1. Multi-scale and -contrast sensorless adaptive optics optical coherence tomography

    Multi-scale and -contrast sensorless adaptive optics optical coherence tomography

    Background: The roles of the retinal microvasculature and the retinal pigment epithelium (RPE) in maintaining the health and metabolic activity of the retina lend great clinical value to their high-resolution visualization. Methods: By integrating polarization diversity detection (PDD) into multi-scale and -contrast sensorless adaptive optics optical coherence tomography (MSC-SAO-OCT), we have developed a novel multi-contrast SAO OCT system for imaging pigment in the RPE as well as flow in the retinal capillaries using OCT angiography (OCTA). Aberration correction was performed based on the image quality using transmissive deformable optical elements. Results: MSC-SAO-OCTA imaging was performed at multiple fields-of-view (FOVs) with ...

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