needed to decouple the various physical effects involved in the PT-OCT signal to obtain more accurate insight into sample composition. In this work, we propose an analytical model that considers the opto-thermo-mechanical properties of multi-layered samples in 3-D ...

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    5. Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy

      Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy

      Stereotactic body radiotherapy (SBRT) is an emerging cancer treatment due to its logistical and potential therapeutic benefits as compared to conventional radiotherapy. However, its mechanism of action is yet to be fully understood, likely involving the ablation of tumour microvasculature by higher doses per fraction used in SBRT. In this study, we hypothesized that longitudinal imaging and quantification of the vascular architecture may elucidate the relationship between the microvasculature and tumour response kinetics. Pancreatic human tumour xenografts were thus irradiated with single doses of 10 10 , 20 20 and 30 30 Gy to simulate the first fraction of a SBRT ...

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    6. Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography

      Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography

      Objective: Serial sectioning optical coherence tomography (OCT) enables distortion-free volumetric reconstruction of several cubic centimeters of human brain samples. We aimed to identify anatomical features of the ex vivo human brain, such as intraparenchymal blood vessels and axonal fiber bundles, from the OCT data in 3D, using intrinsic optical contrast. Methods: We developed an automatic processing pipeline to enable characterization of the intraparenchymal microvascular network in human brain samples. Results: We demonstrated the automatic extraction of the vessels down to a 20 m in diameter using a filtering strategy followed by a graphing representation and characterization of the geometrical properties ...

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    7. Identification of Fungus-infected Tomato Seeds Based on Full-Field Optical Coherence Tomography

      Identification of Fungus-infected Tomato Seeds Based on Full-Field Optical Coherence Tomography

      The morphological changes of anthracnose (fungus) -infected tomato seeds have been studied to identify the infection and characterize its effect. Full-field optical coherence tomography (FF-OCT) has been utilized as a nondestructive but efficient modality for visualizing the effects of fungal infection. The cross-sectional images extracted from a stack of en face FF-OCT images showed significant changes with infection in the seed structure. First of all, the seed coat disappeared with the infection. The thickness of the seed coat of a healthy seed was measured as 28.2 ㎛, with a standard deviation of 1.2 ㎛. However, for infected seeds the gap ...

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    8. Postdoctoral Fellow in Adaptive Optics Optical Coherence Tomography in Multiple Sclerosis at University of Maryland

      Postdoctoral Fellow in Adaptive Optics Optical Coherence Tomography in Multiple Sclerosis at University of Maryland

      The Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology at the University of Maryland School of Medicine is recruiting for a highly qualified postdoctoral researcher to perform clinical research related to the use of adaptive optics (AO) techniques as applied to optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO). These techniques allow visualization of the living human retina at the level of single cells. The laboratory of Dr. Daniel Harrison at the University of Maryland is collaborating with the laboratories of Drs. Zhuolin Liu and Daniel X. Hammer at the Food and Drug Administration (FDA) to perform clinically ...

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    9. Multi-class classification of breast tissue using optical coherence tomography and attenuation imaging combined via deep learning

      Multi-class classification of breast tissue using optical coherence tomography and attenuation imaging combined via deep learning

      We demonstrate a convolutional neural network (CNN) for multi-class breast tissue classification as adipose tissue, benign dense tissue, or malignant tissue, using multi-channel optical coherence tomography (OCT) and attenuation images, and a novel Matthews correlation coefficient (MCC)-based loss function that correlates more strongly with performance metrics than the commonly used cross-entropy loss. We hypothesized that using multi-channel images would increase tumor detection performance compared to using OCT alone. 5,804 images from 29 patients were used to fine-tune a pre-trained ResNet-18 network. Adding attenuation images to OCT images yields statistically significant improvements in several performance metrics, including benign dense ...

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    10. Intravascular Imaging to Guide Percutaneous Coronary Intervention Will Be Mandatory Soon

      Intravascular Imaging to Guide Percutaneous Coronary Intervention Will Be Mandatory Soon

      Intravascular ultrasound (IVUS) or optical coherence tomography provides superior information to coronary angiography, including cross-sectional true vessel size, amount of calcification, distribution of plaque to inform stent landing zone, stent expansion, and stent edge dissection or uncovered disease, which have been well known as key metrics in percutaneous coronary intervention avoiding future stent failure. 1 Complex lesion morphology is typically defined as an unprotected left main lesion, severely calcified lesion, long lesion, bifurcation lesion, chronic total occlusion, or in-stent restenosis in which optimal percutaneous coronary intervention is far more difficult than other lesions. 2-4 Thus, they have a greater chance ...

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    11. Research Scientist for Optical Diagnostics Opening at Envista Holdings Corporation

      Research Scientist for Optical Diagnostics Opening at Envista Holdings Corporation

      We are seeking a Research Scientist for Optical Diagnostics to be part of an innovative research team, based in Rochester, NY, with the mission of developing new optical technologies for improving measurement and diagnosis in dentistry. We are a part of DEXIS, an Envista company. Dental professionals have known the DEXIS brand as the leader in digital intraoral radiography and diagnostic software innovation for over 20 years. DEXIS products represent a full portfolio of award-winning imaging and digital solutions including cone-beam computed tomography (CBCT), handheld x-rays, intraoral scanners, sensors, and navigated surgical solutions. With one of the largest installed bases ...

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    12. Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band

      Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band

      Ultrahigh resolution optical coherence tomography (UHR-OCT) can image microscopic features that are not visible with the standard OCT resolution of 5-15 µm. In previous studies, high-speed UHR-OCT has been accomplished within the visible (VIS) and near-infrared (NIR-I) spectral ranges, specifically within 550-950 nm. Here, we present a spectral domain UHR-OCT system operating in a short-wavelength infrared (SWIR) range from 1000 to 1600 nm using a supercontinuum light source and an InGaAs-based spectrometer. We obtained an axial resolution of 2.6 µm in air, the highest ever recorded in the SWIR window to our knowledge, with deeper penetration into tissues than ...

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    13. Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system

      Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system

      Optical coherence tomography (OCT) has become an important tool for measuring the vibratory response of the living cochlea. It stands alone in its capacity to measure the intricate motion of the hearing organ through the surrounding otic capsule bone. Nevertheless, as an extension of phase-sensitive OCT, it is only capable of measuring motion along the optical axis. Hence, measurements are 1-D. To overcome this limitation and provide a measure of the 3-D vector of motion in the cochlea, we developed an OCT system with three sample arms in a single interferometer. Taking advantage of the long coherence length of our ...

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    14. Fiber-laser platform for precision brain surgery

      Fiber-laser platform for precision brain surgery

      Minimally invasive neurological surgeries are increasingly being sought after for treatment in neurological pathologies and oncology. A critical limitation in these minimally invasive procedures is lack of specialized tools that allow for space-time controlled delivery of sufficient energy for coagulation and cutting of tissue. Advent of fiber-lasers provide high average power with improved beam quality (lower M 2 ), biocompatible silica fiber delivery, reduced cost of manufacturing, and radiant output stability over long operating periods. Despite these advancements, no fiber-laser based surgical tools are currently available for tissue resection in vivo . Here we demonstrate a first to our knowledge, fiber-laser platform ...

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    15. Registration of histological brain images onto optical coherence tomography images based on shape information

      Registration of histological brain images onto optical coherence tomography images based on shape information

      Identifying tumour infiltration zones during tumour resection in order to excise as much tumour tissue as possible without damaging healthy brain tissue is still a major challenge in neurosurgery. The detection of tumour infiltrated regions so far requires histological analysis of biopsies taken from at expected tumour boundaries. The gold standard for histological analysis is the staining of thin cut specimen and the evaluation by a neuropathologist. This work presents a way to transfer the histological evaluation of a neuropathologist onto optical coherence tomography (OCT) images. OCT is a method suitable for real time in vivo imaging during neurosurgery however ...

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    16. Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways

      Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways

      In the imaging of airway tissue, optical coherence tomography (OCT) provides cross-sectional images of tissue structures, shows cilia movement and mucus secretion, but does not provide sufficient contrast to differentiate individual cells. By using fast sequences of microscopic resolution OCT (mOCT) images, OCT can use small signal fluctuations to overcome lack in contrast and speckle noise. In this way, OCT visualizes airway morphology on a cellular level and allows the tracking of the dynamic behavior of immune cells, as well as mucus transport and secretion. Here, we demonstrate that mOCT, by using temporal tissue fluctuation as contrast (dynamic mOCT), provides ...

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    17. Linewidth considerations for MEMS tunable VCSEL LiDAR

      Linewidth considerations for MEMS tunable VCSEL LiDAR

      The flexible membranes used in MEMS tunable VCSELs are so small and light that thermally induced vibrations can impact laser performance. We measure the thermal vibration spectrum of such a membrane showing peaks at the spatial vibration mode resonant frequencies of the membrane/plate. These vibrations result in a theoretical floor to the linewidth of the VCSEL. Frequency domain LiDAR and optical coherence tomography systems can get around this thermal linewidth limit with adequate clock measurement and processing. Essentially an OCT/LiDAR sweep with a concomitantly measured clock is a feed-forward linewidth reduction scheme. This can be achieved because the ...

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    18. Laboratory system for optical coherence tomography (OCT) using a laser plasma source of soft x-rays and extreme ultraviolet and focusing ellipsoidal optics

      Laboratory system for optical coherence tomography (OCT) using a laser plasma source of soft x-rays and extreme ultraviolet and focusing ellipsoidal optics

      Optical coherence tomography (OCT) with the use of soft x-rays (SXR) and extreme ultraviolet (EUV) has been recently demonstrated [Fuchs et al. Sci. Rep.6, 20658 (2016)10.1038/srep20658; Fuchs et al. Optica4, 903 (2017)10.1364/OPTICA.4.000903]. This new imaging technique, named XCT, makes it possible to obtain cross-sectional and tomographic images of objects with nanometer spatial resolution. The article presents a newly developed laboratory system for XCT using a compact laser plasma light source operating in the SXR and EUV spectral ranges. The source is based on a gas puff target containing Kr gas or ...

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    19. Optical coherence tomography reveals heterogeneity of the brain tissue and vasculature in the ischemic region after photothrombotic stroke in mice

      Optical coherence tomography reveals heterogeneity of the brain tissue and vasculature in the ischemic region after photothrombotic stroke in mice

      We demonstrate in vivo imaging of the ischemic area in the mouse brain after photostroke using a custom prototype Gaussian‑beam optical coherence tomography (OCT) setup in which the near infrared imaging beam and the green photoinducing light pass through the same objective lens. The goal of our research was analysis of vascularity of the ischemic area during 2‑week progress of stroke and correlating the hypo‑ and hyperreflective OCT scattering areas with the location of activated microglia and astroglia. Angiogenesis, which was assessed using angiomaps, showed that the area of vessels in the ischemic center increased until day 7 ...

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    20. Optical coherence tomography in coronary atherosclerosis assessment and intervention

      Optical coherence tomography in coronary atherosclerosis assessment and intervention

      Since optical coherence tomography (OCT) was first performed in humans two decades ago, this imaging modality has been widely adopted in research on coronary atherosclerosis and adopted clinically for the optimization of percutaneous coronary intervention. In the past 10 years, substantial advances have been made in the understanding of in vivo vascular biology using OCT. Identification by OCT of culprit plaque pathology could potentially lead to a major shift in the management of patients with acute coronary syndromes. Detection by OCT of healed coronary plaque has been important in our understanding of the mechanisms involved in plaque destabilization and healing ...

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    21. Coherent Optical Detection of Middle Ear Disease

      Coherent Optical Detection of Middle Ear Disease

      Otitis media (OM) is the most common diagnosis in pediatric patients seen for illness in the United States, affects 90% of all children, and is the most common indication for antimicrobial therapy and surgery in young children. Despite many attempts to improve diagnosis, treatment, and prevention, OM continues its highly prevalent impact on children and substantial ongoing morbidity. OM continues as the most common cause of hearing loss in children and leads to speech, educational and other developmental delays. OM causes life-threatening complications and is expensive, resulting in over $5 billion annually in U.S. health care expenditures. Despite the ...

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    22. Uncover scientific innovations with Heidelberg Engineering at ARVO 2022

      Uncover scientific innovations with Heidelberg Engineering at ARVO 2022

      Heidelberg Engineering presents various scientific innovations at the annual meeting of the Association for Research in Vision and Ophthalmology (ARVO) Heidelberg Engineering showcases its research capabilities at this year’s ARVO congress that takes place in Denver, Colorado, USA, from May 1–4. The team looks forward to reconnecting with the global research community after two years of solely virtual ARVO meetings, and to demonstrating various scientific innovations and state-of-the-art technologies at the Heidelberg Engineering booth (#2412). The research technologies shown cover a wide range of applications – from retina diagnostics and glaucoma research, cellular and metabolic imaging, to anterior segment ...

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    23. Digital Angiography Reading Center (DARC)/WorldCare Clinical Adds Voxeleron To Analysis Pipeline

      Digital Angiography Reading Center (DARC)/WorldCare Clinical Adds Voxeleron To Analysis Pipeline

      DARC Continues Investment in Best-in-Class Ophthalmology Service with Orion™ by Voxeleron OCT Image Analysis Software Voxeleron, a cloud-based platform provider that analyzes and tracks all formats of ophthalmic data, announced today that Digital Angiography Reading Center (DARC) / WorldCare Clinical has selected Orion by Voxeleron for use in image analysis. Orion is a vendor-neutral platform that analyzes OCT images from multiple devices within a common platform, significantly consolidating and minimizing the reading center’s requirements for software and devices. Orion's automated centration and segmentation software, including unique editing features, offer increased accuracy with an intuitive interface to reduce errors while ...

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      Mentions: Voxeleron
    24. Professor Adrian Podoleanu Career Celebration, Canterbury 26-27 May 2022

      Professor Adrian Podoleanu Career Celebration, Canterbury 26-27 May 2022

      We're delighted to announce that an event will take place in Canterbury, UK, on Thursday 26 (afternoon) and Friday 27 May (all day), to celebrate our colleague Prof Adrian Podoleanu's career achievements to date. http://cc22.aogkent.uk/ There will be a few dozen in-person participants to the event, which will take place on the University of Kent campus, while many others, located across various continents, will join online. For those coming here there will be a gala dinner on Friday as well. While we want to emphasize that Adrian is not about to retire any time soon ...

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