Use of Optical Coherence Tomography Retinal Thickness Deviation Map for Hydroxychloroquine Retinopathy Screening
Objective To investigate the use of a retinal thickness deviation map generated from swept-source optical coherence tomography (SS-OCT) images for hydroxychloroquine (HCQ) retinopathy screening. Design Retrospective cohort study Subjects This study included 1,192 Korean patients with a history of HCQ treatment—881 (1,723 eyes) in the discovery set and 311 (591 eyes) in the validation set. Patients were screened for retinal toxicity using SS-OCT, fundus autofluorescence, and standard automated perimetry. Methods According to the 2016 American Academy of Ophthalmology guidelines, HCQ retinopathy was diagnosed by the presence of abnormalities on ≥1 objective structural tests alongside corresponding visual field ...
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