1. Ultrahigh-Resolution Optical Coherence Tomography Investigation of Age-Related Changes in the Photoreceptors, Retinal Pigment Epithelium and Bruch’s Membrane

    Ultrahigh-Resolution Optical Coherence Tomography Investigation of Age-Related Changes in the Photoreceptors, Retinal Pigment Epithelium and Bruch’s Membrane

    Purpose : Aging is the biggest risk factor for age-related macular degeneration (AMD). Previous histological and ultrastructural studies have suggested that photoreceptors (PR), retinal pigment epithelium (RPE), and Bruch’s membrane (BM) undergo changes with aging and in AMD. A new high-speed, ultrahigh-resolution optical coherence tomography (UHR OCT) prototype instrument with depth tracking and software motion correction was used to investigate PR/RPE/BM alterations in normal aging and early AMD. Methods : We developed a high-speed UHR OCT instrument with 2.7 µm axial resolution and 128 kHz A-scan rate. A galvanometer scanner actuates the OCT reference arm to match the ...

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