1. Characterization of New Optical Imaging Biomarkers of Peripheral Nerve Overstimulation

    Characterization of New Optical Imaging Biomarkers of Peripheral Nerve Overstimulation

    An animal study was designed to explore the potentially damaging effects of electrical overstimulation on peripheral nerves using a polarization‐sensitive optical coherence tomography (PS‐OCT) imaging and stimulation platform. Lewis rats (n = 15) were divided into 3 groups with 2 different levels of stimulation applied to the exposed sciatic nerve: Group 1 (sham control): 0.0 mA/0 Hz, Group 2: 3.4 mA/50 Hz, and Group 3: 6.8 mA/100 Hz. On day 1, the protocol contains Von Frey and walking track behavioral tests, followed by sciatic nerve exposure surgery (left leg). Electrical stimulation of the ...

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