1. Automated quantification of choriocapillaris anatomical features in ultrahigh-speed optical coherence tomography angiograms

    Automated quantification of choriocapillaris anatomical features in ultrahigh-speed optical coherence tomography angiograms

    In vivo visualization and quantification of choriocapillaris vascular anatomy is a fundamental step in understanding the relation between choriocapillaris degradation and atrophic retinopathies, including geographic atrophy. We describe a process utilizing ultrahigh-speed swept-source optical coherence tomography and a custom-designed “local min-max normalized masking” algorithm to extract in vivo anatomical metrics of the choriocapillaris. We used a swept-source optical coherence tomography system with a 1.6 MHz A-scan rate to image healthy retinas. With the postprocessing algorithm, we reduced noise, optimized visibility of vasculature, and skeletonized the vasculature within the images. These skeletonizations were in 89 % 89% agreement with those made ...

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