1. Enzymatic vitreolysis with recombinant microplasminogen and tissue plasminogen activator

    Purpose To generate microplasmin (Plm) using recombinant microplasminogen (Plg) and recombinant tissue plasminogen activator (rt-PA) before intravitreous injection and to investigate the efficacy of Plm in inducing posterior vitreous detachment (PVD). Methods Forty-eight female or male New Zealand white rabbits were randomized into three groups. Recombinant human Plg was incubated with rt-PA with a 200:1 molar ratio at 37°C for 40 min. The right eyes of groups 1, 2, and 3, were injected with 0.5, 1.0, and 1.5 U Plm in 0.1 ml respectively, and 0.1 ml balanced salt solution (BSS) was injected ...

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