1. ASSESSING TERATOGEN-INDUCED CHANGES IN MURINE FETAL BRAIN VASCULATURE USING IN UTERO OPTICAL COHERENCE TOMOGRAPHY (Thesis)

    ASSESSING TERATOGEN-INDUCED CHANGES IN MURINE FETAL BRAIN VASCULATURE USING IN UTERO OPTICAL COHERENCE TOMOGRAPHY (Thesis)

    This dissertation reports the use of in utero optical coherence tomography to evaluate changes in vasculature in a developing murine fetal brain caused due to prenatal exposure to teratogens. Embryogenesis is a highly complex process that is extremely vulnerable to external factors. Proper visualization of embryonic development is crucial to understand the basic physiological processes and identify defects if any. This dissertation is divided into two major sections: 1) assessing teratogen induced changes in the murine fetal brain vasculature during the second trimester equivalent period (chapters 2-4) and 2) combining optical coherence tomography with Brillouin microscopy to image and evaluate ...

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