1. Featured Articles

    1-17 of 17
    1. Volumetric laser endomicroscopy in Barrett’s esophagus: interobserver agreement for interpretation of Barrett’s esophagus and associated neoplasia among high-frequency users

      Volumetric laser endomicroscopy in Barrett’s esophagus: interobserver agreement for interpretation of Barrett’s esophagus and associated neoplasia among high-frequency users

      Abstract Background and Aims Targeting neoplasia in Barrett’s esophagus (BE) is challenging. Volumetric laser endomicroscopy (VLE) is a new imaging technique that allows for real time cross-sectional microstructure imaging that can detect BE neoplasia. The interobserver agreement among users in practice is unknown. Methods Eight high-volume users of VLE from different academic centers in the United States evaluated 120-stored VLE images blinded to the endoscopic and clinical findings. There were 30 images for each tissue type: gastric cardia, esophageal squamous mucosa, non-neoplastic BE, and neoplastic BE. Each image with BE had corresponding histology confirming the tissue diagnosis. Each normal ...

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    2. OCT Expanded Clinical Data Analysis (OCT Aboard Space Station)

      OCT Expanded Clinical Data Analysis (OCT Aboard Space Station)

      Vision changes identified in long duration space fliers has led to a more comprehensive clinical monitoring protocol. Optical Coherence Tomography (OCT) was recently implemented on board the International Space Station in 2013. NASA is collaborating with Heidelberg Engineering to expand our current OCT data analysis capability by implementing a volumetric approach. Volumetric maps will be created by combining the circle scan, the disc block scan, and the radial scan. This assessment may provide additional information about the optic nerve and further characterize changes related microgravity exposure. We will discuss challenges with collection and analysis of OCT data, present the results ...

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    3. Accuracy of coronary computed tomography angiography for bioresorbable scaffold luminal investigation: a comparison with optical coherence tomography

      Accuracy of coronary computed tomography angiography for bioresorbable scaffold luminal investigation: a comparison with optical coherence tomography

      To establish the accuracy of coronary computed tomography angiography (CTA) for in-scaffold quantitative evaluation with optical coherence tomography (OCT) as a reference. The translucent backbone of the bioresorbable scaffold allow us to evaluate non-invasively the coronary lumen with coronary CTA. In the ABSORB first-in-man studies, coronary CTA was shown to be feasible for quantitative luminal assessment. Nevertheless, a comparison with an intravascular modality with higher resolution has never been performed. In the ABSORB Cohort B trial, 101 patient with non-complex lesions were treated with the fully biodegradable vascular scaffold. For this analysis, all patients who underwent coronary CTA at 18 ...

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    4. Optical Modalities for Embryonic Imaging

      Optical Modalities for Embryonic Imaging

      tudies of disease etiology often rely on the murine (mouse) model, which provides valuable genotypic information. Yet associated phenotypic information from murine embryos is often lacking. Of the various techniques that have been proposed for imaging such embryos, optical modalities may provide the best compromise among speed, penetration depth and resolution. This year, we developed approaches to improve embryonic imaging with optical coherence tomography (OCT), 1 and also provided a detailed comparison of OCT and another modality, optical projection tomography (OPT), in murine-embryo studies. 2 Most commonly used for ophthalmological imaging, 3 OCT has proved a powerful embryonic-imaging modality as ...

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    5. High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source

      High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source

      The three most important metrics in optical coherence tomography (OCT) are resolution, speed, and sensitivity. Because there is a complex interplay between these metrics, no previous work has obtained the best performance in all three metrics simultaneously. We demonstrate that a high-power supercontinuum source, in combination with parallel spectral-domain OCT, achieves an unparalleled combination of resolution, speed, and sensitivity. This system captures cross-sectional images spanning 4    mm × 0.5    mm 4  mm×0.5  mm at 1,024,000 lines/s with 2 × 14    μm 2×14  μm resolution ( axial × transverse axial×transverse ) at a sensitivity of 113 dB. Imaging ...

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    6. A view of the current and future role of optical coherence tomography in the management of age-related macular degeneration

      A view of the current and future role of optical coherence tomography in the management of age-related macular degeneration

      Optical coherence tomography (OCT) has become an established diagnostic technology in the clinical management of age-related macular degeneration (AMD). OCT is being used for primary diagnosis, evaluation of therapeutic efficacy, and long-term monitoring. Computer-based advances in image analysis provide complementary imaging tools such as OCT angiography, further novel automated analysis methods as well as feature detection and prediction of prognosis in disease and therapy by machine learning. In early AMD, pathognomonic features such as drusen, pseudodrusen, and abnormalities of the retinal pigment epithelium (RPE) can be imaged in a qualitative and quantitative way to identify early signs of disease activity ...

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    7. Postdoctoral Position in Optical Coherence Tomography / Optical Coherence Elastography at University of Houston

      Postdoctoral Position in Optical Coherence Tomography / Optical Coherence Elastography at University of Houston

      Description: The Biomedical Optics Laboratory ( http://bol.egr.uh.edu ) in Department of Biomedical Engineering at the University of Houston, TX invites applications for one or more postdoctoral scholar positions in the area of system development and image/signal processing from optical coherence tomography (OCT) and optical coherence elastography (OCE). The successful applicants will join dynamic team to work in the area of OCT and OCE for projects such as high-resolution imaging of live embryonic development and biomechanics of tissues and cells. Excellent opportunities exist for collaboration with clinicians from Texas Medical Center. The initial appointment will be full-time, for ...

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    8. Classification and analysis of human ovarian tissue using full field optical coherence tomography

      Classification and analysis of human ovarian tissue using full field optical coherence tomography

      In this study, a full field optical coherence tomography (FFOCT) system was used to analyze and classify normal and malignant human ovarian tissue. 14 ovarian tissue samples (7 normal, 7 malignant) were imaged with the FFOCT system and five features were extracted by analyzing the normalized image histogram from 56 FFOCT images, based on the differences in the morphology of the normal and malignant tissue samples. A generalized linear model (GLM) classifier was trained using 36 images, and sensitivity of 95.3% and specificity of 91.1% was obtained. 20 images were used to test the model, and a sensitivity ...

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    9. Optical computing for optical coherence tomography

      Optical computing for optical coherence tomography

      We propose an all-optical Fourier transformation system for real-time massive data processing in high speed optical coherence tomography (OCT). In the so-called optical computing OCT, fast Fourier transformation (FFT) of A-scan signal is optically processed in real time before being detected by photoelectric detector. Therefore, the processing time for interpolation and FFT in traditional Fourier domain OCT can be dramatically eliminated. A processing rate of 10 mega-A-scans/second was experimentally achieved, which is, to our knowledge, the highest speed for OCT imaging. Due to its fiber based all-optical configuration, this optical computing OCT system is ideal for ultrahigh speed volumetric ...

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    10. Dynamic nanomechanical analysis of the vocal fold structure in excised larynges

      Dynamic nanomechanical analysis of the vocal fold structure in excised larynges

      Objectives/Hypothesis Quantification of clinical outcomes after vocal fold (VF) interventions is challenging with current technology. High-speed digital imaging and optical coherence tomography (OCT) of excised larynges assess intact laryngeal function, but do not provide critical biomechanical information. We developed a protocol to quantify tissue properties in intact, excised VFs using dynamic nanomechanical analysis (nano-DMA) to obtain precise biomechanical properties in the micrometer scale. Study Design Experimental animal study. Methods Three pig larynges were bisected in the sagittal plane, maintaining an intact anterior commissure, and subjected to nano-DMA at nine locations with a 250-μm flat-tip punch and frequency sweep ...

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    11. In vivo imaging of coral tissue and skeleton with optical coherence tomography

      In vivo imaging of coral tissue and skeleton with optical coherence tomography

      Optical coherence tomography (OCT) is a non-invasive three-dimensional imaging technique with micrometer resolution allowing microstructural characterization of tissues in vivo and in real time. We present the first application of OCT for in vivo imaging of tissue and skeleton structure of intact living corals spanning a variety of morphologies and tissue thickness. OCT visualized different coral tissue layers (e.g. endoderm vs ectoderm), special structures such as mesenterial filaments and skeletal cavities, as well as mucus release from living corals. We also developed a new approach for non-invasive imaging and quantification of chromatophores containing green fluorescent protein (GFP)-like host ...

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    12. Postdoc Opening in the School of Medicine at the University of Pittsburgh

      Postdoc Opening in the School of Medicine at the University of Pittsburgh

      Description: A postdoctoral research position is available in the Department of Ophthalmology at the University of Pittsburgh School of Medicine for a highly motivated researcher with an interest in applying advanced adaptive optics ophthalmoscopy techniques to study the living human retina at the level of single cells. The candidate will assist Dr. Ethan Rossi in the design and construction of an adaptive optics scanning laser ophthalmoscope and deploy it to study retinal diseases. A candidate with a strong background in optics instrumentation is sought to assist in building an adaptive optics scanning light ophthalmoscope (AOSLO) based on a recently built ...

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    13. Wasatch Photonics MicroAngio, 2017 Prism Award Finalist

      Wasatch Photonics MicroAngio, 2017 Prism Award Finalist

      Wasatch Photonics Inc., a leading provider for gratings, spectrometers and optical coherence tomography instrumentation, is pleased to announce its new 3D MicroAngio technology has been selected as a Prism Award Finalist in the highly competitive Biomedical Instrumentation category. WP MicroAngio was created for high-resolution angiographic imaging for research and original equipment manufacturer (OEM) applications. Unlike other OCT angiography systems, the WP MicroAngio offers custom probe designs for each specific application, such as retina, brain or skin, for the highest quality images. WP software drives the system and provides both 3D images and one-click options for sampling, processing and motion correction ...

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    14. Using light to map the circuitry of the brain

      Using light to map the circuitry of the brain

      Lehigh University bio-engineers are first to explore the use of highly-sensitive, non-invasive optical coherence tomography (OCT) to examine neuron-to-neuron communication in live tissue. Scientific progress has provided a solid understanding of the anatomy of the brain. However, there is still no reliable way to examine neuron to neuron communication, as it happens--a key to understanding the correlation between brain structure and brain function. Chao Zhou , assistant professor of bioengineering at Lehigh University, likens our current brain-mapping ability to a Global Positioning System (GPS) that can help a user locate a city, but cannot offer a street-level view. With current imaging ...

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    15. ZEISS receives the first US FDA Clearance for Swept-Source OCT posterior ocular imaging with PLEX Elite 9000

      ZEISS receives the first US FDA Clearance for Swept-Source OCT posterior ocular imaging with PLEX Elite 9000

      Having received the first US FDA Clearance for OCT Angiography technology in September 2015, the Medical Technology business group of ZEISS now announces receiving the first US FDA Clearance for Swept-Source OCT imaging technology for posterior ocular structures with ZEISS PLEX ® Elite 9000. This powerful, cutting-edge Swept-Source OCT and OCT Angiography platform was designed for advanced retina research and is at the core of the Advanced Retina Imaging (A R I) Network 1 . The A R I Network, led by Philip J. Rosenfeld, MD, PhD, is a unique global consortium of clinicians and scientists from around the world working at ...

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    16. NinePoint Medical Announces Substantial Hospital Reimbursement Increase for Procedures Using the NvisionVLE Imaging System with Real-time Targeting

      NinePoint Medical Announces Substantial Hospital Reimbursement Increase for Procedures Using the NvisionVLE Imaging System with Real-time Targeting

      NinePoint Medical, Inc., a transformative medical device company pioneering the use of an advanced imaging platform for gastrointestinal applications, announced today that the U.S. Centers for Medicare & Medicaid Services (CMS) has published its 2017 final fee schedule. The annual update includes a material increase to the reimbursement rate for CPT Code 43252 1 ( upper GI endoscopy with optical endomicroscopy ), used for esophageal procedures using the NvisionVLE Imaging System with Real-time Targeting. According to the final 2017 CMS fee schedule, starting January 1, 2017, the reimbursement rate for CPT code 43252 in the hospital out-patient setting increases 131% from $1 ...

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    1-17 of 17
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