1. Multi-parameter characterization of atherosclerotic plaques based on optical coherence tomography, photoacoustic and viscoelasticity imaging

    Multi-parameter characterization of atherosclerotic plaques based on optical coherence tomography, photoacoustic and viscoelasticity imaging

    Detection of atherosclerotic plaque vulnerability is the critical step in prevention of acute coronary events. Fibrous cap thickness, lipid core size, and inflammation extent are three key parameters for assessing plaque vulnerability. Here, we report on multimodality imaging of mice aortic plaques using a system that integrates optical coherence tomography (OCT), photoacoustic imaging (PAI), and photoacoustic viscoelasticity imaging (PAVEI). The thickness of fibrous cap is accurately evaluated by OCT, and PAI helps to determine the distribution and size of lipid core. The mechanical properties of plaques are closely related to the plaque compositions and the content and distribution of macrophages ...

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