1. In Vivo Characterization of the Deformation of the Human Optic Nerve Head Using Optical Coherence Tomography and Digital Volume Correlation

    In Vivo Characterization of the Deformation of the Human Optic Nerve Head Using Optical Coherence Tomography and Digital Volume Correlation

    We developed a method to measure the 3-dimensional (3D) strain field in the optic nerve head (ONH) in vivo between two intraocular pressures (IOP). Radial optical coherence tomography (OCT) scans were taken of the ONH of 5 eyes from 5 glaucoma patients before and after IOP-lowering surgery and from 5 eyes from 3 glaucoma suspect patients before and after raising IOP by wearing tight-fitting swimming goggles. Scans taken at higher and lower IOP were compared using a custom digital volume correlation (DVC) algorithm to calculate strains in the anterior lamina cribrosa (ALC), retina, and choroid. Changes in anterior lamina depth ...

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