1. Intracardiac radiofrequency ablation in living swine guided by polarization-sensitive optical coherence tomography

    Intracardiac radiofrequency ablation in living swine guided by polarization-sensitive optical coherence tomography

    Significance: Pulmonary vein isolation with catheter-based radiofrequency ablation (RFA) is carried out frequently to treat atrial fibrillation. However, RFA lesion creation is only guided by indirect information (e.g., temperature, impedance, and contact force), which may result in poor lesion quality (e.g., nontransmural) and can lead to reoccurrence or complications. Aim: The feasibility of guiding intracardiac RFA with an integrated polarization-sensitive optical coherence tomography (PSOCT)-RFA catheter in the right atria (RA) of living swine is demonstrated. Approach : In total, 12 sparse lesions were created in the RA of three living swine using an integrated PSOCT-RFA catheter with standard ...

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