Quantifying the effect of milli-molar glucose concentration on thickness of rabbit cornea with optical coherence tomography

Entities Mentioned

• University of Houston
• Kirill V. Larin
• Mohamad G. Ghosn

1. The cornea contributes about 65% of the eye's ability to refract light. Thus, any fluctuation in corneal thickness can cause noticeable changes in vision. The presence of glucose molecules induces a driving force for water to leave the collagen fibrils in the cornea due to the concentration gradient created, thus changing its thickness. In this study, the effect of various milli-molar glucose concentrations on corneal thickness was explored using Optical Coherence Tomography. Whole rabbit eyes were placed in a specially designed dish while immersed in saline to ensure proper hydration of the eye. The cornea was imaged for 10 minutes. ... (Read Full Article)

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