1. Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size

    Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size

    Knowledge of optical properties, such as the refractive index (RI), of biological tissues is important in optical imaging, as they influence the distribution and propagation of light in tissue. To accurately study the response of cancerous cells to drugs, optimised imaging protocols are required. This study uses a simple custom-built spectral domain optical coherence tomography (OCT) system to conduct RI measurements of multicellular spheroids, three-dimensional in-vitro culture systems, of the cell line HCT116. The spheroid RIs are compared to study the effect of growth time. To improve confocal microscopy imaging protocols, two immersion media (glycerol and ScaleView-A2) matching the spheroid ...

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