1. Featured Articles

    1-26 of 26
    1. Eckhaus Instability in the Fourier-Domain Mode Locked Fiber Laser Cavity

      Eckhaus Instability in the Fourier-Domain Mode Locked Fiber Laser Cavity

      High frequency fluctuation in the optical signal generated in Fourier-Domain Mode Locked fiber laser (FDML-FL), which is the major problem and degrades the laser performance, is not yet fully analyzed or studied. The basic theory which is causing this high frequency fluctuation is required to clearly understand its dynamics and to control it for various applications. In this letter, by analyzing the signal and system dynamics of FDML-FL, we theoretically demonstrate that the high frequency fluctuation is induced by the intrinsic instability of frequency offset of the signal in cavity with nonlinear gain and spectral filter. Unlike the instabilities observed ...

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    2. Extended depth of focus for coherence-based cellular imaging

      Extended depth of focus for coherence-based cellular imaging

      Improving lateral resolution for cross-sectional optical coherence tomography (OCT) imaging is difficult due to the rapid divergence of light once it is focused to a small spot. To overcome this obstacle, we introduce a fiber optics system that generates a coaxially focused multimode (CAFM) beam for depth of focus (DOF) extension. We fabricated a CAFM beam OCT probe and show that the DOF is more than fivefold that of a conventional Gaussian beam, enabling cross-sectional imaging of biological tissues with clearly resolved cellular and subcellular structures over more than a 400 μm depth range. The compact and straightforward design and ...

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    3. Postdoctoral Fellow, Bioengineering at University of Maryland - College Park

      Postdoctoral Fellow, Bioengineering at University of Maryland - College Park

      We are seeking a postdoctoral fellow to pursue research on developing novel optical imaging devices and applications on cancer diagnosis, functional brain imaging and tissue engineering. Candidates must hold a Ph.D. in engineering, physics, or related fields and have prior experience with Optics, OCT, Microscopy (e.g. fluorescence, confocal, Two-photon), and image analysis software development. Experience with cell culture and/or animals experiments is a plus. Please submit a cover letter with a brief description of research experience, interests, and career goals (≤ 2 pages), CV with complete list of publications, and contact information for 3 references in a single ...

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    4. Research Associate/ Research Fellow at University of Western Australia

      Research Associate/ Research Fellow at University of Western Australia

      Job no: 499166 Work type: full-time Location: Crawley Categories: Engineering and Mathematical Sciences UWA Faculty of Engineering and Mathematical Sciences School of Electrical, Electronic and Computer Engineering 1 year fixed term appointment Level A/B position: $67,352 - $114,250 per annum The University of Western Australia (UWA) is ranked amongst the top Australian universities and a member of the prestigious Group of Eight research-intensive universities ranked among the top 100 universities in the world. About the work area You will be a member of BRITElab in the School of Electrical, Electronic and Computer Engineering within the Faculty of Engineering ...

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    5. Postdoctoral Research Scientist Position at Colgate-Palmolive Company in Piscataway New Jersey

      Postdoctoral Research Scientist Position at Colgate-Palmolive Company in Piscataway New Jersey

      Colgate-Palmolive is a leading global consumer products company, tightly focused on Oral Care, Personal Care, Home Care and Pet Nutrition. Colgate sells its products in over 200 countries and territories around the world under such internationally recognized brand names as Colgate, Palmolive, Speed Stick, Lady Speed Stick, Softsoap, Irish Spring, Protex, Sorriso, Kolynos, elmex, Tom’s of Maine, Sanex, Ajax, Axion, Fabuloso, Soupline and Suavitel, as well as Hill’s Science Diet, Hill’s Prescription Diet and Hill’s Ideal Balance. For more information about Colgate’s global business, visit the Company’s web site at http://www.colgatepalmolive.com ...

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    6. Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples

      Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples

      A visible light spectral domain optical coherence microscopy system was developed. A high axial resolution of 0.88 µm in tissue was achieved using a broad visible light spectrum (425 − 685 nm). Healthy human brain tissue was imaged to quantify the difference between white (WM) and grey matter (GM) in intensity and attenuation. The high axial resolution enables the investigation of amyloid-beta plaques of various sizes in human brain tissue and animal models of Alzheimer’s disease (AD). By performing a spectroscopic analysis of the OCM data, differences in the characteristics for WM, GM, and neuritic amyloid-beta plaques were found ...

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    7. Optical coherence tomography to guide percutaneous treatment of coronary bifurcation disease

      Optical coherence tomography to guide percutaneous treatment of coronary bifurcation disease

      Introduction : Cardiovascular disease remains the most common cause of death worldwide. Enormous progress in the technology and applicability of percutaneous techniques to treat obstructive coronary heart disease has been made, and the number of percutaneous coronary interventions (PCI) is increasing. Coronary bifurcations are involved in a substantial number of PCIs and despite recent advances, bifurcation PCI remains a challenge in terms of immediate success and long-term outcome. Angiography has a limited capacity for showing important features of the 3 dimensional coronary vessel anatomy, position of stent struts and exact wire positions and is therefore suboptimal for guiding bifurcation PCI. Intracoronary ...

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    8. Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source

      Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source

      Endoscopic optical coherence tomography (OCT) instruments are mostly side viewing and rely on at least one proximal scan, thus limiting accuracy of volumetric imaging and en face visualization. Previous forward-viewing OCT devices had limited axial scan speeds. We report a forward-viewing fiber scanning 3D-OCT probe with 900 μm field of view and 5 μm transverse resolution, imaging at 1 MHz axial scan rate in the human gastrointestinal tract. The probe is 3.3 mm diameter and 20 mm rigid length, thus enabling passage through the endoscopic channel. The scanner has 1.8 kHz resonant frequency, and each volumetric acquisition takes ...

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    9. Postdoctoral Fellow: Biophotonics and Computer Vision Stanford University, Stanford, CA

      Postdoctoral Fellow: Biophotonics and Computer Vision Stanford University, Stanford, CA

      The Stanford Biomedical Optics Group (http://sbo.stanford.edu), in close collaboration with clinical researchers in the School of Medicine (urology), seeks highly motivated research associate with excellent computer programming and image processing skills along with a good background / strong interest in optics, microscopy or medical imaging and interest or experience in computer vision. Stanford University provides an outstanding environment for solid technical research with clinical impact. Applicants will work closely with clinical collaborators and will spend a significant amount of time observing and guiding clinical research activities while working on a heavily computer vision programming-­‐oriented research project. Time ...

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    10. Optovue First in US to Receive FDA Clearance for Corneal Epithelial Thickness Mapping New Mapping Technique May be Early Indicator of Ocular Health

      Optovue First in US to Receive FDA Clearance for Corneal Epithelial Thickness Mapping New Mapping Technique May be Early Indicator of Ocular Health

      Optovue announced today that the U.S. Food and Drug Administration (FDA) has cleared the company’s epithelial thickness mapping software (epi-mapping) for quantitative measurements of the epithelial and stromal layers of the cornea. Epi-mapping is the first non-contact, quantitative method for corneal epithelia and stromal measurements, and it is the first and only FDA-cleared product indicated to provide corneal epithelia and stromal measurements that aid in the diagnosis, documentation and management of ocular health and diseases in the adult population. “The measurement of corneal epithelial thickness is becoming more recognized as a vital part of assessing patients for refractive ...

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      Mentions: Optovue Jay Wei FDA
    11. Low Endothelial Shear Stress Predicts Evolution to High-Risk Coronary Plaque Phenotype in the Future A Serial Optical Coherence Tomography and Computational Fluid Dynamics Stud

      Low Endothelial Shear Stress Predicts Evolution to High-Risk Coronary Plaque Phenotype in the Future A Serial Optical Coherence Tomography and Computational Fluid Dynamics Stud

      Background— Low endothelial shear stress (ESS) is associated with plaque progression and vulnerability. To date, changes in plaque phenotype over time in relation to ESS have not been studied in humans. The aim of this study was to investigate whether local ESS can predict subsequent changes to plaque phenotype using optical coherence tomography. Methods and Results— A total of 25 coronary arteries from 20 patients who underwent baseline and 6-month follow-up optical coherence tomography were included. Arteries were divided into serial 3-mm segments, and plaque characteristics were evaluated in each segment. A total of 145 segments were divided into low-ESS ...

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    12. Optical coherence tomography and non-linear microscopy for paintings – a study of the complementary capabilities and laser degradation effects

      Optical coherence tomography and non-linear microscopy for paintings – a study of the complementary capabilities and laser degradation effects

      his paper examines for the first time the potential complementary imaging capabilities of Optical coherence tomography (OCT) and non-linear microscopy (NLM) for multi-modal 3D examination of paintings following the successful application of OCT to the in situ, non-invasive examination of varnish and paint stratigraphy of historic paintings and the promising initial studies of NLM of varnish samples. OCT provides image contrast through the optical scattering and absorption properties of materials, while NLM provides molecular information through multi-photon fluorescence and higher harmonics generation (second and third harmonic generation). OCT is well-established in the in situ non-invasive imaging of the stratigraphy of ...

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    13. A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head

      A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head

      Purpose. To develop a deep learning approach to digitally-stain optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods. A horizontal B-scan was acquired through the center of the ONH using OCT (Spectralis) for 1 eye of each of 100 subjects (40 normal & 60 glaucoma). All images were enhanced using adaptive compensation. A custom deep learning network was then designed and trained with the compensated images to digitally stain (i.e. highlight) 6 tissue layers of the ONH. The accuracy of our algorithm was assessed (against manual segmentations) using the Dice coefficient, sensitivity, and specificity. We further studied ...

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    14. Intravascular imaging for characterization of coronary atherosclerosis

      Intravascular imaging for characterization of coronary atherosclerosis

      This short review surveys recent developments in coronary intravascular imaging technologies. We present an outline of the applications of intravascular imaging for guidance of percutaneous coronary interventions and imaging of atherosclerosis, along with emerging clinical evidence for use. Imaging of tissue composition is important for understanding the relation between the presence of a lesion and clinical sequelae. We describe the recent innovations to enable imaging of unstable atherosclerotic plaques, focusing on the emergence of experimental multimodal imaging technology.

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    15. Optical coherence tomography with nanoscale axial resolution using a laser-driven high-harmonic source

      Optical coherence tomography with nanoscale axial resolution using a laser-driven high-harmonic source

      Extreme ultraviolet microscopy is technologically demanding and thus largely confined to synchrotron radiation facilities. However, specific benefits like high resolution and exceptional material contrast provide strong motivation for the development of table-top alternatives. We report on the first demonstration of coherence tomography, i.e., noninvasive cross-sectional imaging, with high harmonics. A depth resolution of 24 nm and very good material contrast are achieved. Excessively demanding optics for extreme ultraviolet radiation are avoided and artifacts due to the elementary geometry are suppressed with a novel three-step one-dimensional phase-retrieval algorithm. The images are recorded in reflection geometry, facilitating the analysis of, e ...

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    16. From lab to clinic

      From lab to clinic

      Last month I visited my eye doctor, Harold Jacobson, for a routine checkup. After reading rows of ever-smaller letters, just as I had when my eyes were first tested in the 1970s, I asked him what new technology he was most excited about. “Optical coherence tomography,” he replied. “It’s a game changer!” Jacobson had bought an OCT scanner after my previous visit, so I got to see the game changer firsthand. As a patient, I briefly looked into a pair of eyepieces. As an ophthalmologist, Jacobson reviewed a wealth of information on the scanner’s screen. Beside cross sections ...

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    17. Optical coherence tomography image-guided smart laser knife for surgery

      Optical coherence tomography image-guided smart laser knife for surgery

      Background and Objective Surgical oncology can benefit from specialized tools that enhance imaging and enable precise cutting and removal of tissue without damage to adjacent structures. The combination of high-resolution, fast optical coherence tomography (OCT) co-aligned with a nanosecond pulsed thulium (Tm) laser offers advantages over conventional surgical laser systems. Tm lasers provide superior beam quality, high volumetric tissue removal rates with minimal residual thermal footprint in tissue, enabling a reduction in unwanted damage to delicate adjacent sub-surface structures such as nerves or micro-vessels. We investigated such a combined Tm/OCT system with co-aligned imaging and cutting beams—a configuration ...

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    18. Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines

      Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines

      Background Dynamic optical coherence tomography (D-OCT) has recently been introduced in dermatology. In contrast to ‚Standard’ OCT imaging, which exclusively relies on the morphological analysis of the tissue, D-OCT allows the in-vivo visualisation of blood flow. Preliminary D-OCT data showed differences in the vascularisation of nevus to melanoma transition, suggesting that this technology may help to differentiate between benign and malignant lesions. Objective Several factors may influence the quality of D-OCT imaging. Therefore, standard operating procedures as well as a common terminology are required for better validation and comparison of the images. Methods Here we present practical guidelines for optimal ...

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    19. Real-time imaging adds interactive dimension to vitreoretinal surgery, training

      Real-time imaging adds interactive dimension to vitreoretinal surgery, training

      First introduced in the early 1990s, OCT is a noninvasive imaging technique that obtains high-resolution, cross-sectional images of the retina and other ophthalmic tissues. In recent years, this technology has transitioned from being only available in the clinic to being able to be utilized in the operating room. Intraoperative OCT has allowed ophthalmologists to access real-time imaging of vitreoretinal surgery for the first time, adding a new dimension to surgery and education, according to a 2016 study published in Eye (London) by Justis P. Ehlers, MD. There are several FDA-approved systems with optional add-ons to improve performance. Companies such as ...

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    20. Notal Vision Welcomes Roni Amiel as Chief Information Officer

      Notal Vision Welcomes Roni Amiel as Chief Information Officer

      Notal Vision, Ltd., a privately-held ophthalmic company focused on cloud-based, patient-activated, home telemonitoring technologies, is pleased to announce the appointment of Roni Amiel as Chief Information Officer (CIO). In this newly created position, Mr. Amiel will be responsible for advancing the Company's cloud-based technology and capabilities to expand their competitive advantage, and will report to Quinton Oswald , Chief Executive Officer of Notal Vision. "Drawing on his extensive information technology (IT) leadership and medical systems expertise, Roni will help us execute our strategic goals so that we can continue to deliver an outstanding patient and physician experience. Elevating this IT ...

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      Mentions: Notal Vision
    21. Noniterative digital aberration correction for cellular resolution retinal optical coherence tomography in vivo

      Noniterative digital aberration correction for cellular resolution retinal optical coherence tomography in vivo

      High-resolution imaging of the human retina has always been a challenge due to imperfect optical properties of the human cornea and lens, which limit the achievable resolution. We present a noniterative digital aberration correction (DAC) to achieve aberration-free cellular-level resolution in optical coherence tomography (OCT) images of the human retina in vivo . The system used is a line-field spectral-domain OCT system with a high tomogram rate, reaching 2.5 kHz. Such a high speed enables us to successfully apply digital aberration correction for not only imaging of human cone photoreceptors but also to obtain an aberration- and defocus-corrected 3D volume ...

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    22. Ph.D. Student Position in Optical Coherence Tomography at University of Basel in Switzerland

      Ph.D. Student Position in Optical Coherence Tomography at University of Basel in Switzerland

      The Department of Biomedical Engineering (DBE) has recently been awarded a Flagship project from the Werner Siemens Foundation (Zug/Switzerland). The principal aim of this interdisciplinary project called Minimally Invasive Robot Assisted Computer-guided LaserosteotomE (MIRACLE) is the development of a minimally invasive robotic endoscope for cutting bone with laser light. The successful PhD candidate will be part of an interdisciplinary team of biomedical engineers, mechatronics engineers, computer scientists, physicists, and medical doctors. He or she will be able to contribute to the development of a disruptive technology in robotic surgery. Topic Description In this project, the Ph.D. candidate will ...

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      Mentions: Siemens Azhar Zam
    23. Non-destructive analysis of flake properties in automotive paints with full-field optical coherence tomography and 3D segmentation

      Non-destructive analysis of flake properties in automotive paints with full-field optical coherence tomography and 3D segmentation

      Automotive coating systems are designed to protect vehicle bodies from corrosion and enhance their aesthetic value. The number, size and orientation of small metallic flakes in the base coat of the paint has a significant effect on the appearance of automotive bodies. It is important for quality assurance (QA) to be able to measure the properties of these small flakes, which are approximately 10 μm in radius, yet current QA techniques are limited to measuring layer thickness. We design and develop a time-domain (TD) full-field (FF) optical coherence tomography (OCT) system to scan automotive panels volumetrically, non-destructively and without contact ...

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    24. Optical Coherence Tomography Findings in Patients with Coronary Stent Thrombosis: A Report of the PREvention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Consortium

      Optical Coherence Tomography Findings in Patients with Coronary Stent Thrombosis: A Report of the PREvention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Consortium

      Background —Stent thrombosis (ST) is a serious complication following coronary stenting. Intravascular optical coherence tomography (OCT) may provide insights into mechanistic processes leading to ST. We performed a prospective, multicenter study to evaluate OCT findings in patients with ST. Methods —Consecutive patients presenting with ST were prospectively enrolled in a registry using a centralized telephone registration system. After angiographic confirmation of ST, OCT imaging of the culprit vessel was performed with frequency domain OCT. Clinical data were collected according to a standardized protocol. OCT acquisitions were analyzed at a core laboratory. Dominant and contributing findings were adjudicated by an imaging ...

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    25. Viewing a Weld Seam in 360°: New Scan Solution Utilizes OCT Technology to Coaxially Track and Inspect Seams

      Viewing a Weld Seam in 360°: New Scan Solution Utilizes OCT Technology to Coaxially Track and Inspect Seams

      At the Laser World of Photonics tradeshow in Munich, Germany, Blackbird Robotersysteme GmbH (acknowledged remote welding expert and SCANLAB GmbH associate company) will present an entirely new scan solution prototype with integrated distance sensor. Based on optical coherence tomography (OCT), the system detects and measures 3D laser weld seam topographies in high resolution. This is particularly advantageous for industrial system integrators and users looking to secure process safety and comprehensive quality management without a separate monitoring solution. In healthcare OCT has proven itself as an examination technique for opththamology, skin analysis, cancer diagnosis and more. For patients, this optical measurement ...

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    26. Beckman Foundation Names Dr. James G. Fujimoto of the Massachusetts Institute of Technology as 2017 Beckman-Argyros Vision Research Award Winner

      Beckman Foundation Names Dr. James G. Fujimoto of the Massachusetts Institute of Technology as 2017 Beckman-Argyros Vision Research Award Winner

      The Arnold and Mabel Beckman Foundation has announced James G. Fujimoto, Ph.D ., the Elihu Thomson Professor of Electrical Engineering and Computer Science at the Massachusetts Institute of Technology, as its 2017 Beckman-Argyros Vision Research Award winner. Presented annually, the award recognizes an individual who has made and is continuing to make significant transformative breakthroughs in vision research; particularly through the development of an innovative technology or fundamental scientific breakthrough that has been applied to, aided and/or improved the vision sciences. Dr. Fujimoto and MIT will receive $100,000 and $400,000, respectively, to further advance the application of ...

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    1-26 of 26
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