Featured Articles

1. Spontaneous Recanalization of a Coronary Artery After Thrombotic Occlusion: In Vivo Demonstration With Optical Coherence Tomography

   Explore Article JACC (9 hours, 48 min ago) Cardiology

   A 50-year-old man with a recent embolic stroke was referred by a neurologist for abnormal electrocardiography results consistent with large anterior myocardial infarction. Echocardiogram results showed akinesis of the anteroapical left ventricular wall without obvious mural thrombus and an ejection fraction of 45%. There was no evidence of an intracardiac shunt. Coronary angiography revealed irregular linear filling defects in the mid left anterior descending artery (A) (line 1 and 2 indicate the length of optical coherence tomography pullback). Optical coherence tomography showed multiple channels surrounding a larger central lumen (B, arrowheads). The channels were seen to communicate both with each ... (Read Full Article)
   

   Comment on Article Mentions:   Massachusetts General Hospital   Ik-Kyung Jang   Harvard University

2. Optical Coherence Tomography of the Larynx Using the Niris System

   Explore Article BCDecker (15 hours, 59 min ago) Otolaryngology

   OBJECTIVES:To present our experience using the first commercially available optical coherence tomography (OCT) device for use in the head, neck, and upper aerodigestive tract and to determine the feasibility and efficacy of this system in comparison with our previous experience using other research OCT systems.METHODS:Using the Niris OCT imaging system (Imalux, Cleveland, OH), we obtained OCT images of benign and premalignant laryngeal disease in 33 patients undergoing surgical head and neck endoscopy. This imaging system has a spatial depth resolution of 10 to 20 μm and a depth scanning range of 2.2 mm, obtaining images of 200 × 200 pixels ... (Read Full Article)
   

   Comment on Article Mentions:   Imalux   Zhongping Chen   Jeong H. Kim

3. In-stent restenosis associated with stent malapposition: Seven year optical coherence tomography findings

   Explore Article International Journal of Cardiology (Mar 14 2010) Cardiology

   Abstract: Stent thrombosis and in-stent restenosis remain significant issues in post-coronary angioplasty care despite advances in anti-platelet therapy and stent technology. Angiographic predictors of stent failure have been proposed, but its precise mechanism has been difficult to elucidate on conventional coronary angiography and intravascular ultrasound due to the low resolution of either approach. Optical coherence tomography (OCT) as a high-resolution intracoronary imaging modality has enabled more detailed insight into the interaction between implanted stent and underlying endothelium, the evolution of unstable plaque, and the pathogenesis of late lumen loss, affirming its place as an essential tool in the modern-day cardiac ... (Read Full Article)
   

   Comment on Article Mentions:   Peter Barlis   University of Melbourne

4. Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats

   Explore Article ScienceDirect (Mar 14 2010) Neurology , Ophthalmology

   Purpose To obtain three-dimensional images from retinal transplants in live animals and evaluate the placement and structural quality of the transplants. Methods Donor retinal sheets were isolated from E19 fetuses of transgenic rats expressing human alkaline phosphatase (hPAP), and transplanted to the subretinal space of 19–56 days old S334ter-3 rat recipients with fast retinal degeneration (average age at surgery 32 days). A total of 143 rats were imaged 1 day to 2.8 months after surgery, using a Fourier-domain optical coherence tomography (FDOCT) system, with an axial resolution of 3.5 μm. The CCD A-line integration time was set at 200 μs ... (Read Full Article)
   

   Comment on Article Mentions:   Zhongping Chen   UC Irvine

5. Lihong Wang and Hsin-I Wu receive Goodman Book Writing Award from SPIE and OSA

   Explore Article Home: SPIE.org (Mar 11 2010)

   BELLINGHAM, Washington, and WASHINGTON, D.C., USA -- Lihong V. Wang and Hsin-I Wu are recipients of the 2010 Joseph W. Goodman Book Writing Award for their book Biomedical Optics: Principles and Imaging, the Optical Society (OSA) and SPIE have announced. The Goodman Award, a biennial award funded by a personal gift from Joseph W. and Hon Mai Goodman, recognizes a recent and outstanding book in the field of optics and photonics that has contributed significantly to research, teaching, or the optics and photonics industry. This year, the Goodman Book Writing Award will be bestowed upon Wang and Wu at the ... (Read Full Article)
   

   Comment on Article Mentions:   Lihong V. Wang   Texas A&M University   Hsin-i Wu

6. Gold Nanorods: Multifunctional Agents for Cancer Imaging and Therapy

   Explore Article SpringerLink Home (Mar 11 2010) Oncology

   Gold nanorods (GNRs) are strongly absorbing at near-infrared (NIR) frequencies and can be employed as multifunctional agents for biological imaging and theragnostics. GNRs can support nonlinear optical microscopies based on two-photon-excited luminescence and can enhance the contrast of biomedical imaging modalities such as optical coherence tomography and photoacoustic tomography. GNRs are also efficient at mediating the conversion of NIR light energy into heat and can generate localized photothermal effects. However, future clinical applications will require the rigorous removal of CTAB, a micellar surfactant used in GNR synthesis, and reliable methods of surface functionalization for cell-selective targeting and for minimizing nonspecific ... (Read Full Article)
   

   Comment on Article Mentions:   Purdue University   Alexander Wei

7. Potential of optical coherence tomography for early diagnosis of oral malignancies

   Explore Article Expert Reviews (Mar 11 2010) Oncology

   With nearly 1,500,000 new patients diagnosed every year in the USA, cancer poses a considerable challenge to healthcare today. Oral cancer is responsible for a sizeable portion of deaths due to cancer, primarily because it is diagnosed at a late stage when the prognosis is poor. Current methods for diagnosing oral cancer need to be augmented by better early detection, monitoring and screening modalities. A new approach is needed that provides real-time, accurate, noninvasive diagnosis. The results of early clinical trials using in vivo optical coherence tomography for the diagnosis of oral dysplasia and malignancy are encouraging. (Read Full Article)
   

   Comment on Article Mentions:   UC Irvine   Petra Wilder-Smith

8. Imaging of subcutaneous blood vessels and flow velocity profiles by optical coherence tomography

   Explore Article SpringerLink Home (Mar 11 2010) Dermatology , Doppler

   We have applied a compact low power rapid scanning Doppler Optical Coherence Tomography system to monitor multi-dimensional velocity profiles within the complex vessels and simultaneous real-time non-invasive imaging of skin tissues morphology in vivo, in the wavelength range of 1.3–1.5 nm. Optical clearing of skin tissues has been utilized to achieve depth of OCT images up to 1.7 mm. Current approach enables applying low-power (0.4–0.5 mW) and low-noise broadband near-infrared light sources and obtaining OCT images with down to 12 μm spatial resolution. Two-dimensional time-domain OCT images of complex flow velocity profiles in blood vessel phantom and in vivo subcutaneous ... (Read Full Article)
   

   Comment on Article Mentions:   Medical University of Vienna   University of Otago   Igor V. Meglinski

9. A new device for assessing changes in skin viscoelasticity using indentation and optical measurement

   Explore Article www3.interscience.wiley.com (Mar 10 2010) Dermatology

   Skin is a viscoelastic material, comprised of fluidic and fibrous components. Changes in viscoelasticity can arise due to a number of conditions including dehydration, swelling (associated with injury or disease), impaired heart function, rehydration therapy, ageing, scarring, sun exposure and genetic conditions affecting connective tissue. Quantification of changes in skin viscoelasticity due to these processes is of great clinical interest in the fields of therapy monitoring, wound healing and disease screening. However, devices currently available to measure aspects of the mechanical properties of skin have limitations in ease-of-use, accessibility, and depth of measurement. This paper describes a new technique to ... (Read Full Article)
   

   Comment on Article Mentions:   Imperial College London   University of Limerick

10. Clinical optical coherence tomography of early articular cartilage degeneration in persons with degenerative meniscal tears

    Explore Article www3.interscience.wiley.com (Mar 10 2010)

    Objective: Quantitative and nondestructive methods for clinical diagnosis and staging of articular cartilage degeneration are important to evaluation of potential disease modifying treatments for osteoarthritis. Optical Coherence Tomography (OCT) is a novel imaging technology that can generate microscopic resolution cross-sectional images of articular cartilage in near real time. This study tests the hypotheses that OCT can be used clinically to identify early cartilage degeneration, and that OCT correlates with MRI T2 values and arthroscopy. Methods: Patients undergoing arthroscopy for degenerative meniscal tears were recruited under IRB approved protocols. 30 consecutive subjects completing preoperative 3.0T MRI, arthroscopy, and intraoperative OCT comprised ... (Read Full Article)
    

    Comment on Article Mentions:   University of Pittsburgh   Constance R. Chu

11. Motion artifact suppression in full-field optical coherence tomography

    Explore Article opticsinfobase.org (Mar 8 2010)

    Significant motion artifacts limit the performance of conventional full-field optical coherence tomography (FF-OCT) for in-vivo imaging. We present a theoretical and experimental study of those limitations. A new FF-OCT system suppressing most of artifacts due to sample motions is demonstrated using instantaneous phase shifting with nonpolarizing optics and pulsed illumination. The experimental setup is based on a Linnik-type interferometer illuminated by the superluminescence emission from a Ti:Al2O3 waveguide crystal. En face tomographic images are calculated as a combination of two phase-opposed interferometric images acquired simultaneously by two CCD cameras placed at both outputs of the interferometer, with a spatial resolution ... (Read Full Article)
    

    Comment on Article Mentions:   Arnaud Dubois   Institut d'Optique

12. Morphologic characteristics of late stent malapposition after drug-eluting stents implantation by optical coherence tomography follow-up

    Explore Article Chinese Medical Journal (Mar 8 2010) Cardiology

    Background Late stent malapposition was frequently observed after DES implantation, which has been associated with the occurrence of late stent thrombosis due to poor neointimal coverage. This study was designed to evaluate the frequency of late stent malapposition at least 1 year after different DESs implantation by optical coherence tomography (OCT).Methods Angiographic and OCT examinations were given to 68 patients who had received total 126 various DESs implantation for at least 1 year to detect late stent malapposition. Malapposed strut distance (MSD), malapposed strut area (MSA), reference lumen area (RLA) and reference stent area (RSA) were checked with off-line OCT ... (Read Full Article)
    

    Comment on Article Mentions:   LightLab Imaging   Lightlab ImageWire

13. Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography

    Explore Article www3.interscience.wiley.com (Mar 7 2010) Oncology

    Here we examined the effect of human normal breast (NB) and breast cancer (BC) tissues in vitro after treatment with glycerol in conjunction with ultrasound (surgeonperformed, SP) by OCT for functional imaging to monitor. 60% glycerol (G) and SP was simultaneously applied for 5 min. Depth- and time-resolved profiles for OCT signal enhancement were presented. The results show that OCT imaging depth of breast tissues after treatment with 60% G in combined with SP more obviously improved than that after application of glycerol alone. The permeability coefficient of 60% glycerol in 60% G/NB, 60% G/BC, 60% G/SP/NB, and 60% G/SP/BC ... (Read Full Article)
    

    Comment on Article

14. Gene Deletion Screen for Cardiomyopathy in Adult Drosophila Identifies a New Notch Ligand

    Explore Article Circulation Research (Mar 7 2010) Cardiology , Developmental Biology

    Rationale: Drosophila has been recognized as a model to study human cardiac diseases. Objective: Despite these findings, and the wealth of tools that are available to the fly community, forward genetic screens for adult heart phenotypes have been rarely performed because of the difficulty in accurately measuring cardiac function in adult Drosophila. Methods and Results: Using optical coherence tomography to obtain real-time analysis of cardiac function in awake Drosophila, we performed a genomic deficiency screen in adult flies. Based on multiple complementary approaches, we identified CG31665 as a novel gene causing dilated cardiomyopathy. CG31665, which we name weary (wry), has ... (Read Full Article)
    

    Comment on Article Mentions:   Duke University   Bioptigen

15. Australia & New Zealand Optical Coherence Tomography Workshop May 7th, 2010

    Explore Article Optical Coherence Tomography News (Mar 5 2010) Cardiology

    “Welcome to the Inaugural Australia & New Zealand Optical Coherence Tomography Workshop. We have set out a program with an internationally recognized faculty to review the use of OCT and discuss its exciting role in Interventional Cardiology. Thank you for joining us”. Peter Barlis & Rob Whitbourn. Enquiries to info@anzoct.org or go to www.anzoct.org. false false false EN-US X-NONE X-NONE (Read Full Article)
    

    Comment on Article Mentions:   Peter Barlis   University of Melbourne   LightLab Imaging

16. Ce^3+:YAG double-clad crystal-fiber-based optical coherence tomography on fish cornea

    Explore Article opticsinfobase.org (Mar 4 2010) Broadband Sources

    A Ce3+:YAG double-clad crystal fiber (DCF) visible emission was used as the light source for optical coherence tomography (OCT). The visible emission was produced from a 10 μm core DCF pumped by a diode laser. The broadband emission and short central wavelength of this light source enabled the realization of 1.5 μm axial resolution in air. The relatively clean spectrum reduced the side lobe of its point-spread function, and therefore facilitated the generation of a high-quality image with less crosstalk between adjacent image pixels. As a demonstration, an Aplocheilus lineatus goldfish was experimented on to map out the stroma of ... (Read Full Article)
    

    Comment on Article Mentions:   National Taiwan University

17. Clinical studies of frequency domain optical coherence tomography in the coronary arteries: the first 200 patients

    Explore Article SPIE Digital Library (Mar 4 2010) Cardiology

    We report clinical study results of three-dimensional (3D) in vivo imaging of human coronary arteries using frequency domain optical coherence tomography (FD-OCT). At the time of this report, over 2000 patients in over 10 countries have been imaged using FD-OCT systems and disposable fiberoptic catheters developed by LightLab Imaging Inc. The first commercial versions of the systems were introduced in Europe in May 2009. The system operates at 50,000 axial lines/s, performing a 50 mm spiral pullback in 2.5 seconds with a rotational frame rate of 100 Hz. The commercial system employs a proprietary micro-cavity swept laser, allowing imaging of ... (Read Full Article)
    

    Comment on Article Mentions:   LightLab Imaging   Desmond C. Adler   Joseph M. Schmitt

18. In Vivo Supervised Analysis of Stent Reendothelialization From Optical Coherence Tomography

    Explore Article IEEE Xplore (Mar 4 2010)

    The aim of this study is to interactively assess reendothelialization of stents at an accuracy of down to a few micrometer by analyzing endovascular optical coherence tomography (OCT) sequences. Vessel wall and stent struts are automatically detected by using morphological, gradient, and symmetry operators coupled with active contour models; alerts are issued to ask for user supervision over some extreme irregular geometries caused by thrombotic lesions or dissections. A complete distance map is then computed from sparse distances measured between wall and struts. Missing values are interpolated by thin-plate spline (TPS) functions. Accuracy and robustness are increased by taking into ... (Read Full Article)
    

    Comment on Article Mentions:   LightLab Imaging   University of Montreal   Lightlab ImageWire

19. 1st Massachusetts General Hospital OCT Registry Symposium Scheduled for March 13, 2010

    Explore Article Optical Coherence Tomography News (Mar 3 2010) Cardiology

    The utilization of OCT has grown tremendously since the launch of the world’s first frequency domain OCT system (FD-OCT) from LightLab Imaging, Inc. in late 2009. Over 9,000 cases were performed last year, slightly less than the cumulative cases performed in the three years prior with the older Time Domain OCT which was much slower and harder to use. “OCT has come a long way". States Dr. Ik-Kyung Jang. "I have used the new system and it is really fast and easy to use. Because of its data acquisition speed no occlusion is required and the image quality is improved ... (Read Full Article)
    

    Comment on Article Mentions:   Massachusetts General Hospital   Ik-Kyung Jang   LightLab Imaging

20. Visualizing ocular perfusion with optical microangiography

    Explore Article Home: SPIE.org (Mar 3 2010) Ophthalmology

    Better assessment of ocular blood circulation may provide important diagnostic and treatment information for eye pathologies such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Currently, the preferred methods to visualize ocular blood perfusion in the clinic are fluorescein angiography (FA) and indocyanine green angiography (ICGA). Both provide detailed maps of the retina and choroid that are useful in decision making. However, injecting dyes with possible side effects is undesirable. Moreover, those methods cannot provide depth-resolved visualization of vasculatures. Therefore, a noninvasive technique that can show retinal and choroidal blood perfusion in depth would be a significant advance. We have ... (Read Full Article)
    

    Comment on Article Mentions:   Ruikang K. Wang   Lin An   Oregon Health & Science University

21. Cement not included – 10:1 return on investment from federal infrastructure investment in photonics

    Explore Article Optical Coherence Tomography News (Mar 3 2010) Other Business News

    Responding to the credit crisis and resulting global recession, national governments around the world are furiously pumping cement-truck loads of money into infrastructure projects. Some of these economic stimulus initiatives will work, some will fail, and few will offer a specific Return On Investment (ROI). Roads, bridges buildings and last generation manufacturing jobs are important – and easy to justify in a political context. Yet building a next generation of successful “cement not included” innovation companies will in turn generate long-term jobs, exports, tax bases, and ultimately pay the tab on the short-term stimulus spends. (Read Full Article)
    

    Comment on Article Mentions:   National Research Council Canada

22. Mechanical compression for biotissue image enhancement in optical coherence tomography

    Explore Article SPIE Digital Library (Feb 11 2010)

    The paper discusses application of mechanical compression for contrasting structural components of biotissues with different mechanical properties in optical coherence tomography (OCT) images. Ex vivo study on human rectum samples and in vivo study on human thin skin samples are performed. It is shown that for ex vivo sample the contrast between epithelial and stroma layers increases with increase in applied pressure. For in vivo sample it is shown that at weak constant applied pressure the contrast between epidermal and dermal layer increases exhibiting maximum after 2-3 minutes since pressure application. Monte Carlo simulations of OCT images of human rectum ... (Read Full Article)
    

    Comment on Article Mentions:   Nizhny Novgorod State Medical Academy   Russian Academy of Sciences   Alexander I. Abelevich

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