1. Use of Vibrational Optical Coherence Tomography to Characterize Skin Lesions and a Congenital Nevus

    Use of Vibrational Optical Coherence Tomography to Characterize Skin Lesions and a Congenital Nevus

    We have used vibrational optical coherence tomography (VOCT) to image and measure the mechanical properties of normal skin and skin lesions. It is observed that in a congenital nevus and normal skin, the cellular epidermis is qualitatively not as bright as in skin lesions including basal cell carcinoma, actinic keratosis and a melanocytic nevus. Melanin and cytochrome c oxidase are reported to attenuate the reflection of near-infrared light at a wavelength of 810 nm and therefore may explain the reduced reflection of light in a congenital nevus and normal skin under conditions where cytochrome c oxidase levels would be expected ...

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