1. Application of automated quantification of fluid volumes to anti-VEGF therapy of neovascular age-related macular degeneration

    Application of automated quantification of fluid volumes to anti-VEGF therapy of neovascular age-related macular degeneration

    Purpose Anti-VEGF treatment of neovascular age-related macular degeneration (AMD) is a highly effective advance in the retinal armentarium. Optical coherence tomography (OCT) offering three-dimensional imaging of the retina is widely used to guide treatment. Although poor outcomes reported from clinical practice are multifactorial, availability of reliable, reproducible, and quantitative evaluation tools to accurately measure the fluid response i.e. a “VEGF meter” may be a better means of monitoring and treating than the current purely qualitative evaluation used in clinical practice. Design Post-hoc analysis of a phase III, randomized, multicenter study. Participants Study eyes of 1095 treatment-naive subjects receiving pro-re-nata ...

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