1. Heartbeat OCE: corneal biomechanical response to simulated heartbeat pulsation measured by optical coherence elastography

    Heartbeat OCE: corneal biomechanical response to simulated heartbeat pulsation measured by optical coherence elastography

    Significance: It is generally agreed that the corneal mechanical properties are strongly linked to many eye diseases and could be used to assess disease progression and response to therapies. Elastography is the most notable method of assessing corneal mechanical properties, but it generally requires some type of external excitation to induce a measurable displacement in the tissue. Aim: We present Heartbeat Optical Coherence Elastography (Hb-OCE), a truly passive method that can measure the elasticity of the cornea based on intrinsic corneal displacements induced by the heartbeat. Approach: Hb-OCE measurements were performed in untreated and UV-A/riboflavin cross-linked porcine corneas ex ...

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