1. Optical Coherence Tomography of Animal Models of Retinitis Pigmentosa: From Animal Studies to Clinical Applications

    Optical Coherence Tomography of Animal Models of Retinitis Pigmentosa: From Animal Studies to Clinical Applications

    Purpose . The aim of this study was to understand the relationship between the findings of spectral-domain optical coherence tomography (SD-OCT) of previously reported animal models of retinitis pigmentosa (RP) associated with known genetic mutations and their background structural and functional changes. Methods . We reviewed previous publications reporting the SD-OCT findings of animal models of RP and summarized the characteristic findings of SD-OCT in nine different animal models ( RCS –/– , RHO P23H, RHO S334ter, RHO –/– , Rpe65 –/– , rp12, Pde6β –/– (rd1 and rd10), and Arr1 –/– ) of human RP. Results . Despite the various abnormal structural changes found in these different animal models, progressive thinning of ...

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