New Device Performs 3D “Optical Biopsies” Of Skin
DAMAE Medical and NKT Photonics have worked together under the Eurostar financing program to combine the cutting-edge Line-field Confocal Optical Coherence Tomography (LC-OCT) imaging technology, developed by DAMAE Medical, with the innovative supercontinuum laser technology provided by NKT Photonics.
With a broadband SuperK white light laser as a key component, DAMAE Medical has developed an in vivo skin imaging device which performs “optical biopsies” based on the new LC-OCT technology.
This unique technique couples the technological advantages of OCT and confocal microscopy: high resolution at high penetration depth. The broadband near-infrared light from the laser combined with high aperture microscope objectives guarantee an isotropic cellular resolution of 1 micron.
With the combination of 3 imaging modes – vertical, horizontal, and 3D – the handheld imaging probe enables the dermatologist to visualize the epidermis and dermis in real-time; and get a better understanding of skin pathologies at the cellular level thus accelerating their management and facilitating access to non-invasive diagnostics and treatments.
The LC-OCT device is used together with dermoscopy to provide a more accurate diagnosis. The device reduces the number of biopsies of benign lesions and allows earlier detection of melanoma and more precise diagnosis of non-melanoma skin cancers. Moreover, it can guide surgery with more accurate presurgical margins, avoiding unnecessarily large scars and reducing the risk of recurrence.
Moreover, 3D imaging capabilities at this level opens the way for leveraging from the potential of the finest image analysis technologies, providing access to robust algorithms for segmentation and quantification of skin microstructures, thus facilitating the dermatologist LC-OCT-based therapeutic decisions.
Anaïs Barut, CEO of DAMAE Medical, explains, “This cooperation is the natural extension of a fruitful collaboration initiated 3 years ago with the development of LC-OCT. The project has paved the way for the industrial scale-up of an unprecedented combination of technologies in the field of medical imaging”.
“It is truly exciting to see how our SuperK white light lasers are enabling this entirely new field of medical imaging. With their broad white light, they ensure the high-resolution images dermatologists need”, says Jesper Toft Olesen, Product Line Manager at NKT Photonics. “DAMAE’s cutting-edge device can save lives and we are proud to deliver the advanced lasers that make it all possible“.
Throughout Europe, a CE-marked clinical device is used in clinical trials to validate the accuracy of LC-OCT diagnostics in onco-dermatology before the launch onto the market by the end of 2020.
Get a live demonstration at Photonics West / BiOS, booth 3201
See a live presentation of the LC-OCT device at Photonics West, booth #3201 or attend talks by DAMAE Medical or NKT Photonics for more technical information on the LC-OCT technology and preliminary clinical results of its use in dermatological applications:
- Handheld line-field confocal optical coherence tomography for dermatology
Jonas Ogien, Olivier Levecq, Maxime Cazalas, Mariano Suppa, Véronique del Marmol, Josep Malvehy, Elisa Cinotti, Pietro Rubegni, Jean Luc Perrot, Arnaud Dubois
Sunday 2 February 2020 2:00 PM to 2:20 PM
- Video-mosaicking of human skin in vivo using handheld line-field confocal optical coherence tomography (poster)
Jonas Ogien, Anthony Daures, Maxime Cazalas, Olivier Levecq, Arnaud Dubois
Sunday 2 February 2020 5:30 PM to 7:00 PM
- Switchable vertical/horizontal section imaging with line-field confocal optical coherence tomography
Jonas Ogien, Olivier Levecq, Hicham Azimani, Arnaud Dubois
Tuesday 4 February 2020 1:30 PM to 1:45 PM
About DAMAE Medical
DAMAE Medical is an innovative French medical imaging company that aims to address the global issue of skin cancer by providing dermatologists with a new in vivo imaging device for an in-depth skin examination, based on Line-field Confocal Optical Coherence Tomography (LC-OCT). This unparalleled technology enables skin imaging with cellular-resolution similar to histology, without the need for tissue excision and processing. www.damaemedical.fr
CEO & co-founder
28 rue de Turbigo, 75003 Paris, France
About NKT Photonics
NKT Photonics is the leading supplier of high-performance fiber lasers and photonic crystal fibers. Our main markets are within imaging, sensing and material processing. Our products include ultrafast lasers, such as supercontinuum sources, low noise fiber lasers, distributed temperature sensing systems, and a wide range of specialty fibers. NKT Photonics has its headquarters in Denmark with sales and service worldwide. NKT Photonics is wholly owned by NKT A/S. www.nktphotonics.com
Jesper Toft Olsen
SuperK Product Line Manager
Blokken 84, 3460 Birkeroed, Denmark