1. First Use of Optical Coherence Tomography on In Vivo Inflammatory Acne‐Like Lesions: A Murine Model

    First Use of Optical Coherence Tomography on In Vivo Inflammatory Acne‐Like Lesions: A Murine Model

    Background and Objectives Successful outcomes of clinical studies for acne vulgaris depend greatly on achieving statistically significant reduction in acne lesion count and improvement in Investigator's Global Assessment score of the investigational drug product against its vehicle control. To date, there has not been a validated preclinical acne model to evaluate investigational drug products in order to improve the probability of clinical success. An inflammatory acne‐like lesion mouse model developed in‐house has previously been used for clinical guidance in our drug development program. In this study, we aim to implement and assess the adequacy of swept‐source ...

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