1. Featured Articles

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    1. Innovative Endoscopies to Be Clinically Used in the Near Future

      Innovative Endoscopies to Be Clinically Used in the Near Future

      In contrast to traditional single-lens endoscopies, recently introduced full-spectrum endoscopy (FUSE) scopes include multiple lenses providing a much wider field of view. In many studies, FUSE was shown to be feasible, effective, and safe, and FUSE colonoscopy yielded higher polyp (PDR), adenoma (ADR), and diverticular (DDR) detection rates than did traditional colonoscopy, without therapeutic failure or complications. Moreover, using FUSE gastroscopy, the prevalence of duodenal peri-ampullary diverticula (DPAD) in the general population could be analyzed without using ERCP. In the future, the next generation of modified FUSE system is expected to be useful in direct peroral cholangioscopy and in simultaneous ...

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    2. OCT for early quality evaluation of tooth–composite bond in clinical trials

      OCT for early quality evaluation of tooth–composite bond in clinical trials

      Objectives To evaluate early quality of composite restorations with a universal adhesive in different application modes clinically and with optical coherence tomography (OCT). Methods 22 patients with four non-carious cervical lesions each received composite restorations (Filtek Supreme TM XTE, 3 M). The universal adhesive Scotchbond Universal TM (SBU, 3 M) was applied with three etching protocols: self-etch (SE), selective-enamel-etch (SEE) and etch-and-rinse (ER). The etch-and-rinse adhesive OptiBond TM FL (OFL, Kerr) served as a control. Restorations were imaged by OCT (Thorlabs) directly after application (t 0 ). After 14 days (t 1 ) and 6 month (t 2 ) OCT imaging (interfacial adhesive ...

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    3. Clinical efficacy of aspirin with identification of intimal morphology by optical coherence tomography in preventing event recurrence in patients with vasospasm-induced acute coronary syndrome

      Clinical efficacy of aspirin with identification of intimal morphology by optical coherence tomography in preventing event recurrence in patients with vasospasm-induced acute coronary syndrome

      Using optical coherence tomography (OCT), we found that there were morphological differences in the coronary intima between patients with vasospasm-induced acute coronary syndrome (VACS) and those with stable variant angina. We investigated whether aspirin use would protect against chest pain recurrence in patients with VACS. A retrospective cohort study was performed. Patients with ST-segment elevation who were confirmed to have VACS by a provocation test were included. OCT was performed at the index event and when chest pain recurred to assess intimal morphology. Chest pain recurrence was defined as the first revisit to the emergency room with angina. Propensity score ...

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    4. Position for Application Engineer in OCT, based in Shenzhen, China

      Position for Application Engineer in OCT, based in Shenzhen, China

      AlazarTech, a manufacturer of high-performance, low‑cost PC-Based Instruments, invites applications for the position of Application Engineer to work in the Shenzhen office of Scott Engineering Ltd. to provide pre-sales and post-sales technical sales support to AlazarTech customers, test and calibrate AlazarTech products, and assist customers in adapting example programs supplied by AlazarTech to their specific needs. Responsibilities include: Communicating with customers to understand their application and matching it to the appropriate AlazarTech product Making remote and on-site demonstrations of AlazarTech products for customers (pre-sales) Testing and verifying products received from AlazarTech prior to shipment to customer, as added Quality ...

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      Mentions: AlazarTech
    5. Volumetric optical coherence microscopy with a high space-bandwidth-time product enabled by hybrid adaptive optics

      Volumetric optical coherence microscopy with a high space-bandwidth-time product enabled by hybrid adaptive optics

      Optical coherence microscopy (OCM) is a promising modality for high resolution imaging, but has limited ability to capture large-scale volumetric information about dynamic biological processes with cellular resolution. To enhance the throughput of OCM, we implemented a hybrid adaptive optics (hyAO) approach that combines computational adaptive optics with an intentionally aberrated imaging beam generated via hardware adaptive optics. Using hyAO, we demonstrate the depth-equalized illumination and collection ability of an astigmatic beam compared to a Gaussian beam for cellular-resolution imaging. With this advantage, we achieved volumetric OCM with a higher space-bandwidth- time product compared to Gaussian-beam acquisition that employed focus-scanning ...

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    6. Photonic force optical coherence elastography for three-dimensional mechanical microscopy

      Photonic force optical coherence elastography for three-dimensional mechanical microscopy

      Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead oscillations. In contrast, radiation pressure from a low-numerical aperture optical beam can apply transversely localized force over an extended depth range. Here we present photonic force optical coherence elastography (PF-OCE), leveraging phase-sensitive interferometric detection to track sub-nanometer oscillations of beads, embedded in viscoelastic hydrogels, induced by modulated radiation pressure. Since the displacements caused by ultra-low radiation-pressure force are typically obscured ...

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    7. Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation

      Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation

      Realistic simulation of image formation in optical coherence tomography, based on Maxwell’s equations, has recently been demonstrated for sample volumes of practical significance. Yet, there remains a limitation whereby reducing the size of cells used to construct a computational grid, thus allowing for a more realistic representation of scatterer microstructure, necessarily reduces the overall sample size that can be modelled. This is a significant problem since, as is well known, the microstructure of a scatterer significantly influences its scattering properties. Here we demonstrate that an optimized scatterer design can overcome this problem resulting in good agreement between simulated and ...

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    8. Endoscopic optical coherence tomography with a flexible fiber bundle

      Endoscopic optical coherence tomography with a flexible fiber bundle

      We demonstrate in vivo endoscopic optical coherence tomography (OCT) imaging in the forward direction using a flexible fiber bundle (FB). In comparison to current conventional forward-looking probe schemes, our approach simplifies the endoscope design by avoiding the integration of any beam steering components in the distal probe end due to two-dimensional scanning of a focused light beam over the proximal FB surface. We describe the challenges that arise when OCT imaging with an FB is performed, such as multimoding or cross coupling. The performance of different FBs varying in parameters, such as numerical aperture, core size, core structure, and flexibility ...

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    9. OCT Angiography Summit 2018 - Portland Oregon, August 3rd, 2018

      OCT Angiography Summit 2018 - Portland Oregon, August 3rd, 2018

      OCT Angiography Summit 2018 CME Conference will be held in Portland, Oregon on August 4, 2018 at the Portland Marriott Downtown Waterfront. This annual event brings together world-renowned experts to teach and discuss the latest technological advancements and emerging clinical applications for OCT angiography - the new no-injection method of visualizing the ocular circulation in 3 dimensions. The hot topics this year: Detecting choroidal neovascularization prior to leakage - is the clinically important? Can OCT angiography replace visual field in glaucoma assessment? 3D vascular anatomy of the retina by adaptive-optics & projection-resolved OCT angiograpahy. Other attractions: Exhibitions of commercially-available OCT angiography systems. Kick-off ...

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    10. Multiple Research Scientist and Post-Doctoral Positions in OCT Available at the University of Washington, Seattle.

      Multiple Research Scientist and Post-Doctoral Positions in OCT Available at the University of Washington, Seattle.

      There are multiple research scientists and postdoctoral positions immediately available at the Wang Lab [Biophotonics and Imaging Laboratory (BAIL)], Department of Bioengineering, University of Washington, Seattle, WA. These positions are associated with research grants sponsored by the National Institutes of Health, Washington Research Foundation and Medical Industries, with a focus on clinical translation of optical coherence tomography to Ophthalmology, Dermatology and Dentistry. The research areas in BAIL include optical coherence tomography, optical micro-angiography (OCTA), photoacoustic imaging (PAI), multiphoton microscopy, hyperspectral imaging and their applications in small animal models (stroke, Alzheimers’ disease, heart developments and repair, retinopathy, cancer, and sensory stimulations ...

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    11. Optovue Receives FDA Clearance for AngioAnalytics – the World’s First OCT Angiography Metrics

      Optovue Receives FDA Clearance for AngioAnalytics – the World’s First OCT Angiography Metrics

      Optovue announced FDA 510(k) clearance of AngioAnalytics™, the world’s first optical coherence tomography angiography (OCTA) blood vessel measurement technology to help clinicians manage diseases that cause progressive blindness. The company also received clearance for its three-dimensional projection artifact removal (3D PAR) software, which greatly improves OCTA image quality and enables accurate measurement and interpretation of OCTA images. AngioAnalytics and 3D PAR are commercially available in the U.S. “AngioAnalytics and 3D PAR are game changers because they 'erase' overlying inner retinal blood vessel artifacts allowing for better visualization and more accurate measurement of the outer retina and choroidal ...

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      Mentions: Optovue Jay Wei FDA
    12. Postdoctoral Research Fellow Position in the Ocular Imaging Program at the Singapore Eye Research Institute

      Postdoctoral Research Fellow Position in the Ocular Imaging Program at the Singapore Eye Research Institute

      The Singapore Eye Research Institute (SERI) serves as Singapore’s national research institute for ophthalmic and vision research. SERI functions as the research arm of the various clinical ophthalmic centres in Singapore, including the Singapore National Eye Centre (SNEC), the national clinical centre for ophthalmology in Singapore. SERI has developed a world-leading reputation in broad-based clinical translational research programmes for eye diseases. Recently SERI has established an ocular imaging program together with Nanyang Technological University (NTU) under the directorship of Prof. Leopold Schmetterer. SERI is seeking a highly qualified individual to take on a significant role in this rapidly expanding ...

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    13. Research Scientist Position at IPG Photonics

      Research Scientist Position at IPG Photonics

      R&D Scientist (Sensors) The IPG Photonics (NASDAQ:IPGP) Canada invents, develops and produces market-disrupting sensor technology that enables unprecedented capabilities to visualize, understand and control laser manufacturing processes. The group’s products are integrated with IPG’s world-leading photonic material processing solutions and are used to provide quality assurance for high-power industrial laser processing applications in advanced manufacturing environments around the world. Our technology empowers many household brands to offer increasingly safe, efficient and performant solutions to consumers and industry alike. We are seeking a new member of our R&D team to accelerate our scientific and product development ...

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    14. Real-time visualization and interaction with static and live optical coherence tomography volumes in immersive virtual reality

      Real-time visualization and interaction with static and live optical coherence tomography volumes in immersive virtual reality

      Virtual reality (VR) head-mounted displays are an attractive technology for viewing intrasurgical optical coherence tomography (OCT) volumes because they liberate surgeons from microscope oculars. We demonstrate real-time, interactive viewing of OCT volumes in a commercial HTC Vive immersive VR system using previously reported ray casting techniques. Furthermore, we show interactive manipulation and sectioning of volumes using handheld controllers and guidance of mock surgical procedures in porcine eyes exclusively within VR. To the best of our knowledge, we report the first immersive VR-OCT viewer with stereo ray casting volumetric renders, arbitrary sectioning planes, and live acquisition support. We believe VR-OCT volume ...

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    15. In vitro and clinical evaluation of optical coherence tomography for the detection of subgingival calculus and root cementum

      In vitro and clinical evaluation of optical coherence tomography for the detection of subgingival calculus and root cementum

      This study evaluated the effectiveness of swept-source optical coherence tomography (ss-OCT) for detecting calculus and root cementum during periodontal therapy. Optical coherence tomography (OCT) images were taken before and after removal of subgingival calculus from extracted teeth and compared with non-decalcified histological sections. Porcine gingival sheets of various thicknesses were applied to the root surfaces of extracted teeth with calculus and OCT images were taken. OCT images were also taken before and after scaling and root planing (SRP) in human patients. In vitro , calculus was clearly detected as a white-gray amorphous structure on the root surface, which disappeared after removal ...

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    16. A review in enormity of OCT and its enduring understanding of vulnerable plaque in coronary bifurcation lesion

      A review in enormity of OCT and its enduring understanding of vulnerable plaque in coronary bifurcation lesion

      Optical coherence tomography (OCT) has emerged as one of the most promising tools to assist the optimization of percutaneous coronary intervention (PCI). Its ability to provide unique information on the plaque at high risk for rupture, plaque composition, the thickness of the fibrous cap, the presence of macrophage and thrombi has not only assisted simple PCI but also in many complex bifurcation lesions PCI. OCT has helped to provide valuable anatomic information to optimize stent implantation and adapt PCI strategy in individual patients. This review article summarizes the current role of OCT as an imaging technology and prediction of vulnerable ...

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    17. Optical Engineering Opening at Oculus

      Optical Engineering Opening at Oculus

      We are looking for an Optical Engineer to join our Brain-Computer Interface (BCI) team in Menlo Park, CA. In this role, you will be responsible for building optical systems, including light sources, sensors, waveguides, and related technology building blocks to enable next generation architectures for novel neural interface technologies. Our research is focused on developing functional brain-computer interface (BCI) technologies for use in consumer electronic products. Our team collaborates extensively with small companies and academic institutions, and publishes in peer-reviewed journals. Responsibilities Build, evaluate and characterize electro-optic systems in a laboratory environment Perform simulations, modeling and prototyping for next-generation optical ...

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      Mentions: Michael A. Choma
    18. The clinical significance of echo-attenuated plaque in stable angina pectoris compared with acute coronary syndromes: A combined intravascular ultrasound and optical coherence tomography study

      The clinical significance of echo-attenuated plaque in stable angina pectoris compared with acute coronary syndromes: A combined intravascular ultrasound and optical coherence tomography study

      Background Echo-attenuated plaque (EA) on intravascular ultrasound (IVUS) is related to poor outcomes after percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) patients. However, the clinical significance of EA in stable angina pectoris (SAP) patients compared with that in ACS patients remains unclear. We assessed the relationships between EA and unstable plaque characteristics in patients with ACS and SAP. Methods We investigated 609 coronary lesions in 609 patients (234 with ACS; 375 with SAP) undergoing pre-intervention IVUS and optical coherence tomography (OCT). The differences in plaque morphology and post-PCI outcomes were assessed according to the clinical status of ACS ...

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    19. Optical coherence tomography (OCT) with 2 nm axial resolution using a compact laser plasma soft X-ray source

      Optical coherence tomography (OCT) with 2 nm axial resolution using a compact laser plasma soft X-ray source

      We present optical coherence tomography (OCT) with 2 nm axial resolution using broadband soft X-ray radiation (SXR) from a compact laser plasma light source. The laser plasma was formed by the interaction of nanosecond laser pulses with a gaseous target in a double stream gas puff target approach. The source was optimized for efficient SXR emission from the krypton/helium gas puff target in the 2 to 5 nm spectral range, encompassing the entire “water-window” spectral range from 2.3 nm to 4.4 nm wavelength. The coherence parameters of the SXR radiation allowed for the OCT measurements of a ...

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    20. PhotoniCare Receives $2.1 Million National Institute of Health Phase IIb Small Business Innovation Research Award

      PhotoniCare Receives $2.1 Million National Institute of Health Phase IIb Small Business Innovation Research Award

      PhotoniCare, a medical device company headquartered in Champaign, Illinois, received a $2.1 million award through the National Institute of Health (NIH) Phase llb Small Business Innovation Research (SBIR) program. The National Institute of Deafness & Communications Disorders (NIDCD), part of the NIH, is funding this award. The NIDCD conducts and supports research in the normal and disordered processes of hearing, balance, taste, smell, voice, speech, and language. In fiscal years 2015 and 2016 PhotoniCare was awarded SBIR Phase ll funding from the NIDCD. The SBIR program is the mechanism by which the NIH and other Federal agencies bring innovative solutions ...

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    21. Adaptable switching schemes for time-encoded multichannel optical coherence tomography

      Adaptable switching schemes for time-encoded multichannel optical coherence tomography

      We introduce the approach of variable time encoding for multichannel optical coherence tomography (OCT). High-speed fiber optical switches are applied for sequential sample arm switching to enable quasisimultaneous image acquisition from three different orientation angles. In comparison with previous multichannel OCT (using simultaneous sample illumination), time-encoded multichannel OCT has no need for division of illumination power among the respective channels to satisfy laser safety requirements. Especially for ophthalmic applications—in particular retinal imaging, which the presented prototype was developed for—this advantage strongly influences image quality through an enhanced sensitivity. Nevertheless, time encoding comes at the cost of a decrease ...

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    22. Heidelberg Engineering’s SPECTRALIS OCT2 Module Headed to the International Space Station

      Heidelberg Engineering’s SPECTRALIS OCT2 Module Headed to the International Space Station

      NASA has been conducting research on the effects of microgravity on vision using the SPECTRALIS imaging platform since 2013. Heidelberg Engineering, a privately-held imaging solutions company focused on advanced diagnostic instruments for eye care professionals, announced the continuation of the SPECTRALIS space odyssey as the SPECTRALIS imaging platform with the company’s next-generation OCT2 Module is headed for the International Space Station (ISS). NASA launched the SPECTRALIS with OCT2 Module to the ISS aboard the Antares 230 Cygnus CRS OA-9, also known as Orbital Sciences CRS Flight 9E on May 21, 2018 from Wallops Island, Virginia. The device will be ...

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    23. Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)

      Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)

      Background: Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis of tissue and have the potential to offer additive diagnostic information. Objective: This study has 2 separate primary objectives. The first is to assess the technical feasibility and safety of ...

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    24. Postdoctoral positions open at Boston University School of Medicine, Boston Medical Center

      Postdoctoral positions open at Boston University School of Medicine, Boston Medical Center

      Postdoctoral positions open at Boston University School of Medicine, Boston Medical Center. Our lab develops and implements optical imaging method in biomedical applications. We work closely with clinicians to translate the latest imaging technologies into clinical settings. The current focus of the lab is ophthalmic imaging for retinal diseases, and endoscopic imaging for GI and intravascular diseases. We are collaborative, interdisciplinary and also highly productive with several new imaging methods developed in recent two years. The lab is located in the vibrant Boston area, providing an excellent living environment out of work. We are looking for strong postdoc candidates with ...

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