1. Featured Articles

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    1. Abbott Agrees to Buy St. Jude in $25 Billion Deal

      Abbott Agrees to Buy St. Jude in $25 Billion Deal

      Abbott Laboratories agreed to acquire St. Jude Medical Inc. in a cash-and-stock deal valued at $25 billion that would create one of the leading makers of heart-related devices. Under the deal, Abbott agreed to swap $46.75 in cash and 0.8708 shares for each St. Jude share. The offer values each St. Jude share at about $85, representing a 37% premium to the stock’s closing price Wednesday. Shares of Abbott fell 7% to $40.60 in early trading, while St. Jude rose 25% to $77.70. The companies said the deal merges St. Jude’s strong positions in ...

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      Mentions: St. Jude Medical
    2. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today several dual-probe catheters have been introduced including combined near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), that is already commercially available, IVUS-optical coherence tomography (OCT), the OCT-NIRS, the OCT-near infrared fluorescence (NIRF) molecular ...

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    3. Mount Sinai Health System Experts Share Skin Cancer Tips and Patient Stories for Skin Cancer Awareness Month and Melanoma Monday

      Mount Sinai Health System Experts Share Skin Cancer Tips and Patient Stories for Skin Cancer Awareness Month and Melanoma Monday

      Skin cancer is the most common form of cancer in the United States, with one in five Americans developing it over the course of their lives. It’s also one of the most preventable types of cancers. In recognition of May’s Skin Cancer Awareness Month and Melanoma Monday on May 2nd, Mount Sinai Health System experts are arming the public with vital tips on prevention and offering FREE skin cancer screenings. Experts Available for Interview • Mark G. Lebwohl , MD, Sol and Clara Kest Professor of Dermatology, Kimberly and Eric J. Waldman Professor and Chair of the Kimberly and Eric ...

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    4. Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model

      Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model

      It is known that the progression of oral cancer is accompanied by changes in both tissue biochemistry and morphology. A multimodal imaging approach combining functional and structural imaging modalities could therefore provide a more comprehensive prognosis of oral cancer. This idea forms the central theme of the current study, wherein this premise is examined in the context of a multimodal imaging system that combines fluorescence lifetime imaging (FLIM) and optical coherence tomography (OCT). Towards this end, in the first part of the present study, the diagnostic advantage obtained by using both fluorescence intensity and lifetime information is assessed. In the ...

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    5. Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy: a serial optical coherence tomography study

      Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy: a serial optical coherence tomography study

      Objective: Previous studies have suggested that intensive statin therapy, compared with moderate statin therapy, provided greater reduction of LDL and better protection against major cardiovascular events. However, the exact dose-dependent mechanism of plaque stabilization remains unclear. The aim of this study is to investigate the three-dimensional (3D) response of fibrous caps overlying lipid plaques to statin therapy. Methods: We applied a novel computer algorithm to investigate the fibrous cap 3D morphological change over time in patients with coronary artery disease. Patients were treated with either atorvastatin 20 mg/day (moderate intensity) or atorvastatin 60 mg/day (high intensity). Optical coherence ...

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    6. Novel microscope-integrated stereoscopic heads-up display for intrasurgical optical coherence tomography

      Novel microscope-integrated stereoscopic heads-up display for intrasurgical optical coherence tomography

      Intra-operative optical coherence tomography (OCT) requires a display technology which allows surgeons to visualize OCT data without disrupting surgery. Previous research and commercial intrasurgical OCT systems have integrated heads-up display (HUD) systems into surgical microscopes to provide monoscopic viewing of OCT data through one microscope ocular. To take full advantage of our previously reported real-time volumetric microscope-integrated OCT (4D MIOCT) system, we describe a stereoscopic HUD which projects a stereo pair of OCT volume renderings into both oculars simultaneously. The stereoscopic HUD uses a novel optical design employing spatial multiplexing to project dual OCT volume renderings utilizing a single micro-display ...

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    7. OCT Angiography: Technology and Applications Webcast April 26th 2016, 1:00 EST

      OCT Angiography: Technology and Applications Webcast April 26th 2016, 1:00 EST

      Optical Coherence Tomography (OCT) has become the most widely used optical technique for medical imaging over the last decade. The technology is standard of care for diagnosis and disease management for several ophthalmic conditions and represents a market of over 500 million US dollars per year. Like other established medical imaging technologies, OCT is making its move from structural to functional imaging with advent of OCT angiography. However, unlike most other techniques OCT angiography does not rely on external contrast agents, making it particularly useful. This presentation will discuss principles and technology behind OCT angiography. A brief history of development ...

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    8. 4D imaging of cardiac trabeculae contracting in vitro using gated OCT

      4D imaging of cardiac trabeculae contracting in vitro using gated OCT

      Cardiac trabeculae are widely used as experimental muscle preparations for studying heart muscle. However, their geometry (diameter, length, and shape) can vary not only amongst samples, but also within a sample, leading to inaccuracies in estimating their stress production, volumetric energy output, and/or oxygen consumption. Hence, it is desirable to have a system that can accurately image each trabecula in vitro during an experiment. To this end, we constructed an optical coherence tomography (OCT) system and implemented a gated imaging procedure to image actively contracting trabeculae and reconstruct their time-varying geometry. By imaging a single cross section while monitoring ...

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    9. Post-doctoral Associate Position in Biophotonics/Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics/Biomedical Optical Imaging at Lehigh University

      Position description: A full-time Postdoctoral Associate position in Biophotonics / Biomedical Optical Imaging is available at Lehigh University starting ASAP . The primary purpose of this position will be for a highly motivated individual to develop advanced optical imaging techniques for novel biomedical applications in vitro and/or in vivo . Compensation is commensurate with experience. Qualifications: Ph.D. in Electrical Engineering, Physics, Applied Physics, Biomedical Engineering / Bioengineering or related fields. Hands-on experience with optical coherence tomography (OCT), especially phase-sensitive Fourier-domain OCT, is preferred. Good publication record and communication skills. Strong programming skills (Matlab, Labview, C++ and GPU programming) are pluses. Research areas ...

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    10. Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications

      Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications

      Recent advances in optical coherence tomography (OCT)-based angiography have demonstrated a variety of biomedical applications in the diagnosis and therapeutic monitoring of diseases with vascular involvement. While promising, its imaging field of view (FOV) is however still limited (typically less than 9 mm 2 ), which somehow slows down its clinical acceptance. In this paper, we report a high-speed spectral-domain OCT operating at 1310 nm to enable wide FOV up to 750 mm 2 . Using optical microangiography (OMAG) algorithm, we are able to map vascular networks within living biological tissues. Thanks to 2,048 pixel-array line scan InGaAs camera operating ...

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    11. OCT in Central Nervous System Disease: The Eye as a Window to the Brain (Textbook)

      OCT in Central Nervous System Disease: The Eye as a Window to the Brain (Textbook)

      This book reviews recent important advances in the use of optical coherence tomography (OCT) in order to analyze neurodegeneration within the retina through the quantification of axonal loss. Detailed information is provided on the role of OCT as a promising tool for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. The disorders considered include multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment ...

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    12. Michael Jenkins Wins American Association of Anatomists (AAA) Young Investigator Award

      Michael Jenkins Wins American Association of Anatomists (AAA) Young Investigator Award

      Ceremony at AAA's 2016 annual meeting at Experimental Biology (EB) in San Diego, CA. The ceremony is being held at The Marriot Marquis San Diego Marina on Tuesday, April 5, 2016, at 7pm. Young Investigator awards recognize investigators in the early stages of their careers who have made important contributions to biomedical science through their research in cell/molecular biology, comparative neuroanatomy, developmental biology, or the morphological sciences. The 2016 Young Investigator Award winners are:...Michael Jenkins, Ph.D. , of Case Western Reserve University , will be honored with a plaque for his early contributions to the field of developmental ...

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    13. Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows

      Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows

      We present a new OCT method for flow speed quantification and directional velocimetry: particle streak velocimetry-OCT (PSV-OCT). PSV-OCT generates two-dimensional, 2.5-vector component ( v x ,| v y |, v z ) maps of microscale flow velocity fields. Knowledge of 2.5-vector components also enables the estimation of total flow speed. The enabling insight behind PSV-OCT is that tracer particles in sparsely-seeded fluid flow trace out streaks in ( x,z,t )-space. The streak orientations in x-t and z-t yield v x and v z , respectively. The in-plane ( x-z plane) residence time yields the out-of-plane speed | v y |. Vector component values are generated ...

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    14. Choice of Intracoronary Imaging: When to Use Intravascular Ultrasound or Optical Coherence Tomography

      Choice of Intracoronary Imaging: When to Use Intravascular Ultrasound or Optical Coherence Tomography

      Intracoronary imaging has the capability of accurately measuring vessel and stenosis dimensions, assessing vessel integrity, characterising lesion morphology and guiding optimal percutaneous coronary intervention (PCI). Coronary angiography used to detect and assess coronary stenosis severity has limitations. The 2D nature of fluoroscopic imaging provides lumen profile only and the assessment of coronary stenosis by visual estimation is subjective and prone to error. Performing PCI based on coronary angiography alone is inadequate for determining key metrics of the vessel such as dimension, extent of disease, and plaque distribution and composition. The advent of intracoronary imaging has offset the limitations of angiography ...

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    15. Classification of calcium in intravascular OCT images for the purpose of intervention planning

      Classification of calcium in intravascular OCT images for the purpose of intervention planning

      The presence of extensive calcification is a primary concern when planning and implementing a vascular percutaneous intervention such as stenting. If the balloon does not expand, the interventionalist must blindly apply high balloon pressure, use an atherectomy device, or abort the procedure. As part of a project to determine the ability of Intravascular Optical Coherence Tomography (IVOCT) to aid intervention planning, we developed a method for automatic classification of calcium in coronary IVOCT images. We developed an approach where plaque texture is modeled by the joint probability distribution of a bank of filter responses where the filter bank was chosen ...

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    16. Development of in vivo tissue-engineered microvascular grafts with an ultra small diameter of 0.6 mm (MicroBiotubes): acute phase evaluation by optical coherence tomography and magnetic resonance angiography

      Development of in vivo tissue-engineered microvascular grafts with an ultra small diameter of 0.6 mm (MicroBiotubes): acute phase evaluation by optical coherence tomography and magnetic resonance angiography

      Biotubes, i.e., in vivo tissue-engineered connective tubular tissues, are known to be effective as vascular replacement grafts with a diameter greater than several millimeters. However, the performance of biotubes with smaller diameters is less clear. In this study, MicroBiotubes with diameters <1 mm were prepared, and their patency was evaluated noninvasively by optical coherence tomography (OCT) and magnetic resonance angiography (MRA). MicroBiotube molds, containing seven stainless wires (diameter 0.5 mm) covered with silicone tubes (outer diameter 0.6 mm) per mold, were embedded into the dorsal subcutaneous pouches of rats. After 2 months, the molds were harvested with ...

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    17. Non-invasive optical assessment of viscosity of middle ear effusions in otitis media

      Non-invasive optical assessment of viscosity of middle ear effusions in otitis media

      In vivo Optical Coherence Tomography (OCT) image of a human tympanic membrane and Middle Ear Effusion (MEE) (top), with a CCD image of the tympanic membrane surface (inset). Below is the corresponding time-lapse M-mode OCT data acquired along the white dotted line over time, which can be analyzed to determine the Stokes–Einstein diffusion coefficient of the effusion. Eustachian tube dysfunction can cause fluid to collect within the middle ear cavity and form a middle ear effusion (MEE). MEEs can persist for weeks or months and cause hearing loss as well as speech and learning delays in young children. The ...

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    18. μOCT imaging using depth of focus extension by self-imaging wavefront division in a common-path fiber optic probe

      μOCT imaging using depth of focus extension by self-imaging wavefront division in a common-path fiber optic probe

      Optical coherence tomography (OCT) is an attractive medical modality due to its ability to acquire high-resolution, cross-sectional images inside the body using flexible, small-diameter, scanning fiber optic probes. Conventional, cross-sectional OCT imaging technologies have approximately 10-μm axial resolution and 30-μm lateral resolution, specifications that enable the visualization of microscopic architectural morphology. While this resolution is useful for many clinical applications, it is insufficient for resolving individual cells that characterize many diseases. To address this gap, a supercontinuum-laser-based, μm-resolution OCT (μOCT) system and a 500 μm-diameter, extended depth of focus single fiber optic probe for endoscopic and intravascular imaging ...

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    19. Research Fellow Opening at the University of Western Australia in Nanoscope-In-a-Needle | Ref: 496429

      Research Fellow Opening at the University of Western Australia in Nanoscope-In-a-Needle | Ref: 496429

      SCHOOL OF ELECTRICAL, ELECTRONIC & COMPUTER ENGINEERING OPTICAL+BIOMEDICAL ENGINEERING LABORATORY 3-year appointment, (continuous employment subject to funding) Salary range: Level B $93,182 - $110,654 p.a. Research & Development In Biomedical Photonics/Optical Microscopy (Australia) The University of Western Australia (UWA) is ranked amongst the top Australian universities and a member of the prestigious Group of Eight research-intensive universities ranked among the top 100 universities in the world. Do you have a flare for building optical systems and want to make a difference in biology? Building on our Microscope-in-a-Needle programme, we are taking the next step in resolution to build ...

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    20. Myocardial imaging using ultrahigh-resolution spectral domain optical coherence tomography

      Myocardial imaging using ultrahigh-resolution spectral domain optical coherence tomography

      We present an ultrahigh-resolution spectral domain optical coherence tomography (OCT) system in 800 nm with a low-noise supercontinuum source (SC) optimized for myocardial imaging. The system was demonstrated to have an axial resolution of 2.72 μm  with a large imaging depth of 1.78 mm and a 6-dB falloff range of 0.89 mm. The lateral resolution ( 5.52  μm ) was compromised to enhance the image penetration required for myocardial imaging. The noise of the SC source was analyzed extensively and an imaging protocol was proposed for SC-based OCT imaging with appreciable contrast. Three-dimensional datasets were acquired ex vivo ...

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    21. Optical coherence tomography: A pathway from research to clinical practice

      Optical coherence tomography: A pathway from research to clinical practice

      For more than half a century, coronary angiography has been the goldstandard diagnostic test for the assessment of coronary artery disease, but it does not provide information about the components of the vascular wall, atherosclerosic disease burden, or the interaction of local devices with coronary artery walls.  The development of intracoronary imaging techniques, such as optical coherence tomography (OCT), was conceived with the objective to overcome coronary angiography limitations.

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    22. Comparison of caries diagnostic modalities: A clinical study in 40 subjects

      Comparison of caries diagnostic modalities: A clinical study in 40 subjects

      Background and Objectives Few studies have been published that evaluate the usefulness of different caries- diagnostic modalities in general dental practice. The goal of this study was to compare the results of screening for coronal dental caries in a general dental practice using clinical observations, radiographs, laser fluorescence (DIAGNOdent™) (LF), and optical coherence tomography (OCT). Diagnostic agreement between OCT and LF versus standard clinical techniques for detecting caries was determined in 40 subjects. Study Designs/Materials and Methods Forty patients with >1 coronal carious lesion as determined by prescreening using clinical examination and radiographs were enrolled in this study. Subjects ...

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    23. Safety of optical coherence tomography in daily practice: a comparison with intravascular ultrasound

      Safety of optical coherence tomography in daily practice: a comparison with intravascular ultrasound

      Aims Previous studies have reported the safety and feasibility of both time-domain optical coherence tomography (TD-OCT) and Fourier-domain OCT (FD-OCT) in highly selected patients and clinical settings. However, the generalizability of these data is limited, and data in unselected patient populations reflecting a routine cathlab practice are lacking. We compared safety of intracoronary FD-OCT imaging to intravascular ultrasound (IVUS) imaging in a large real-world series of consecutive patients who underwent invasive imaging during coronary catheterization in our centre. Methods and results This is a prospective, single-centre registry of patients scheduled for coronary angiography or intervention undergoing intracoronary imaging with FD-OCT ...

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    24. Wasatch Photonics launches label-free angiography technique based on optical coherence tomography

      Wasatch Photonics launches label-free angiography technique based on optical coherence tomography

      Wasatch Photonics Inc., a leading provider for gratings, spectrometers and optical coherence tomography instrumentation, announced Monday (March 21), the launch of a new imaging device, WP MicroAngio, for high-resolution angiographic imaging for research and original equipment manufacturer (OEM) applications. MicroAngio technology allows visualization of blood vessels at a microscopic level without using external contrast agents. The device, based on a variation of optical coherence tomography (OCT), creates a three-dimensional profile of the micro vasculature. WP MicroAngio is to be used for several medical research applications related to animal model imaging in ophthalmology, dermatology, oncology and other areas. MicroAngio, the new ...

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