Featured Articles

1. Measurement of signal intensity depth profiles in rat brains with cardiac arrest maintaining primary temperature by wide-field optical coherence tomography

   Explore Article opticsinfobase.org (Aug 31 2010) Neurology

   We have already reported that after an injection for euthanasia, the signal intensity of optical coherence tomography (OCT) images are 2.7 times increased before cardiac arrest (CA) using OCT and rat brains without temperature control to show the potential of OCT to monitor tissue viability in brains [Appl. Opt. 48, 4354 (2009)]. In this paper, we similarly measured maintaining the primary temperature of rat brains. It was confirmed that when maintaining the primary temperature, the time courses of the ratios of signal intensity (RSIs) were almost the same as those without temperature control. RSIs after CA varied from 1.6 to ... (Read Full Article)
   

   Comment on Article Mentions:   Manabu Sato   Yamagata University

2. Elastographic contrast generation in optical coherence tomography from a localized shear stress

   Explore Article IOPscience (Aug 31 2010)

   A technique for generating contrast in two-dimensional shear strain elastograms from a localized stress is presented. The technique involves generating a non-uniform, localized stress via a magnetically actuated implant. Its effectiveness is demonstrated using finite-element simulations and a phantom study provides experimental verification of this. The method is applied to a superficial cancerous lesion model represented as a stiff inclusion in normal tissue. The lesion was best distinguished from its surroundings using total shear strain elastograms, rather than individual strain components. In experimental phantom studies, the lesion was imaged using optical coherence tomography (OCT) and could still be distinguished in ... (Read Full Article)
   

   Comment on Article Mentions:   Michelson Diagnostics   Jon Holmes   Pete H. Tomlins

3. Method and apparatus for measurement of optical properties in tissue

   Explore Article uspto.gov (Aug 31 2010) Patents , Probes

   A method of analyzing tissue includes inserting a radiation source into tissue, impinging radiation upon the tissue, obtaining a sample signal of the radiation that impinges upon the tissue, and determining a refractive index of the tissue from the sample signal. The method may also include determining at least one other optical property of the tissue. The method may provide for identifying tissue as part of a biopsy method. A device for analyzing tissue may include a low-coherence interferometer and a probe optically coupled to the interferometer, where the probe includes a radiation source. (Read Full Article)
   

   Comment on Article Mentions:   Stephen A. Boppart   Julian J. Armstrong   David D. Sampson

4. Postdoctoral Position in The Biomedical Optics Laboratory at the University of Houston

   Explore Article Optical Coherence Tomography News (Aug 29 2010) Jobs & Studentships

   The Biomedical Optics Laboratory (http://www.egr.uh.edu/bol/) in Department of Biomedical Engineering at the University of Houston, TX invites applications for a postdoctoral scholar position in the area of optical coherence tomography (OCT) imaging and biophotonics. The initial appointment will be full-time, for a 12 month period. Salary will be based on level of experience. Renewal of the appointment will be contingent upon the availability of adequate funding and performance. The position is available immediately and review of the applications is ongoing. Applicants must have strong experience and interest in OCT system development and software engineering (using LabView , C/C++, OpenMP, multithreading). ... (Read Full Article)
   

   Comment on Article Mentions:   Kirill V. Larin   University of Houston

5. Optical Coherence Tomography in Canada One-Day Symposium September 28, 2010

   Explore Article Optical Coherence Tomography News (Aug 29 2010)

   The Industrial Materials Institute (IMI) organizes a one-day symposium on Optical Coherence Tomography (OCT) on Tuesday September 28, 2010, at Université Laval (Quebec City). The goals of the symposium are to increase networking between research groups and to provide interested parties an overview of the current status of OCT research in Canada. (Read Full Article)
   

   Comment on Article Mentions:   Novacam Technologies   Kostadinka K. Bizheva   Victor X. D. Yang

6. Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation

   Explore Article opticsinfobase.org (Aug 27 2010) Ophthalmology

   Stephanie J. Chiu, , Peter Nicholas, Cynthia A. Toth, Joseph A. Izatt, Sina FarsiuSegmentation of anatomical and pathological structures in ophthalmic images is crucial for the diagnosis and study of ocular diseases. However, manual segmentation is often a time-consuming and subjective process. This paper presents an automatic approach for segmenting retinal layers in Spectral ... [Opt. Express 18, 19413-19428 (2010)] (Read Full Article)
   

   Comment on Article Mentions:   Cynthia A. Toth   Joseph A. Izatt   Duke University

7. Real-time processing for full-range Fourier-domain optical-coherence tomography with zero-filling interpolation using multiple graphic processing units

   Explore Article opticsinfobase.org (Aug 26 2010)

   The real-time display of full-range, 2048 axial pixel×1024 lateral pixel, Fourier-domain optical-coherence tomography (FD-OCT) images is demonstrated. The required speed was achieved by using dual graphic processing units (GPUs) with many stream processors to realize highly parallel processing. We used a zero-filling technique, including a forward Fourier transform, a zero padding to increase the axial data-array size to 8192, an inverse-Fourier transform back to the spectral domain, a linear interpolation from wavelength to wavenumber, a lateral Hilbert transform to obtain the complex spectrum, a Fourier transform to obtain the axial profiles, and a log scaling. The data-transfer time of the ... (Read Full Article)
   

   Comment on Article Mentions:   Yuuki Watanabe   Yamagata University

8. Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution

   Explore Article ScienceDirect (Aug 25 2010) Dermatology

   In this study, we used optical coherence tomography (OCT) to extensively investigate, for the first time, the effect that microneedle (MN) geometry (MN height, and MN interspacing) and force of application have upon penetration characteristics of soluble poly(methyl vinyl ether-co-maleic anhydride, PMVE/MA) MN arrays into neonatal porcine skin in vitro. The results from OCT investigations were then used to design optimal and suboptimal MN-based drug delivery systems and evaluate their drug delivery profiles cross full thickness and dermatomed neonatal porcine skin in vitro. It was found that increasing the force used for MN application resulted in a significant increase in ... (Read Full Article)
   

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9. Detection of early colorectal cancer development in the azoxymethane rat carcinogenesis model with Fourier domain low coherence interferometry

   Explore Article opticsinfobase.org (Aug 25 2010) Oncology

   Fourier domain low coherence interferometry (fLCI) is an emerging optical technique used to quantitatively assess cell nuclear morphology in tissue as a means of detecting early cancer development. In this work, we use the azoxymethane rat carcinogenesis model, a well characterized and established model for colon cancer research, to demonstrate the ability of fLCI to distinguish between normal and preneoplastic ex-vivo colon tissue. The results show highly statistically significant differences between the measured cell nuclear diameters of normal and azoxymethane-treated tissues, thus providing strong evidence that fLCI may be a powerful tool for non-invasive, quantitative detection of early changes associated ... (Read Full Article)
   

   Comment on Article Mentions:   Francisco E. Robles   Yizheng Zhu   Duke University

10. Senior Software Engineer Opening at Diagnostic Photonics

    Explore Article Optical Coherence Tomography News (Aug 24 2010) Jobs & Studentships

    Senior Software Engineer Leadership. Responsibility. Impact. We are seeking a bright, energetic, and motivated senior software engineer to lead the development of the system software and user interface for a revolutionary medical imaging system. Our product could one day be used in imaging applications for millions of Americans each year, and we endeavor to improve the quality of human life. The senior software engineer will work with other talented engineers and university researchers on the company’s world-class imaging technology. We are offering a compensation package that includes a competitive base salary and an opportunity for stock options. Benefits include 401(k), ... (Read Full Article)
    

    Comment on Article Mentions:   Diagnostic Photonics

11. Changes and Current State of Diagnosis of Lung Cancer After Development of the Flexible Bronchofiberscope

    Explore Article Oxford Journals (Aug 24 2010) Oncology , Pulmonology

    The flexible bronchofiberscope developed by Ikeda et al. has brought about revolutionary changes in the diagnosis and treatment of lung cancer. Advances in this device are continuing to emerge and lesions even smaller than those visible to the naked eye can now be visualized. In addition, the use of ultrasound now enables diagnosis of extramural bronchial lesions. Bronchoscopy is also used for the treatment of early hilar lung cancer, and in patients with airway stenosis due to advanced cancer, laser therapy, brachytherapy, and stenting can be performed. The bronchofiberscope is also very useful for tissue sampling from the lung periphery. ... (Read Full Article)
    

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12. 5th International Graduate Summer School - Biophotonics '11 - May 14, 2011 in Ven, Sweden

    Explore Article Biomedical Optics and New Laser Systems (Aug 24 2010)

    Over the past decade, optical methods and instruments based on light interacting with tissue have emerged as powerful techniques for bio-medical diagnostics, monitoring wide spectra of tissue function and pathology together with therapy. The purpose of the 5th International Graduate summer school Biophotonics '11 is to provide education for students at the highest international level within these areas. Moreover, by inviting renowned lecturers from all over the world, the educational program is held in an international atmosphere enhancing exchange of scientific ideas and technological advances within the fields of biomedical optics and closely related areas. The 5th International Graduate summer ... (Read Full Article)
    

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13. PhD scholarship in non-contact assessment of food quality using optical imaging methods at Technical University of Denmark

    Explore Article Optical Coherence Tomography News (Aug 24 2010) Jobs & Studentships

    DTU Fotonik seeks a qualified candidate for a vacant PhD position. Candidates are invited to apply following the online procedure below.Project descriptionThe aim of the research project is to relate relevant food quality characteristics to optical properties of the food material. In particular, utilizing multiple scattering effects to quantify parameters such as scatterer size, orientation, and density distributions. In this project, different methodologies will be investigated. One method is based on extracting optical properties from diffuse reflectance profiles relating the optical properties to the physical properties of the sample. Another method is based on optical coherence microscopy from which optical ... (Read Full Article)
    

    Comment on Article Mentions:   Peter E. Andersen   Technical University of Denmark

14. Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial

    Explore Article Heart (Aug 24 2010) Cardiology

    Background A potentially adverse vascular response to overlapping drug eluting stents (DES) has been suggested in current research. Objective To evaluate the impact of baseline disease severity at the site of stent overlap. Methods and results This is a substudy of ODESSA, a prospective, randomised controlled trial designed to evaluate healing of overlapping stents. 71/77 patients with a total of 86 overlapping stents were studied: 25 sirolimus, 24 paclitaxel, 26 zotarolimus-eluting stents; and 11 bare metal stents (BMS). Patients were categorised into high-grade stenosis (HGS, ≥70% diameter stenosis) and low-grade stenosis (LGS, <70%) at the site of stent overlap. Angiography ... (Read Full Article)
    

    Comment on Article Mentions:   Case Western Reserve University   National Institutes of Health   LightLab Imaging

15. >400 kHz repetition rate wavelength-swept laser and application to high-speed optical frequency domain imaging

    Explore Article opticsinfobase.org (Aug 23 2010) Tunable Sources

    We demonstrate a high-speed wavelength-swept laser with a tuning range of 104nm (1228–1332nm) and a repetition rate of 403kHz. The design of the laser utilizes a high-finesse polygon-based wavelength-scanning filter and a short-length unidirectional ring resonator. Optical frequency domain imaging of the human skin in vivo is presented using this laser, and the system shows sensitivity of higher than 98dB with single-side ranging depth of 1.7mm over 4dB sensitivity roll-off. (Read Full Article)
    

    Comment on Article Mentions:   Wang Yuhl Oh   Benjamin J. Vakoc   Milen Shishkov

16. Piezo motors, actuators streamline medical device performance

    Explore Article Control Engineering (Aug 23 2010)

    For the execution of precise movements with medical equipment, the latest piezoceramic motors and actuators are more compact, require lower voltage, deliver higher torque, have shorter response time, generate less heat, and are nonmagnetic and vacuum compatible, compared to conventional electromagnetic motors. Improvements in the design of medical equipment for better streamlined functionality and performance are influenced by research, design, modeling, testing, prototyping, and U.S. FDA and EU approvals of new mechatronic devices, or the integration of changes to existing designs. These usually represent a sizable capital investment of resources well before the equipment goes into serial production. Design considerations ... (Read Full Article)
    

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17. Combined image-processing algorithms for improved optical coherence tomography of prostate nerves

    Explore Article SPIE Digital Library (Aug 20 2010) Urology

    Cavernous nerves course along the surface of the prostate gland and are responsible for erectile function. These nerves are at risk of injury during surgical removal of a cancerous prostate gland. In this work, a combination of segmentation, denoising, and edge detection algorithms are applied to time-domain optical coherence tomography (OCT) images of rat prostate to improve identification of cavernous nerves. First, OCT images of the prostate are segmented to differentiate the cavernous nerves from the prostate gland. Then, a locally adaptive denoising algorithm using a dual-tree complex wavelet transform is applied to reduce speckle noise. Finally, edge detection is ... (Read Full Article)
    

    Comment on Article Mentions:   Nathaniel M. Fried   Shahab Chitchian   Johns Hopkins University

18. Parametric imaging of cancer with optical coherence tomography

    Explore Article SPIE Digital Library (Aug 19 2010) Oncology

    We present a parametric optical coherence tomography (OCT) technique to improve contrast between malignant and healthy non-neoplastic tissue. The technique incorporates a fully automated method to extract tissue attenuation characteristics. Results are represented visually as a parametric en face image, where the parameter used for contrast is indicative of the relative optical attenuation coefficient of the tissue. We present the first parametric OCT images of human lymph nodes containing malignant cells, and demonstrate improved tissue contrast over en face OCT images. (Read Full Article)
    

    Comment on Article Mentions:   University of Western Australia   Steven L. Jacques   Loretta Scolaro

19. Enhancing Detection of Bladder Carcinoma In Situ by 3-Dimensional Optical Coherence Tomography

    Explore Article The Journal of Urology (Aug 17 2010) Oncology , Urology

    Purpose: We examined the usefulness of 3-dimensional optical coherence tomography to enhance the diagnosis of urothelial carcinoma in situ.Materials and Methods: By expressing SV40T antigen with uroplakin II promoter, carcinoma in situ readily develops in SV40T transgenic mice at about ages 8 to 20 weeks and then frank high grade papillary carcinoma develops in bladder epithelium. We examined 10 control and 40 SV40T mice during weeks 8 to 20 after birth by parallel en face white light imaging and 3-dimensional optical coherence tomography, and compared results with histology findings. We applied quantitative analysis of computer aided detection to 3-dimensional tomography ... (Read Full Article)
    

    Comment on Article Mentions:   SUNY at Stony Brook   Yingtian Pan

20. The Vulnerable Atherosclerotic Plaque: Scope of the Literature

    Explore Article Annals of Internal Medicine (Aug 17 2010) Cardiology

    The scope of recent literature on the concept of “vulnerable plaque” was reviewed by examining 463 abstracts of primary and review articles identified through MEDLINE (2003 to April 2010). Proposed definition criteria of vulnerable plaque included active inflammation, a thin cap with a large lipid core, endothelial denudation, fissured cap, severe stenosis, or combinations of these findings. In 242 primary studies, histopathology, biomarkers and imaging of carotid and coronary artery plaques were evaluated for features suggestive of vulnerability. Notably, 89% of these studies were cross-sectional in design and exclusively conducted in patients with known cardiovascular disease. None of the imaging ... (Read Full Article)
    

    Comment on Article Mentions:   Tufts University

21. Depth-resolved Imaging and Displacement Measurement Techniques Viewed as Linear Filtering Operations

    Explore Article SpringerLink Home (Aug 17 2010)

    The last 5 years have seen the emergence of a family of optical interferometric techniques that provide deformation measurements throughout three-dimensional (3-D) weakly scattering materials. They include wavelength scanning interferometry (WSI), tilt scanning interferometry (TSI), phase contrast spectral optical coherence tomography (PC SOCT) and hyperspectral interferometry (HSI) and can be thought of as a marriage between the phase sensing capabilities of Phase Shifting Interferometry and the depth-sensing capabilities of Optical Coherence Tomography. It was recently shown that some closely related 3-D optical imaging techniques can be treated as shift-invariant linear filtering operations. In this paper, we extend that work to ... (Read Full Article)
    

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22. Optical Biopsy at the Bedside

    Explore Article Archives of Dermatology, a monthly peer (Aug 16 2010) Dermatology

    Skin biopsy is essential for the diagnosis of many cutaneous conditions. Beyond the cost and technical considerations, it is an invasive, painful, and scarring procedure. These factors lead dermatologists to be selective about what and when we biopsy, resulting in potential delay and misdiagnosis. Biopsy also is subject to sampling error; because it changes the tissue permanently, it is not amenable to longitudinal evaluation. Because specimen processing creates a delay, some treatment options are limited. Hence, there is a need to develop new noninvasive methods to permit immediate microscopic visualization of tissues in vivo or ex vivo. One might consider ... (Read Full Article)
    

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23. 3-Dimensional Optical Coherence Tomography Assessment of Jailed Side Branches by Bioresorbable Vascular Scaffolds: A Proposal for Classification

    Explore Article interventions.onlinejacc.org (Aug 16 2010) Cardiology

    Objectives The purpose of this study is to assess jailing of side branches (SB) by the everolimus-eluting, bioresorbable vascular scaffold (BVS) with 3-dimensional (3D) optical coherence tomography (OCT) reconstruction. Background Because BVS struts at the SB orifice are suspected of being bioresorbed and/or forming a neointimal bridge, OCT has been used to evaluate the struts in detail at that particular site. Our understanding of the 3D relationship of the strut and the SB orifice is limited by the use of 2-dimensional OCT images. Fourier-domain OCT enables reliable 3D reconstruction of coronary vessels. Methods The ABSORB Cohort B (A Clinical Evaluation ... (Read Full Article)
    

    Comment on Article Mentions:   LightLab Imaging   Patrick W. Serruys   Evelyn Regar

24. Comparison of optical coherence tomography, microcomputed tomography, and histology at a three-dimensionally imaged trabecular bone sample

    Explore Article SPIE Digital Library (Aug 16 2010)

    We investigate optical coherence tomography (OCT) as a method for imaging bone. The OCT images are compared directly to those of the standard methods of bone histology and microcomputed tomography (µCT) on a single, fixed human femoral trabecular bone sample. An advantage of OCT over bone histology is its noninvasive nature. OCT also images the lamellar structure of trabeculae at slightly higher contrast than normal bone histology. While µCT visualizes the trabecular framework of the whole sample, OCT can image additionally cells with a penetration depth limited approximately to 1 mm. The most significant advantage of OCT, however, is the ... (Read Full Article)
    

    Comment on Article Mentions:   Catholic University of Leuven   Christoph Kasseck   Marita Kratz

25. Separating the scattering and absorption coefficients using the real and imaginary parts of the refractive index with low-coherence interferometry

    Explore Article opticsinfobase.org (Aug 16 2010)

    We present an analytical method that yields the real and imaginary parts of the refractive index (RI) from low-coherence interferometry measurements, leading to the separation of the scattering and absorption coefficients of turbid samples. The imaginary RI is measured using time-frequency analysis, with the real part obtained by analyzing the nonlinear phase induced by a sample. A derivation relating the real part of the RI to the nonlinear phase term of the signal is presented, along with measurements from scattering and nonscattering samples that exhibit absorption due to hemoglobin. (Read Full Article)
    

    Comment on Article Mentions:   Francisco E. Robles   Adam Wax   Duke University

26. Alzheimer's disease: Visual system review

    Explore Article Optometry (Jan 15 2010) Neurology , Ophthalmology

    Background Ten million baby boomers in the United States will get Alzheimer's disease. Optometrists can benefit from understanding the impact the Alzheimer's disease process has on the visual system. This can result in more effective management of the condition and in more effective communication with members of the Alzheimer's disease multidisciplinary team. Methods This is a review of the literature but by no means a completely exhaustive review. Alzheimer's disease is a complex disease. A rapidly expanding body of knowledge covers multiple disciplines. Results The visual system shows deficits early in the degenerative process of Alzheimer's disease. Biomarkers through the ... (Read Full Article)
    

    Comment on Article Mentions:   Boston University   Denise A. Valenti

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