1. Featured Articles

    1-23 of 23
    1. Research Associate/Research Fellow Optical Coherence Elastography at University of Western Australia

      Research Associate/Research Fellow Optical Coherence Elastography at University of Western Australia

      Job no: 493993 Work type: full-time Location: Crawley Categories: Engineering / Computing and Mathematics SCHOOL OF ELECTRICAL, ELECTRONIC & COMPUTER ENGINEERING OPTICAL+BIOMEDICAL ENGINEERING LABORATORY 2 year appointment, with the possibility of extension Salary range: Level A $63,332 - $85,942 p.a. or Level B $90,468 - $107,431 p.a. (dependent on qualifications and experience) Research & Development In Biomedical Photonics (Australia) The University of Western Australia (UWA) is a member of Australia's prestigious Group of Eight and ranked among the top 100 universities (88 th in the world) with a broad and balanced coverage of disciplines in the arts ...

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    2. Optical coherence tomography vs intravascular ultrasound in the evaluation of observer variability and reliability in the assessment of stent deployment: The OCTIVUS Study

      Optical coherence tomography vs intravascular ultrasound in the evaluation of observer variability and reliability in the assessment of stent deployment: The OCTIVUS Study

      Abstract Objectives : To compare the variability in the assessment of coronary stents among interventional cardiologists (readers) using Optical Coherence Tomography (OCT) and Intravascular ultrasound (IVUS). Background : IVUS is established and validated in the evaluation of coronary stent. For cardiologists without core lab expertise, the utility of IVUS is limited by image quality. OCT yields higher image resolution, however, the consistency with which these readers interpret OCT images has not been fully evaluated or compared with IVUS. Methods : OCT and IVUS image sets (5 pairs) obtained following stent placement were reviewed by readers with clinical experience with both modalities. Parameters assessed ...

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    3. Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis

      Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis

      The labial minor salivary glands (LSGs) are easily accessible mucus-secreting structures of the alimentary tract that may provide new information on the basis of gastrointestinal complications of cystic fibrosis (CF). It was shown that they are destructed in the course of cystic fibrosis. We employed wide-field, micrometer resolution in vivo optical coherence tomography to assess the surface density of LSGs in 18 patients with CF and 18 healthy subjects. The median LSGs’ surface densities in CF patients, and in the control group were 4.32 glands/cm 2 and 6.58 glands/cm 2 , respectively (p = 0.006; Mann-Whitney U ...

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    4. High resolution Fourier domain optical coherence tomography in the 2 um wavelength range using a broadband supercontinuum source

      High resolution Fourier domain optical coherence tomography in the 2 um wavelength range using a broadband supercontinuum source

      A 220 nm bandwidth supercontinuum source in the two-micron wavelength range has been developed for use in a Fourier domain optical coherence tomography (FDOCT) system. This long wavelength source serves to enhance probing depth in highly scattering material with low water content. We present results confirming improved penetration depth in high opacity paint samples while achieving the high axial resolution needed to resolve individual paint layers. This is the first FDOCT developed in the 2 μm wavelength regime that allows fast, efficient capturing of 3D image cubes at a high axial resolution of 13 μm in air (or 9 μm ...

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    5. Noninvasive depth-resolved optical measurements of the tympanic membrane and middle ear for differentiating otitis media

      Noninvasive depth-resolved optical measurements of the tympanic membrane and middle ear for differentiating otitis media

      Objective/Hypothesis In this study, optical coherence tomography (OCT) is used to noninvasively and quantitatively determine tympanic membrane (TM) thickness and the presence and thickness of any middle-ear biofilm located behind the TM. These new metrics offer the potential to differentiate normal, acute, and chronic otitis media (OM) infections in pediatric subjects. Study Design Case series with comparison group. Methods The TM thickness of 34 pediatric subjects was acquired using a custom-built, handheld OCT system following a traditional otoscopic ear exam. Results Overall thickness (TM and any associated biofilm) was shown to be statistically different for normal, acute, and chronic ...

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    6. Real-time automated thickness measurement of the in vivo human tympanic membrane using optical coherence tomography

      Real-time automated thickness measurement of the in vivo human tympanic membrane using optical coherence tomography

      Background: Otitis media (OM), an infection in the middle ear, is extremely common in the pediatric population. Current gold-standard methods for diagnosis include otoscopy for visualizing the surface features of the tympanic membrane (TM) and making qualitative assessments to determine middle ear content. OM typically presents as an acute infection, but can progress to chronic OM, and after numerous infections and antibiotic treatments over the course of many months, this disease is often treated by surgically inserting small tubes in the TM to relieve pressure, enable drainage, and provide aeration to the middle ear. Diagnosis and monitoring of OM is ...

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    7. In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe

      In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe

      We report multimodal imaging of human oral cavity in vivo based on simultaneous wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography (PS-OCT) with a forward-viewing imaging probe. Wide-field reflectance/fluorescence imaging and PS-OCT were to provide both morphological and fluorescence information on the surface, and structural and birefringent information below the surface respectively. The forward-viewing probe was designed to access the oral cavity through the mouth with dimensions of approximately 10 mm in diameter and 180 mm in length. The probe had field of view (FOV) of approximately 5.5 mm in diameter, and adjustable depth of field (DOF ...

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    8. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Position description: A full-time Postdoctoral Associate position in Biophotonics / Biomedical Optical Imaging is available at Lehigh University starting ASAP . The primary purpose of this position will be for a highly motivated individual to develop advanced optical imaging techniques for novel biomedical applications in vitro and/or in vivo . Compensation is commensurate with experience. Qualifications: Ph.D. in Electrical Engineering, Physics, Applied Physics, Biomedical Engineering / Bioengineering or related fields. Hands-on experience with optical coherence tomography (OCT), especial swept-source OCT, is preferred. Good publication record and communication skills. Strong programming skills (Matlab, Labview, C++ and GPU programming) are pluses. Research areas: The ...

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    9. New developments in optical coherence tomography

      New developments in optical coherence tomography

      Purpose of review: Optical coherence tomography (OCT) has become the cornerstone technology for clinical ocular imaging in the past few years. The technology is still rapidly evolving with newly developed applications. This manuscript reviews recent innovative OCT applications for glaucoma diagnosis and management. Recent findings: The improvements made in the technology have resulted in increased scanning speed, axial and transverse resolution, and more effective use of the OCT technology as a component of multimodal imaging tools. At the same time, the parallel evolution in novel algorithms makes it possible to efficiently analyze the increased volume of acquired data. Summary: The ...

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    10. Influence of nanoparticles accumulation on optical properties of human normal and cancerous liver tissue in vitro estimated by OCT

      Influence of nanoparticles accumulation on optical properties of human normal and cancerous liver tissue in vitro estimated by OCT

      In this work, the potential use of nanoparticles as contrast agents by using spectral domain optical coherence tomography (SD-OCT) in liver tissue was demonstrated. Gold nanoparticles (average size of 25 and 70 nm), were studied in human normal and cancerous liver tissues in vitro , respectively. Each sample was monitored with SD-OCT functional imaging for 240 min. Continuous OCT monitoring showed that, after application of gold nanoparticles, the OCT signal intensities of normal liver and cancerous liver tissue both increase with time, and the larger nanoparticles tend to produce a greater signal enhancement in the same type of tissue. The results ...

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    11. Identification of layers in optical coherence tomography of skin: comparative analysis of experimental and Monte Carlo simulated images

      Identification of layers in optical coherence tomography of skin: comparative analysis of experimental and Monte Carlo simulated images

      Background/purpose The goal of the study is comparative analysis of the layers in OCT images and the morphological structure of skin with thick and thin epidermis. Methods We analyzed the difference between skin with thin and thick epidermis in two ways. The first approach consisted in determination of the thicknesses of layers of skin with thin and thick epidermis of different localizations from experimental OCT images. The second approach was to develop numerical models fitting experimental OCT images based on Monte Carlo simulations revealing structure and optical parameters of layers of skin with thick and thin epidermis. Results The ...

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    12. In vivo imaging of human photoreceptor mosaic with wavefront sensorless adaptive optics optical coherence tomography

      In vivo imaging of human photoreceptor mosaic with wavefront sensorless adaptive optics optical coherence tomography

      Wavefront sensorless adaptive optics optical coherence tomography (WSAO-OCT) is a novel imaging technique for in vivo high-resolution depth-resolved imaging that mitigates some of the challenges encountered with the use of sensor-based adaptive optics designs. This technique replaces the Hartmann Shack wavefront sensor used to measure aberrations with a depth-resolved image-driven optimization algorithm, with the metric based on the OCT volumes acquired in real-time. The custom-built ultrahigh-speed GPU processing platform and fast modal optimization algorithm presented in this paper was essential in enabling real-time, in vivo imaging of human retinas with wavefront sensorless AO correction. WSAO-OCT is especially advantageous for developing ...

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    13. Bioptigen Awarded $458,000 from North Carolina Biotechnology Center to Advance Intrasurgical OCT System Development

      Bioptigen Awarded $458,000 from North Carolina Biotechnology Center to Advance Intrasurgical OCT System Development

      Bioptigen announced today that it has been awarded a Strategic Growth Loan from the North Carolina Biotechnology Center totaling $458,000 to support development of the company’s Intrasurgical OCT imaging system. Optical Coherence Tomography or ‘OCT’ is a form of highresolution imaging that has been compared to ultrasound imaging, though OCT uses light rather than sound to create the images. Bioptigen’s EnFocusTM Intrasurgical OCT system will provide 3D visualization simultaneous with and coregistered to images from surgical ophthalmic microscopes. Bioptigen is known globally for its FDA-cleared handheld OCT system for pediatric imaging, and for providing industry leading OCT ...

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    14. Optical coherence tomography guided microinjections in live mouse embryos: high-resolution targeted manipulation for mouse embryonic research

      Optical coherence tomography guided microinjections in live mouse embryos: high-resolution targeted manipulation for mouse embryonic research

      The ability to conduct highly localized delivery of contrast agents, viral vectors, therapeutic or pharmacological agents, and signaling molecules or dyes to live mammalian embryos is greatly desired to enable a variety of studies in the field of developmental biology, such as investigating the molecular regulation of cardiovascular morphogenesis. To meet such a demand, we introduce, for the first time, the concept of employing optical coherence tomography (OCT)-guide microinjections in live mouse embryos, which provides precisely targeted manipulation with spatial resolution at the micrometer scale. The feasibility demonstration is performed with experimental studies on cultured live mouse embryos at ...

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    15. A case report of differentiating staphylococcal scalded skin syndrome and toxic epidermal necrolysis by optical coherence tomography

      A case report of differentiating staphylococcal scalded skin syndrome and toxic epidermal necrolysis by optical coherence tomography

      Background Staphylococcal scalded skin syndrome (SSSS) and toxic epidermal necrolysis (TEN) both present with acute onset, high morbidity and significant mortality. Rapid diagnosis is therefore of importance. The aim of this study was to investigate and compare the presentation of these diseases using optical coherence tomography (OCT). Methods Two male patients with bullous diseases, SSSS and TEN, respectively, were photographed digitally, examined using dermoscopy, OCT scanned and subsequently biopsied in the said order. Results The bullous skin was visualized by OCT showing two distinct images: the SSSS-patient displayed superficial hyporefletive flaccid structures with a split high in the thickened (0 ...

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    16. Measurements of the thermal coefficient of optical attenuation at different depth regions of in vivo human skins using optical coherence tomography: a pilot study

      Measurements of the thermal coefficient of optical attenuation at different depth regions of in vivo human skins using optical coherence tomography: a pilot study

      We present detailed measurement results of optical attenuation’s thermal coefficients (referenced to the temperature of the skin surface) in different depth regions of in vivo human forearm skins using optical coherence tomography (OCT). We first design a temperature control module with an integrated optical probe to precisely control the surface temperature of a section of human skin. We propose a method of using the correlation map to identify regions in the skin having strong correlations with the surface temperature of the skin and find that the attenuation coefficient in these regions closely follows the variation of the surface temperature ...

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    17. Three dimensional mesoscale analysis of translamellar cross-bridge morphologies in the annulus fibrosus using optical coherence tomography

      Three dimensional mesoscale analysis of translamellar cross-bridge morphologies in the annulus fibrosus using optical coherence tomography

      The defining characteristic of the annulus fibrosus (AF) of the intervertebral disc (IVD) has long been the lamellar structures that consist of highly ordered collagen fibers arranged in alternating oblique angles from one layer to the next. However, a series of recent histologic studies have demonstrated that AF lamellae contain elastin- and type VI collagen-rich secondary “cross-bridge” structures across lamellae. In this study, we use optical coherence tomography (OCT) to elucidate the three-dimensional (3-D) morphologies of these translamellar cross-bridges in AF tissues. Mesoscale volumetric images by OCT revealed a 3-D network of heterogeneously distributed cross-bridges. The results of this study ...

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    18. Injection-depth-locking axial motion guided handheld micro-injector using CP-SSOCT

      Injection-depth-locking axial motion guided handheld micro-injector using CP-SSOCT

      This paper presents a handheld micro-injector system using common-path swept source optical coherence tomography (CP-SSOCT) as a distal sensor with highly accurate injection-depth-locking. To achieve real-time, highly precise, and intuitive freehand control, the system used graphics processing unit (GPU) to process the oversampled OCT signal with high throughput and a smart customized motion monitoring control algorithm. A performance evaluation was conducted with 60-insertions and fluorescein dye injection tests to show how accurately the system can guide the needle and lock to the target depth. The evaluation tests show our system can guide the injection needle into the desired depth with ...

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    19. Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment

      Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment

      We demonstrate a prototype system of polarization-sensitive optical coherence tomography (PS-OCT) designed for clinical studies of the anterior eye segment imaging. The system can measure Jones matrices of the sample with depth-multiplexing of two orthogonal incident polarizations and polarization-sensitive detection. An optical clock is generated using a quadrature modulator and a logical circuit to double the clock frequency. Systematic artifacts in measured Jones matrices are theoretically analyzed and numerically compensated using signals at the surface of the sample. Local retardation images of filtering blebs after trabeculectomy show improved visualization of subconjunctival tissue, sclera, and scar tissue of the bleb wall ...

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    20. 3-D Adaptive Sparsity Based Image Compression with Applications to Optical Coherence Tomography

      3-D Adaptive Sparsity Based Image Compression with Applications to Optical Coherence Tomography

      We present a novel general-purpose compression method for tomographic images, termed 3D adaptive sparse representation based compression (3D-ASRC). In this paper, we focus on applications of 3D-ASRC for the compression of ophthalmic 3D optical coherence tomography (OCT) images. The 3D-ASRC algorithm exploits correlations among adjacent OCT images to improve compression performance, yet is sensitive to preserving their differences. Due to the inherent denoising mechanism of the sparsity based 3D-ASRC, the quality of the compressed images are often better than the raw images they are based on. Experiments on clinical-grade retinal OCT images demonstrate the superiority of the proposed 3D-ASRC over ...

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    21. Diagnosing Lung Carcinomas with Optical Coherence Tomography

      Diagnosing Lung Carcinomas with Optical Coherence Tomography

      Rationale: Lung carcinoma diagnosis on tissue biopsy can be challenging due to insufficient tumor and lack of architectural information. Optical coherence tomography (OCT) is a high-resolution imaging modality that visualizes tissue microarchitecture in volumes orders of magnitude larger than biopsy. It has been proposed that OCT could potentially replace tissue biopsy. Objectives: We aim to determine if OCT could replace histology in diagnosing lung carcinomas . We develop and validate OCT interpretation criteria for common primary lung carcinomas : adenocarcinoma, squamous cell carcinoma (SCC), and poorly differentiated carcinoma . Methods: A total of 82 ex vivo tumor samples were included in a blinded ...

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    22. Parameter estimation of atherosclerotic tissue optical properties from three-dimensional intravascular optical coherence tomography

      Parameter estimation of atherosclerotic tissue optical properties from three-dimensional intravascular optical coherence tomography

      We developed robust, three-dimensional methods, as opposed to traditional A-line analysis, for estimating the optical properties of calcified, fibrotic, and lipid atherosclerotic plaques from in vivo coronary artery intravascular optical coherence tomography clinical pullbacks. We estimated attenuation μ t and backscattered intensity I 0 from small volumes of interest annotated by experts in 35 pullbacks. Some results were as follows: noise reduction filtering was desirable, parallel line (PL) methods outperformed individual line methods, root mean square error was the best goodness-of-fit, and α -trimmed PL ( α -T-PL) was the best overall method. Estimates of μ t were calcified ( 3.84 ± 0.95     mm − 1 ...

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    23. Developmental and morphological studies in Japanese medaka with ultra-high resolution optical coherence tomography

      Developmental and morphological studies in Japanese medaka with ultra-high resolution optical coherence tomography

      We propose ultra-high resolution optical coherence tomography to study the morphological development of internal organs in medaka fish in the post-embryonic stages at micrometer resolution. Different stages of Japanese medaka were imaged after hatching in vivo with an axial resolution of 2.8 µm in tissue. Various morphological structures and organs identified in the OCT images were then compared with the histology. Due to the medaka’s close resemblance to vertebrates, including humans, these morphological features play an important role in morphogenesis and can be used to study diseases that also occur in humans.

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    1-23 of 23
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