1. Automated Deformation-Based Analysis of 3D Optical Coherence Tomography in Diabetic Retinopathy

    Automated Deformation-Based Analysis of 3D Optical Coherence Tomography in Diabetic Retinopathy

    Diabetic retinopathy (DR) is a significant microvascular complication of diabetes mellitus and a leading cause of vision impairment in working age adults. Optical coherence tomography (OCT) is a routinely used clinical tool to observe retinal structural and thickness alterations in DR. Pathological changes that alter the normal anatomy of the retina, such as intraretinal edema, pose great challenges for conventional layer-based analysis of OCT images. We present an alternative approach for the automated analysis of OCT volumes in DR research based on nonlinear registration. In our work, we first obtain an anatomically consistent volume of interest (VOI) in different OCT ...

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