1. Multimodal imaging including optical coherence tomography angiography in patients with type B Niemann–Pick disease

    Multimodal imaging including optical coherence tomography angiography in patients with type B Niemann–Pick disease

    Purpose To evaluate accumulation patterns of deposits in retinal layers of type B Niemann–Pick patients by multimodal imaging. Methods Seven patients with type B Niemann–Pick disease were included in this study. All participants underwent a complete ophthalmologic evaluation, high-resolution digital colour imaging, spectral-domain optical coherence tomography, blue light fundus autofluorescence and optical coherence tomography angiography (OCTA). Results We demonstrated different accumulation patterns in the retinal ganglion cell layer, the retinal nerve fibre layer and the subfoveolar region by multimodal imaging. Local retinal capillary nonflow areas in the superficial plexus, increased vascular tortuosity and deformed foveal avascular areas were ...

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