1. Synthesis of NaGdF4:Er3+/Yb3+ Upconversion Particles as Exogenous Contrast Agent for Swept-Source Optical Coherence Tomography: In vitro Animal Tissue Imaging

    Synthesis of NaGdF4:Er3+/Yb3+ Upconversion Particles as Exogenous Contrast Agent for Swept-Source Optical Coherence Tomography: In vitro Animal Tissue Imaging

    Swept-source optical coherence tomography (SSOCT) is a non-contact, non-invasive bioimaging tool that usesvarious probes to get high contrast images. Rare-earth based upconversion particles (UCPs) providea uniqueplatform to enhance the capabilities of bioimaging techniques. The UCPs can act as contrast enhancers for SSOCT with additional optical functionality and hence in this work upconversion emission optimized PVP/NaGdF4:Er3+/Yb3+UCPs were synthesized and then injected to chicken breast tissues to enhance the SSOCT images. As synthesized samples have shown good biocompatibility towards HEK293, HeLa cell lines and showed apparent enhancement in contrast to SSOCT images. Additionally, compared to the bare NaGdF4 ...

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