1. Does cannabis use amplify the effect of prenatal alcohol exposure and vice versa?

    Does cannabis use amplify the effect of prenatal alcohol exposure and vice versa?

    An unforeseen consequence of normalization of marijuana use is that adolescents and adults of childbearing age are increasingly engaged in a practice of Simultaneous Alcohol and Cannabinoid (SAC) use, or co-ingestion. A recent U.S. hospital-based assessment revealed that at the time of birth, about 22% of assessed umbilical cords were positive for marijuana. "It is likely, given the documented synergy between ethanol and cannabinoids, that their combined ingestion will, as hypothesized, result in increased neurogenic and neurovascular deficits in exposed offspring," said Kirill Larin, University of Houston professor of biomedical engineering. Larin and collaborator Rajesh Miranda of Texas A ...

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    1. It is likely, given the documented synergy between ethanol and cannabinoids, that their combined ingestion will, as hypothesized, result in increased neurogenic and neurovascular deficits in exposed offspring.
    2. Our studies will focus on the effects of SAC on the formation of nerve tissue and blood vessels, the complementary growth that supports fetal brain development.
    3. With the increased potency of today's marijuana, as well as the street availability of potent synthetic cannabinoids, a re-evaluation of potential developmental harms is imperative.
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