Magnetic Resonance Contrast Agents in Optical Clearing: Prospects for Multimodal Tissue Imaging
Skin optical clearing effect ex vivo and in vivo was achieved by topical application of low molecular weight paramagnetic magnetic resonance contrast agents. This novel feature has not been explored before. By using collimated transmittance the diffusion coefficients of three clinically used magnetic resonance contrast agents, i.e. Gadovist®, Magnevist® and Dotarem® as well as X‐ray contrast agent Visipaque® in mouse skin were determined ex vivo as (4.29±0.39)×10 ‐7 cm 2 /sec, (5.00±0.72)×10 –7 cm 2 /sec, (3.72±0.67)×10 –7 cm 2 /sec, and (1.64±0.18 ...
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