1. Fabrication of thin and flexible PDMS membranes for biomechanical test applications

    For continuous analysis of mechanical properties of soft biological tissues during mechanical stimulation we developed a bioreactor to apply controlled periodic deflection to a probe. The probe attached on an elastic membrane produces a counterpressure if a certain gas volume is applied to the pressure chamber under the membrane. The related counterpressure-volume relationship describes the mechanical properties of the membrane-probe combination. To improve the signal-to-noise ratio of measurements the use of highly flexible membranes is advantageous. We developed a specific adapter, attached securely to the central thread of a centrifuge, to fabricate silicone membranes on carrier rings with reproducible mechanical ...
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