Clinical feasibility of optical coherence elastography for tumour margin assessment in breast-conserving surgery (Thesis)
Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to tumour being found within the margin of the excised lump, determined days following surgery. The work presented in this thesis aims to develop a widefield optical coherence elastography system suitable for intraoperative margin assessment to reduce additional procedures. Early feasibility studies are presented investigating the ability for three optical coherence elastography variants to visualise a range of tumour morphologies In human breast tissue. The thesis demonstrates the clinical feasibility of optical coherence elastography for tumour margin assessment and provides a strong foundation for future clinical translation.