1. Functional-Optical Coherence Tomography: A non-invasive approach to assess the sympathetic nervous system and intrinsic vascular regulation

    Functional-Optical Coherence Tomography: A non-invasive approach to assess the sympathetic nervous system and intrinsic vascular regulation

    Sympathetic nervous system dysregulation and vascular impairment in neuronal tissue beds are hallmarks of prominent cardiorespiratory diseases. However, an accurate and convenient method of assessing SNA and local vascular regulation is lacking, hindering routine clinical and research assessments. To address this, we investigated whether spectral domain optical coherence tomography (OCT), that allows investigation of retina and choroid vascular responsiveness, reflects sympathetic activity in order to develop a quick, easy and non-invasive sympathetic index. Here, we compare choroid and retina vascular perfusion density (VPD) acquired with OCT and heart rate variability (HRV) to microneurography. We recruited 6 healthy males (26±3y ...

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