1. Researchers at OCT Medical Imaging Inc., along with researchers at Caltech and UCSD Develop Genetically Encodable and Acoustically Erasable Contrast Reagent for Optical Coherence Tomography

    Researchers at OCT Medical Imaging Inc., along with researchers at Caltech and UCSD Develop Genetically Encodable and Acoustically Erasable Contrast Reagent for Optical Coherence Tomography

    Dr. Ramalingam's group at OCT Medical Imaging in collaboration with researchers at Caltech and UCSD have developed, first genetically encodable and acoustically erasable contrast reagent for Optical Coherence Tomography (OCT). Here, we introduce gas vesicles, a class of naturally evolved gas-filled protein nanostructures, as genetically encodable OCT contrast agents. The differential refractive index of their gas compartments relative to surrounding aqueous tissue and their nanoscale motion enables gas vesicles to be detected by static and dynamic OCT. Furthermore, the OCT contrast of gas vesicles can be selectively erased in situ with ultrasound, allowing unambiguous assignment of their location. In this our group in association with researchers from Caltech and UCSD  demonstrate the use of gas vesicles as reporter genes in bacterial colonies and as purified contrast agents in vivo in the mouse retina. Our results expand the utility of OCT to image a wider variety of cellular and molecular processes.  This paper is Published online at

    https://pubs.acs.org/doi/10.1021/acsnano.9b08432

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