1. Spectral domain - Optical coherence tomography (SD-OCT) as a monitoring tool for alterations in mouse lenses

    Spectral domain - Optical coherence tomography (SD-OCT) as a monitoring tool for alterations in mouse lenses

    The eye lens displayes a variety of phenotypes in the wake of genetical modifications or environmental influences. Therefore, a high-resolution in vivo imaging method for the lens is desirable. Optical coherence tomography (OCT) has become a powerful imaging tool in ophthalmology, especially for retinal imaging in small animal models such as mice. Here, we demonstrate an optimized approach specifically for anterior eye segment imaging with spectral domain OCT (SD-OCT) on several known murine lens cataract mutants. Scheimpflug and histological section images on the same eye were used in parallel to assess the observed pathologies. With SD-OCT images, we obtained detailed ...

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