1. Novel, vessel anatomy adjusting drug‐coated balloon—Preclinical evaluation in peripheral porcine arteries

    Novel, vessel anatomy adjusting drug‐coated balloon—Preclinical evaluation in peripheral porcine arteries

    Background The diameter of balloons or stents is selected according to the estimated reference vessel diameter and do not adapt to the vessel anatomy. The aim of the present preclinical studies was to investigate a novel, vessel anatomy adjusting hypercompliant drug‐coated balloon catheter (HCDCB). Methods Hypercompliant balloon membranes were coated in a constricted state with high drug density. Drug adherence was investigated in vitro, transfer to the porcine peripheral arteries and longitudinal distribution in vivo. In young domestic swine, neointimal proliferation was induced by vessel overstretch and continuous irritation by permanent stents. Uncoated hypercompliant balloons (HCB), and standard uncoated ...

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