1. The actinic dysplasia syndrome – diagnostic approaches defining a new concept in field carcinogenesis with multiple cSCC

    The actinic dysplasia syndrome – diagnostic approaches defining a new concept in field carcinogenesis with multiple cSCC

    Usually, SCC lesions are surrounded by a number of clinically visible and non‐visible (subclinical) areas of actinically damaged skin containing cells with dysplasia, and thus may be designated actinic dysplasia syndrome. The epithelial damage is caused mainly by UV radiation, inducing mutations in keratinocytes that may confer growth advantages resulting in preneoplastic fields. The development of visible dysplastic lesions (actinic keratosis – AK) and subsequent progression to invasive SCC requires further mutations in cancer‐associated genes, like tumour suppressor genes and cell cycle regulators. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) represent a considerable advantage for the investigation ...

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