1. Clinical Practice Settings vs Clinical Trials Is Artificial Intelligence the Answer?

    Clinical Practice Settings vs Clinical Trials Is Artificial Intelligence the Answer?

    At clinical conferences and in publications, use of the term real world is widespread. It describes physicians’ accumulated experience in treating patients. It is contrasted with academic trials. Randomized clinical trials differ from practice in that they have fixed prespecified inclusion and exclusion criteria, adherence to a prespecified protocol, and ideally good patient retention. Randomized clinical trials have an advantage against observational studies when comparing treatments because they largely control for confounders, bias, and chance. Patient and treatment selection bias, losses to follow-up, outcome measurement, and imaging variability as well as many other confounding and bias factors can have large ...

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