1. Retinal specialist versus artificial intelligence detection of retinal fluid from optical coherence tomography: AREDS2 10-year Follow-On

    Retinal specialist versus artificial intelligence detection of retinal fluid from optical coherence tomography: AREDS2 10-year Follow-On

    Purpose To evaluate the performance of retinal specialists in detecting retinal fluid presence in spectral domain optical coherence tomography (SD-OCT) macular volume scans from eyes with age-related macular degeneration (AMD), and to compare performance with the artificial intelligence (AI)-based Notal OCT Analyzer (NOA). Design Prospective comparison of retinal fluid grades from human retinal specialists and the NOA on SD-OCT scans from two commonly used devices (Cirrus and Spectralis). Participants 1,127 eyes of 651 Age-Related Eye Disease Study 2 10-year (AREDS2-10Y) participants with SD-OCT scans graded for fluid presence/absence by reading center (RC) graders. Methods The AREDS2-10Y investigators ...

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