1. Multimodality Imaging-Based Characterization of Regional Material Properties in a Murine Model of Aortic Dissection

    Multimodality Imaging-Based Characterization of Regional Material Properties in a Murine Model of Aortic Dissection

    hronic infusion of angiotensin-II in atheroprone ( ApoE −/− ) mice provides a reproducible model of dissection in the suprarenal abdominal aorta, often with a false lumen and intramural thrombus that thickens the wall. Such lesions exhibit complex morphologies, with different regions characterized by localized changes in wall composition, microstructure, and properties. We sought to quantify the multiaxial mechanical properties of murine dissecting aneurysm samples by combining in vitro extension-distension data with full-field multimodality measurements of wall strain and thickness to inform an inverse material characterization using the virtual fields method. A key advance is the use of a digital volume correlation approach ...

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