Hemodynamic measurements from individual blood cells in early mammalian embryos with Doppler swept source OCT

Entities Mentioned

• University of Houston
• Kirill V. Larin
• Baylor College of Medicine

1. The most common and lethal birth defects affect the cardiovascular (CV) system. The mouse is a superior model for identifying and understanding mammalian CV birth defects, but there is a great need for tools that can detect early and subtle deficiencies in cardiac function in mouse embryos. We combined swept source optical coherence tomography (SS-OCT) with live mouse embryo culture protocols to generate structural two-dimensional and three-dimensional imaging and hemodynamic measurements in a live 8.5 day embryo just a few hours after the beginning of a heartbeat. Our data show that individual circulating blood cells can be visualized with structural ... (Read Full Article)

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