1. Elastin peptides increase lung cancer cell growth in 3D models

    The lung is an organ heavily involved in cancer as both the origin of lung cancer and where metastases from tumours originating in other organs develop. Therefore, it is obvious that the interaction between cancer cells and lung tissue plays a role in cancer development, invasion, and/or growth. Out of all the components of the lung's extracellular matrix, elastin fragmentation products, the so-called elastin peptides, have been associated with tumour growth and invasion. Therefore, we studied using a 3D model whether elastin peptides could increase the proliferative activity of lung cancer cells. To this purpose, we grew lung ...
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