1. Lessons Learned From Avastin and OCT–The Great, the Good, the Bad, and the Ugly

    Lessons Learned From Avastin and OCT–The Great, the Good, the Bad, and the Ugly

    Purpose: To describe the synergistic benefits and cost savings from the use of optical coherence tomography (OCT) and vascular endothelial growth factor (VEGF) inhibitors, particularly intravitreal bevacizumab, in the treatment of exudative age-related macular degeneration (AMD). Design: Retrospective literature review and personal perspective. Methods: Retrospective literature review and personal perspective. Results: The introduction of the first clinically useful OCT instrument coincided with early-phase clinical trials of a drug that would become known as ranibizumab. OCT provided a noninvasive imaging strategy that unambiguously showed the macular fluid associated with exudative AMD and the ability of anti-VEGF therapy to resolve this fluid ...

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