1. Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability

    Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability

    It is a widely believed paradigm that intimal angiogenesis in coronary atherosclerosis contributes to plaque instability through both hemorrhagic plaque expansion and cholesterol deposition. 1 However, this article supports an alternative concept in which angiogenesis is actually essential for plaque stabilization and healing. 2 , 3 The prevailing paradigm has its origins primarily in histopathology work from the 1980s by Barger’s group reported by Kamat et al. 4 We argue that misinterpretation of their results has skewed the understanding of vulnerable plaque for >35 years. This misconception still endures in recent plaque angiogenesis reviews, affecting understanding of acute coronary syndromes ...

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