1. A spectral-domain optical coherence tomographic analysis of Rdh5-/- mice retina

    A spectral-domain optical coherence tomographic analysis of Rdh5-/- mice retina

    Purpose To investigate the longitudinal findings of spectral-domain optical coherence tomography (SD-OCT) in relation to the morphologic features in Rdh5 knockout ( Rdh5 -/- ) mice. Materials and methods The mouse retina was segmented into four layers; the inner retinal (A), outer plexiform and outer nuclear (B), rod/cone (C), and retinal pigment epithelium (RPE)/choroid (D) layers. The thickness of each retinal layer of Rdh5 -/- mice was longitudinally and quantitatively measured at six time points from postnatal months (PM) 1 to PM6 using SD-OCT. Age-matched C57BL/6J mice were employed as wild-type controls. The data were statistically compared using Student’s t ...

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