Cholesterol crystal-induced coronary inflammation: Insights from optical coherence tomography and pericoronary adipose tissue computed tomography attenuation
Vascular inflammation is a key driver of atherogenesis and atherothrombosis. 1 Free cholesterol accumulation within the arterial wall formulates cholesterol crystals, which incite a local inflammatory response. 1 Intracoronary optical coherence tomography (OCT) enables in vivo visualization of cholesterol crystals, shown to associate with features of plaque vulnerability. 2 Recent evidence demonstrates that coronary inflammation propagates “inside-out” to pericoronary adipose tissue (PCAT), with proinflammatory cytokines inhibiting adipocyte lipid accumulation.