1. Application of optical coherence tomography and optical path length method for monitoring corneal thickness and refractive index change during corneal cross-linking

    Application of optical coherence tomography and optical path length method for monitoring corneal thickness and refractive index change during corneal cross-linking

    Corneal cross-linking (CXL) using UVA irradiation with a riboflavin photosensitizer has emerged as a new treatment paradigm for corneal ectatic disorders. The thickness threshold for protection of intraocular structures has often been challenged with ongoing developments, and corneal thinning becomes an important safety concern, especially for patients with thin corneas. In this study with an ex vivo bovine eye model, we monitored corneal thinning and corneal refractive index changes using optical coherence tomography (OCT) integrated with an adaptation of the optical path length method. CXL experiments were performed based on the standard protocol that includes removal of the corneal epithelium ...

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