1. Featured Articles

    1-13 of 13
    1. Capabilities of Gabor-domain optical coherence microscopy for the assessment of corneal disease

      Capabilities of Gabor-domain optical coherence microscopy for the assessment of corneal disease

      To identify the microstructural modification of the corneal layers during the course of the disease, optical technologies have been pushing the boundary of innovation to achieve cellular resolution of deep layers of the cornea. Gabor-domain optical coherence microscopy (GD-OCM), an optical coherence tomography-based technique that can achieve an isotropic of ∼2-μm resolution over a volume of 1  mm  ×  1  mm  ×  1.2  mm, was developed to investigate the microstructural modifications of corneal layers in four common corneal diseases. Since individual layer visualization without cutting through several layers is challenging due to corneal curvature, a flattening algorithm was developed to ...

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    2. Postdoctoral Research Fellow Position within the PARIS High Resolution Retinal Imaging Group

      Postdoctoral Research Fellow Position within the PARIS High Resolution Retinal Imaging Group

      A postdoctoral research fellow position is available within the PARIS high resolution retinal imaging group at the Quinze Vingts National Ophthalmology Hospital and Vision Institute in Paris, France. This is an excellent opportunity for a candidate to use adaptive optics ophthalmoscopy (AOO) and optical coherence tomography to conduct visual optics research in a clinical ophthalmology setting. The postdoc will work with a team of clinicians, engineers and scientists to develop, adapt and apply novel AOO modalities to imaging retinal disease in the context of a multi-centric project funded by the European Research Council (ERC), involving renowned partners expert in high ...

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    3. Research Associate / Postdoctoral Fellow in Adaptive Optics and Optical Coherence Tomography at Indiana University

      Research Associate / Postdoctoral Fellow in Adaptive Optics and Optical Coherence Tomography at Indiana University

      The Advanced Ophthalmic Imaging Laboratory at Indiana University is looking to fill a postdoctoral fellow or research associateposition. The successful candidate will join a team of scientists and engineers that are developing adaptive optics–optical coherence tomography (AO-OCT) for studying structure and function of the living human retina at the cellular level. The system is opening exciting new directions to study both normal and pathological vision. The laboratory ( www.opt.indiana.edu/dtmiller/Index.aspx ) is part of an active and well-funded community of vision scientists and engineers working in the areas of visual optics, retinal imaging, OCT, and adaptive ...

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    4. Development of a clinical prototype of a miniature hand-held optical coherence tomography probe for prematurity and pediatric ophthalmic imaging

      Development of a clinical prototype of a miniature hand-held optical coherence tomography probe for prematurity and pediatric ophthalmic imaging

      We report a novel design and operation of a highly integrated miniature handheld OCT probe, with high-speed angiography function that can be used in clinical settings for young children and infants, providing rapid, non-invasive structural and angiographic imaging of the retina and choroid. The imaging system is operated at 200 kHz, with 3D OCT and OCTA scan time of 0.8 and 3.2 seconds, respectively, and the scanning angle on the pupil is ± 36°, covering the full perifoveal region. Operator assisting features of the direct-view iris camera and on-probe display are integrated into the hand-held probe, and the fixation ...

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    5. Retinal single-layer analysis with optical coherence tomography (OCT) in schizophrenia spectrum disorder

      Retinal single-layer analysis with optical coherence tomography (OCT) in schizophrenia spectrum disorder

      Background Volume reductions in brain structures of patients with schizophrenia spectrum disorder (SSD) have repeatedly been found in voxel-based morphometry MRI studies. Hence, an underlying neurodegenerative etiological component of SSD is currently being discussed. In recent years, the imaging method of optical coherence tomography (OCT) has shown its potential in evaluating structural changes in the retina in patients with confirmed neurodegenerative disorders, providing a window into the brain. Methods Twenty-six patients with schizophrenia or schizoaffective disorder and 23 age- and sex-matched healthy controls were examined with the Heidelberg Spectralis OCT system to derive a single-layer analysis of both retinas. The ...

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    6. Avinger Announces Publication of Study Demonstrating Positive Clinical Outcomes for Patients Treated with Pantheris Prior to Antirestenotic Therapy

      Avinger Announces Publication of Study Demonstrating Positive Clinical Outcomes for Patients Treated with Pantheris Prior to Antirestenotic Therapy

      Avinger, Inc. (NASDAQ: AVGR ), a leading developer of image-guided, catheter-based systems for the diagnosis and treatment of patients with Peripheral Artery Disease (PAD), today announced the publication of very promising clinical outcomes data from a study evaluating the performance of the Pantheris® Lumivascular atherectomy system combined with antirestenotic therapy in the treatment of PAD. This retrospective single-center, single-arm study has been published in the April 2019 issue of the peer-reviewed Journal of Cardiovascular Surgery under the title "Optical Coherence Tomography Guided Directional Atherectomy with Antirestenotic Therapy for Femoropopliteal Arterial Disease." The study analyzed the clinical outcomes of 33 patients (37 ...

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    7. Optical computing optical coherence tomography with conjugate suppression by dispersion

      Optical computing optical coherence tomography with conjugate suppression by dispersion

      For all imaging techniques, such as optical coherence tomography (OCT), fast imaging speed is always of high demand. Optical computing OCT ( OC2T) has achieved ultrahigh speed for real time 3D imaging without post data processing, but its spatial resolution is lowered down due to an imperfect Fourier transformation in the optical computing process. In this Letter, we illustrate the theory of OC2T and prove that the dispersion imbalance between reference arm and sample arm may be introduced to improve the resolution. Furthermore, this novel OC2T technique can also enable a conjugate restrained OCT imaging without any data processing, achieving ∼ 2 ...

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    8. Effect of solvent lamination on roll-to-roll hot-embossed PMMA microchannels evaluated by optical coherence tomography

      Effect of solvent lamination on roll-to-roll hot-embossed PMMA microchannels evaluated by optical coherence tomography

      Manufacturing of microfluidic based diagnostic devices requires small tolerances and uniform quality to guarantee reliable and repeatable test results. This work describes characterization of morphological changes that occur to a hot embossed PMMA microfluidic channel after solvent lamination with a PMMA lid. A non-contact cross-sectional analysis of the lidded microfluidic device was performed by optical coherence tomography (OCT). The solvent induced morphology change led to a porous structure in bottom corners of hot-embossed channels, which allowed a fluid to absorb in the material. The measurements of solvent diffusion showed faster diffusion rate at the corners of the channel, in which ...

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    9. Spatiotemporal optical coherence (STOC) manipulation suppresses coherent cross-talk in full-field swept-source optical coherence tomography

      Spatiotemporal optical coherence (STOC) manipulation suppresses coherent cross-talk in full-field swept-source optical coherence tomography

      Full-field swept-source optical coherence tomography (FF-SS-OCT) provides high-resolution depth-resolved images of the sample by parallel Fourier-domain interferometric detection. Although FF-SS-OCT implements high-speed volumetric imaging, it suffers from the cross-talk-generated noise from spatially coherent lasers. This noise reduces the transversal image resolution, which in turn, limits the wide adaptation of FF-SS-OCT for practical and clinical applications. Here, we introduce the novel spatiotemporal optical coherence (STOC) manipulation. In STOC the time-varying inhomogeneous phase masks are used to modulate the light incident on the sample. By properly adjusting these phase masks, the spatial coherence can be reduced. Consequently, the cross-talk-generated noise is suppressed ...

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    10. Novel approach for weld depth determination using optical coherence tomography measurement in laser deep penetration welding of aluminum and steel

      Novel approach for weld depth determination using optical coherence tomography measurement in laser deep penetration welding of aluminum and steel

      The optical coherence tomography (OCT) is a measuring technology which is well-established in medical engineering since the early 1990s. More recently, the technology found its way into laser materials processing where it is used for seam tracking and inspection and also for monitoring and control of deep-penetration laser welding. In this work, deep-penetration laser welding of aluminum and steel using an OCT-system for in-process monitoring of the weld depth was investigated. It is shown that statistical data processing is mandatory to extract the actual keyhole depth. Therefore, two different measures, percentile filtering and considering the frequency distribution of the OCT-data ...

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    11. Post-doctoral Adaptive Optics Research Fellow at U.S. Food and Drug Administration

      Post-doctoral Adaptive Optics Research Fellow at U.S. Food and Drug Administration

      Seeking a highly motivated post-doctoral Adaptive Optics Research Fellow to work at the U.S. Food and Drug Administration, Center for Devices and Radiological Health. The candidate will work in the Division of Biomedical Physics under the direction of Drs. Zhuolin Liu and Daniel X. Hammer and perform research with the FDA multimodal adaptive optics (mAO) imager. The FDA mAO imaging system allows visualization of different retinal cells, including ganglion cells, retinal pigment epithelial cells, and photoreceptors. The candidate will be expected to: conduct human imaging in healthy and diseased eyes, perform data processing, analysis and presentation, develop new and ...

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    12. New England College of Optometry Professor Releases OCT Visual Atlas app – OCTaVIA

      New England College of Optometry Professor Releases OCT Visual Atlas app – OCTaVIA

      OCTaVIA, a visual reference OCT app, is now available free to eye care professionals and optometry/ophthalmology students of all levels on the Apple App Store. The iOS Optical Coherence Tomography (OCT) app was developed by Dr. Elena Z Biffi, Assistant Professor, New England College of Optometry (NECO) and attending optometrist at South Boston Community Health Center to assist in the diagnosis and management of retinal disorders in their daily practice. Dr. Biffi notes, “There is an urgent need in education and clinical practice for a dedicated smartphone/tablet app that can present a well-annotated OCT images for multiple diseases ...

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    13. PhD Studentship in Biomedical Optics and Retinal Imaging at The University of Illinois at Chicago

      PhD Studentship in Biomedical Optics and Retinal Imaging at The University of Illinois at Chicago

      A PhD position is available in the Biomedical Optics and Functional Imaging group within the Department of Bioengineering, University of Illinois at Chicago. Our research lab is working on ultra-wide field fundus photography, functional optical coherence tomography (OCT), OCT angiography (OCTA), super-resolution ophthalmoscopy, retinal image analysis and classification ( https://yaolab.bioe.uic.edu/ ). The PhD student will be involved for imaging instrument development and/or experimental study of retinal morphology & physiology. The specific study plan of the student can be flexible based on his/her education background and interest. The successful candidate should have a BS/MS degree in Optical ...

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      Mentions: Xincheng Yao
    1-13 of 13
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