1. Measuring 3D Optic Nerve Head Deformations using Digital Volume Correlation of in vivo Optical Coherence Tomography Data (Thesis)

    Measuring 3D Optic Nerve Head Deformations using Digital Volume Correlation of in vivo Optical Coherence Tomography Data (Thesis)

    The optic nerve head (ONH), located in the back of the eye, is a critical site in understanding the pathophysiology of glaucoma. However, longitudinal changes of the ONH as disease develops have not been well characterized. Our goal was to develop an improved tool to quantify these changes in an in vivo monkey model of glaucoma. Longitudinal spectral-domain optical coherence tomography (OCT) imaging of the ONH was performed every other week under manometric intraocular pressure (IOP) control (10 mmHg) in a monkey during baseline and after induction of unilateral experimental glaucoma. We developed a computational pipeline that applied digital volume ...

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