1. Optical Coherence Tomography Angiography for Mapping Cerebral Microvasculature Based on Normalized Differentiation Analysis

    Optical Coherence Tomography Angiography for Mapping Cerebral Microvasculature Based on Normalized Differentiation Analysis

    Optical coherence tomography angiography (OCTA) is a label‐free, noninvasive biomedical imaging modality for mapping microvascular networks and quantifying blood flow velocities in vivo . Simple computation and fast processing are critical for the OCTA in some applications. Herein, we report on a normalized differentiation method for mapping cerebral microvasculature with the advantages of simple analysis and high image quality, benefitting from computation of differentiation and characteristics of normalization. Normalized differentiation values are validated to have a nearly linear relationship with flow velocities in a range using a flow phantom. The measurements in a rat cerebral cortex show that the OCTA ...

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