1. Retinal nerve fibre layer imaging compared with histological measurements in a human eye

    Purpose A feasibility study comparing retinal nerve fibre layer (RNFL) thickness values obtained with imaging devices against RNFL thickness measurements obtained histologically in a human eye. Design A single patient scheduled for orbital exenteration, who still possessed a healthy functioning eye. Methods Before surgery, the eye was imaged using optical coherence tomography (OCT) and scanning laser polarimetry (SLP). After orbital exenteration, the globe was sectioned, and 100 equidistant RNFL thickness measurements were obtained for each of four concentric rings centred on the optic disc, with diameters of 3.0, 3.5, 4.0, and 4.5 mm. Results RNFL thickness ...

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