1. Angiographic Imaging of an In Vivo Mouse Brain as a Guiding Star for Automatic Digital Refocusing in OCT

    Angiographic Imaging of an In Vivo Mouse Brain as a Guiding Star for Automatic Digital Refocusing in OCT

    A method allows the extraction of the recovery factor that maximizes the image contrast of OCT (optical coherence tomography) and/or OCTA (OCT angiography) of a living subject is proposed in this study. Due to the finite depth of focus in imaging optics, the volume OCT imaging suffers from blurriness in the lateral resolution. By utilizing the digital hologram method or angular spectrum method, the blurred image can be refocused. However, for in vivo OCT imaging, evaluation of the image focus is not easy, owing to the cloudy structure of the brain. In the proposed method, the blood flow signals ...

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